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PubTator4TogoVar

Id Subject Object Predicate Lexical cue proteinmutation
26744328_0 1013-1019 ProteinMutation denotes G2019S rs34637584
26744328_1 1145-1151 ProteinMutation denotes G2019S rs34637584

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-11 Q9Y6H5 denotes Synphilin-1
T2 0-11 PR:000015323 denotes Synphilin-1
T3 0-11 Q99ME3 denotes Synphilin-1
T4 30-35 PR:Q5S006 denotes LRRK2
T5 30-35 PR:000003033 denotes LRRK2
T6 30-35 PR:Q5S007 denotes LRRK2
T11 65-84 D010300 denotes Parkinson's disease
T12 65-84 D010300 denotes Parkinson's disease
T16 106-113 6308 denotes leucine
T17 106-113 SO:0001437 denotes leucine
T15 106-113 CHEBI:15603 denotes leucine
T18 106-113 D007930 denotes leucine
T19 106-113 CHEBI:25017 denotes leucine
T20 106-113 D007930 denotes leucine
T21 119-125 SO:0001068 denotes repeat
T22 136-141 PR:Q5S006 denotes LRRK2
T23 136-141 PR:000003033 denotes LRRK2
T24 136-141 PR:Q5S007 denotes LRRK2
T26 149-180 D020734 denotes autosomal-dominant Parkinsonism
T27 149-180 D020734 denotes autosomal-dominant Parkinsonism
T34 241-248 SO:0000104 denotes protein
T33 241-248 PR:000000001 denotes protein
T30 241-248 GO:0003675 denotes protein
T31 241-248 CHEBI:36080 denotes protein
T32 241-248 CHEBI:11122 denotes protein
T35 280-292 GO:0009405 denotes pathogenesis
T36 296-301 PR:Q5S006 denotes LRRK2
T37 296-301 PR:000003033 denotes LRRK2
T38 296-301 PR:Q5S007 denotes LRRK2
T43 309-328 D010300 denotes Parkinson's disease
T44 309-328 D010300 denotes Parkinson's disease
T47 409-414 PR:Q5S006 denotes LRRK2
T48 409-414 PR:000003033 denotes LRRK2
T49 409-414 PR:Q5S007 denotes LRRK2
T50 431-442 Q9Y6H5 denotes synphilin-1
T51 431-442 PR:000015323 denotes synphilin-1
T52 431-442 Q99ME3 denotes synphilin-1
T54 444-447 O14300 denotes SP1
T55 444-447 PR:O14300 denotes SP1
T56 444-447 Q9DF68 denotes SP1
T57 444-447 PR:000000133 denotes SP1
T59 444-447 PR:Q76LW6 denotes SP1
T60 444-447 P84632 denotes SP1
T61 444-447 PR:Q01714 denotes SP1
T62 444-447 P09179 denotes SP1
T63 444-447 PR:O89090 denotes SP1
T64 444-447 PR:P08047 denotes SP1
T66 444-447 PR:Q8L7N4 denotes SP1
T67 444-447 PR:000006271 denotes SP1
T68 444-447 PR:Q8N907 denotes SP1
T53 444-447 CVCL_VQ86 denotes SP1
T58 444-447 CVCL_R987 denotes SP1
T65 444-447 CVCL_AZ65 denotes SP1
T69 444-447 CVCL_5785 denotes SP1
T74 464-471 SO:0000104 denotes protein
T71 464-471 CHEBI:36080 denotes protein
T72 464-471 CHEBI:11122 denotes protein
T73 464-471 PR:000000001 denotes protein
T70 464-471 GO:0003675 denotes protein
T75 494-503 D051843 denotes synuclein
T76 494-503 P37379 denotes synuclein
T77 531-543 GO:0009405 denotes pathogenesis
T78 545-550 PR:Q5S006 denotes LRRK2
T79 545-550 PR:000003033 denotes LRRK2
T80 545-550 PR:Q5S007 denotes LRRK2
T82 585-588 O14300 denotes SP1
T83 585-588 PR:O14300 denotes SP1
T84 585-588 Q9DF68 denotes SP1
T85 585-588 PR:000000133 denotes SP1
T87 585-588 PR:Q76LW6 denotes SP1
T88 585-588 P84632 denotes SP1
T89 585-588 PR:Q01714 denotes SP1
T90 585-588 P09179 denotes SP1
T91 585-588 PR:O89090 denotes SP1
T92 585-588 PR:P08047 denotes SP1
T94 585-588 PR:Q8L7N4 denotes SP1
T95 585-588 PR:000006271 denotes SP1
T96 585-588 PR:Q8N907 denotes SP1
T81 585-588 CVCL_VQ86 denotes SP1
T86 585-588 CVCL_R987 denotes SP1
T93 585-588 CVCL_AZ65 denotes SP1
T97 585-588 CVCL_5785 denotes SP1
T99 597-600 O14300 denotes SP1
T100 597-600 PR:O14300 denotes SP1
T101 597-600 Q9DF68 denotes SP1
T102 597-600 PR:000000133 denotes SP1
T104 597-600 PR:Q76LW6 denotes SP1
T105 597-600 P84632 denotes SP1
T106 597-600 PR:Q01714 denotes SP1
T107 597-600 P09179 denotes SP1
T108 597-600 PR:O89090 denotes SP1
T109 597-600 PR:P08047 denotes SP1
T111 597-600 PR:Q8L7N4 denotes SP1
T112 597-600 PR:000006271 denotes SP1
T113 597-600 PR:Q8N907 denotes SP1
T98 597-600 CVCL_VQ86 denotes SP1
T103 597-600 CVCL_R987 denotes SP1
T110 597-600 CVCL_AZ65 denotes SP1
T114 597-600 CVCL_5785 denotes SP1
T115 649-654 PR:Q5S006 denotes LRRK2
T116 649-654 PR:000003033 denotes LRRK2
T117 649-654 PR:Q5S007 denotes LRRK2
T118 673-679 SO:0000417 denotes domain
T120 698-701 O14300 denotes SP1
T121 698-701 PR:O14300 denotes SP1
T122 698-701 Q9DF68 denotes SP1
T123 698-701 PR:000000133 denotes SP1
T125 698-701 PR:Q76LW6 denotes SP1
T126 698-701 P84632 denotes SP1
T127 698-701 PR:Q01714 denotes SP1
T128 698-701 P09179 denotes SP1
T129 698-701 PR:O89090 denotes SP1
T130 698-701 PR:P08047 denotes SP1
T132 698-701 PR:Q8L7N4 denotes SP1
T133 698-701 PR:000006271 denotes SP1
T134 698-701 PR:Q8N907 denotes SP1
T119 698-701 CVCL_VQ86 denotes SP1
T124 698-701 CVCL_R987 denotes SP1
T131 698-701 CVCL_AZ65 denotes SP1
T135 698-701 CVCL_5785 denotes SP1
T136 707-712 PR:Q5S006 denotes LRRK2
T137 707-712 PR:000003033 denotes LRRK2
T138 707-712 PR:Q5S007 denotes LRRK2
T139 723-728 PR:Q5S006 denotes LRRK2
T140 723-728 PR:000003033 denotes LRRK2
T141 723-728 PR:Q5S007 denotes LRRK2
T143 790-793 O14300 denotes SP1
T144 790-793 PR:O14300 denotes SP1
T145 790-793 Q9DF68 denotes SP1
T146 790-793 PR:000000133 denotes SP1
T148 790-793 PR:Q76LW6 denotes SP1
T149 790-793 P84632 denotes SP1
T150 790-793 PR:Q01714 denotes SP1
T151 790-793 P09179 denotes SP1
T152 790-793 PR:O89090 denotes SP1
T153 790-793 PR:P08047 denotes SP1
T155 790-793 PR:Q8L7N4 denotes SP1
T156 790-793 PR:000006271 denotes SP1
T157 790-793 PR:Q8N907 denotes SP1
T142 790-793 CVCL_VQ86 denotes SP1
T147 790-793 CVCL_R987 denotes SP1
T154 790-793 CVCL_AZ65 denotes SP1
T158 790-793 CVCL_5785 denotes SP1
T159 817-822 PR:Q5S006 denotes LRRK2
T160 817-822 PR:000003033 denotes LRRK2
T161 817-822 PR:Q5S007 denotes LRRK2
T162 852-857 PR:Q5S006 denotes LRRK2
T163 852-857 PR:000003033 denotes LRRK2
T164 852-857 PR:Q5S007 denotes LRRK2
T165 858-873 GO:0016301 denotes kinase activity
T167 906-909 O14300 denotes SP1
T168 906-909 PR:O14300 denotes SP1
T169 906-909 Q9DF68 denotes SP1
T170 906-909 PR:000000133 denotes SP1
T172 906-909 PR:Q76LW6 denotes SP1
T173 906-909 P84632 denotes SP1
T174 906-909 PR:Q01714 denotes SP1
T175 906-909 P09179 denotes SP1
T176 906-909 PR:O89090 denotes SP1
T177 906-909 PR:P08047 denotes SP1
T179 906-909 PR:Q8L7N4 denotes SP1
T180 906-909 PR:000006271 denotes SP1
T181 906-909 PR:Q8N907 denotes SP1
T166 906-909 CVCL_VQ86 denotes SP1
T171 906-909 CVCL_R987 denotes SP1
T178 906-909 CVCL_AZ65 denotes SP1
T182 906-909 CVCL_5785 denotes SP1
T184 913-918 SO:0000646 denotes siRNA
T183 913-918 D034741 denotes siRNA
T185 928-933 PR:Q5S006 denotes LRRK2
T186 928-933 PR:000003033 denotes LRRK2
T187 928-933 PR:Q5S007 denotes LRRK2
T188 961-971 2294143 denotes Drosophila
T189 961-971 504603 denotes Drosophila
T190 961-971 2294139 denotes Drosophila
T191 961-971 2294145 denotes Drosophila
T192 961-971 2294141 denotes Drosophila
T193 961-971 2294142 denotes Drosophila
T194 961-971 2294144 denotes Drosophila
T195 961-971 2294140 denotes Drosophila
T196 961-971 D004330 denotes Drosophila
T197 961-971 2080301 denotes Drosophila
T199 998-1001 O14300 denotes SP1
T200 998-1001 PR:O14300 denotes SP1
T201 998-1001 Q9DF68 denotes SP1
T202 998-1001 PR:000000133 denotes SP1
T204 998-1001 PR:Q76LW6 denotes SP1
T205 998-1001 P84632 denotes SP1
T206 998-1001 PR:Q01714 denotes SP1
T207 998-1001 P09179 denotes SP1
T208 998-1001 PR:O89090 denotes SP1
T209 998-1001 PR:P08047 denotes SP1
T211 998-1001 PR:Q8L7N4 denotes SP1
T212 998-1001 PR:000006271 denotes SP1
T213 998-1001 PR:Q8N907 denotes SP1
T198 998-1001 CVCL_VQ86 denotes SP1
T203 998-1001 CVCL_R987 denotes SP1
T210 998-1001 CVCL_AZ65 denotes SP1
T214 998-1001 CVCL_5785 denotes SP1
T215 1020-1025 PR:Q5S006 denotes LRRK2
T216 1020-1025 PR:000003033 denotes LRRK2
T217 1020-1025 PR:Q5S007 denotes LRRK2
T218 1029-1035 SO:0000985 denotes double
T219 1036-1046 SO:0000781 denotes transgenic
T220 1047-1057 2294143 denotes Drosophila
T221 1047-1057 504603 denotes Drosophila
T222 1047-1057 2294139 denotes Drosophila
T223 1047-1057 2294145 denotes Drosophila
T224 1047-1057 2294141 denotes Drosophila
T225 1047-1057 2294142 denotes Drosophila
T226 1047-1057 2294144 denotes Drosophila
T227 1047-1057 2294140 denotes Drosophila
T228 1047-1057 D004330 denotes Drosophila
T229 1047-1057 2080301 denotes Drosophila
T231 1124-1127 O14300 denotes SP1
T232 1124-1127 PR:O14300 denotes SP1
T233 1124-1127 Q9DF68 denotes SP1
T234 1124-1127 PR:000000133 denotes SP1
T236 1124-1127 PR:Q76LW6 denotes SP1
T237 1124-1127 P84632 denotes SP1
T238 1124-1127 PR:Q01714 denotes SP1
T239 1124-1127 P09179 denotes SP1
T240 1124-1127 PR:O89090 denotes SP1
T241 1124-1127 PR:P08047 denotes SP1
T243 1124-1127 PR:Q8L7N4 denotes SP1
T244 1124-1127 PR:000006271 denotes SP1
T245 1124-1127 PR:Q8N907 denotes SP1
T230 1124-1127 CVCL_VQ86 denotes SP1
T235 1124-1127 CVCL_R987 denotes SP1
T242 1124-1127 CVCL_AZ65 denotes SP1
T246 1124-1127 CVCL_5785 denotes SP1
T247 1152-1157 PR:Q5S006 denotes LRRK2
T248 1152-1157 PR:000003033 denotes LRRK2
T249 1152-1157 PR:Q5S007 denotes LRRK2
T254 1166-1174 3628 denotes dopamine
T250 1166-1174 CHEBI:59905 denotes dopamine
T251 1166-1174 CHEBI:18243 denotes dopamine
T252 1166-1174 D004298 denotes dopamine
T253 1166-1174 D004298 denotes dopamine
T255 1175-1181 CL:0000540 denotes neuron
T256 1199-1204 PR:Q5S006 denotes LRRK2
T257 1199-1204 PR:000003033 denotes LRRK2
T258 1199-1204 PR:Q5S007 denotes LRRK2
T259 1205-1220 GO:0016310 denotes phosphorylation
T260 1224-1230 SO:0000985 denotes double
T261 1231-1241 SO:0000781 denotes transgenic
T263 1284-1287 O14300 denotes SP1
T264 1284-1287 PR:O14300 denotes SP1
T265 1284-1287 Q9DF68 denotes SP1
T266 1284-1287 PR:000000133 denotes SP1
T268 1284-1287 PR:Q76LW6 denotes SP1
T269 1284-1287 P84632 denotes SP1
T270 1284-1287 PR:Q01714 denotes SP1
T271 1284-1287 P09179 denotes SP1
T272 1284-1287 PR:O89090 denotes SP1
T273 1284-1287 PR:P08047 denotes SP1
T275 1284-1287 PR:Q8L7N4 denotes SP1
T276 1284-1287 PR:000006271 denotes SP1
T277 1284-1287 PR:Q8N907 denotes SP1
T262 1284-1287 CVCL_VQ86 denotes SP1
T267 1284-1287 CVCL_R987 denotes SP1
T274 1284-1287 CVCL_AZ65 denotes SP1
T278 1284-1287 CVCL_5785 denotes SP1
T279 1306-1311 PR:Q5S006 denotes LRRK2
T280 1306-1311 PR:000003033 denotes LRRK2
T281 1306-1311 PR:Q5S007 denotes LRRK2

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 93-275 DRI_Outcome denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant Parkinsonism with pleomorphic pathology including deposits of aggregated protein and neuronal degeneration.
T2 276-358 DRI_Background denotes The pathogenesis of LRRK2-linked Parkinson's disease (PD) is not fully understood.
T3 359-544 DRI_Approach denotes Here, using co-immunoprecipitation, we found that LRRK2 interacted with synphilin-1 (SP1), a cytoplasmic protein that interacts with α-synuclein and has implications in PD pathogenesis.
T4 545-680 DRI_Outcome denotes LRRK2 interacted with the N-terminus of SP1 whereas SP1 predominantly interacted with the C-terminus of LRRK2, including kinase domain.
T5 681-779 DRI_Background denotes Co-expression of SP1 with LRRK2 increased LRRK2-induced cytoplasmic aggregation in cultured cells.
T6 780-892 DRI_Background denotes Moreover, SP1 also attenuated mutant LRRK2-induced toxicity and reduced LRRK2 kinase activity in cultured cells.
T7 893-952 DRI_Background denotes Knockdown of SP1 by siRNA enhanced LRRK2 neuronal toxicity.
T8 953-1109 DRI_Background denotes In vivo Drosophila studies, co-expression of SP1 and mutant G2019S-LRRK2 in double transgenic Drosophila increased survival and improved locomotor activity.
T9 1110-1253 DRI_Outcome denotes Expression of SP1 protects against G2019S-LRRK2-induced dopamine neuron loss and reduced LRRK2 phosphorylation in double transgenic fly brains.
T10 1254-1305 DRI_Outcome denotes Our findings demonstrate that SP1 attenuates mutant
T11 1328-1374 DRI_Outcome denotes phenotypes and plays a neural protective role.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26744328-0#0#11#gene9627 0-11 gene9627 denotes Synphilin-1
26744328-0#30#35#gene120892 30-35 gene120892 denotes LRRK2
26744328-0#65#84#diseaseC0030567 65-84 diseaseC0030567 denotes Parkinson's disease
26744328-1#13#41#gene120892 106-134 gene120892 denotes leucine-rich repeat kinase 2
26744328-1#43#48#gene120892 136-141 gene120892 denotes LRRK2
26744328-1#56#87#diseaseC0752098 149-180 diseaseC0752098 denotes autosomal-dominant Parkinsonism
26744328-3#93#112#gene8548 452-471 gene8548 denotes cytoplasmic protein
26744328-3#169#171#diseaseC0030567 528-530 diseaseC0030567 denotes PD
0#11#gene962765#84#diseaseC0030567 26744328-0#0#11#gene9627 26744328-0#65#84#diseaseC0030567 associated_with Synphilin-1,Parkinson's disease
30#35#gene12089265#84#diseaseC0030567 26744328-0#30#35#gene120892 26744328-0#65#84#diseaseC0030567 associated_with LRRK2,Parkinson's disease
13#41#gene12089256#87#diseaseC0752098 26744328-1#13#41#gene120892 26744328-1#56#87#diseaseC0752098 associated_with leucine-rich repeat kinase 2,autosomal-dominant Parkinsonism
43#48#gene12089256#87#diseaseC0752098 26744328-1#43#48#gene120892 26744328-1#56#87#diseaseC0752098 associated_with LRRK2,autosomal-dominant Parkinsonism
93#112#gene8548169#171#diseaseC0030567 26744328-3#93#112#gene8548 26744328-3#169#171#diseaseC0030567 associated_with cytoplasmic protein,PD