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PubMed:26710934 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Long-Term Expression of the Human CFTR Gene in Mouse Airway via Helper-Dependent Adenoviral Vector Delivery and Transient Immunosuppression.
T2 141-308 Sentence denotes Sustained expression of the CFTR gene is a major challenge to gene therapy with either viral or nonviral vectors with immune response to vector and transgene products.
T3 309-433 Sentence denotes One strategy to achieve sustained CFTR expression is to modulate the host immune system through transient immunosuppression.
T4 434-723 Sentence denotes In this study, we examined cyclophosphamide (cytoxan), dexamethasone (Dex), and a combination of cyclosporin, methylprednisolone, and azathioprine (combination) for their effects on long-term expression of the human CFTR delivered with helper-dependent adenoviral vectors in mouse airways.
T5 724-889 Sentence denotes We found that cyclophosphamide significantly enhanced long-term expression of the transgenic human CFTR and the reporter gene LacZ by reducing host immune responses.
T6 890-1000 Sentence denotes Dex administration greatly reduced neutralizing antibody production but had no effect on transgene expression.
T7 1001-1140 Sentence denotes Treatment with a combination of cyclosporin A, azathioprine, and methylprednisolone affected neither CFTR gene expression nor inflammation.
T8 1141-1259 Sentence denotes Our data suggest that transient immunosuppression might be a strategy to improve sustained expression in gene therapy.
T1 0-140 Sentence denotes Long-Term Expression of the Human CFTR Gene in Mouse Airway via Helper-Dependent Adenoviral Vector Delivery and Transient Immunosuppression.
T2 141-308 Sentence denotes Sustained expression of the CFTR gene is a major challenge to gene therapy with either viral or nonviral vectors with immune response to vector and transgene products.
T3 309-433 Sentence denotes One strategy to achieve sustained CFTR expression is to modulate the host immune system through transient immunosuppression.
T4 434-723 Sentence denotes In this study, we examined cyclophosphamide (cytoxan), dexamethasone (Dex), and a combination of cyclosporin, methylprednisolone, and azathioprine (combination) for their effects on long-term expression of the human CFTR delivered with helper-dependent adenoviral vectors in mouse airways.
T5 724-889 Sentence denotes We found that cyclophosphamide significantly enhanced long-term expression of the transgenic human CFTR and the reporter gene LacZ by reducing host immune responses.
T6 890-1000 Sentence denotes Dex administration greatly reduced neutralizing antibody production but had no effect on transgene expression.
T7 1001-1140 Sentence denotes Treatment with a combination of cyclosporin A, azathioprine, and methylprednisolone affected neither CFTR gene expression nor inflammation.
T8 1141-1259 Sentence denotes Our data suggest that transient immunosuppression might be a strategy to improve sustained expression in gene therapy.