PubMed:26853551
Annnotations
sonoma2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 0-16 | GENE | denotes | Stem Cell Factor |
| T1 | 21-35 | GENE | denotes | Interleukin-31 |
| T2 | 36-46 | MPA | denotes | Expression |
| T3 | 48-59 | REG | denotes | Association |
| T4 | 65-68 | GENE | denotes | IgE |
| T5 | 98-104 | DISEASE | denotes | Atopic |
| T6 | 109-135 | DISEASE | denotes | Nonatopic Bronchial Asthma |
| T7 | 137-153 | DISEASE | denotes | Bronchial asthma |
| T8 | 167-188 | DISEASE | denotes | inflammatory disorder |
| T9 | 277-293 | GENE | denotes | stem cell factor |
| T10 | 295-298 | GENE | denotes | SCF |
| T11 | 304-318 | GENE | denotes | interleukin-31 |
| T12 | 320-325 | GENE | denotes | IL-31 |
| T13 | 331-335 | REG | denotes | play |
| T14 | 344-348 | REG | denotes | role |
| T15 | 352-368 | DISEASE | denotes | bronchial asthma |
| T16 | 416-427 | REG | denotes | association |
| T17 | 435-451 | GENE | denotes | stem cell factor |
| T18 | 456-470 | GENE | denotes | interleukin-31 |
| T19 | 471-481 | MPA | denotes | expression |
| T20 | 493-507 | GENE | denotes | immunoglobulin |
| T21 | 539-545 | DISEASE | denotes | atopic |
| T22 | 550-576 | DISEASE | denotes | nonatopic bronchial asthma |
| T23 | 560-576 | DISEASE | denotes | bronchial asthma |
| T24 | 600-603 | GENE | denotes | IgE |
| T25 | 713-723 | MPA | denotes | expression |
| T26 | 727-730 | GENE | denotes | SCF |
| T27 | 735-740 | GENE | denotes | IL-31 |
| T28 | 791-797 | MPA | denotes | levels |
| T29 | 801-804 | GENE | denotes | SCF |
| T30 | 814-820 | DISEASE | denotes | atopic |
| T31 | 866-872 | POSREG | denotes | higher |
| T32 | 1024-1029 | GENE | denotes | IL-31 |
| T33 | 1176-1187 | REG | denotes | correlation |
| T34 | 1196-1199 | GENE | denotes | SCF |
| T35 | 1201-1206 | GENE | denotes | IL-31 |
| T36 | 1265-1268 | GENE | denotes | IgE |
| T37 | 1365-1376 | REG | denotes | correlation |
| T38 | 1385-1388 | GENE | denotes | SCF |
| T39 | 1390-1395 | GENE | denotes | IL-31 |
| T40 | 1400-1412 | CPA | denotes | FEV-1/ FVC % |
| T41 | 1414-1417 | CPA | denotes | CRP |
| T42 | 1422-1430 | CPA | denotes | wheezing |
| T43 | 1422-1430 | DISEASE | denotes | wheezing |
| T44 | 1431-1438 | REG | denotes | existed |
| T45 | 1473-1476 | GENE | denotes | SCF |
| T46 | 1481-1486 | GENE | denotes | IL-31 |
| T47 | 1505-1509 | REG | denotes | role |
| T48 | 1523-1535 | MPA | denotes | inflammation |
| T49 | 1523-1535 | DISEASE | denotes | inflammation |
| T50 | 1540-1549 | POSREG | denotes | enhancing |
| T51 | 1550-1558 | CPA | denotes | severity |
| T52 | 1562-1575 | DISEASE | denotes | atopic asthma |
| T53 | 1622-1632 | REG | denotes | associated |
| T54 | 1650-1660 | NEGREG | denotes | reductions |
| T55 | 1664-1667 | GENE | denotes | SCF |
| T56 | 1672-1677 | GENE | denotes | IL-31 |
| T57 | 1683-1693 | MPA | denotes | expression |
| T58 | 1705-1717 | POSREG | denotes | improvements |
| T59 | 1721-1734 | CPA | denotes | lung function |
| T60 | 1736-1750 | CPA | denotes | symptom scores |
| T61 | 1755-1784 | CPA | denotes | bronchial hyperresponsiveness |
| T62 | 1755-1784 | DISEASE | denotes | bronchial hyperresponsiveness |
| T63 | 1802-1806 | CPA | denotes | PD20 |
| R0 | T0 | T2 | ThemeOf | Stem Cell Factor,Expression |
| R1 | T0 | T3 | ThemeOf | Stem Cell Factor,Association |
| R2 | T2 | T3 | ThemeOf | Expression,Association |
| R3 | T4 | T3 | ThemeOf | IgE,Association |
| R4 | T5 | T3 | ThemeOf | Atopic,Association |
| R5 | T6 | T3 | ThemeOf | Nonatopic Bronchial Asthma,Association |
| R6 | T9 | T13 | ThemeOf | stem cell factor,play |
| R7 | T9 | T14 | ThemeOf | stem cell factor,role |
| R8 | T10 | T13 | ThemeOf | SCF,play |
| R9 | T10 | T14 | ThemeOf | SCF,role |
| R10 | T11 | T13 | ThemeOf | interleukin-31,play |
| R11 | T11 | T14 | ThemeOf | interleukin-31,role |
| R12 | T12 | T13 | ThemeOf | IL-31,play |
| R13 | T12 | T14 | ThemeOf | IL-31,role |
| R14 | T14 | T13 | ThemeOf | role,play |
| R15 | T15 | T13 | ThemeOf | bronchial asthma,play |
| R16 | T15 | T14 | ThemeOf | bronchial asthma,role |
| R17 | T19 | T16 | ThemeOf | expression,association |
| R18 | T17 | T16 | ThemeOf | stem cell factor,association |
| R19 | T17 | T19 | ThemeOf | stem cell factor,expression |
| R20 | T18 | T16 | ThemeOf | interleukin-31,association |
| R21 | T18 | T19 | ThemeOf | interleukin-31,expression |
| R22 | T20 | T16 | ThemeOf | immunoglobulin,association |
| R23 | T20 | T19 | ThemeOf | immunoglobulin,expression |
| R24 | T21 | T16 | ThemeOf | atopic,association |
| R25 | T21 | T19 | ThemeOf | atopic,expression |
| R26 | T22 | T16 | ThemeOf | nonatopic bronchial asthma,association |
| R27 | T22 | T19 | ThemeOf | nonatopic bronchial asthma,expression |
| R28 | T26 | T25 | ThemeOf | SCF,expression |
| R29 | T27 | T25 | ThemeOf | IL-31,expression |
| R30 | T28 | T31 | ThemeOf | levels,higher |
| R31 | T29 | T28 | ThemeOf | SCF,levels |
| R32 | T29 | T31 | ThemeOf | SCF,higher |
| R33 | T30 | T28 | ThemeOf | atopic,levels |
| R34 | T30 | T31 | ThemeOf | atopic,higher |
| R35 | T34 | T33 | ThemeOf | SCF,correlation |
| R36 | T35 | T33 | ThemeOf | IL-31,correlation |
| R37 | T36 | T33 | ThemeOf | IgE,correlation |
| R38 | T37 | T44 | ThemeOf | correlation,existed |
| R39 | T38 | T37 | ThemeOf | SCF,correlation |
| R40 | T38 | T44 | ThemeOf | SCF,existed |
| R41 | T39 | T37 | ThemeOf | IL-31,correlation |
| R42 | T39 | T44 | ThemeOf | IL-31,existed |
| R43 | T40 | T37 | ThemeOf | FEV-1/ FVC %,correlation |
| R44 | T40 | T44 | ThemeOf | FEV-1/ FVC %,existed |
| R45 | T41 | T37 | ThemeOf | CRP,correlation |
| R46 | T41 | T44 | ThemeOf | CRP,existed |
| R47 | T42 | T37 | ThemeOf | wheezing,correlation |
| R48 | T42 | T44 | ThemeOf | wheezing,existed |
| R49 | T45 | T47 | ThemeOf | SCF,role |
| R50 | T46 | T47 | ThemeOf | IL-31,role |
| R51 | T48 | T47 | ThemeOf | inflammation,role |
| R52 | T51 | T47 | ThemeOf | severity,role |
| R53 | T51 | T50 | ThemeOf | severity,enhancing |
| R54 | T52 | T47 | ThemeOf | atopic asthma,role |
| R55 | T52 | T50 | ThemeOf | atopic asthma,enhancing |
| R56 | T52 | T51 | ThemeOf | atopic asthma,severity |
| R57 | T57 | T54 | ThemeOf | expression,reductions |
| R58 | T54 | T58 | CauseOf | reductions,improvements |
| R59 | T55 | T54 | ThemeOf | SCF,reductions |
| R60 | T55 | T57 | ThemeOf | SCF,expression |
| R61 | T56 | T54 | ThemeOf | IL-31,reductions |
| R62 | T56 | T57 | ThemeOf | IL-31,expression |
| R63 | T57 | T53 | ThemeOf | expression,associated |
| R64 | T59 | T58 | ThemeOf | lung function,improvements |
| R65 | T60 | T58 | ThemeOf | symptom scores,improvements |
| R66 | T61 | T58 | ThemeOf | bronchial hyperresponsiveness,improvements |
| R67 | T63 | T58 | ThemeOf | PD20,improvements |
sonoma
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T-0 | 0-16 | GENE | denotes | Stem Cell Factor |
| T-1 | 21-35 | GENE | denotes | Interleukin-31 |
| T-2 | 36-46 | MPA | denotes | Expression |
| T-3 | 48-59 | REG | denotes | Association |
| T-4 | 65-68 | GENE | denotes | IgE |
| T-5 | 98-104 | DISEASE | denotes | Atopic |
| T-6 | 109-135 | DISEASE | denotes | Nonatopic Bronchial Asthma |
| T-7 | 137-153 | DISEASE | denotes | Bronchial asthma |
| T-8 | 352-368 | DISEASE | denotes | bronchial asthma |
| T-9 | 416-427 | REG | denotes | association |
| T-10 | 435-451 | GENE | denotes | stem cell factor |
| T-11 | 456-470 | GENE | denotes | interleukin-31 |
| T-12 | 471-481 | MPA | denotes | expression |
| T-13 | 493-509 | GENE | denotes | immunoglobulin E |
| T-14 | 539-545 | DISEASE | denotes | atopic |
| T-15 | 550-576 | DISEASE | denotes | nonatopic bronchial asthma |
| T-16 | 600-603 | GENE | denotes | IgE |
| T-17 | 713-723 | MPA | denotes | expression |
| T-18 | 727-730 | GENE | denotes | SCF |
| T-19 | 735-740 | GENE | denotes | IL-31 |
| T-20 | 791-797 | MPA | denotes | levels |
| T-21 | 801-804 | GENE | denotes | SCF |
| T-22 | 866-872 | POSREG | denotes | higher |
| T-23 | 1176-1187 | REG | denotes | correlation |
| T-24 | 1196-1199 | GENE | denotes | SCF |
| T-25 | 1201-1206 | GENE | denotes | IL-31 |
| T-26 | 1365-1376 | REG | denotes | correlation |
| T-27 | 1385-1388 | GENE | denotes | SCF |
| T-28 | 1390-1395 | GENE | denotes | IL-31 |
| T-29 | 1400-1412 | CPA | denotes | FEV-1/ FVC % |
| T-30 | 1414-1417 | CPA | denotes | CRP |
| T-31 | 1422-1430 | DISEASE | denotes | wheezing |
| T-32 | 1523-1535 | MPA | denotes | inflammation |
| T-33 | 1540-1549 | POSREG | denotes | enhancing |
| T-34 | 1550-1558 | CPA | denotes | severity |
| T-35 | 1562-1575 | DISEASE | denotes | atopic asthma |
| T-36 | 1650-1660 | NEGREG | denotes | reductions |
| T-37 | 1664-1667 | GENE | denotes | SCF |
| T-38 | 1672-1677 | GENE | denotes | IL-31 |
| T-39 | 1683-1693 | MPA | denotes | expression |
| T-40 | 1705-1717 | POSREG | denotes | improvements |
| T-41 | 1721-1734 | CPA | denotes | lung function |
| T-42 | 1736-1750 | CPA | denotes | symptom scores |
| T-43 | 1755-1800 | CPA | denotes | bronchial hyperresponsiveness to methacholine |
| R-7 | T-38 | T-39 | ThemeOf | IL-31,expression |
| R-8 | T-39 | T-36 | ThemeOf | expression,reductions |
| R-9 | T-43 | T-40 | ThemeOf | bronchial hyperresponsiveness to methacholine,improvements |
| R-10 | T-42 | T-40 | ThemeOf | symptom scores,improvements |
| R-11 | T-21 | T-22 | ThemeOf | SCF,higher |
| R-12 | T-21 | T-20 | ThemeOf | SCF,levels |
| R-13 | T-41 | T-40 | ThemeOf | lung function,improvements |
| R-14 | T-6 | T-3 | ThemeOf | Nonatopic Bronchial Asthma,Association |
| R-15 | T-10 | T-9 | ThemeOf | stem cell factor,association |
| R-16 | T-19 | T-17 | ThemeOf | IL-31,expression |
| R-17 | T-18 | T-17 | ThemeOf | SCF,expression |
| R-24 | T-20 | T-22 | ThemeOf | levels,higher |
| R-25 | T-24 | T-23 | ThemeOf | SCF,correlation |
| R-26 | T-25 | T-23 | ThemeOf | IL-31,correlation |
| R-27 | T-30 | T-26 | ThemeOf | CRP,correlation |
| R-28 | T-29 | T-26 | ThemeOf | FEV-1/ FVC %,correlation |
| R-0 | T-0 | T-2 | ThemeOf | Stem Cell Factor,Expression |
| R-1 | T-1 | T-2 | ThemeOf | Interleukin-31,Expression |
| R-2 | T-35 | T-34 | ThemeOf | atopic asthma,severity |
| R-3 | T-35 | T-33 | ThemeOf | atopic asthma,enhancing |
| R-4 | T-37 | T-36 | ThemeOf | SCF,reductions |
| R-5 | T-37 | T-39 | ThemeOf | SCF,expression |
| R-6 | T-38 | T-36 | ThemeOf | IL-31,reductions |
| R-18 | T-14 | T-9 | ThemeOf | atopic,association |
| R-19 | T-15 | T-9 | ThemeOf | nonatopic bronchial asthma,association |
| R-20 | T-11 | T-12 | ThemeOf | interleukin-31,expression |
| R-21 | T-12 | T-9 | ThemeOf | expression,association |
| R-22 | T-2 | T-3 | ThemeOf | Expression,Association |
| R-23 | T-5 | T-3 | ThemeOf | Atopic,Association |
| R-29 | T-34 | T-33 | ThemeOf | severity,enhancing |
| R-30 | T-4 | T-3 | ThemeOf | IgE,Association |
| R-31 | T-13 | T-9 | ThemeOf | immunoglobulin E,association |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-47 | Sentence | denotes | Stem Cell Factor and Interleukin-31 Expression: |
| T2 | 48-136 | Sentence | denotes | Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma. |
| T3 | 137-236 | Sentence | denotes | Bronchial asthma is a chronic inflammatory disorder which remains a significant cause of morbidity. |
| T4 | 237-369 | Sentence | denotes | Recently, it has been reported that the stem cell factor (SCF) and interleukin-31 (IL-31) may play a major role in bronchial asthma. |
| T5 | 370-577 | Sentence | denotes | The aim of the current study was to study the association of the stem cell factor and interleukin-31 expression with serum immunoglobulin E among Egyptian patients with atopic and nonatopic bronchial asthma. |
| T6 | 578-786 | Sentence | denotes | After measuring serum IgE using total enzyme linked immunosorbent assay (ELISA), Ribonucleic acid (RNA) was isolated to determine gene expression of SCF and IL-31 by real-time polymerase chain reaction (PCR). |
| T7 | 787-951 | Sentence | denotes | The levels of SCF mRNAs in atopic asthmatic patients' PBMCs were significantly higher than those in controls (p = 0.0001**) and nonatopic asthmatics (p = 0.0001**). |
| T8 | 952-1137 | Sentence | denotes | There was a high statistical significant difference also with regard to IL-31 between atopic asthmatics and controls (p = 0.0001**) and between them and nonatopic patients (p = 0.014*). |
| T9 | 1138-1355 | Sentence | denotes | There was a strong significant direct correlation between SCF, IL-31 (r = 0.827 and p = 0.0001**) and between both of them and IgE in asthmatics (r = 0.543 and p = 0.0001**) (r = 0.443 and p = 0.0001**), respectively. |
| T10 | 1356-1439 | Sentence | denotes | A direct correlation between SCF, IL-31 and FEV-1/ FVC %, CRP and wheezing existed. |
| T11 | 1440-1576 | Sentence | denotes | These findings suggest that both SCF and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma. |
| T12 | 1577-1843 | Sentence | denotes | Augmented inhaled glucocorticoid therapy was associated with significant reductions in SCF and IL-31 mRNA expression as well as improvements in lung function, symptom scores and bronchial hyperresponsiveness to methacholine (PD20) in atopic and nonatopic asthmatics. |
| T1 | 0-47 | Sentence | denotes | Stem Cell Factor and Interleukin-31 Expression: |
| T2 | 48-136 | Sentence | denotes | Association with IgE among Egyptian Patients with Atopic and Nonatopic Bronchial Asthma. |
| T3 | 137-236 | Sentence | denotes | Bronchial asthma is a chronic inflammatory disorder which remains a significant cause of morbidity. |
| T4 | 237-369 | Sentence | denotes | Recently, it has been reported that the stem cell factor (SCF) and interleukin-31 (IL-31) may play a major role in bronchial asthma. |
| T5 | 370-577 | Sentence | denotes | The aim of the current study was to study the association of the stem cell factor and interleukin-31 expression with serum immunoglobulin E among Egyptian patients with atopic and nonatopic bronchial asthma. |
| T6 | 578-786 | Sentence | denotes | After measuring serum IgE using total enzyme linked immunosorbent assay (ELISA), Ribonucleic acid (RNA) was isolated to determine gene expression of SCF and IL-31 by real-time polymerase chain reaction (PCR). |
| T7 | 787-951 | Sentence | denotes | The levels of SCF mRNAs in atopic asthmatic patients' PBMCs were significantly higher than those in controls (p = 0.0001**) and nonatopic asthmatics (p = 0.0001**). |
| T8 | 952-1137 | Sentence | denotes | There was a high statistical significant difference also with regard to IL-31 between atopic asthmatics and controls (p = 0.0001**) and between them and nonatopic patients (p = 0.014*). |
| T9 | 1138-1355 | Sentence | denotes | There was a strong significant direct correlation between SCF, IL-31 (r = 0.827 and p = 0.0001**) and between both of them and IgE in asthmatics (r = 0.543 and p = 0.0001**) (r = 0.443 and p = 0.0001**), respectively. |
| T10 | 1356-1439 | Sentence | denotes | A direct correlation between SCF, IL-31 and FEV-1/ FVC %, CRP and wheezing existed. |
| T11 | 1440-1576 | Sentence | denotes | These findings suggest that both SCF and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma. |
| T12 | 1577-1843 | Sentence | denotes | Augmented inhaled glucocorticoid therapy was associated with significant reductions in SCF and IL-31 mRNA expression as well as improvements in lung function, symptom scores and bronchial hyperresponsiveness to methacholine (PD20) in atopic and nonatopic asthmatics. |