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PubMed:26795139 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26795139-1#0#13#gene5444 101-114 gene5444 denotes Paraoxonase-1
26795139-1#15#19#gene5444 116-120 gene5444 denotes PON1
26795139-1#103#118#diseaseC0004153 204-219 diseaseC0004153 denotes atherosclerosis
0#13#gene5444103#118#diseaseC0004153 26795139-1#0#13#gene5444 26795139-1#103#118#diseaseC0004153 associated_with Paraoxonase-1,atherosclerosis
15#19#gene5444103#118#diseaseC0004153 26795139-1#15#19#gene5444 26795139-1#103#118#diseaseC0004153 associated_with PON1,atherosclerosis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T147 101-114 gene:5444 denotes Paraoxonase-1
T148 204-219 disease:C0004153 denotes atherosclerosis
T149 116-120 gene:5444 denotes PON1
R1 T147 T148 associated_with Paraoxonase-1,atherosclerosis
R2 T149 T148 associated_with PON1,atherosclerosis

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-88 Sentence denotes Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis.
TextSentencer_T2 89-100 Sentence denotes OBJECTIVES:
TextSentencer_T3 101-268 Sentence denotes Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme implicated in the pathogenesis of atherosclerosis by protecting lipoproteins against peroxidation.
TextSentencer_T4 269-446 Sentence denotes PON1 has two genetic polymorphisms both due to amino acid substitution, one involving glutamine and arginine at position 192 and the other leucine and methionine at position 55.
TextSentencer_T5 447-542 Sentence denotes Recent reports suggest that nephrolithiasis and atherosclerosis share a number of risk factors.
TextSentencer_T6 543-679 Sentence denotes Our study aimed to compare the effects of PON1 192, PON1 55 polymorphisms, and PON1 activity in patients with urolithiasis and controls.
TextSentencer_T7 680-858 Sentence denotes MATERIALS AND METHODS: PON1's arylesterase/paraoxonase activities and phenotype were determined in 158 stone forming cases (Group 1) and 138 non-stone forming controls (Group 2).
TextSentencer_T8 859-981 Sentence denotes The PON1 192 and PON1 55 polymorphisms were studied by polymerase chain reaction/restriction fragment length polymorphism.
TextSentencer_T9 982-990 Sentence denotes RESULTS:
TextSentencer_T10 991-1105 Sentence denotes Paraoxonase activity was significantly lower in Group 1 than Group 2 (112 ± 31.8 vs. 208 ± 53.1 IU/L) (p < 0.001).
TextSentencer_T11 1106-1169 Sentence denotes The PON1 L55M polymorphism was significantly higher in Group 1.
TextSentencer_T12 1170-1235 Sentence denotes The "M" allele coding for PON1 was higher in Group 1 (p < 0.001).
TextSentencer_T13 1236-1359 Sentence denotes PON1 192 RR homozygotes had significantly higher PON1 activity than QR and QQ genotypes among all the patients (p < 0.001).
TextSentencer_T14 1360-1371 Sentence denotes CONCLUSION:
TextSentencer_T15 1372-1481 Sentence denotes The results of our study demonstrate that the PON1 55 gene "M" allele is associated with renal stone disease.
TextSentencer_T16 1482-1560 Sentence denotes Individuals possessing the "M" allele have a higher incidence of urolithiasis.
TextSentencer_T17 1561-1666 Sentence denotes The results of this study provide genetic evidence that the PON1 gene may play a role in stone formation.
TextSentencer_T18 1667-1770 Sentence denotes PON1 genotype determination may provide a tool to identify individuals who are at risk of urolithiasis.
T1 0-88 Sentence denotes Serum paraoxonase-1 gene polymorphism and enzyme activity in patients with urolithiasis.
T2 89-100 Sentence denotes OBJECTIVES:
T3 101-268 Sentence denotes Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme implicated in the pathogenesis of atherosclerosis by protecting lipoproteins against peroxidation.
T4 269-446 Sentence denotes PON1 has two genetic polymorphisms both due to amino acid substitution, one involving glutamine and arginine at position 192 and the other leucine and methionine at position 55.
T5 447-542 Sentence denotes Recent reports suggest that nephrolithiasis and atherosclerosis share a number of risk factors.
T6 543-679 Sentence denotes Our study aimed to compare the effects of PON1 192, PON1 55 polymorphisms, and PON1 activity in patients with urolithiasis and controls.
T7 680-858 Sentence denotes MATERIALS AND METHODS: PON1's arylesterase/paraoxonase activities and phenotype were determined in 158 stone forming cases (Group 1) and 138 non-stone forming controls (Group 2).
T8 859-981 Sentence denotes The PON1 192 and PON1 55 polymorphisms were studied by polymerase chain reaction/restriction fragment length polymorphism.
T9 982-990 Sentence denotes RESULTS:
T10 991-1105 Sentence denotes Paraoxonase activity was significantly lower in Group 1 than Group 2 (112 ± 31.8 vs. 208 ± 53.1 IU/L) (p < 0.001).
T11 1106-1169 Sentence denotes The PON1 L55M polymorphism was significantly higher in Group 1.
T12 1170-1235 Sentence denotes The "M" allele coding for PON1 was higher in Group 1 (p < 0.001).
T13 1236-1359 Sentence denotes PON1 192 RR homozygotes had significantly higher PON1 activity than QR and QQ genotypes among all the patients (p < 0.001).
T14 1360-1371 Sentence denotes CONCLUSION:
T15 1372-1481 Sentence denotes The results of our study demonstrate that the PON1 55 gene "M" allele is associated with renal stone disease.
T16 1482-1560 Sentence denotes Individuals possessing the "M" allele have a higher incidence of urolithiasis.
T17 1561-1666 Sentence denotes The results of this study provide genetic evidence that the PON1 gene may play a role in stone formation.
T18 1667-1770 Sentence denotes PON1 genotype determination may provide a tool to identify individuals who are at risk of urolithiasis.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 0-5 http://purl.obolibrary.org/obo/UBERON_0001977 denotes Serum

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 0-5 http://purl.obolibrary.org/obo/UBERON_0001977 denotes Serum