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PubMed:26715202 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 49-52 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T2 49-52 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T3 519-522 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T4 519-522 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T5 857-860 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T6 857-860 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T7 906-909 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T8 906-909 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T9 960-963 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T10 960-963 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T11 1252-1255 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T12 1252-1255 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T13 1301-1304 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T14 1301-1304 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T3 519-522 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T5 857-860 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T7 906-909 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T9 960-963 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T11 1252-1255 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T13 1301-1304 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 49-52 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T2 519-522 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T3 857-860 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T4 906-909 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T5 960-963 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T6 1252-1255 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T7 1301-1304 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-91 Sentence denotes Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
TextSentencer_T2 92-268 Sentence denotes Mammalian cell surfaces are decorated with a variety of glycan chains that orchestrate development and defense and are exploited by pathogens for cellular attachment and entry.
TextSentencer_T3 269-475 Sentence denotes While glycosidic linkages are, in principle, flexible, the conformational space that a given glycan can sample is subject to spatial and electrostatic restrictions imposed by its overall chemical structure.
TextSentencer_T4 476-716 Sentence denotes Here, we show how the glycan moiety of the GM1 ganglioside, a branched, monosialylated pentasaccharide that serves as a ligand for various proteins, undergoes differential conformational selection in its interactions with different lectins.
TextSentencer_T5 717-1022 Sentence denotes Using STD NMR and X-ray crystallography, we found that the innate immune regulator Complement Factor H (FH) binds a previously not reported GM1 conformation that is not compatible with the GM1 binding sites of other structurally characterized GM1-binding lectins such as the Simian Virus 40 (SV40) capsid.
TextSentencer_T6 1023-1232 Sentence denotes Molecular dynamics simulations of the free glycan in explicit solvent on the ten microsecond timescale reveal that the FH-bound conformation nevertheless corresponds to a minimum in the Gibbs free energy plot.
TextSentencer_T7 1233-1511 Sentence denotes In contrast to the GM1 conformation recognized by SV40 the FH-bound GM1 conformation is associated with poor NOE restraints, explaining how it escaped (1)H-(1)H NOE restrained modeling in the past and highlighting the necessity for ensemble representations of glycan structures.
T1 0-91 Sentence denotes Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
T2 92-268 Sentence denotes Mammalian cell surfaces are decorated with a variety of glycan chains that orchestrate development and defense and are exploited by pathogens for cellular attachment and entry.
T3 269-475 Sentence denotes While glycosidic linkages are, in principle, flexible, the conformational space that a given glycan can sample is subject to spatial and electrostatic restrictions imposed by its overall chemical structure.
T4 476-716 Sentence denotes Here, we show how the glycan moiety of the GM1 ganglioside, a branched, monosialylated pentasaccharide that serves as a ligand for various proteins, undergoes differential conformational selection in its interactions with different lectins.
T5 717-1022 Sentence denotes Using STD NMR and X-ray crystallography, we found that the innate immune regulator Complement Factor H (FH) binds a previously not reported GM1 conformation that is not compatible with the GM1 binding sites of other structurally characterized GM1-binding lectins such as the Simian Virus 40 (SV40) capsid.
T6 1023-1232 Sentence denotes Molecular dynamics simulations of the free glycan in explicit solvent on the ten microsecond timescale reveal that the FH-bound conformation nevertheless corresponds to a minimum in the Gibbs free energy plot.
T7 1233-1511 Sentence denotes In contrast to the GM1 conformation recognized by SV40 the FH-bound GM1 conformation is associated with poor NOE restraints, explaining how it escaped (1)H-(1)H NOE restrained modeling in the past and highlighting the necessity for ensemble representations of glycan structures.
T1 0-91 Sentence denotes Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.
T2 92-268 Sentence denotes Mammalian cell surfaces are decorated with a variety of glycan chains that orchestrate development and defense and are exploited by pathogens for cellular attachment and entry.
T3 269-475 Sentence denotes While glycosidic linkages are, in principle, flexible, the conformational space that a given glycan can sample is subject to spatial and electrostatic restrictions imposed by its overall chemical structure.
T4 476-716 Sentence denotes Here, we show how the glycan moiety of the GM1 ganglioside, a branched, monosialylated pentasaccharide that serves as a ligand for various proteins, undergoes differential conformational selection in its interactions with different lectins.
T5 717-1022 Sentence denotes Using STD NMR and X-ray crystallography, we found that the innate immune regulator Complement Factor H (FH) binds a previously not reported GM1 conformation that is not compatible with the GM1 binding sites of other structurally characterized GM1-binding lectins such as the Simian Virus 40 (SV40) capsid.
T6 1023-1232 Sentence denotes Molecular dynamics simulations of the free glycan in explicit solvent on the ten microsecond timescale reveal that the FH-bound conformation nevertheless corresponds to a minimum in the Gibbs free energy plot.
T7 1233-1511 Sentence denotes In contrast to the GM1 conformation recognized by SV40 the FH-bound GM1 conformation is associated with poor NOE restraints, explaining how it escaped (1)H-(1)H NOE restrained modeling in the past and highlighting the necessity for ensemble representations of glycan structures.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 49-52 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T2 49-52 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T3 519-522 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T4 519-522 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T5 857-860 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T6 857-860 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T7 906-909 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T8 906-909 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T9 960-963 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T10 960-963 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T11 1252-1255 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T12 1252-1255 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T13 1301-1304 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T14 1301-1304 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 53-64 FMAID:82816 denotes ganglioside
_T2 53-64 FMAID:196811 denotes ganglioside
_T3 102-115 FMAID:212684 denotes cell surfaces
_T4 102-115 FMAID:200942 denotes cell surfaces
_T5 107-115 FMAID:50594 denotes surfaces
_T6 107-115 FMAID:146300 denotes surfaces
_T7 523-534 FMAID:82816 denotes ganglioside
_T8 523-534 FMAID:196811 denotes ganglioside
_T9 538-546 FMAID:226028 denotes branched
_T10 538-546 FMAID:226027 denotes branched
_T11 615-623 FMAID:67257 denotes proteins
_T12 615-623 FMAID:165447 denotes proteins
_T13 663-675 FMAID:61795 denotes selection in
_T14 663-675 FMAID:165243 denotes selection in

uniprot-human

Id Subject Object Predicate Lexical cue
T1 723-726 http://www.uniprot.org/uniprot/Q06520 denotes STD
T2 821-823 http://www.uniprot.org/uniprot/P07954 denotes FH
T3 1142-1144 http://www.uniprot.org/uniprot/P07954 denotes FH
T4 1292-1294 http://www.uniprot.org/uniprot/P07954 denotes FH

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 394-401 http://www.uniprot.org/uniprot/Q9EQE5 denotes spatial

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 24-36 http://purl.bioontology.org/ontology/NCBITAXON/11642 denotes Simian Virus
T2 24-36 http://purl.bioontology.org/ontology/NCBITAXON/46771 denotes Simian Virus
T3 24-39 http://purl.bioontology.org/ontology/NCBITAXON/585074 denotes Simian Virus 40
T4 24-39 http://purl.bioontology.org/ontology/NCBITAXON/10633 denotes Simian Virus 40
T5 31-36 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes Virus
T6 992-1004 http://purl.bioontology.org/ontology/NCBITAXON/11642 denotes Simian Virus
T7 992-1004 http://purl.bioontology.org/ontology/NCBITAXON/46771 denotes Simian Virus
T8 992-1007 http://purl.bioontology.org/ontology/NCBITAXON/10633 denotes Simian Virus 40
T9 992-1007 http://purl.bioontology.org/ontology/NCBITAXON/585074 denotes Simian Virus 40
T10 999-1004 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes Virus

GO-BP

Id Subject Object Predicate Lexical cue
T1 179-190 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2 238-246 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T3 776-789 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T4 776-799 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune regulator
T5 790-799 http://purl.obolibrary.org/obo/GO_0065007 denotes regulator

GO-MF

Id Subject Object Predicate Lexical cue
T1 40-44 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T2 825-830 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T3 910-917 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 964-971 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 40-44 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T6 825-830 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T7 910-917 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 964-971 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 40-44 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T10 825-830 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T11 910-917 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 964-971 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 40-44 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T14 825-830 http://purl.obolibrary.org/obo/GO_0005488 denotes binds
T15 910-917 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16 964-971 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17 596-602 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand

GO-CC

Id Subject Object Predicate Lexical cue
T1 102-106 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 102-115 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surfaces

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 49-52 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T2 519-522 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T3 857-860 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T4 906-909 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T5 960-963 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T6 1252-1255 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T7 1301-1304 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 723-726 Disease denotes STD http://purl.obolibrary.org/obo/MONDO_0021681

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 519-522 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 857-860 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 906-909 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T5 960-963 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T6 1252-1255 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T7 1301-1304 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 24-39 OrganismTaxon denotes Simian Virus 40 1891767
T2 992-1007 OrganismTaxon denotes Simian Virus 40 1891767
T3 1009-1013 OrganismTaxon denotes SV40 1891767
T4 1283-1287 OrganismTaxon denotes SV40 1891767

Glycosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 49-52 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 519-522 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 857-860 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 906-909 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 960-963 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 1252-1255 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 1301-1304 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 343-348 Body_part denotes space http://purl.obolibrary.org/obo/UBERON_0000464