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PubMed:26810187 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26810187-0#0#6#gene5111 108-114 gene5111 denotes Cyclin
26810187-0#70#75#gene2064 573-578 gene2064 denotes HER-2
26810187-0#93#106#diseaseC0006142 596-609 diseaseC0006142 denotes breast cancer
26810187-0#93#106#diseaseC0678222 596-609 diseaseC0678222 denotes breast cancer
26810187-0#93#106#diseaseC0006142 596-609 diseaseC0006142 denotes breast cancer
26810187-0#93#106#diseaseC0678222 596-609 diseaseC0678222 denotes breast cancer
0#6#gene511193#106#diseaseC0006142 26810187-0#0#6#gene5111 26810187-0#93#106#diseaseC0006142 associated_with Cyclin,breast cancer
0#6#gene511193#106#diseaseC0678222 26810187-0#0#6#gene5111 26810187-0#93#106#diseaseC0678222 associated_with Cyclin,breast cancer
0#6#gene511193#106#diseaseC0006142 26810187-0#0#6#gene5111 26810187-0#93#106#diseaseC0006142 associated_with Cyclin,breast cancer
0#6#gene511193#106#diseaseC0678222 26810187-0#0#6#gene5111 26810187-0#93#106#diseaseC0678222 associated_with Cyclin,breast cancer
70#75#gene206493#106#diseaseC0006142 26810187-0#70#75#gene2064 26810187-0#93#106#diseaseC0006142 associated_with HER-2,breast cancer
70#75#gene206493#106#diseaseC0678222 26810187-0#70#75#gene2064 26810187-0#93#106#diseaseC0678222 associated_with HER-2,breast cancer
70#75#gene206493#106#diseaseC0006142 26810187-0#70#75#gene2064 26810187-0#93#106#diseaseC0006142 associated_with HER-2,breast cancer
70#75#gene206493#106#diseaseC0678222 26810187-0#70#75#gene2064 26810187-0#93#106#diseaseC0678222 associated_with HER-2,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1842 108-114 gene:5111 denotes Cyclin
T1843 596-609 disease:C0006142 denotes breast cancer
T1844 573-578 gene:2064 denotes HER-2
R1 T1842 T1843 associated_with Cyclin,breast cancer
R2 T1842 T1843 associated_with Cyclin,breast cancer
R3 T1844 T1843 associated_with HER-2,breast cancer
R4 T1844 T1843 associated_with HER-2,breast cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-107 Sentence denotes Cyclin E amplification, over-expression, and relapse-free survival in HER-2-positive primary breast cancer.
TextSentencer_T2 108-205 Sentence denotes Cyclin E is a well-characterized cell cycle regulator and an amplified oncogene in breast cancer.
TextSentencer_T3 206-283 Sentence denotes Over-expression of cyclin E has generally been associated with poor survival.
TextSentencer_T4 284-396 Sentence denotes Recent studies have shown an interaction between HER-2 (ERBB2) and cyclin E, but the exact mechanism is unknown.
TextSentencer_T5 397-485 Sentence denotes Interestingly, cyclin E over-expression has been associated with trastuzumab resistance.
TextSentencer_T6 486-656 Sentence denotes We studied cyclin E over-expression, CCNE1 amplification, and relapse-free survival in HER-2-positive primary breast cancers treated with and without trastuzumab therapy.
TextSentencer_T7 657-760 Sentence denotes Formalin-fixed paraffin-embedded tissue samples from 202 HER-2-positive breast carcinomas were studied.
TextSentencer_T8 761-865 Sentence denotes Expression levels of cyclin E and proliferation marker Ki-67 were determined using immunohistochemistry.
TextSentencer_T9 866-1024 Sentence denotes Chromogenic in situ hybridization (CISH) with a gene-specific bacterial artificial chromosome (BAC) probe was used to analyze presence of CCNE1 amplification.
TextSentencer_T10 1025-1118 Sentence denotes Majority of HER-2-positive breast carcinomas exhibited nuclear staining for cyclin E protein.
TextSentencer_T11 1119-1180 Sentence denotes Cyclin E was highly expressed (≥50 % cells) in 37 % of cases.
TextSentencer_T12 1181-1256 Sentence denotes Incidence of CCNE1 amplification (≥6 gene copies/cell or clusters) was 8 %.
TextSentencer_T13 1257-1378 Sentence denotes Cyclin E amplification and over-expression were strongly associated with each other, grade, hormone receptors, and Ki-67.
TextSentencer_T14 1379-1557 Sentence denotes Neither high cyclin E expression nor CCNE1 amplification was associated with relapse-free survival (RFS) irrespective of short-term (9-week regimen) adjuvant trastuzumab therapy.
TextSentencer_T15 1558-1668 Sentence denotes These results confirm cyclin E and HER-2 gene co-amplification in a fraction of HER-2-positive breast cancers.
TextSentencer_T16 1669-1844 Sentence denotes Cyclin E is frequently over-expressed but appears to have limited value as a prognostic or predictive factor in HER-2-positive breast cancer regardless of trastuzumab therapy.
T1 0-107 Sentence denotes Cyclin E amplification, over-expression, and relapse-free survival in HER-2-positive primary breast cancer.
T2 108-205 Sentence denotes Cyclin E is a well-characterized cell cycle regulator and an amplified oncogene in breast cancer.
T3 206-283 Sentence denotes Over-expression of cyclin E has generally been associated with poor survival.
T4 284-396 Sentence denotes Recent studies have shown an interaction between HER-2 (ERBB2) and cyclin E, but the exact mechanism is unknown.
T5 397-485 Sentence denotes Interestingly, cyclin E over-expression has been associated with trastuzumab resistance.
T6 486-656 Sentence denotes We studied cyclin E over-expression, CCNE1 amplification, and relapse-free survival in HER-2-positive primary breast cancers treated with and without trastuzumab therapy.
T7 657-760 Sentence denotes Formalin-fixed paraffin-embedded tissue samples from 202 HER-2-positive breast carcinomas were studied.
T8 761-865 Sentence denotes Expression levels of cyclin E and proliferation marker Ki-67 were determined using immunohistochemistry.
T9 866-1024 Sentence denotes Chromogenic in situ hybridization (CISH) with a gene-specific bacterial artificial chromosome (BAC) probe was used to analyze presence of CCNE1 amplification.
T10 1025-1118 Sentence denotes Majority of HER-2-positive breast carcinomas exhibited nuclear staining for cyclin E protein.
T11 1119-1180 Sentence denotes Cyclin E was highly expressed (≥50 % cells) in 37 % of cases.
T12 1181-1256 Sentence denotes Incidence of CCNE1 amplification (≥6 gene copies/cell or clusters) was 8 %.
T13 1257-1378 Sentence denotes Cyclin E amplification and over-expression were strongly associated with each other, grade, hormone receptors, and Ki-67.
T14 1379-1557 Sentence denotes Neither high cyclin E expression nor CCNE1 amplification was associated with relapse-free survival (RFS) irrespective of short-term (9-week regimen) adjuvant trastuzumab therapy.
T15 1558-1668 Sentence denotes These results confirm cyclin E and HER-2 gene co-amplification in a fraction of HER-2-positive breast cancers.
T16 1669-1844 Sentence denotes Cyclin E is frequently over-expressed but appears to have limited value as a prognostic or predictive factor in HER-2-positive breast cancer regardless of trastuzumab therapy.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 93-99 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 191-197 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 596-602 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 729-735 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1052-1058 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1653-1659 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1796-1802 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 690-696 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 690-696 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 93-99 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 191-197 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 596-602 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 729-735 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1052-1058 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1653-1659 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1796-1802 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast