PubMed:26838602
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 882-901 | Disease | denotes | bacterial infection | http://purl.obolibrary.org/obo/MONDO_0005113 |
| T2 | 1502-1506 | Disease | denotes | pest | http://purl.obolibrary.org/obo/MONDO_0019095 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 342-348 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
| T2 | 1058-1064 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
| T3 | 1187-1193 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 342-348 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
| T2 | 1058-1064 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
| T3 | 1187-1193 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 882-901 | Disease | denotes | bacterial infection | MONDO:0005113 |
| T2 | 1502-1506 | Disease | denotes | pest | MONDO:0019095 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 588-598 | Organism | denotes | Drosophila | 2081351|32281|7215 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-118 | Sentence | denotes | Chitinases and Imaginal disc growth factors organize the extracellular matrix formation at barrier tissues in insects. |
| T2 | 119-293 | Sentence | denotes | The cuticle forms an apical extracellular-matrix (ECM) that covers exposed organs, such as epidermis, trachea and gut, for organizing morphogenesis and protection of insects. |
| T3 | 294-379 | Sentence | denotes | Recently, we reported that cuticle proteins and chitin are involved in ECM formation. |
| T4 | 380-509 | Sentence | denotes | However, molecular mechanisms that control assembly, maturation and replacement of the ECM and its components are not well known. |
| T5 | 510-725 | Sentence | denotes | Here we investigated the poorly described glyco-18-domain hydrolase family in Drosophila and identified the Chitinases (Chts) and imaginal-disc-growth-factors (Idgfs) that are essential for larval and adult molting. |
| T6 | 726-945 | Sentence | denotes | We demonstrate that Cht and idgf depletion results in deformed cuticles, larval and adult molting defects, and insufficient protection against wounding and bacterial infection, which altogether leads to early lethality. |
| T7 | 946-1099 | Sentence | denotes | We show that Cht2/Cht5/Cht7/Cht9/Cht12 and idgf1/idgf3/idgf4/idgf5/idgf6 are needed for organizing proteins and chitin-matrix at the apical cell surface. |
| T8 | 1100-1203 | Sentence | denotes | Our data indicate that normal ECM formation requires Chts, which potentially hydrolyze chitin-polymers. |
| T9 | 1204-1341 | Sentence | denotes | We further suggest that the non-enzymatic idgfs act as structural proteins to maintain the ECM scaffold against chitinolytic degradation. |
| T10 | 1342-1515 | Sentence | denotes | Conservation of Chts and Idgfs proposes analogous roles in ECM dynamics across the insect taxa, indicating that Chts/Idgfs are new targets for species specific pest control. |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 15-28 | Body_part | denotes | Imaginal disc | http://purl.obolibrary.org/obo/UBERON_0000939 |
| T2 | 44-52 | Body_part | denotes | organize | http://purl.obolibrary.org/obo/UBERON_0003062|http://purl.obolibrary.org/obo/UBERON_3010449|http://purl.obolibrary.org/obo/UBERON_3010457 |
| T5 | 57-77 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T6 | 123-130 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/UBERON_0001001|http://purl.obolibrary.org/obo/UBERON_0001002|http://purl.obolibrary.org/obo/UBERON_0004882 |
| T9 | 147-167 | Body_part | denotes | extracellular-matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T10 | 169-172 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T11 | 210-219 | Body_part | denotes | epidermis | http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0007376 |
| T13 | 221-228 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T16 | 233-236 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907 |
| T19 | 321-328 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/UBERON_0001001|http://purl.obolibrary.org/obo/UBERON_0001002|http://purl.obolibrary.org/obo/UBERON_0004882 |
| T22 | 365-368 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T23 | 467-470 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T24 | 640-653 | Body_part | denotes | imaginal-disc | http://purl.obolibrary.org/obo/UBERON_0000939 |
| T25 | 1130-1133 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T26 | 1295-1298 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T27 | 1401-1404 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 57-77 | Body_part | denotes | extracellular matrix | FMA:9672 |
| T2 | 99-106 | Body_part | denotes | tissues | FMA:9637 |
| T3 | 147-167 | Body_part | denotes | extracellular-matrix | FMA:9672 |
| T4 | 169-172 | Body_part | denotes | ECM | FMA:9672 |
| T5 | 210-219 | Body_part | denotes | epidermis | FMA:70596 |
| T6 | 221-228 | Body_part | denotes | trachea | FMA:7394 |
| T7 | 233-236 | Body_part | denotes | gut | FMA:7199 |
| T8 | 365-368 | Body_part | denotes | ECM | FMA:9672 |
| T9 | 467-470 | Body_part | denotes | ECM | FMA:9672 |
| T10 | 1086-1098 | Body_part | denotes | cell surface | FMA:67653 |
| T11 | 1130-1133 | Body_part | denotes | ECM | FMA:9672 |
| T12 | 1295-1298 | Body_part | denotes | ECM | FMA:9672 |
| T13 | 1401-1404 | Body_part | denotes | ECM | FMA:9672 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 15-28 | Body_part | denotes | Imaginal disc | http://purl.obolibrary.org/obo/MAT_0000064 |
| T2 | 123-130 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/MAT_0000150 |
| T3 | 140-146 | Body_part | denotes | apical | http://purl.obolibrary.org/obo/MAT_0000484 |
| T4 | 210-219 | Body_part | denotes | epidermis | http://purl.obolibrary.org/obo/MAT_0000154 |
| T5 | 221-228 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |
| T6 | 233-236 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/MAT_0000043 |
| T7 | 321-328 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/MAT_0000150 |
| T8 | 640-653 | Body_part | denotes | imaginal-disc | http://purl.obolibrary.org/obo/MAT_0000064 |
| T9 | 789-797 | Body_part | denotes | cuticles | http://purl.obolibrary.org/obo/MAT_0000150 |
| T10 | 1079-1085 | Body_part | denotes | apical | http://purl.obolibrary.org/obo/MAT_0000484 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 221-228 | OrganismTaxon | denotes | trachea | 988164 |
| T2 | 588-598 | OrganismTaxon | denotes | Drosophila | 2081351|32281|7215 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 15-28 | Body_part | denotes | Imaginal disc | http://purl.obolibrary.org/obo/MAT_0000064 |
| T2 | 123-130 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/MAT_0000150 |
| T3 | 140-146 | Body_part | denotes | apical | http://purl.obolibrary.org/obo/MAT_0000484 |
| T4 | 210-219 | Body_part | denotes | epidermis | http://purl.obolibrary.org/obo/MAT_0000154 |
| T5 | 221-228 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |
| T6 | 233-236 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/MAT_0000043 |
| T7 | 321-328 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/MAT_0000150 |
| T8 | 640-653 | Body_part | denotes | imaginal-disc | http://purl.obolibrary.org/obo/MAT_0000064 |
| T9 | 789-797 | Body_part | denotes | cuticles | http://purl.obolibrary.org/obo/MAT_0000150 |
| T10 | 1079-1085 | Body_part | denotes | apical | http://purl.obolibrary.org/obo/MAT_0000484 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 15-28 | Body_part | denotes | Imaginal disc | http://purl.obolibrary.org/obo/UBERON_0000939 |
| T2 | 44-52 | Body_part | denotes | organize | http://purl.obolibrary.org/obo/UBERON_0003062|http://purl.obolibrary.org/obo/UBERON_3010449|http://purl.obolibrary.org/obo/UBERON_3010457 |
| T5 | 57-77 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T6 | 123-130 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/UBERON_0001001|http://purl.obolibrary.org/obo/UBERON_0001002|http://purl.obolibrary.org/obo/UBERON_0004882 |
| T9 | 147-167 | Body_part | denotes | extracellular-matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T10 | 169-172 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T11 | 210-219 | Body_part | denotes | epidermis | http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0007376 |
| T13 | 221-228 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T16 | 233-236 | Body_part | denotes | gut | http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907 |
| T19 | 321-328 | Body_part | denotes | cuticle | http://purl.obolibrary.org/obo/UBERON_0001001|http://purl.obolibrary.org/obo/UBERON_0001002|http://purl.obolibrary.org/obo/UBERON_0004882 |
| T22 | 365-368 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T23 | 467-470 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T24 | 640-653 | Body_part | denotes | imaginal-disc | http://purl.obolibrary.org/obo/UBERON_0000939 |
| T25 | 1130-1133 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T26 | 1295-1298 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |
| T27 | 1401-1404 | Body_part | denotes | ECM | http://purl.obolibrary.org/obo/GO_0031012 |