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PubMed:26744332 JSONTXT

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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
26744332_0 969-975 ProteinMutation denotes G2019S rs34637584
26744332_1 1258-1264 ProteinMutation denotes R1441C rs33939927
26744332_2 805-811 ProteinMutation denotes G2019S rs34637584
26744332_3 980-986 ProteinMutation denotes R1441C rs33939927
26744332_4 504-510 ProteinMutation denotes G2019S rs34637584
26744332_5 815-821 ProteinMutation denotes R1441C rs33939927
26744332_6 524-530 ProteinMutation denotes R1441C rs33939927

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T4 6-9 SO:0000153 denotes BAC
T5 10-20 SO:0000781 denotes transgenic
T6 10-25 D055647 denotes transgenic rats
T10 47-53 CHEBI:57504 denotes L-DOPA
T11 47-53 D007980 denotes L-DOPA
T12 47-53 D007980 denotes L-DOPA
T13 47-53 CHEBI:15765 denotes L-DOPA
T23 99-107 3628 denotes dopamine
T19 99-107 CHEBI:59905 denotes dopamine
T20 99-107 CHEBI:18243 denotes dopamine
T21 99-107 D004298 denotes dopamine
T22 99-107 D004298 denotes dopamine
T25 139-146 6308 denotes leucine
T26 139-146 SO:0001437 denotes leucine
T24 139-146 CHEBI:15603 denotes leucine
T27 139-146 D007930 denotes leucine
T28 139-146 CHEBI:25017 denotes leucine
T29 139-146 D007930 denotes leucine
T30 152-158 SO:0001068 denotes repeat
T31 169-174 PR:Q5S006 denotes LRRK2
T32 169-174 PR:000003033 denotes LRRK2
T33 169-174 PR:Q5S007 denotes LRRK2
T34 184-194 D000067562 denotes late-onset
T35 184-194 D000067562 denotes late-onset
T36 196-214 C566739 denotes autosomal dominant
T41 215-234 D010300 denotes Parkinson's disease
T42 215-234 D010300 denotes Parkinson's disease
T49 273-281 3628 denotes dopamine
T45 273-281 CHEBI:59905 denotes dopamine
T46 273-281 CHEBI:18243 denotes dopamine
T47 273-281 D004298 denotes dopamine
T48 273-281 D004298 denotes dopamine
T51 297-327 UBERON:0001966 denotes substantia nigra pars compacta
T52 297-327 UBERON:0001965 denotes substantia nigra pars compacta
T53 314-318 PR:P07814 denotes pars
T54 314-318 PR:000007144 denotes pars
T60 342-350 3628 denotes dopamine
T56 342-350 CHEBI:59905 denotes dopamine
T57 342-350 CHEBI:18243 denotes dopamine
T58 342-350 D004298 denotes dopamine
T59 342-350 D004298 denotes dopamine
T61 351-368 GO:0007268 denotes neurotransmission
T66 441-460 D010300 denotes Parkinson's disease
T67 441-460 D010300 denotes Parkinson's disease
T70 461-466 PR:Q5S006 denotes LRRK2
T71 461-466 PR:000003033 denotes LRRK2
T72 461-466 PR:Q5S007 denotes LRRK2
T73 516-522 D020558 denotes GTPase
T74 552-557 PR:Q5S006 denotes LRRK2
T75 552-557 PR:000003033 denotes LRRK2
T76 552-557 PR:Q5S007 denotes LRRK2
T77 584-592 SO:0000001 denotes sequence
T82 694-713 D010300 denotes Parkinson's disease
T83 694-713 D010300 denotes Parkinson's disease
T86 733-738 PR:Q5S006 denotes LRRK2
T87 733-738 PR:000003033 denotes LRRK2
T88 733-738 PR:Q5S007 denotes LRRK2
T89 739-770 SO:0000153 denotes bacterial artificial chromosome
T90 749-759 32630 denotes artificial
T91 760-770 GO:0005694 denotes chromosome
T93 771-781 SO:0000781 denotes transgenic
T94 771-786 D055647 denotes transgenic rats
T98 833-842 SO:0000817 denotes wild-type
T99 843-848 PR:Q5S006 denotes LRRK2
T100 843-848 PR:000003033 denotes LRRK2
T101 843-848 PR:Q5S007 denotes LRRK2
T102 868-873 D006801 denotes human
T103 874-879 PR:Q5S006 denotes LRRK2
T104 874-879 PR:000003033 denotes LRRK2
T105 874-879 PR:Q5S007 denotes LRRK2
T106 916-924 SO:0000167 denotes promoter
T107 994-1004 SO:0000781 denotes transgenic
T108 994-1009 D055647 denotes transgenic rats
T112 1018-1024 CHEBI:57504 denotes L-DOPA
T113 1018-1024 D007980 denotes L-DOPA
T114 1018-1024 D007980 denotes L-DOPA
T115 1018-1024 CHEBI:15765 denotes L-DOPA
T125 1073-1081 3628 denotes dopamine
T121 1073-1081 CHEBI:59905 denotes dopamine
T122 1073-1081 CHEBI:18243 denotes dopamine
T123 1073-1081 D004298 denotes dopamine
T124 1073-1081 D004298 denotes dopamine
T127 1207-1237 UBERON:0001966 denotes substantia nigra pars compacta
T128 1207-1237 UBERON:0001965 denotes substantia nigra pars compacta
T129 1224-1228 PR:P07814 denotes pars
T130 1224-1228 PR:000007144 denotes pars
T136 1238-1246 3628 denotes dopamine
T132 1238-1246 CHEBI:59905 denotes dopamine
T133 1238-1246 CHEBI:18243 denotes dopamine
T134 1238-1246 D004298 denotes dopamine
T135 1238-1246 D004298 denotes dopamine
T137 1265-1270 PR:Q5S006 denotes LRRK2
T138 1265-1270 PR:000003033 denotes LRRK2
T139 1265-1270 PR:Q5S007 denotes LRRK2
T140 1271-1281 SO:0000781 denotes transgenic
T141 1271-1286 D055647 denotes transgenic rats
T145 1311-1320 MOP:0000569 denotes reduction
T150 1393-1401 3628 denotes dopamine
T146 1393-1401 CHEBI:59905 denotes dopamine
T147 1393-1401 CHEBI:18243 denotes dopamine
T148 1393-1401 D004298 denotes dopamine
T149 1393-1401 D004298 denotes dopamine
T155 1432-1440 3628 denotes dopamine
T151 1432-1440 CHEBI:59905 denotes dopamine
T152 1432-1440 CHEBI:18243 denotes dopamine
T153 1432-1440 D004298 denotes dopamine
T154 1432-1440 D004298 denotes dopamine
T160 1512-1519 SO:0000104 denotes protein
T159 1512-1519 PR:000000001 denotes protein
T157 1512-1519 CHEBI:36080 denotes protein
T158 1512-1519 CHEBI:11122 denotes protein
T156 1512-1519 GO:0003675 denotes protein
T162 1544-1574 UBERON:0001966 denotes substantia nigra pars compacta
T163 1544-1574 UBERON:0001965 denotes substantia nigra pars compacta
T164 1561-1565 PR:P07814 denotes pars
T165 1561-1565 PR:000007144 denotes pars
T171 1606-1614 3628 denotes dopamine
T167 1606-1614 CHEBI:59905 denotes dopamine
T168 1606-1614 CHEBI:18243 denotes dopamine
T169 1606-1614 D004298 denotes dopamine
T170 1606-1614 D004298 denotes dopamine
T176 1647-1654 SO:0000104 denotes protein
T175 1647-1654 PR:000000001 denotes protein
T173 1647-1654 CHEBI:36080 denotes protein
T174 1647-1654 CHEBI:11122 denotes protein
T172 1647-1654 GO:0003675 denotes protein
T177 1671-1681 GO:0008219 denotes cell death
T182 1704-1723 D010300 denotes Parkinson's disease
T183 1704-1723 D010300 denotes Parkinson's disease
T186 1839-1844 D006801 denotes human
T187 1852-1857 PR:Q5S006 denotes LRRK2
T188 1852-1857 PR:000003033 denotes LRRK2
T189 1852-1857 PR:Q5S007 denotes LRRK2
T190 1907-1915 CHEBI:59905 denotes dopamine
T191 1907-1915 CHEBI:18243 denotes dopamine
T192 1907-1915 D004298 denotes dopamine
T193 1907-1915 D004298 denotes dopamine
T194 1907-1915 3628 denotes dopamine
T197 1978-1989 D010300 denotes Parkinson's
T198 1978-1989 D010300 denotes Parkinson's

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 126-421 DRI_Challenge denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) lead to late-onset, autosomal dominant Parkinson's disease, characterized by the degeneration of dopamine neurons of the substantia nigra pars compacta, a deficit in dopamine neurotransmission and the development of motor and non-motor symptoms.
T2 422-558 DRI_Background denotes The most prevalent Parkinson's disease LRRK2 mutations are located in the kinase (G2019S) and GTPase (R1441C) encoding domains of LRRK2.
T3 559-948 DRI_Challenge denotes To better understand the sequence of events that lead to progressive neurophysiological deficits in vulnerable neurons and circuits in Parkinson's disease, we have generated LRRK2 bacterial artificial chromosome transgenic rats expressing either G2019S or R1441C mutant, or wild-type LRRK2, from the complete human LRRK2 genomic locus, including endogenous promoter and regulatory regions.
T4 949-1160 DRI_Background denotes Aged (18-21 months) G2019S and R1441C mutant transgenic rats exhibit L-DOPA-responsive motor dysfunction, impaired striatal dopamine release as determined by fast-scan cyclic voltammetry, and cognitive deficits.
T5 1161-1257 DRI_Background denotes In addition, in vivo recordings of identified substantia nigra pars compacta dopamine neurons in
T6 1271-1410 DRI_Background denotes transgenic rats reveal an age-dependent reduction in burst firing, which likely results in further reductions to striatal dopamine release.
T7 1411-1724 DRI_Background denotes These alterations to dopamine circuit function occur in the absence of neurodegeneration or abnormal protein accumulation within the substantia nigra pars compacta, suggesting that nigrostriatal dopamine dysfunction precedes detectable protein aggregation and cell death in the development of Parkinson's disease.
T8 1725-2003 DRI_Outcome denotes In conclusion, our longitudinal deep-phenotyping provides novel insights into how the genetic burden arising from human mutant LRRK2 manifests as early pathophysiological changes to dopamine circuit function and highlights a potential model for testing Parkinson's therapeutics.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
26744332-2#102#108#geners33939927 524-530 geners33939927 denotes R1441C
26744332-2#82#88#geners34637584 504-510 geners34637584 denotes G2019S
26744332-2#19#38#diseaseC0030567 441-460 diseaseC0030567 denotes Parkinson's disease
26744332-4#31#37#geners33939927 980-986 geners33939927 denotes R1441C
26744332-4#93#104#diseaseC3887505 1042-1053 diseaseC3887505 denotes dysfunction
26744332-4#192#210#diseaseC0009241 1141-1159 diseaseC0009241 denotes cognitive deficits
26744332-4#192#210#diseaseC0338656 1141-1159 diseaseC0338656 denotes cognitive deficits
102#108#geners3393992719#38#diseaseC0030567 26744332-2#102#108#geners33939927 26744332-2#19#38#diseaseC0030567 associated_with R1441C,Parkinson's disease
82#88#geners3463758419#38#diseaseC0030567 26744332-2#82#88#geners34637584 26744332-2#19#38#diseaseC0030567 associated_with G2019S,Parkinson's disease
31#37#geners3393992793#104#diseaseC3887505 26744332-4#31#37#geners33939927 26744332-4#93#104#diseaseC3887505 associated_with R1441C,dysfunction
31#37#geners33939927192#210#diseaseC0009241 26744332-4#31#37#geners33939927 26744332-4#192#210#diseaseC0009241 associated_with R1441C,cognitive deficits
31#37#geners33939927192#210#diseaseC0338656 26744332-4#31#37#geners33939927 26744332-4#192#210#diseaseC0338656 associated_with R1441C,cognitive deficits

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26744332-1#13#41#gene120892 139-167 gene120892 denotes leucine-rich repeat kinase 2
26744332-1#43#48#gene120892 169-174 gene120892 denotes LRRK2
26744332-1#280#294#diseaseC0426980 406-420 diseaseC0426980 denotes motor symptoms
26744332-1#70#108#diseaseC3489791 196-234 diseaseC3489791 denotes autosomal dominant Parkinson's disease
26744332-1#280#294#diseaseC0426980 406-420 diseaseC0426980 denotes motor symptoms
26744332-2#39#44#gene120892 461-466 gene120892 denotes LRRK2
26744332-2#130#135#gene120892 552-557 gene120892 denotes LRRK2
26744332-2#19#38#diseaseC0030567 441-460 diseaseC0030567 denotes Parkinson's disease
13#41#gene120892280#294#diseaseC0426980 26744332-1#13#41#gene120892 26744332-1#280#294#diseaseC0426980 associated_with leucine-rich repeat kinase 2,motor symptoms
13#41#gene12089270#108#diseaseC3489791 26744332-1#13#41#gene120892 26744332-1#70#108#diseaseC3489791 associated_with leucine-rich repeat kinase 2,autosomal dominant Parkinson's disease
13#41#gene120892280#294#diseaseC0426980 26744332-1#13#41#gene120892 26744332-1#280#294#diseaseC0426980 associated_with leucine-rich repeat kinase 2,motor symptoms
43#48#gene120892280#294#diseaseC0426980 26744332-1#43#48#gene120892 26744332-1#280#294#diseaseC0426980 associated_with LRRK2,motor symptoms
43#48#gene12089270#108#diseaseC3489791 26744332-1#43#48#gene120892 26744332-1#70#108#diseaseC3489791 associated_with LRRK2,autosomal dominant Parkinson's disease
43#48#gene120892280#294#diseaseC0426980 26744332-1#43#48#gene120892 26744332-1#280#294#diseaseC0426980 associated_with LRRK2,motor symptoms
39#44#gene12089219#38#diseaseC0030567 26744332-2#39#44#gene120892 26744332-2#19#38#diseaseC0030567 associated_with LRRK2,Parkinson's disease
130#135#gene12089219#38#diseaseC0030567 26744332-2#130#135#gene120892 26744332-2#19#38#diseaseC0030567 associated_with LRRK2,Parkinson's disease