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PubMed:26844271 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26844271-0#23#27#gene4613 23-27 gene4613 denotes MYCN
26844271-0#118#131#diseaseC0027819 118-131 diseaseC0027819 denotes Neuroblastoma
26844271-4#25#28#gene4609 436-439 gene4609 denotes MYC
26844271-4#63#76#diseaseC0027819 474-487 diseaseC0027819 denotes neuroblastoma
26844271-4#78#80#diseaseC0027819 489-491 diseaseC0027819 denotes NB
23#27#gene4613118#131#diseaseC0027819 26844271-0#23#27#gene4613 26844271-0#118#131#diseaseC0027819 associated_with MYCN,Neuroblastoma
25#28#gene460963#76#diseaseC0027819 26844271-4#25#28#gene4609 26844271-4#63#76#diseaseC0027819 associated_with MYC,neuroblastoma
25#28#gene460978#80#diseaseC0027819 26844271-4#25#28#gene4609 26844271-4#78#80#diseaseC0027819 associated_with MYC,NB

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2661 23-27 gene:4613 denotes MYCN
T2662 118-131 disease:C0027819 denotes Neuroblastoma
T2663 436-439 gene:4609 denotes MYC
T2664 474-487 disease:C0027819 denotes neuroblastoma
T2665 489-491 disease:C0027819 denotes NB
R1 T2661 T2662 associated_with MYCN,Neuroblastoma
R2 T2663 T2664 associated_with MYC,neuroblastoma
R3 T2663 T2665 associated_with MYC,NB

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells.
TextSentencer_T2 139-218 Sentence denotes Dysregulated expression of MYC family genes is a hallmark of many malignancies.
TextSentencer_T3 219-333 Sentence denotes Unfortunately, these proteins are not amenable to blockade by small molecules or protein-based therapeutic agents.
TextSentencer_T4 334-410 Sentence denotes Therefore, we must find alternative approaches to target MYC-driven cancers.
TextSentencer_T5 411-501 Sentence denotes Amplification of MYCN, a MYC family member, predicts high-risk neuroblastoma (NB) disease.
TextSentencer_T6 502-697 Sentence denotes We have shown that R9-caPep blocks the interaction of PCNA with its binding partners and selectively kills human NB cells, especially those with MYCN amplification, and we now show the mechanism.
TextSentencer_T7 698-776 Sentence denotes We found elevated levels of DNA replication stress in MYCN-amplified NB cells.
TextSentencer_T8 777-1009 Sentence denotes R9-caPep exacerbated DNA replication stress in MYCN-amplified NB cells and NB cells with an augmented level of MYC by interfering with DNA replication fork extension, leading to Chk1 dependence and susceptibility to Chk1 inhibition.
TextSentencer_T9 1010-1073 Sentence denotes We describe how these effects may be exploited for treating NB.
T1 0-138 Sentence denotes The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells.
T2 139-218 Sentence denotes Dysregulated expression of MYC family genes is a hallmark of many malignancies.
T3 219-333 Sentence denotes Unfortunately, these proteins are not amenable to blockade by small molecules or protein-based therapeutic agents.
T4 334-410 Sentence denotes Therefore, we must find alternative approaches to target MYC-driven cancers.
T5 411-501 Sentence denotes Amplification of MYCN, a MYC family member, predicts high-risk neuroblastoma (NB) disease.
T6 502-697 Sentence denotes We have shown that R9-caPep blocks the interaction of PCNA with its binding partners and selectively kills human NB cells, especially those with MYCN amplification, and we now show the mechanism.
T7 698-776 Sentence denotes We found elevated levels of DNA replication stress in MYCN-amplified NB cells.
T8 777-1009 Sentence denotes R9-caPep exacerbated DNA replication stress in MYCN-amplified NB cells and NB cells with an augmented level of MYC by interfering with DNA replication fork extension, leading to Chk1 dependence and susceptibility to Chk1 inhibition.
T9 1010-1073 Sentence denotes We describe how these effects may be exploited for treating NB.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 933-942 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extension

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 933-942 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extension