Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-98 |
Sentence |
denotes |
Autophagy Promotes Microglia Activation Through Beclin-1-Atg5 Pathway in Intracerebral Hemorrhage. |
T2 |
99-210 |
Sentence |
denotes |
Previous study demonstrates that intracerebral hemorrhage (ICH) promotes microglia activation and inflammation. |
T3 |
211-292 |
Sentence |
denotes |
However, the exact mechanism of microglia activation induced by ICH is not clear. |
T4 |
293-477 |
Sentence |
denotes |
In this experiment, microglia autophagy was examined using electron microscopy, conversion of light chain 3(LC3), and monodansylcadaverine (MDC) staining to detect autophagic vacuoles. |
T5 |
478-539 |
Sentence |
denotes |
We found that ICH induced microglia autophagy and activation. |
T6 |
540-766 |
Sentence |
denotes |
The suppression of autophagy using either pharmacologic inhibitors (3-methyladenine, bafilomycin A1) or RNA interference in essential autophagy genes (BECN1 and ATG5) decreased the microglia activation and inflammation in ICH. |
T7 |
767-826 |
Sentence |
denotes |
Moreover, autophagy inhibitors reduced brain damage in ICH. |
T8 |
827-988 |
Sentence |
denotes |
In conclusion, these data indicate that ICH contributes to microglia autophagic activation through BECN1 and ATG5 and provide the therapeutical strategy for ICH. |
T1 |
0-98 |
Sentence |
denotes |
Autophagy Promotes Microglia Activation Through Beclin-1-Atg5 Pathway in Intracerebral Hemorrhage. |
T2 |
99-210 |
Sentence |
denotes |
Previous study demonstrates that intracerebral hemorrhage (ICH) promotes microglia activation and inflammation. |
T3 |
211-292 |
Sentence |
denotes |
However, the exact mechanism of microglia activation induced by ICH is not clear. |
T4 |
293-477 |
Sentence |
denotes |
In this experiment, microglia autophagy was examined using electron microscopy, conversion of light chain 3(LC3), and monodansylcadaverine (MDC) staining to detect autophagic vacuoles. |
T5 |
478-539 |
Sentence |
denotes |
We found that ICH induced microglia autophagy and activation. |
T6 |
540-766 |
Sentence |
denotes |
The suppression of autophagy using either pharmacologic inhibitors (3-methyladenine, bafilomycin A1) or RNA interference in essential autophagy genes (BECN1 and ATG5) decreased the microglia activation and inflammation in ICH. |
T7 |
767-826 |
Sentence |
denotes |
Moreover, autophagy inhibitors reduced brain damage in ICH. |
T8 |
827-988 |
Sentence |
denotes |
In conclusion, these data indicate that ICH contributes to microglia autophagic activation through BECN1 and ATG5 and provide the therapeutical strategy for ICH. |