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PubMed:26732594 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Autophagy Promotes Microglia Activation Through Beclin-1-Atg5 Pathway in Intracerebral Hemorrhage.
T2 99-210 Sentence denotes Previous study demonstrates that intracerebral hemorrhage (ICH) promotes microglia activation and inflammation.
T3 211-292 Sentence denotes However, the exact mechanism of microglia activation induced by ICH is not clear.
T4 293-477 Sentence denotes In this experiment, microglia autophagy was examined using electron microscopy, conversion of light chain 3(LC3), and monodansylcadaverine (MDC) staining to detect autophagic vacuoles.
T5 478-539 Sentence denotes We found that ICH induced microglia autophagy and activation.
T6 540-766 Sentence denotes The suppression of autophagy using either pharmacologic inhibitors (3-methyladenine, bafilomycin A1) or RNA interference in essential autophagy genes (BECN1 and ATG5) decreased the microglia activation and inflammation in ICH.
T7 767-826 Sentence denotes Moreover, autophagy inhibitors reduced brain damage in ICH.
T8 827-988 Sentence denotes In conclusion, these data indicate that ICH contributes to microglia autophagic activation through BECN1 and ATG5 and provide the therapeutical strategy for ICH.
T1 0-98 Sentence denotes Autophagy Promotes Microglia Activation Through Beclin-1-Atg5 Pathway in Intracerebral Hemorrhage.
T2 99-210 Sentence denotes Previous study demonstrates that intracerebral hemorrhage (ICH) promotes microglia activation and inflammation.
T3 211-292 Sentence denotes However, the exact mechanism of microglia activation induced by ICH is not clear.
T4 293-477 Sentence denotes In this experiment, microglia autophagy was examined using electron microscopy, conversion of light chain 3(LC3), and monodansylcadaverine (MDC) staining to detect autophagic vacuoles.
T5 478-539 Sentence denotes We found that ICH induced microglia autophagy and activation.
T6 540-766 Sentence denotes The suppression of autophagy using either pharmacologic inhibitors (3-methyladenine, bafilomycin A1) or RNA interference in essential autophagy genes (BECN1 and ATG5) decreased the microglia activation and inflammation in ICH.
T7 767-826 Sentence denotes Moreover, autophagy inhibitors reduced brain damage in ICH.
T8 827-988 Sentence denotes In conclusion, these data indicate that ICH contributes to microglia autophagic activation through BECN1 and ATG5 and provide the therapeutical strategy for ICH.