> top > docs > PubMed:26774442 > annotations

PubMed:26774442 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 59-205 DRI_Approach denotes Expanded tandem repeat sequences in DNA are associated with at least 40 human genetic neurological, neurodegenerative, and neuromuscular diseases.
T2 206-368 DRI_Approach denotes Repeat expansion can occur during parent-to-offspring transmission, and arise at variable rates in specific tissues throughout the life of an affected individual.
T3 369-541 DRI_Challenge denotes Since the ongoing somatic repeat expansions can affect disease age-of-onset, severity, and progression, targeting somatic expansion holds potential as a therapeutic target.
T4 542-613 DRI_Approach denotes Thus, understanding the factors that regulate this mutation is crucial.
T5 614-730 DRI_Background denotes DNA repair, in particular mismatch repair (MMR), is the major driving force of disease-associated repeat expansions.
T6 731-869 DRI_Background denotes In contrast to its anti-mutagenic roles, mammalian MMR curiously drives the expansion mutations of disease-associated (CAG)·(CTG) repeats.
T7 870-1144 DRI_Outcome denotes Recent advances have broadened our knowledge of both the MMR proteins involved in disease repeat expansions, including: MSH2, MSH3, MSH6, MLH1, PMS2, and MLH3, as well as the types of repeats affected by MMR, now including: (CAG)·(CTG), (CGG)·(CCG), and (GAA)·(TTC) repeats.
T8 1145-1315 DRI_Background denotes Mutagenic slipped-DNA structures have been detected in patient tissues, and the size of the slip-out and their junction conformation can determine the involvement of MMR.
T9 1316-1445 DRI_Background denotes Furthermore, the formation of other unusual DNA and R-loop structures is proposed to play a key role in MMR-mediated instability.
T10 1446-1568 DRI_Outcome denotes A complex correlation is emerging between tissues showing varying amounts of repeat instability and MMR expression levels.
T11 1569-1786 DRI_Approach denotes Notably, naturally occurring polymorphic variants of DNA repair genes can have dramatic effects upon the levels of repeat instability, which may explain the variation in disease age-of-onset, progression and severity.
T12 1787-1867 DRI_Challenge denotes An increasing grasp of these factors holds prognostic and therapeutic potential.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-7 D004194 denotes Disease
T2 0-7 D004194 denotes Disease
T3 19-25 SO:0001068 denotes repeat
T4 42-57 GO:0006298 denotes mismatch repair
T5 68-74 37565 denotes tandem
T7 68-81 SO:0000705 denotes tandem repeat
T11 95-98 SO:0000352 denotes DNA
T10 95-98 CHEBI:16991 denotes DNA
T12 95-98 D004247 denotes DNA
T9 95-98 GO:0005574 denotes DNA
T13 131-136 D006801 denotes human
T14 159-176 D019636 denotes neurodegenerative
T15 159-176 D019636 denotes neurodegenerative
T18 182-204 D009468 denotes neuromuscular diseases
T19 182-204 D009468 denotes neuromuscular diseases
T20 395-401 SO:0001068 denotes repeat
T21 424-431 D004194 denotes disease
T22 424-431 D004194 denotes disease
T23 593-601 SO:0000109 denotes mutation
T26 614-617 SO:0000352 denotes DNA
T24 614-617 GO:0005574 denotes DNA
T25 614-617 CHEBI:16991 denotes DNA
T27 614-617 D004247 denotes DNA
T28 614-624 GO:0006281 denotes DNA repair
T29 640-655 GO:0006298 denotes mismatch repair
T30 657-660 GO:0006298 denotes MMR
T31 657-660 CVCL_E779 denotes MMR
T32 657-660 P22897 denotes MMR
T33 657-660 PR:000002972 denotes MMR
T34 657-660 Q61830 denotes MMR
T35 693-700 D004194 denotes disease
T36 693-700 D004194 denotes disease
T37 712-718 SO:0001068 denotes repeat
T40 782-785 P22897 denotes MMR
T41 782-785 PR:000002972 denotes MMR
T42 782-785 Q61830 denotes MMR
T39 782-785 CVCL_E779 denotes MMR
T38 782-785 GO:0006298 denotes MMR
T43 830-837 D004194 denotes disease
T44 830-837 D004194 denotes disease
T45 850-853 CVCL_D569 denotes CAG
T46 927-930 GO:0006298 denotes MMR
T48 927-930 P22897 denotes MMR
T49 927-930 PR:000002972 denotes MMR
T50 927-930 Q61830 denotes MMR
T47 927-930 CVCL_E779 denotes MMR
T51 931-939 CHEBI:36080 denotes proteins
T52 952-959 D004194 denotes disease
T53 952-959 D004194 denotes disease
T54 960-966 SO:0001068 denotes repeat
T56 990-993 CHEBI:16768 denotes MSH
T60 990-993 D009074 denotes MSH
T61 990-993 D009074 denotes MSH
T62 990-994 PR:000010666 denotes MSH2
T63 990-994 PR:P25847 denotes MSH2
T64 990-994 PR:P43246 denotes MSH2
T65 990-994 P22711 denotes MSH2
T66 990-994 PR:P22711 denotes MSH2
T67 990-994 PR:P54275 denotes MSH2
T68 990-994 PR:O74773 denotes MSH2
T69 990-994 PR:P43247 denotes MSH2
T70 990-994 PR:Q553L4 denotes MSH2
T71 990-994 PR:O24617 denotes MSH2
T73 996-999 CHEBI:16768 denotes MSH
T77 996-999 D009074 denotes MSH
T78 996-999 D009074 denotes MSH
T79 996-1000 PR:O65607 denotes MSH3
T80 996-1000 PR:000010667 denotes MSH3
T81 996-1000 PR:Q59Y41 denotes MSH3
T82 996-1000 PR:P25336 denotes MSH3
T83 996-1000 PR:P20585 denotes MSH3
T84 996-1000 PR:P26359 denotes MSH3
T85 996-1000 PR:P13705 denotes MSH3
T86 996-1000 PR:Q1ZXH0 denotes MSH3
T88 1002-1005 CHEBI:16768 denotes MSH
T92 1002-1005 D009074 denotes MSH
T93 1002-1005 D009074 denotes MSH
T94 1002-1006 PR:P52701 denotes MSH6
T95 1002-1006 PR:P54276 denotes MSH6
T96 1002-1006 PR:Q9VUM0 denotes MSH6
T97 1002-1006 PR:Q55GU9 denotes MSH6
T98 1002-1006 PR:O04716 denotes MSH6
T99 1002-1006 PR:Q03834 denotes MSH6
T100 1002-1006 PR:O74502 denotes MSH6
T101 1002-1006 PR:000010670 denotes MSH6
T102 1008-1012 PR:Q9ZRV4 denotes MLH1
T103 1008-1012 PR:P38920 denotes MLH1
T104 1008-1012 PR:Q54KD8 denotes MLH1
T106 1008-1012 PR:Q9JK91 denotes MLH1
T107 1008-1012 PR:P97679 denotes MLH1
T108 1008-1012 PR:Q9P7W6 denotes MLH1
T109 1008-1012 PR:000010442 denotes MLH1
T110 1008-1012 PR:P40692 denotes MLH1
T105 1008-1012 CVCL_G669 denotes MLH1
T111 1014-1017 CHEBI:53396 denotes PMS
T114 1014-1017 CHEBI:53430 denotes PMS
T116 1014-1017 CHEBI:8055 denotes PMS
T117 1014-1018 PR:P54279 denotes PMS2
T118 1014-1018 PR:F1NQJ3 denotes PMS2
T119 1014-1018 PR:P38920 denotes PMS2
T120 1014-1018 PR:000012914 denotes PMS2
T121 1014-1018 PR:P54278 denotes PMS2
T122 1024-1028 PR:F4JN26 denotes MLH3
T123 1024-1028 PR:Q12083 denotes MLH3
T124 1024-1028 PR:000010443 denotes MLH3
T125 1024-1028 PR:Q9UHC1 denotes MLH3
T126 1074-1077 GO:0006298 denotes MMR
T128 1074-1077 P22897 denotes MMR
T129 1074-1077 PR:000002972 denotes MMR
T130 1074-1077 Q61830 denotes MMR
T127 1074-1077 CVCL_E779 denotes MMR
T131 1095-1098 CVCL_D569 denotes CAG
T133 1114-1117 PR:Q5XVF0 denotes CCG
T132 1114-1117 CVCL_R838 denotes CCG
T134 1125-1128 PR:Q6P7A9 denotes GAA
T135 1125-1128 PR:000007752 denotes GAA
T136 1125-1128 PR:P10253 denotes GAA
T137 1125-1128 PR:P70699 denotes GAA
T139 1125-1128 PR:Q9MYM4 denotes GAA
T138 1125-1128 CHEBI:144460 denotes GAA
T142 1163-1166 SO:0000352 denotes DNA
T140 1163-1166 GO:0005574 denotes DNA
T141 1163-1166 CHEBI:16991 denotes DNA
T143 1163-1166 D004247 denotes DNA
T145 1256-1264 SO:0000699 denotes junction
T144 1256-1264 UBERON:0007651 denotes junction
T146 1311-1314 GO:0006298 denotes MMR
T147 1311-1314 CVCL_E779 denotes MMR
T148 1311-1314 P22897 denotes MMR
T149 1311-1314 PR:000002972 denotes MMR
T150 1311-1314 Q61830 denotes MMR
T151 1333-1342 GO:0009058 denotes formation
T154 1360-1363 SO:0000352 denotes DNA
T152 1360-1363 GO:0005574 denotes DNA
T153 1360-1363 CHEBI:16991 denotes DNA
T155 1360-1363 D004247 denotes DNA
T156 1420-1423 GO:0006298 denotes MMR
T157 1420-1423 CVCL_E779 denotes MMR
T158 1420-1423 P22897 denotes MMR
T159 1420-1423 PR:000002972 denotes MMR
T160 1420-1423 Q61830 denotes MMR
T161 1523-1529 SO:0001068 denotes repeat
T164 1546-1549 P22897 denotes MMR
T165 1546-1549 PR:000002972 denotes MMR
T166 1546-1549 Q61830 denotes MMR
T163 1546-1549 CVCL_E779 denotes MMR
T162 1546-1549 GO:0006298 denotes MMR
T168 1622-1625 CHEBI:16991 denotes DNA
T170 1622-1625 D004247 denotes DNA
T169 1622-1625 SO:0000352 denotes DNA
T167 1622-1625 GO:0005574 denotes DNA
T171 1622-1632 GO:0006281 denotes DNA repair
T172 1684-1690 SO:0001068 denotes repeat
T173 1739-1746 D004194 denotes disease
T174 1739-1746 D004194 denotes disease