PubMed:26692049
Annnotations
GlyCosmos6-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 104-111 | Body_part | denotes | envelop | http://purl.obolibrary.org/obo/GO_0031975 |
| T2 | 169-177 | Body_part | denotes | envelope | http://purl.obolibrary.org/obo/GO_0031975 |
| T3 | 208-215 | Body_part | denotes | process | http://purl.obolibrary.org/obo/UBERON_0004529 |
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 586-593 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
| T2 | 606-613 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 586-593 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
| T2 | 606-613 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-140 | Sentence | denotes | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis. |
| TextSentencer_T2 | 141-262 | Sentence | denotes | Formation of the heterocyst envelope polysaccharide (HEP) is a key process for cyanobacterial heterocyst differentiation. |
| TextSentencer_T3 | 263-482 | Sentence | denotes | The maturation of HEP in Anabaena sp. strain PCC 7120 is controlled by a gene cluster termed HEP island in addition to an operon alr3698-alr3699, which encodes two putative proteins termed Alr3698/HepD and Alr3699/HepE. |
| TextSentencer_T4 | 483-636 | Sentence | denotes | Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively. |
| TextSentencer_T5 | 637-825 | Sentence | denotes | The overall structure of HepE displays a typical GT-B fold of glycosyltransferases, comprising two separate β/α/β Rossmann-fold domains that form an inter-domain substrate-binding crevice. |
| TextSentencer_T6 | 826-949 | Sentence | denotes | Structural analyses combined with enzymatic assays indicate that HepE is a glucosyltransferase using UDPG as a sugar donor. |
| TextSentencer_T7 | 950-1074 | Sentence | denotes | Further site-directed mutageneses enable us to assign the key residues that stabilize the sugar donor and putative acceptor. |
| TextSentencer_T8 | 1075-1281 | Sentence | denotes | Based on the comparative structural analyses, we propose a putative catalytic cycle of HepE, which undergoes "open-closed-open" conformational changes upon binding to the substrates and release of products. |
| TextSentencer_T9 | 1282-1402 | Sentence | denotes | These findings provide structural and catalytic insights into the first enzyme involved in the HEP biosynthesis pathway. |
| T1 | 0-140 | Sentence | denotes | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis. |
| T2 | 141-262 | Sentence | denotes | Formation of the heterocyst envelope polysaccharide (HEP) is a key process for cyanobacterial heterocyst differentiation. |
| T3 | 263-482 | Sentence | denotes | The maturation of HEP in Anabaena sp. strain PCC 7120 is controlled by a gene cluster termed HEP island in addition to an operon alr3698-alr3699, which encodes two putative proteins termed Alr3698/HepD and Alr3699/HepE. |
| T4 | 483-636 | Sentence | denotes | Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively. |
| T5 | 637-825 | Sentence | denotes | The overall structure of HepE displays a typical GT-B fold of glycosyltransferases, comprising two separate β/α/β Rossmann-fold domains that form an inter-domain substrate-binding crevice. |
| T6 | 826-949 | Sentence | denotes | Structural analyses combined with enzymatic assays indicate that HepE is a glucosyltransferase using UDPG as a sugar donor. |
| T7 | 950-1074 | Sentence | denotes | Further site-directed mutageneses enable us to assign the key residues that stabilize the sugar donor and putative acceptor. |
| T8 | 1075-1281 | Sentence | denotes | Based on the comparative structural analyses, we propose a putative catalytic cycle of HepE, which undergoes "open-closed-open" conformational changes upon binding to the substrates and release of products. |
| T9 | 1282-1402 | Sentence | denotes | These findings provide structural and catalytic insights into the first enzyme involved in the HEP biosynthesis pathway. |
| T1 | 0-140 | Sentence | denotes | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis. |
| T2 | 141-262 | Sentence | denotes | Formation of the heterocyst envelope polysaccharide (HEP) is a key process for cyanobacterial heterocyst differentiation. |
| T3 | 263-482 | Sentence | denotes | The maturation of HEP in Anabaena sp. strain PCC 7120 is controlled by a gene cluster termed HEP island in addition to an operon alr3698-alr3699, which encodes two putative proteins termed Alr3698/HepD and Alr3699/HepE. |
| T4 | 483-636 | Sentence | denotes | Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively. |
| T5 | 637-825 | Sentence | denotes | The overall structure of HepE displays a typical GT-B fold of glycosyltransferases, comprising two separate β/α/β Rossmann-fold domains that form an inter-domain substrate-binding crevice. |
| T6 | 826-949 | Sentence | denotes | Structural analyses combined with enzymatic assays indicate that HepE is a glucosyltransferase using UDPG as a sugar donor. |
| T7 | 950-1074 | Sentence | denotes | Further site-directed mutageneses enable us to assign the key residues that stabilize the sugar donor and putative acceptor. |
| T8 | 1075-1281 | Sentence | denotes | Based on the comparative structural analyses, we propose a putative catalytic cycle of HepE, which undergoes "open-closed-open" conformational changes upon binding to the substrates and release of products. |
| T9 | 1282-1402 | Sentence | denotes | These findings provide structural and catalytic insights into the first enzyme involved in the HEP biosynthesis pathway. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 586-593 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
| T2 | 606-613 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 84-92 | OrganismTaxon | denotes | Anabaena | NCBItxid:1163 |
| T2 | 288-299 | OrganismTaxon | denotes | Anabaena sp | NCBItxid:1167 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 308-311 | Disease | denotes | PCC | http://purl.obolibrary.org/obo/MONDO_0004974|http://purl.obolibrary.org/obo/MONDO_0022673 |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 112-126 | FMAID:82785 | denotes | polysaccharide |
| _T2 | 112-126 | FMAID:196779 | denotes | polysaccharide |
| _T3 | 112-126 | FMAID:196735 | denotes | polysaccharide |
| _T4 | 112-126 | FMAID:82746 | denotes | polysaccharide |
| _T5 | 178-192 | FMAID:196735 | denotes | polysaccharide |
| _T6 | 178-192 | FMAID:196779 | denotes | polysaccharide |
| _T7 | 178-192 | FMAID:82746 | denotes | polysaccharide |
| _T8 | 178-192 | FMAID:82785 | denotes | polysaccharide |
| _T9 | 336-340 | FMAID:198663 | denotes | gene |
| _T10 | 336-348 | FMAID:198017 | denotes | gene cluster |
| _T11 | 336-348 | FMAID:84082 | denotes | gene cluster |
| _T12 | 436-444 | FMAID:165447 | denotes | proteins |
| _T13 | 436-444 | FMAID:67257 | denotes | proteins |
| _T14 | 586-593 | FMAID:196732 | denotes | glucose |
| _T15 | 586-593 | FMAID:82743 | denotes | glucose |
| _T16 | 606-613 | FMAID:82743 | denotes | glucose |
| _T17 | 606-613 | FMAID:196732 | denotes | glucose |
| _T18 | 937-942 | FMAID:196724 | denotes | sugar |
| _T19 | 1040-1045 | FMAID:196724 | denotes | sugar |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 194-197 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HEP |
| T2 | 281-284 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HEP |
| T3 | 356-359 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HEP |
| T4 | 1377-1380 | http://www.uniprot.org/uniprot/Q9Y251 | denotes | HEP |
| T5 | 194-197 | http://www.uniprot.org/uniprot/O15197 | denotes | HEP |
| T6 | 281-284 | http://www.uniprot.org/uniprot/O15197 | denotes | HEP |
| T7 | 356-359 | http://www.uniprot.org/uniprot/O15197 | denotes | HEP |
| T8 | 1377-1380 | http://www.uniprot.org/uniprot/O15197 | denotes | HEP |
| T9 | 536-539 | http://www.uniprot.org/uniprot/P08519 | denotes | apo |
| T10 | 686-688 | http://www.uniprot.org/uniprot/Q9NYU2 | denotes | GT |
| T11 | 686-688 | http://www.uniprot.org/uniprot/P51161 | denotes | GT |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 297-299 | http://www.uniprot.org/uniprot/Q03404 | denotes | sp |
| T2 | 686-688 | http://www.uniprot.org/uniprot/P51162 | denotes | GT |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 220-234 | http://purl.bioontology.org/ontology/NCBITAXON/102234 | denotes | cyanobacterial |
| T2 | 220-234 | http://purl.bioontology.org/ontology/NCBITAXON/1117 | denotes | cyanobacterial |
| T3 | 288-299 | http://purl.bioontology.org/ontology/NCBITAXON/1167 | denotes | Anabaena sp |
| T4 | 288-299 | http://purl.bioontology.org/ontology/NCBITAXON/1447071 | denotes | Anabaena sp |
| T5 | 349-355 | http://purl.bioontology.org/ontology/NCBITAXON/62951 | denotes | termed |
| T6 | 445-451 | http://purl.bioontology.org/ontology/NCBITAXON/62951 | denotes | termed |
| T7 | 1288-1296 | http://purl.bioontology.org/ontology/STY/T033 | denotes | findings |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 112-139 | http://purl.obolibrary.org/obo/GO_0000271 | denotes | polysaccharide biosynthesis |
| T2 | 127-139 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T3 | 1381-1393 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T4 | 127-150 | http://purl.obolibrary.org/obo/GO_0015943 | denotes | biosynthesis. Formation |
| T5 | 141-150 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | Formation |
| T6 | 141-168 | http://purl.obolibrary.org/obo/GO_0043158 | denotes | Formation of the heterocyst |
| T7 | 235-261 | http://purl.obolibrary.org/obo/GO_0043158 | denotes | heterocyst differentiation |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 574-578 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | bind |
| T2 | 809-816 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T3 | 1231-1238 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T4 | 574-578 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | bind |
| T5 | 809-816 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T6 | 1231-1238 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T7 | 574-578 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | bind |
| T8 | 809-816 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T9 | 1231-1238 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T10 | 574-578 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | bind |
| T11 | 809-816 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
| T12 | 1231-1238 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 104-111 | http://purl.obolibrary.org/obo/GO_0009274 | denotes | envelop |
| T2 | 169-177 | http://purl.obolibrary.org/obo/GO_0009274 | denotes | envelope |
GlycoBiology-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 220-234 | http://purl.obolibrary.org/obo/MAT_0000192 | denotes | cyanobacterial |
GlyTouCan-IUPAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| GlycanIUPAC_T1 | 194-197 | "http://rdf.glycoinfo.org/glycan/G53038OI" | denotes | HEP |
| GlycanIUPAC_T2 | 281-284 | "http://rdf.glycoinfo.org/glycan/G53038OI" | denotes | HEP |
| GlycanIUPAC_T3 | 356-359 | "http://rdf.glycoinfo.org/glycan/G53038OI" | denotes | HEP |
| GlycanIUPAC_T4 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G53038OI" | denotes | HEP |
| GlycanIUPAC_T5 | 194-197 | "http://rdf.glycoinfo.org/glycan/G71412NI" | denotes | HEP |
| GlycanIUPAC_T6 | 281-284 | "http://rdf.glycoinfo.org/glycan/G71412NI" | denotes | HEP |
| GlycanIUPAC_T7 | 356-359 | "http://rdf.glycoinfo.org/glycan/G71412NI" | denotes | HEP |
| GlycanIUPAC_T8 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G71412NI" | denotes | HEP |
| GlycanIUPAC_T9 | 194-197 | "http://rdf.glycoinfo.org/glycan/G95181HA" | denotes | HEP |
| GlycanIUPAC_T10 | 281-284 | "http://rdf.glycoinfo.org/glycan/G95181HA" | denotes | HEP |
| GlycanIUPAC_T11 | 356-359 | "http://rdf.glycoinfo.org/glycan/G95181HA" | denotes | HEP |
| GlycanIUPAC_T12 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G95181HA" | denotes | HEP |
| GlycanIUPAC_T13 | 194-197 | "http://rdf.glycoinfo.org/glycan/G33888ZV" | denotes | HEP |
| GlycanIUPAC_T14 | 281-284 | "http://rdf.glycoinfo.org/glycan/G33888ZV" | denotes | HEP |
| GlycanIUPAC_T15 | 356-359 | "http://rdf.glycoinfo.org/glycan/G33888ZV" | denotes | HEP |
| GlycanIUPAC_T16 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G33888ZV" | denotes | HEP |
| GlycanIUPAC_T17 | 194-197 | "http://rdf.glycoinfo.org/glycan/G72383QV" | denotes | HEP |
| GlycanIUPAC_T18 | 281-284 | "http://rdf.glycoinfo.org/glycan/G72383QV" | denotes | HEP |
| GlycanIUPAC_T19 | 356-359 | "http://rdf.glycoinfo.org/glycan/G72383QV" | denotes | HEP |
| GlycanIUPAC_T20 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G72383QV" | denotes | HEP |
| GlycanIUPAC_T21 | 194-197 | "http://rdf.glycoinfo.org/glycan/G52595WA" | denotes | HEP |
| GlycanIUPAC_T22 | 281-284 | "http://rdf.glycoinfo.org/glycan/G52595WA" | denotes | HEP |
| GlycanIUPAC_T23 | 356-359 | "http://rdf.glycoinfo.org/glycan/G52595WA" | denotes | HEP |
| GlycanIUPAC_T24 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G52595WA" | denotes | HEP |
| GlycanIUPAC_T25 | 194-197 | "http://rdf.glycoinfo.org/glycan/G65441IM" | denotes | HEP |
| GlycanIUPAC_T26 | 281-284 | "http://rdf.glycoinfo.org/glycan/G65441IM" | denotes | HEP |
| GlycanIUPAC_T27 | 356-359 | "http://rdf.glycoinfo.org/glycan/G65441IM" | denotes | HEP |
| GlycanIUPAC_T28 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G65441IM" | denotes | HEP |
| GlycanIUPAC_T29 | 194-197 | "http://rdf.glycoinfo.org/glycan/G64989KP" | denotes | HEP |
| GlycanIUPAC_T30 | 281-284 | "http://rdf.glycoinfo.org/glycan/G64989KP" | denotes | HEP |
| GlycanIUPAC_T31 | 356-359 | "http://rdf.glycoinfo.org/glycan/G64989KP" | denotes | HEP |
| GlycanIUPAC_T32 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G64989KP" | denotes | HEP |
| GlycanIUPAC_T33 | 194-197 | "http://rdf.glycoinfo.org/glycan/G39900ZC" | denotes | HEP |
| GlycanIUPAC_T34 | 281-284 | "http://rdf.glycoinfo.org/glycan/G39900ZC" | denotes | HEP |
| GlycanIUPAC_T35 | 356-359 | "http://rdf.glycoinfo.org/glycan/G39900ZC" | denotes | HEP |
| GlycanIUPAC_T36 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G39900ZC" | denotes | HEP |
| GlycanIUPAC_T37 | 194-197 | "http://rdf.glycoinfo.org/glycan/G51147IJ" | denotes | HEP |
| GlycanIUPAC_T38 | 281-284 | "http://rdf.glycoinfo.org/glycan/G51147IJ" | denotes | HEP |
| GlycanIUPAC_T39 | 356-359 | "http://rdf.glycoinfo.org/glycan/G51147IJ" | denotes | HEP |
| GlycanIUPAC_T40 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G51147IJ" | denotes | HEP |
| GlycanIUPAC_T41 | 194-197 | "http://rdf.glycoinfo.org/glycan/G42761PO" | denotes | HEP |
| GlycanIUPAC_T42 | 281-284 | "http://rdf.glycoinfo.org/glycan/G42761PO" | denotes | HEP |
| GlycanIUPAC_T43 | 356-359 | "http://rdf.glycoinfo.org/glycan/G42761PO" | denotes | HEP |
| GlycanIUPAC_T44 | 1377-1380 | "http://rdf.glycoinfo.org/glycan/G42761PO" | denotes | HEP |
| GlycanIUPAC_T45 | 937-942 | "http://rdf.glycoinfo.org/glycan/G59665TO" | denotes | sugar |
| GlycanIUPAC_T46 | 1040-1045 | "http://rdf.glycoinfo.org/glycan/G59665TO" | denotes | sugar |
| GlycanIUPAC_T47 | 937-942 | "http://rdf.glycoinfo.org/glycan/G32915EI" | denotes | sugar |
| GlycanIUPAC_T48 | 1040-1045 | "http://rdf.glycoinfo.org/glycan/G32915EI" | denotes | sugar |
| GlycanIUPAC_T49 | 937-942 | "http://rdf.glycoinfo.org/glycan/G60625TS" | denotes | sugar |
| GlycanIUPAC_T50 | 1040-1045 | "http://rdf.glycoinfo.org/glycan/G60625TS" | denotes | sugar |