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PubMed:26771139 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues.
TextSentencer_T2 110-236 Sentence denotes Survivin overexpression is associated with poor prognosis of human gastric cancer, and is a target for gastric cancer therapy.
TextSentencer_T3 237-304 Sentence denotes YM155 is originally identified as a specific inhibitor of survivin.
TextSentencer_T4 305-390 Sentence denotes In this study, we investigated the antitumor effect of YM155 on human gastric cancer.
TextSentencer_T5 391-573 Sentence denotes Our results showed that YM155 treatment significantly inhibited cell proliferation, reduced colony formation and induced apoptosis of gastric cancer cells in a dose-dependent manner.
TextSentencer_T6 574-760 Sentence denotes Accordingly, YM155 treatment significantly decreased survivin expression without affecting XIAP expression and increased the cleavage of apoptosis-associated proteins caspase 3, 7, 8, 9.
TextSentencer_T7 761-1024 Sentence denotes YM155 significantly inhibited sphere formation of gastric cancer cells, suppressed expansion and growth of the formed spheres (cancer stem cell-like cells, CSCs) and downregulated the protein levels of β-catenin, c-Myc, Cyclin D1 and CD44 in gastric cancer cells.
TextSentencer_T8 1025-1142 Sentence denotes YM155 infusion at 5 mg/kg/day for 7 days markedly inhibited growth of gastric cancer xenograft in a nude mouse model.
TextSentencer_T9 1143-1337 Sentence denotes Immunohistochemistry staining and Western Blot showed that YM155 treatment inhibited expression of survivin and CD44, induced apoptosis and reduced CD44+ CSCs in xenograft tumor tissues in vivo.
TextSentencer_T10 1338-1453 Sentence denotes No obvious pathological changes were observed in organs (e.g. heart, liver, lung and kidney) in YM155-treated mice.
TextSentencer_T11 1454-1639 Sentence denotes Our results demonstrated that YM155 inhibits cell proliferation, induces cell apoptosis, reduces cancer stem cell expansion, and inhibits xenograft tumor growth in gastric cancer cells.
TextSentencer_T12 1640-1746 Sentence denotes Our results elucidate a new mechanism by which YM155 inhibits gastric cancer growth by inhibition of CSCs.
TextSentencer_T13 1747-1807 Sentence denotes YM155 may be a promising agent for gastric cancer treatment.
T1 0-109 Sentence denotes Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues.
T2 110-236 Sentence denotes Survivin overexpression is associated with poor prognosis of human gastric cancer, and is a target for gastric cancer therapy.
T3 237-304 Sentence denotes YM155 is originally identified as a specific inhibitor of survivin.
T4 305-390 Sentence denotes In this study, we investigated the antitumor effect of YM155 on human gastric cancer.
T5 391-573 Sentence denotes Our results showed that YM155 treatment significantly inhibited cell proliferation, reduced colony formation and induced apoptosis of gastric cancer cells in a dose-dependent manner.
T6 574-760 Sentence denotes Accordingly, YM155 treatment significantly decreased survivin expression without affecting XIAP expression and increased the cleavage of apoptosis-associated proteins caspase 3, 7, 8, 9.
T7 761-1024 Sentence denotes YM155 significantly inhibited sphere formation of gastric cancer cells, suppressed expansion and growth of the formed spheres (cancer stem cell-like cells, CSCs) and downregulated the protein levels of β-catenin, c-Myc, Cyclin D1 and CD44 in gastric cancer cells.
T8 1025-1142 Sentence denotes YM155 infusion at 5 mg/kg/day for 7 days markedly inhibited growth of gastric cancer xenograft in a nude mouse model.
T9 1143-1337 Sentence denotes Immunohistochemistry staining and Western Blot showed that YM155 treatment inhibited expression of survivin and CD44, induced apoptosis and reduced CD44+ CSCs in xenograft tumor tissues in vivo.
T10 1338-1453 Sentence denotes No obvious pathological changes were observed in organs (e.g. heart, liver, lung and kidney) in YM155-treated mice.
T11 1454-1639 Sentence denotes Our results demonstrated that YM155 inhibits cell proliferation, induces cell apoptosis, reduces cancer stem cell expansion, and inhibits xenograft tumor growth in gastric cancer cells.
T12 1640-1746 Sentence denotes Our results elucidate a new mechanism by which YM155 inhibits gastric cancer growth by inhibition of CSCs.
T13 1747-1807 Sentence denotes YM155 may be a promising agent for gastric cancer treatment.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26771139-6#234#238#gene960 995-999 gene960 denotes CD44
26771139-6#242#256#diseaseC0024623 1003-1017 diseaseC0024623 denotes gastric cancer
26771139-6#242#256#diseaseC0699791 1003-1017 diseaseC0699791 denotes gastric cancer
234#238#gene960242#256#diseaseC0024623 26771139-6#234#238#gene960 26771139-6#242#256#diseaseC0024623 associated_with CD44,gastric cancer
234#238#gene960242#256#diseaseC0699791 26771139-6#234#238#gene960 26771139-6#242#256#diseaseC0699791 associated_with CD44,gastric cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1330 995-999 gene:960 denotes CD44
T1331 1003-1017 disease:C0024623 denotes gastric cancer
R1 T1330 T1331 associated_with CD44,gastric cancer
R2 T1330 T1331 associated_with CD44,gastric cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 101-108 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 1321-1328 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 1387-1393 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
PD-UBERON-AE-B_T4 1400-1405 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T5 1407-1412 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T6 1414-1418 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T7 1423-1429 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 101-108 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 1321-1328 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 1423-1429 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T4 1387-1393 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
PD-UBERON-AE-B_T5 1414-1418 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T6 1407-1412 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T7 1400-1405 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart