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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-87 Sentence denotes Estrogen receptor-mediated miR-486-5p regulation of OLFM4 expression in ovarian cancer.
TextSentencer_T2 88-223 Sentence denotes Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood.
TextSentencer_T3 224-479 Sentence denotes In a previous study we demonstrated that impairment of estrogen receptor alpha (ERα)-mediated olfactomedin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486-5p.
TextSentencer_T4 480-561 Sentence denotes In this study we investigated the role of OLFM4 in ovarian serous adenocarcinoma.
TextSentencer_T5 562-629 Sentence denotes Ovarian serous adenocarcinoma tissues had reduced OLFM4 expression.
TextSentencer_T6 630-801 Sentence denotes Expression of OLFM4 was positively correlated with ERα expression, and estrogen (E2) treatment in ovarian cancer cells induced OLFM4 expression in an ERα-dependent manner.
TextSentencer_T7 802-921 Sentence denotes In contrast to ERα, miR-486-5p levels were inversely correlated with OLFM4 expression in ovarian serous adenocarcinoma.
TextSentencer_T8 922-1101 Sentence denotes Ovarian cancer cells transfected with miR-486-5p mimics showed decreased OLFM4 mRNA expression, and ovarian cancer cells treated with E2 showed reduced cellular miR-486-5p levels.
TextSentencer_T9 1102-1190 Sentence denotes OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer cells.
TextSentencer_T10 1191-1293 Sentence denotes Low expression of OLFM4 was also associated with high tumor FIGO stage and poor tumor differentiation.
TextSentencer_T11 1294-1404 Sentence denotes These results suggest OLFM4 is downregulated by miR-486-5p, which contributes to ovarian cancer tumorigenesis.
TextSentencer_T12 1405-1562 Sentence denotes Conversely, estrogen receptor signaling downregulates miR-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer.
T1 0-87 Sentence denotes Estrogen receptor-mediated miR-486-5p regulation of OLFM4 expression in ovarian cancer.
T2 88-223 Sentence denotes Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood.
T3 224-479 Sentence denotes In a previous study we demonstrated that impairment of estrogen receptor alpha (ERα)-mediated olfactomedin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486-5p.
T4 480-561 Sentence denotes In this study we investigated the role of OLFM4 in ovarian serous adenocarcinoma.
T5 562-629 Sentence denotes Ovarian serous adenocarcinoma tissues had reduced OLFM4 expression.
T6 630-801 Sentence denotes Expression of OLFM4 was positively correlated with ERα expression, and estrogen (E2) treatment in ovarian cancer cells induced OLFM4 expression in an ERα-dependent manner.
T7 802-921 Sentence denotes In contrast to ERα, miR-486-5p levels were inversely correlated with OLFM4 expression in ovarian serous adenocarcinoma.
T8 922-1101 Sentence denotes Ovarian cancer cells transfected with miR-486-5p mimics showed decreased OLFM4 mRNA expression, and ovarian cancer cells treated with E2 showed reduced cellular miR-486-5p levels.
T9 1102-1190 Sentence denotes OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer cells.
T10 1191-1293 Sentence denotes Low expression of OLFM4 was also associated with high tumor FIGO stage and poor tumor differentiation.
T11 1294-1404 Sentence denotes These results suggest OLFM4 is downregulated by miR-486-5p, which contributes to ovarian cancer tumorigenesis.
T12 1405-1562 Sentence denotes Conversely, estrogen receptor signaling downregulates miR-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26871282-0#0#17#gene2099 88-255 gene2099 denotes Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr
26871282-0#27#34#gene619554 325-475 gene619554 denotes medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486
26871282-0#52#57#gene10562 995-1000 gene10562 denotes OLFM4
26871282-0#72#86#diseaseC0029925 1061-1183 diseaseC0029925 denotes owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer
26871282-0#72#86#diseaseC1140680 1061-1183 diseaseC1140680 denotes owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer
26871282-0#72#86#diseaseC0029925 1061-1183 diseaseC0029925 denotes owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer
26871282-0#72#86#diseaseC1140680 1061-1183 diseaseC1140680 denotes owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer
26871282-0#72#86#diseaseC0029925 1061-1183 diseaseC0029925 denotes owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer
26871282-0#72#86#diseaseC1140680 1061-1183 diseaseC1140680 denotes owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer
26871282-10#22#27#gene10562 1316-1321 gene10562 denotes OLFM4
26871282-10#96#109#diseaseC0596263 1390-1403 diseaseC0596263 denotes tumorigenesis
26871282-2#55#72#gene2099 279-296 gene2099 denotes estrogen receptor
26871282-2#94#108#gene10562 318-332 gene10562 denotes olfactomedin 4
26871282-2#110#115#gene10562 334-339 gene10562 denotes OLFM4
26871282-2#166#193#diseaseC0206687 390-417 diseaseC0206687 denotes endometrioid adenocarcinoma
26871282-2#166#193#diseaseC1569637 390-417 diseaseC1569637 denotes endometrioid adenocarcinoma
26871282-2#166#193#diseaseC0206687 390-417 diseaseC0206687 denotes endometrioid adenocarcinoma
26871282-2#166#193#diseaseC1569637 390-417 diseaseC1569637 denotes endometrioid adenocarcinoma
26871282-2#166#193#diseaseC0206687 390-417 diseaseC0206687 denotes endometrioid adenocarcinoma
26871282-2#166#193#diseaseC1569637 390-417 diseaseC1569637 denotes endometrioid adenocarcinoma
26871282-6#20#27#gene619554 822-829 gene619554 denotes miR-486
26871282-6#69#74#gene10562 871-876 gene10562 denotes OLFM4
26871282-6#89#118#diseaseC1335177 891-920 diseaseC1335177 denotes ovarian serous adenocarcinoma
0#17#gene209972#86#diseaseC0029925 26871282-0#0#17#gene2099 26871282-0#72#86#diseaseC0029925 associated_with "Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
0#17#gene209972#86#diseaseC1140680 26871282-0#0#17#gene2099 26871282-0#72#86#diseaseC1140680 associated_with "Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
0#17#gene209972#86#diseaseC0029925 26871282-0#0#17#gene2099 26871282-0#72#86#diseaseC0029925 associated_with "Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
0#17#gene209972#86#diseaseC1140680 26871282-0#0#17#gene2099 26871282-0#72#86#diseaseC1140680 associated_with "Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
0#17#gene209972#86#diseaseC0029925 26871282-0#0#17#gene2099 26871282-0#72#86#diseaseC0029925 associated_with "Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
0#17#gene209972#86#diseaseC1140680 26871282-0#0#17#gene2099 26871282-0#72#86#diseaseC1140680 associated_with "Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstr","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
27#34#gene61955472#86#diseaseC0029925 26871282-0#27#34#gene619554 26871282-0#72#86#diseaseC0029925 associated_with "medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
27#34#gene61955472#86#diseaseC1140680 26871282-0#27#34#gene619554 26871282-0#72#86#diseaseC1140680 associated_with "medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
27#34#gene61955472#86#diseaseC0029925 26871282-0#27#34#gene619554 26871282-0#72#86#diseaseC0029925 associated_with "medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
27#34#gene61955472#86#diseaseC1140680 26871282-0#27#34#gene619554 26871282-0#72#86#diseaseC1140680 associated_with "medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
27#34#gene61955472#86#diseaseC0029925 26871282-0#27#34#gene619554 26871282-0#72#86#diseaseC0029925 associated_with "medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
27#34#gene61955472#86#diseaseC1140680 26871282-0#27#34#gene619554 26871282-0#72#86#diseaseC1140680 associated_with "medin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486","owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
52#57#gene1056272#86#diseaseC0029925 26871282-0#52#57#gene10562 26871282-0#72#86#diseaseC0029925 associated_with OLFM4,"owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
52#57#gene1056272#86#diseaseC1140680 26871282-0#52#57#gene10562 26871282-0#72#86#diseaseC1140680 associated_with OLFM4,"owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
52#57#gene1056272#86#diseaseC0029925 26871282-0#52#57#gene10562 26871282-0#72#86#diseaseC0029925 associated_with OLFM4,"owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
52#57#gene1056272#86#diseaseC1140680 26871282-0#52#57#gene10562 26871282-0#72#86#diseaseC1140680 associated_with OLFM4,"owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
52#57#gene1056272#86#diseaseC0029925 26871282-0#52#57#gene10562 26871282-0#72#86#diseaseC0029925 associated_with OLFM4,"owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
52#57#gene1056272#86#diseaseC1140680 26871282-0#52#57#gene10562 26871282-0#72#86#diseaseC1140680 associated_with OLFM4,"owed reduced cellular miR-486-5p levels. OLFM4 knockdown enhanced proliferation, migration, and invasion by ovarian cancer"
22#27#gene1056296#109#diseaseC0596263 26871282-10#22#27#gene10562 26871282-10#96#109#diseaseC0596263 associated_with OLFM4,tumorigenesis
55#72#gene2099166#193#diseaseC0206687 26871282-2#55#72#gene2099 26871282-2#166#193#diseaseC0206687 associated_with estrogen receptor,endometrioid adenocarcinoma
55#72#gene2099166#193#diseaseC1569637 26871282-2#55#72#gene2099 26871282-2#166#193#diseaseC1569637 associated_with estrogen receptor,endometrioid adenocarcinoma
55#72#gene2099166#193#diseaseC0206687 26871282-2#55#72#gene2099 26871282-2#166#193#diseaseC0206687 associated_with estrogen receptor,endometrioid adenocarcinoma
55#72#gene2099166#193#diseaseC1569637 26871282-2#55#72#gene2099 26871282-2#166#193#diseaseC1569637 associated_with estrogen receptor,endometrioid adenocarcinoma
55#72#gene2099166#193#diseaseC0206687 26871282-2#55#72#gene2099 26871282-2#166#193#diseaseC0206687 associated_with estrogen receptor,endometrioid adenocarcinoma
55#72#gene2099166#193#diseaseC1569637 26871282-2#55#72#gene2099 26871282-2#166#193#diseaseC1569637 associated_with estrogen receptor,endometrioid adenocarcinoma
94#108#gene10562166#193#diseaseC0206687 26871282-2#94#108#gene10562 26871282-2#166#193#diseaseC0206687 associated_with olfactomedin 4,endometrioid adenocarcinoma
94#108#gene10562166#193#diseaseC1569637 26871282-2#94#108#gene10562 26871282-2#166#193#diseaseC1569637 associated_with olfactomedin 4,endometrioid adenocarcinoma
94#108#gene10562166#193#diseaseC0206687 26871282-2#94#108#gene10562 26871282-2#166#193#diseaseC0206687 associated_with olfactomedin 4,endometrioid adenocarcinoma
94#108#gene10562166#193#diseaseC1569637 26871282-2#94#108#gene10562 26871282-2#166#193#diseaseC1569637 associated_with olfactomedin 4,endometrioid adenocarcinoma
94#108#gene10562166#193#diseaseC0206687 26871282-2#94#108#gene10562 26871282-2#166#193#diseaseC0206687 associated_with olfactomedin 4,endometrioid adenocarcinoma
94#108#gene10562166#193#diseaseC1569637 26871282-2#94#108#gene10562 26871282-2#166#193#diseaseC1569637 associated_with olfactomedin 4,endometrioid adenocarcinoma
110#115#gene10562166#193#diseaseC0206687 26871282-2#110#115#gene10562 26871282-2#166#193#diseaseC0206687 associated_with OLFM4,endometrioid adenocarcinoma
110#115#gene10562166#193#diseaseC1569637 26871282-2#110#115#gene10562 26871282-2#166#193#diseaseC1569637 associated_with OLFM4,endometrioid adenocarcinoma
110#115#gene10562166#193#diseaseC0206687 26871282-2#110#115#gene10562 26871282-2#166#193#diseaseC0206687 associated_with OLFM4,endometrioid adenocarcinoma
110#115#gene10562166#193#diseaseC1569637 26871282-2#110#115#gene10562 26871282-2#166#193#diseaseC1569637 associated_with OLFM4,endometrioid adenocarcinoma
110#115#gene10562166#193#diseaseC0206687 26871282-2#110#115#gene10562 26871282-2#166#193#diseaseC0206687 associated_with OLFM4,endometrioid adenocarcinoma
110#115#gene10562166#193#diseaseC1569637 26871282-2#110#115#gene10562 26871282-2#166#193#diseaseC1569637 associated_with OLFM4,endometrioid adenocarcinoma
20#27#gene61955489#118#diseaseC1335177 26871282-6#20#27#gene619554 26871282-6#89#118#diseaseC1335177 associated_with miR-486,ovarian serous adenocarcinoma
69#74#gene1056289#118#diseaseC1335177 26871282-6#69#74#gene10562 26871282-6#89#118#diseaseC1335177 associated_with OLFM4,ovarian serous adenocarcinoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1634 0-17 gene:2099 denotes Estrogen receptor
T1635 72-86 disease:C0029925 denotes ovarian cancer
T1636 27-34 gene:619554 denotes miR-486
T1637 52-57 gene:10562 denotes OLFM4
T1638 279-296 gene:2099 denotes estrogen receptor
T1639 390-417 disease:C0206687 denotes endometrioid adenocarcinoma
T1640 318-332 gene:10562 denotes olfactomedin 4
T1641 334-339 gene:10562 denotes OLFM4
R1 T1634 T1635 associated_with Estrogen receptor,ovarian cancer
R2 T1634 T1635 associated_with Estrogen receptor,ovarian cancer
R3 T1636 T1635 associated_with miR-486,ovarian cancer
R4 T1636 T1635 associated_with miR-486,ovarian cancer
R5 T1637 T1635 associated_with OLFM4,ovarian cancer
R6 T1637 T1635 associated_with OLFM4,ovarian cancer
R7 T1638 T1639 associated_with estrogen receptor,endometrioid adenocarcinoma
R8 T1638 T1639 associated_with estrogen receptor,endometrioid adenocarcinoma
R9 T1640 T1639 associated_with olfactomedin 4,endometrioid adenocarcinoma
R10 T1640 T1639 associated_with olfactomedin 4,endometrioid adenocarcinoma
R11 T1641 T1639 associated_with OLFM4,endometrioid adenocarcinoma
R12 T1641 T1639 associated_with OLFM4,endometrioid adenocarcinoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 592-599 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 592-599 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues