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PubMed:26762172 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 557-564 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 557-564 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 1482-1489 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 1482-1489 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 557-564 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 1482-1489 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 163-178 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 557-564 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 557-564 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 1482-1489 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 1482-1489 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-114 Sentence denotes Kinetic analysis and molecular modelling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
TextSentencer_T2 115-240 Sentence denotes Heparanase is a β-D-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes.
TextSentencer_T3 241-439 Sentence denotes A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development of anticancer therapies.
TextSentencer_T4 440-656 Sentence denotes SST0001 (roneparstat; Sigma-Tau Research Switzerland S.A.) is a non-anticoagulant 100% N-acetylated and glycol-split heparin acting as a potent heparanase inhibitor, currently in phase I in advanced multiple myeloma.
TextSentencer_T5 657-730 Sentence denotes Herein, the kinetics of heparanase inhibition by roneparstat is reported.
TextSentencer_T6 731-944 Sentence denotes The analysis of dose-inhibition curves confirmed the high potency of roneparstat (IC50 ≈ 3 nM) and showed, at higher concentrations, a Hill coefficient consistent with the engagement of two molecules of inhibitor.
TextSentencer_T7 945-1064 Sentence denotes A homology model of human heparanase GS3 construct was built and used for docking experiments with inhibitor fragments.
TextSentencer_T8 1065-1171 Sentence denotes The model has high structural similarity with the recently reported crystal structure of human heparanase.
TextSentencer_T9 1172-1372 Sentence denotes Different interaction schemes are proposed, which support the hypothesis of a complex binding mechanism involving the recruitment of one or multiple roneparstat chains, depending on its concentration.
TextSentencer_T10 1373-1685 Sentence denotes In particular, docking solutions were obtained in which i) a single roneparstat molecule interacts with both heparin-binding domains (HBD) of heparanase or ii) two fragments of roneparstat interact with either HBD-1 or HBD-2, consistent with the possibility of different inhibitor:enzyme binding stoichiometries.
TextSentencer_T11 1686-1906 Sentence denotes This study provides unique insights into the mode of action of roneparstat as well as clues of its interaction with heparanase at a molecular level, which could be exploited to design novel potential inhibitor molecules.
T1 0-114 Sentence denotes Kinetic analysis and molecular modelling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
T2 115-240 Sentence denotes Heparanase is a β-D-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes.
T3 241-439 Sentence denotes A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development of anticancer therapies.
T4 440-656 Sentence denotes SST0001 (roneparstat; Sigma-Tau Research Switzerland S.A.) is a non-anticoagulant 100% N-acetylated and glycol-split heparin acting as a potent heparanase inhibitor, currently in phase I in advanced multiple myeloma.
T5 657-730 Sentence denotes Herein, the kinetics of heparanase inhibition by roneparstat is reported.
T6 731-944 Sentence denotes The analysis of dose-inhibition curves confirmed the high potency of roneparstat (IC50 ≈ 3 nM) and showed, at higher concentrations, a Hill coefficient consistent with the engagement of two molecules of inhibitor.
T7 945-1064 Sentence denotes A homology model of human heparanase GS3 construct was built and used for docking experiments with inhibitor fragments.
T8 1065-1171 Sentence denotes The model has high structural similarity with the recently reported crystal structure of human heparanase.
T9 1172-1372 Sentence denotes Different interaction schemes are proposed, which support the hypothesis of a complex binding mechanism involving the recruitment of one or multiple roneparstat chains, depending on its concentration.
T10 1373-1685 Sentence denotes In particular, docking solutions were obtained in which i) a single roneparstat molecule interacts with both heparin-binding domains (HBD) of heparanase or ii) two fragments of roneparstat interact with either HBD-1 or HBD-2, consistent with the possibility of different inhibitor:enzyme binding stoichiometries.
T11 1686-1906 Sentence denotes This study provides unique insights into the mode of action of roneparstat as well as clues of its interaction with heparanase at a molecular level, which could be exploited to design novel potential inhibitor molecules.
T1 0-114 Sentence denotes Kinetic analysis and molecular modelling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.
T2 115-240 Sentence denotes Heparanase is a β-D-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes.
T3 241-439 Sentence denotes A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development of anticancer therapies.
T4 440-656 Sentence denotes SST0001 (roneparstat; Sigma-Tau Research Switzerland S.A.) is a non-anticoagulant 100% N-acetylated and glycol-split heparin acting as a potent heparanase inhibitor, currently in phase I in advanced multiple myeloma.
T5 657-730 Sentence denotes Herein, the kinetics of heparanase inhibition by roneparstat is reported.
T6 731-944 Sentence denotes The analysis of dose-inhibition curves confirmed the high potency of roneparstat (IC50 ≈ 3 nM) and showed, at higher concentrations, a Hill coefficient consistent with the engagement of two molecules of inhibitor.
T7 945-1064 Sentence denotes A homology model of human heparanase GS3 construct was built and used for docking experiments with inhibitor fragments.
T8 1065-1171 Sentence denotes The model has high structural similarity with the recently reported crystal structure of human heparanase.
T9 1172-1372 Sentence denotes Different interaction schemes are proposed, which support the hypothesis of a complex binding mechanism involving the recruitment of one or multiple roneparstat chains, depending on its concentration.
T10 1373-1685 Sentence denotes In particular, docking solutions were obtained in which i) a single roneparstat molecule interacts with both heparin-binding domains (HBD) of heparanase or ii) two fragments of roneparstat interact with either HBD-1 or HBD-2, consistent with the possibility of different inhibitor:enzyme binding stoichiometries.
T11 1686-1906 Sentence denotes This study provides unique insights into the mode of action of roneparstat as well as clues of its interaction with heparanase at a molecular level, which could be exploited to design novel potential inhibitor molecules.

GlycoBiology-GDGDB

Id Subject Object Predicate Lexical cue
_T1 822-824 http://acgg.asia/db/diseases/gdgdb?con_ui=CON00386 denotes nM

ICD10

Id Subject Object Predicate Lexical cue
T1 639-655 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 163-170 FMAID:165191 denotes heparan
_T2 163-170 FMAID:67110 denotes heparan
_T3 163-178 FMAID:63023 denotes heparan sulfate
_T4 163-178 FMAID:167405 denotes heparan sulfate
_T5 193-213 FMAID:265717 denotes extracellular matrix
_T6 193-213 FMAID:165194 denotes extracellular matrix
_T7 221-239 FMAID:200943 denotes cellular membranes
_T8 221-239 FMAID:201486 denotes cellular membranes
_T9 221-239 FMAID:63871 denotes cellular membranes
_T10 221-239 FMAID:162305 denotes cellular membranes
_T11 221-239 FMAID:162335 denotes cellular membranes
_T12 230-239 FMAID:30322 denotes membranes
_T13 230-239 FMAID:93573 denotes membranes
_T14 230-239 FMAID:167608 denotes membranes
_T15 230-239 FMAID:7145 denotes membranes
_T16 363-376 FMAID:165191 denotes heparanase an
_T17 363-376 FMAID:67110 denotes heparanase an
_T18 557-564 FMAID:82839 denotes heparin
_T19 557-564 FMAID:167420 denotes heparin
_T20 1482-1489 FMAID:167420 denotes heparin
_T21 1482-1489 FMAID:82839 denotes heparin

uniprot-human

Id Subject Object Predicate Lexical cue
T1 103-113 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T2 256-266 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T3 363-373 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T4 584-594 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T5 681-691 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T6 971-981 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T7 1160-1170 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T8 1515-1525 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T9 1802-1812 http://www.uniprot.org/uniprot/Q9Y251 denotes heparanase
T10 982-985 http://www.uniprot.org/uniprot/Q5F1R6 denotes GS3
T11 1507-1510 http://www.uniprot.org/uniprot/P02042 denotes HBD
T12 1583-1586 http://www.uniprot.org/uniprot/P02042 denotes HBD
T13 1592-1595 http://www.uniprot.org/uniprot/P02042 denotes HBD
T14 1529-1531 http://www.uniprot.org/uniprot/Q8SNA0 denotes ii

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 103-113 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T2 256-266 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T3 363-373 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T4 584-594 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T5 681-691 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T6 971-981 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T7 1160-1170 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T8 1515-1525 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T9 1802-1812 http://www.uniprot.org/uniprot/Q6YGZ1 denotes heparanase
T10 1529-1531 http://www.uniprot.org/uniprot/P04441 denotes ii

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 59-68 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T2 504-507 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non
T3 1266-1275 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 171-178 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T2 221-229 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T3 256-275 http://purl.obolibrary.org/obo/GO_0030305 denotes heparanase activity
T4 342-354 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T5 377-387 http://purl.obolibrary.org/obo/GO_0042056 denotes attractive
T6 403-414 http://purl.obolibrary.org/obo/GO_0032502 denotes development

GO-MF

Id Subject Object Predicate Lexical cue
T1 1258-1265 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 1490-1497 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1661-1668 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 1258-1265 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 1490-1497 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 1661-1668 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 1258-1265 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T8 1490-1497 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1661-1668 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 1258-1265 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11 1490-1497 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 1661-1668 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13 1482-1497 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin-binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 193-206 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T2 193-213 http://purl.obolibrary.org/obo/GO_0031012 denotes extracellular matrix
T3 221-239 http://purl.obolibrary.org/obo/GO_0005886 denotes cellular membranes
T4 230-239 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T5 290-310 http://purl.obolibrary.org/obo/GO_0009986 denotes associated with cell
T6 306-310 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 221-239 http://purl.obolibrary.org/obo/UBERON_0005764 denotes cellular membranes

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 557-564 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T2 1482-1489 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 163-178 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 504-507 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 504-507 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 504-507 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 504-507 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 504-507 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 504-507 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 504-507 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 504-507 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 504-507 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 504-507 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 504-507 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 221-239 http://purl.obolibrary.org/obo/UBERON_0005764 denotes cellular membranes

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 321-326 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 639-655 Disease denotes multiple myeloma http://purl.obolibrary.org/obo/MONDO_0009693
T3 982-985 Disease denotes GS3 http://purl.obolibrary.org/obo/MONDO_0012220
T4 1507-1510 Disease denotes HBD http://purl.obolibrary.org/obo/MONDO_0007799
T5 1583-1586 Disease denotes HBD http://purl.obolibrary.org/obo/MONDO_0007799
T6 1592-1595 Disease denotes HBD http://purl.obolibrary.org/obo/MONDO_0007799

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 321-326 Phenotype denotes tumor HP:0002664
T2 639-655 Phenotype denotes multiple myeloma HP:0006775

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 97-102 OrganismTaxon denotes human 9606
T2 965-970 OrganismTaxon denotes human 9606
T3 1154-1159 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 193-213 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T2 221-239 Body_part denotes cellular membranes http://purl.obolibrary.org/obo/GO_0005886