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PubMed:26865366 JSONTXT

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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 291-301 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T2 829-835 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138

GoldHamster

Id Subject Object Predicate Lexical cue
T2 13-17 PR:P15692 denotes VEGF
T3 13-17 PR:Q00731 denotes VEGF
T5 13-17 PR:O73682 denotes VEGF
T6 13-17 PR:P16612 denotes VEGF
T7 13-17 PR:000017284 denotes VEGF
T8 13-17 PR:P67964 denotes VEGF
T1 13-17 D042461 denotes VEGF
T4 13-17 D042461 denotes VEGF
T9 18-22 SO:0000704 denotes gene
T10 121-125 UBERON:0010707 denotes limb
T11 121-125 UBERON:0002101 denotes limb
T12 121-125 UBERON:0005896 denotes limb
T13 209-217 D012421 denotes ruptures
T14 209-217 D012421 denotes ruptures
T16 285-315 P48798 denotes basic fibroblast growth factor
T17 285-315 Q60487 denotes basic fibroblast growth factor
T19 285-315 P15655 denotes basic fibroblast growth factor
T20 285-315 P03969 denotes basic fibroblast growth factor
T21 285-315 P13109 denotes basic fibroblast growth factor
T22 285-315 Q5IS69 denotes basic fibroblast growth factor
T23 285-315 P48800 denotes basic fibroblast growth factor
T24 285-315 P12226 denotes basic fibroblast growth factor
T25 285-315 P09038 denotes basic fibroblast growth factor
T26 285-315 P48799 denotes basic fibroblast growth factor
T27 285-315 PR:000007489 denotes basic fibroblast growth factor
T28 285-315 P20003 denotes basic fibroblast growth factor
T15 285-315 D016222 denotes basic fibroblast growth factor
T18 285-315 D016222 denotes basic fibroblast growth factor
T29 291-301 CL:0000057 denotes fibroblast
T31 291-315 GO:0005104 denotes fibroblast growth factor
T38 317-321 P48798 denotes bFGF
T39 317-321 Q60487 denotes bFGF
T40 317-321 P15655 denotes bFGF
T41 317-321 P03969 denotes bFGF
T42 317-321 P13109 denotes bFGF
T43 317-321 Q5IS69 denotes bFGF
T44 317-321 P48800 denotes bFGF
T45 317-321 P12226 denotes bFGF
T46 317-321 P09038 denotes bFGF
T47 317-321 P48799 denotes bFGF
T48 317-321 PR:000007489 denotes bFGF
T49 317-321 P20003 denotes bFGF
T50 326-360 D042461 denotes vascular endothelial growth factor
T52 326-360 D042461 denotes vascular endothelial growth factor
T51 326-360 GO:0005172 denotes vascular endothelial growth factor
T55 347-360 P08441 denotes growth factor
T56 347-360 P08072 denotes growth factor
T57 347-360 Q776B5 denotes growth factor
T58 347-360 Q6RZT5 denotes growth factor
T59 347-360 Q8V307 denotes growth factor
T61 362-366 PR:P15692 denotes VEGF
T62 362-366 PR:Q00731 denotes VEGF
T64 362-366 PR:O73682 denotes VEGF
T65 362-366 PR:P16612 denotes VEGF
T66 362-366 PR:000017284 denotes VEGF
T67 362-366 PR:P67964 denotes VEGF
T60 362-366 D042461 denotes VEGF
T63 362-366 D042461 denotes VEGF
T68 368-372 SO:0000704 denotes gene
T69 422-428 SO:0000440 denotes vector
T70 462-466 P48798 denotes bFGF
T71 462-466 Q60487 denotes bFGF
T72 462-466 P15655 denotes bFGF
T73 462-466 P03969 denotes bFGF
T74 462-466 P13109 denotes bFGF
T75 462-466 Q5IS69 denotes bFGF
T76 462-466 P48800 denotes bFGF
T77 462-466 P12226 denotes bFGF
T78 462-466 P09038 denotes bFGF
T79 462-466 P48799 denotes bFGF
T80 462-466 PR:000007489 denotes bFGF
T81 462-466 P20003 denotes bFGF
T83 470-474 PR:P15692 denotes VEGF
T84 470-474 PR:Q00731 denotes VEGF
T86 470-474 PR:O73682 denotes VEGF
T87 470-474 PR:P16612 denotes VEGF
T88 470-474 PR:000017284 denotes VEGF
T89 470-474 PR:P67964 denotes VEGF
T82 470-474 D042461 denotes VEGF
T85 470-474 D042461 denotes VEGF
T90 496-502 UBERON:0000043 denotes tendon
T91 554-560 UBERON:0000043 denotes tendon
T92 657-670 P08441 denotes growth factor
T93 657-670 P08072 denotes growth factor
T94 657-670 Q776B5 denotes growth factor
T95 657-670 Q6RZT5 denotes growth factor
T96 657-670 Q8V307 denotes growth factor
T97 657-679 GO:0008083 denotes growth factor activity
T98 710-714 P48798 denotes bFGF
T99 710-714 Q60487 denotes bFGF
T100 710-714 P15655 denotes bFGF
T101 710-714 P03969 denotes bFGF
T102 710-714 P13109 denotes bFGF
T103 710-714 Q5IS69 denotes bFGF
T104 710-714 P48800 denotes bFGF
T105 710-714 P12226 denotes bFGF
T106 710-714 P09038 denotes bFGF
T107 710-714 P48799 denotes bFGF
T108 710-714 PR:000007489 denotes bFGF
T109 710-714 P20003 denotes bFGF
T111 718-722 PR:P15692 denotes VEGF
T112 718-722 PR:Q00731 denotes VEGF
T114 718-722 PR:O73682 denotes VEGF
T115 718-722 PR:P16612 denotes VEGF
T116 718-722 PR:000017284 denotes VEGF
T117 718-722 PR:P67964 denotes VEGF
T110 718-722 D042461 denotes VEGF
T113 718-722 D042461 denotes VEGF
T118 829-844 D024042 denotes type I collagen
T120 836-844 2714 denotes collagen
T119 836-844 GO:0005202 denotes collagen
T123 855-868 GO:0005576 denotes extracellular
T124 869-878 CHEBI:25367 denotes molecules
T125 915-928 UBERON:2000098 denotes proliferation
T127 962-968 UBERON:0000043 denotes tendon
T128 1011-1015 P48798 denotes bFGF
T129 1011-1015 Q60487 denotes bFGF
T130 1011-1015 P15655 denotes bFGF
T131 1011-1015 P03969 denotes bFGF
T132 1011-1015 P13109 denotes bFGF
T133 1011-1015 Q5IS69 denotes bFGF
T134 1011-1015 P48800 denotes bFGF
T135 1011-1015 P12226 denotes bFGF
T136 1011-1015 P09038 denotes bFGF
T137 1011-1015 P48799 denotes bFGF
T138 1011-1015 PR:000007489 denotes bFGF
T139 1011-1015 P20003 denotes bFGF
T141 1064-1068 PR:P15692 denotes VEGF
T142 1064-1068 PR:Q00731 denotes VEGF
T144 1064-1068 PR:O73682 denotes VEGF
T145 1064-1068 PR:P16612 denotes VEGF
T146 1064-1068 PR:000017284 denotes VEGF
T147 1064-1068 PR:P67964 denotes VEGF
T140 1064-1068 D042461 denotes VEGF
T143 1064-1068 D042461 denotes VEGF
T148 1142-1151 SO:0000902 denotes transgene
T149 1231-1235 SO:0000704 denotes gene
T150 1268-1276 CHEBI:75958 denotes solution
T151 1341-1347 UBERON:0000043 denotes tendon
T152 1414-1420 UBERON:0000043 denotes tendon

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 100-143 DRI_Approach denotes Tendon injury during limb motion is common.
T2 144-281 DRI_Challenge denotes Damaged tendons heal poorly and frequently undergo unpredictable ruptures or impaired motion due to insufficient innate healing capacity.
T3 282-578 DRI_Approach denotes By basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) gene therapy via adeno-associated viral type-2 (AAV2) vector to produce supernormal amount of bFGF or VEGF intrinsically in the tendon, we effectively corrected the insufficiency of the tendon healing capacity.
T4 579-1127 DRI_Approach denotes This therapeutic approach (1) resulted in substantial amelioration of the low growth factor activity with significant increases in bFGF or VEGF from weeks 4 to 6 in the treated tendons (p < 0.05 or p < 0.01), (2) significantly promoted production of type I collagen and other extracellular molecules (p < 0.01) and accelerated cellular proliferation, and (3) significantly increased tendon strength by 68-91% from week 2 after AAV2-bFGF treatment and by 82-210% from week 3 after AAV2-VEGF compared with that of the controls (p < 0.05 or p < 0.01).
T5 1128-1201 DRI_Approach denotes Moreover, the transgene expression dissipated after healing was complete.
T6 1202-1430 DRI_Challenge denotes These findings show that the gene transfers provide an optimistic solution to the insufficiencies of the intrinsic healing capacity of the tendon and offers an effective therapeutic possibility for patients with tendon disunion.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 504-506 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T2 671-679 CVCL_C410|Hybridoma|Mus musculus denotes activity
T3 930-937 CVCL_B528|Embryonic_stem_cell|Homo sapiens denotes and (3)
T4 981-983 CVCL_ZC08|Finite_cell_line|Homo sapiens denotes 68
T5 1254-1256 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T6 1254-1256 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T7 1359-1361 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T8 1359-1361 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 107-113 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 91-98 Body_part denotes tendons http://purl.obolibrary.org/obo/MAT_0000301
T2 100-106 Body_part denotes Tendon http://purl.obolibrary.org/obo/MAT_0000301
T3 121-125 Body_part denotes limb http://purl.obolibrary.org/obo/MAT_0000090
T4 152-159 Body_part denotes tendons http://purl.obolibrary.org/obo/MAT_0000301
T5 496-502 Body_part denotes tendon http://purl.obolibrary.org/obo/MAT_0000301
T6 554-560 Body_part denotes tendon http://purl.obolibrary.org/obo/MAT_0000301
T7 756-763 Body_part denotes tendons http://purl.obolibrary.org/obo/MAT_0000301
T8 962-968 Body_part denotes tendon http://purl.obolibrary.org/obo/MAT_0000301
T9 1341-1347 Body_part denotes tendon http://purl.obolibrary.org/obo/MAT_0000301
T10 1414-1420 Body_part denotes tendon http://purl.obolibrary.org/obo/MAT_0000301

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 100-106 Body_part denotes Tendon http://purl.obolibrary.org/obo/UBERON_0000043
T2 121-125 Body_part denotes limb http://purl.obolibrary.org/obo/UBERON_0002101|http://purl.obolibrary.org/obo/UBERON_0010707
T4 291-301 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T5 496-502 Body_part denotes tendon http://purl.obolibrary.org/obo/UBERON_0000043
T6 554-560 Body_part denotes tendon http://purl.obolibrary.org/obo/UBERON_0000043
T7 855-868 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T8 962-968 Body_part denotes tendon http://purl.obolibrary.org/obo/UBERON_0000043
T9 1341-1347 Body_part denotes tendon http://purl.obolibrary.org/obo/UBERON_0000043
T10 1414-1420 Body_part denotes tendon http://purl.obolibrary.org/obo/UBERON_0000043