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PubMed:26786498 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 466-473 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 964-971 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 466-473 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 964-971 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 466-473 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 964-971 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes Profiling N-Linked Oligosaccharides from IgG by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection.
TextSentencer_T2 131-321 Sentence denotes Understanding and characterizing protein therapeutic glycosylation is important with growing evidence that glycosylation impacts biological efficacy, pharmacokinetics, and cellular toxicity.
TextSentencer_T3 322-447 Sentence denotes Protein expression systems and reactor conditions can impact glycosylation, leading to potentially undesirable glycosylation.
TextSentencer_T4 448-549 Sentence denotes For example, high-mannose species may be present, which are atypical of human antibody glycosylation.
TextSentencer_T5 550-645 Sentence denotes Their presence in the Fc domain has been linked to increased serum clearance of IgG antibodies.
TextSentencer_T6 646-821 Sentence denotes High-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) is an effective tool for determining glycans present in glycoprotein therapeutics.
TextSentencer_T7 822-895 Sentence denotes We report an improved HPAE-PAD method for IgG oligosaccharide separation.
TextSentencer_T8 896-1011 Sentence denotes The neutral glycans are well resolved, including separation of high-mannose species from typical human IgG glycans.
TextSentencer_T9 1012-1184 Sentence denotes Oligosaccharide identification was performed by comparison to known standards in conjunction with selective exoglycosidase digestion of both standards and released glycans.
TextSentencer_T10 1185-1358 Sentence denotes Retention times of known glycans were compared to the retention times of maltose, maltotriose, and maltotetraose standards to define a retention index value for each glycan.
TextSentencer_T11 1359-1494 Sentence denotes These retention indices were used to aid identification of glycans from an example monoclonal antibody sample of unknown glycosylation.
TextSentencer_T12 1495-1590 Sentence denotes Method ruggedness was evaluated across duplicate systems, analysts, and triplicate column lots.
TextSentencer_T13 1591-1769 Sentence denotes Comparing two systems with different analysts and columns, retention time precision RSDs were between 0.63 and 4.0% while retention indices precision RSDs ranged from 0.27-0.56%.
TextSentencer_T14 1770-1877 Sentence denotes The separation is orthogonal to capillary electrophoresis based separation of labeled IgG oligosaccharides.
T5 550-645 Sentence denotes Their presence in the Fc domain has been linked to increased serum clearance of IgG antibodies.
T6 646-821 Sentence denotes High-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) is an effective tool for determining glycans present in glycoprotein therapeutics.
T7 822-895 Sentence denotes We report an improved HPAE-PAD method for IgG oligosaccharide separation.
T8 896-1011 Sentence denotes The neutral glycans are well resolved, including separation of high-mannose species from typical human IgG glycans.
T9 1012-1184 Sentence denotes Oligosaccharide identification was performed by comparison to known standards in conjunction with selective exoglycosidase digestion of both standards and released glycans.
T10 1185-1358 Sentence denotes Retention times of known glycans were compared to the retention times of maltose, maltotriose, and maltotetraose standards to define a retention index value for each glycan.
T11 1359-1494 Sentence denotes These retention indices were used to aid identification of glycans from an example monoclonal antibody sample of unknown glycosylation.
T12 1495-1590 Sentence denotes Method ruggedness was evaluated across duplicate systems, analysts, and triplicate column lots.
T13 1591-1769 Sentence denotes Comparing two systems with different analysts and columns, retention time precision RSDs were between 0.63 and 4.0% while retention indices precision RSDs ranged from 0.27-0.56%.
T14 1770-1877 Sentence denotes The separation is orthogonal to capillary electrophoresis based separation of labeled IgG oligosaccharides.
T1 0-130 Sentence denotes Profiling N-Linked Oligosaccharides from IgG by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection.
T2 131-321 Sentence denotes Understanding and characterizing protein therapeutic glycosylation is important with growing evidence that glycosylation impacts biological efficacy, pharmacokinetics, and cellular toxicity.
T3 322-447 Sentence denotes Protein expression systems and reactor conditions can impact glycosylation, leading to potentially undesirable glycosylation.
T4 448-549 Sentence denotes For example, high-mannose species may be present, which are atypical of human antibody glycosylation.
T1 0-130 Sentence denotes Profiling N-Linked Oligosaccharides from IgG by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection.
T2 131-321 Sentence denotes Understanding and characterizing protein therapeutic glycosylation is important with growing evidence that glycosylation impacts biological efficacy, pharmacokinetics, and cellular toxicity.
T3 322-447 Sentence denotes Protein expression systems and reactor conditions can impact glycosylation, leading to potentially undesirable glycosylation.
T4 448-549 Sentence denotes For example, high-mannose species may be present, which are atypical of human antibody glycosylation.
T5 550-645 Sentence denotes Their presence in the Fc domain has been linked to increased serum clearance of IgG antibodies.
T6 646-821 Sentence denotes High-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) is an effective tool for determining glycans present in glycoprotein therapeutics.
T7 822-895 Sentence denotes We report an improved HPAE-PAD method for IgG oligosaccharide separation.
T8 896-1011 Sentence denotes The neutral glycans are well resolved, including separation of high-mannose species from typical human IgG glycans.
T9 1012-1184 Sentence denotes Oligosaccharide identification was performed by comparison to known standards in conjunction with selective exoglycosidase digestion of both standards and released glycans.
T10 1185-1358 Sentence denotes Retention times of known glycans were compared to the retention times of maltose, maltotriose, and maltotetraose standards to define a retention index value for each glycan.
T11 1359-1494 Sentence denotes These retention indices were used to aid identification of glycans from an example monoclonal antibody sample of unknown glycosylation.
T12 1495-1590 Sentence denotes Method ruggedness was evaluated across duplicate systems, analysts, and triplicate column lots.
T13 1591-1769 Sentence denotes Comparing two systems with different analysts and columns, retention time precision RSDs were between 0.63 and 4.0% while retention indices precision RSDs ranged from 0.27-0.56%.
T14 1770-1877 Sentence denotes The separation is orthogonal to capillary electrophoresis based separation of labeled IgG oligosaccharides.

ICD10

Id Subject Object Predicate Lexical cue
T1 1093-1104 http://purl.bioontology.org/ontology/ICD10/H10 denotes conjunction
T2 1093-1104 http://purl.bioontology.org/ontology/ICD10/H10.9 denotes conjunction

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T19 964-971 FMAID:82801 denotes mannose
_T1 19-35 FMAID:82742 denotes Oligosaccharides
_T2 19-35 FMAID:196731 denotes Oligosaccharides
_T3 41-44 FMAID:167179 denotes IgG
_T4 164-171 FMAID:165447 denotes protein
_T5 164-171 FMAID:67257 denotes protein
_T6 322-329 FMAID:67257 denotes Protein
_T7 322-329 FMAID:165447 denotes Protein
_T8 466-473 FMAID:196796 denotes mannose
_T9 466-473 FMAID:82801 denotes mannose
_T10 526-534 FMAID:167180 denotes antibody
_T11 611-616 FMAID:167330 denotes serum
_T12 630-633 FMAID:167179 denotes IgG
_T13 634-644 FMAID:167180 denotes antibodies
_T14 795-807 FMAID:62925 denotes glycoprotein
_T15 795-807 FMAID:167256 denotes glycoprotein
_T16 864-867 FMAID:167179 denotes IgG
_T17 868-883 FMAID:196731 denotes oligosaccharide
_T18 868-883 FMAID:82742 denotes oligosaccharide
_T20 964-971 FMAID:196796 denotes mannose
_T21 999-1002 FMAID:167179 denotes IgG
_T22 1012-1027 FMAID:196731 denotes Oligosaccharide
_T23 1012-1027 FMAID:82742 denotes Oligosaccharide
_T24 1330-1335 FMAID:214893 denotes index
_T25 1453-1461 FMAID:167180 denotes antibody
_T26 1578-1584 FMAID:76737 denotes column
_T27 1578-1584 FMAID:183891 denotes column
_T28 1641-1648 FMAID:76737 denotes columns
_T29 1641-1648 FMAID:183891 denotes columns
_T30 1802-1811 FMAID:63194 denotes capillary
_T31 1802-1811 FMAID:167591 denotes capillary
_T32 1856-1859 FMAID:167179 denotes IgG
_T33 1860-1876 FMAID:82742 denotes oligosaccharides
_T34 1860-1876 FMAID:196731 denotes oligosaccharides

uniprot-human

Id Subject Object Predicate Lexical cue
T1 734-737 http://www.uniprot.org/uniprot/Q8IX18 denotes PAD
T2 849-852 http://www.uniprot.org/uniprot/Q8IX18 denotes PAD

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1442-1452 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T2 1788-1798 http://purl.bioontology.org/ontology/NCBITAXON/1271577 denotes orthogonal
T3 1802-1811 http://purl.bioontology.org/ontology/NCBITAXON/241203 denotes capillary
T4 1802-1811 http://purl.bioontology.org/ontology/NCBITAXON/119095 denotes capillary

GO-BP

Id Subject Object Predicate Lexical cue
T1 71-79 http://purl.obolibrary.org/obo/GO_0015297 denotes Exchange
T2 669-677 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T3 184-197 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T4 238-251 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T5 383-396 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 433-446 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T7 535-548 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T8 1480-1493 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T9 303-311 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T10 1135-1144 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T11 1185-1194 http://purl.obolibrary.org/obo/GO_0051235 denotes Retention
T12 1239-1248 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T13 1320-1329 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T14 1365-1374 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T15 1650-1659 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T16 1713-1722 http://purl.obolibrary.org/obo/GO_0051235 denotes retention

GO-MF

Id Subject Object Predicate Lexical cue
T1 526-534 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2 634-644 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies

GO-CC

Id Subject Object Predicate Lexical cue
T1 630-644 http://purl.obolibrary.org/obo/GO_0071736 denotes IgG antibodies

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 611-616 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2 734-737 http://purl.obolibrary.org/obo/UBERON_2001977 denotes PAD
T3 849-852 http://purl.obolibrary.org/obo/UBERON_2001977 denotes PAD
T4 1802-1811 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillary

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 461-473 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose
T2 959-971 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 1848-1855 id denotes labeled

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 611-616 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 734-737 http://purl.obolibrary.org/obo/UBERON_2001977 denotes PAD
PD-UBERON-AE-B_T3 849-852 http://purl.obolibrary.org/obo/UBERON_2001977 denotes PAD
PD-UBERON-AE-B_T4 1802-1811 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillary

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1258-1265 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1675-1679 Disease denotes RSDs http://purl.obolibrary.org/obo/MONDO_0011441
T2 1741-1745 Disease denotes RSDs http://purl.obolibrary.org/obo/MONDO_0011441

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1258-1265 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1802-1811 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 520-525 Organism denotes human 9606
T2 993-998 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes Profiling N-Linked Oligosaccharides from IgG by High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection.
T2 131-321 Sentence denotes Understanding and characterizing protein therapeutic glycosylation is important with growing evidence that glycosylation impacts biological efficacy, pharmacokinetics, and cellular toxicity.
T3 322-447 Sentence denotes Protein expression systems and reactor conditions can impact glycosylation, leading to potentially undesirable glycosylation.
T4 448-549 Sentence denotes For example, high-mannose species may be present, which are atypical of human antibody glycosylation.
T5 550-645 Sentence denotes Their presence in the Fc domain has been linked to increased serum clearance of IgG antibodies.
T6 646-821 Sentence denotes High-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) is an effective tool for determining glycans present in glycoprotein therapeutics.
T7 822-895 Sentence denotes We report an improved HPAE-PAD method for IgG oligosaccharide separation.
T8 896-1011 Sentence denotes The neutral glycans are well resolved, including separation of high-mannose species from typical human IgG glycans.
T9 1012-1184 Sentence denotes Oligosaccharide identification was performed by comparison to known standards in conjunction with selective exoglycosidase digestion of both standards and released glycans.
T10 1185-1358 Sentence denotes Retention times of known glycans were compared to the retention times of maltose, maltotriose, and maltotetraose standards to define a retention index value for each glycan.
T11 1359-1494 Sentence denotes These retention indices were used to aid identification of glycans from an example monoclonal antibody sample of unknown glycosylation.
T12 1495-1590 Sentence denotes Method ruggedness was evaluated across duplicate systems, analysts, and triplicate column lots.
T13 1591-1769 Sentence denotes Comparing two systems with different analysts and columns, retention time precision RSDs were between 0.63 and 4.0% while retention indices precision RSDs ranged from 0.27-0.56%.
T14 1770-1877 Sentence denotes The separation is orthogonal to capillary electrophoresis based separation of labeled IgG oligosaccharides.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 611-616 Body_part denotes serum FMA:63083
T2 1802-1811 Body_part denotes capillary FMA:63194

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 520-525 OrganismTaxon denotes human 9606
T2 993-998 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1802-1811 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982