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PubMed:26692049 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 586-593 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 606-613 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 586-593 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 606-613 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-140 Sentence denotes Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis.
TextSentencer_T2 141-262 Sentence denotes Formation of the heterocyst envelope polysaccharide (HEP) is a key process for cyanobacterial heterocyst differentiation.
TextSentencer_T3 263-482 Sentence denotes The maturation of HEP in Anabaena sp. strain PCC 7120 is controlled by a gene cluster termed HEP island in addition to an operon alr3698-alr3699, which encodes two putative proteins termed Alr3698/HepD and Alr3699/HepE.
TextSentencer_T4 483-636 Sentence denotes Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively.
TextSentencer_T5 637-825 Sentence denotes The overall structure of HepE displays a typical GT-B fold of glycosyltransferases, comprising two separate β/α/β Rossmann-fold domains that form an inter-domain substrate-binding crevice.
TextSentencer_T6 826-949 Sentence denotes Structural analyses combined with enzymatic assays indicate that HepE is a glucosyltransferase using UDPG as a sugar donor.
TextSentencer_T7 950-1074 Sentence denotes Further site-directed mutageneses enable us to assign the key residues that stabilize the sugar donor and putative acceptor.
TextSentencer_T8 1075-1281 Sentence denotes Based on the comparative structural analyses, we propose a putative catalytic cycle of HepE, which undergoes "open-closed-open" conformational changes upon binding to the substrates and release of products.
TextSentencer_T9 1282-1402 Sentence denotes These findings provide structural and catalytic insights into the first enzyme involved in the HEP biosynthesis pathway.
T1 0-140 Sentence denotes Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis.
T2 141-262 Sentence denotes Formation of the heterocyst envelope polysaccharide (HEP) is a key process for cyanobacterial heterocyst differentiation.
T3 263-482 Sentence denotes The maturation of HEP in Anabaena sp. strain PCC 7120 is controlled by a gene cluster termed HEP island in addition to an operon alr3698-alr3699, which encodes two putative proteins termed Alr3698/HepD and Alr3699/HepE.
T4 483-636 Sentence denotes Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively.
T5 637-825 Sentence denotes The overall structure of HepE displays a typical GT-B fold of glycosyltransferases, comprising two separate β/α/β Rossmann-fold domains that form an inter-domain substrate-binding crevice.
T6 826-949 Sentence denotes Structural analyses combined with enzymatic assays indicate that HepE is a glucosyltransferase using UDPG as a sugar donor.
T7 950-1074 Sentence denotes Further site-directed mutageneses enable us to assign the key residues that stabilize the sugar donor and putative acceptor.
T8 1075-1281 Sentence denotes Based on the comparative structural analyses, we propose a putative catalytic cycle of HepE, which undergoes "open-closed-open" conformational changes upon binding to the substrates and release of products.
T9 1282-1402 Sentence denotes These findings provide structural and catalytic insights into the first enzyme involved in the HEP biosynthesis pathway.
T1 0-140 Sentence denotes Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis.
T2 141-262 Sentence denotes Formation of the heterocyst envelope polysaccharide (HEP) is a key process for cyanobacterial heterocyst differentiation.
T3 263-482 Sentence denotes The maturation of HEP in Anabaena sp. strain PCC 7120 is controlled by a gene cluster termed HEP island in addition to an operon alr3698-alr3699, which encodes two putative proteins termed Alr3698/HepD and Alr3699/HepE.
T4 483-636 Sentence denotes Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively.
T5 637-825 Sentence denotes The overall structure of HepE displays a typical GT-B fold of glycosyltransferases, comprising two separate β/α/β Rossmann-fold domains that form an inter-domain substrate-binding crevice.
T6 826-949 Sentence denotes Structural analyses combined with enzymatic assays indicate that HepE is a glucosyltransferase using UDPG as a sugar donor.
T7 950-1074 Sentence denotes Further site-directed mutageneses enable us to assign the key residues that stabilize the sugar donor and putative acceptor.
T8 1075-1281 Sentence denotes Based on the comparative structural analyses, we propose a putative catalytic cycle of HepE, which undergoes "open-closed-open" conformational changes upon binding to the substrates and release of products.
T9 1282-1402 Sentence denotes These findings provide structural and catalytic insights into the first enzyme involved in the HEP biosynthesis pathway.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 586-593 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 606-613 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 112-126 FMAID:82785 denotes polysaccharide
_T2 112-126 FMAID:196779 denotes polysaccharide
_T3 112-126 FMAID:196735 denotes polysaccharide
_T4 112-126 FMAID:82746 denotes polysaccharide
_T5 178-192 FMAID:196735 denotes polysaccharide
_T6 178-192 FMAID:196779 denotes polysaccharide
_T7 178-192 FMAID:82746 denotes polysaccharide
_T8 178-192 FMAID:82785 denotes polysaccharide
_T9 336-340 FMAID:198663 denotes gene
_T10 336-348 FMAID:198017 denotes gene cluster
_T11 336-348 FMAID:84082 denotes gene cluster
_T12 436-444 FMAID:165447 denotes proteins
_T13 436-444 FMAID:67257 denotes proteins
_T14 586-593 FMAID:196732 denotes glucose
_T15 586-593 FMAID:82743 denotes glucose
_T16 606-613 FMAID:82743 denotes glucose
_T17 606-613 FMAID:196732 denotes glucose
_T18 937-942 FMAID:196724 denotes sugar
_T19 1040-1045 FMAID:196724 denotes sugar

uniprot-human

Id Subject Object Predicate Lexical cue
T1 194-197 http://www.uniprot.org/uniprot/Q9Y251 denotes HEP
T2 281-284 http://www.uniprot.org/uniprot/Q9Y251 denotes HEP
T3 356-359 http://www.uniprot.org/uniprot/Q9Y251 denotes HEP
T4 1377-1380 http://www.uniprot.org/uniprot/Q9Y251 denotes HEP
T5 194-197 http://www.uniprot.org/uniprot/O15197 denotes HEP
T6 281-284 http://www.uniprot.org/uniprot/O15197 denotes HEP
T7 356-359 http://www.uniprot.org/uniprot/O15197 denotes HEP
T8 1377-1380 http://www.uniprot.org/uniprot/O15197 denotes HEP
T9 536-539 http://www.uniprot.org/uniprot/P08519 denotes apo
T10 686-688 http://www.uniprot.org/uniprot/Q9NYU2 denotes GT
T11 686-688 http://www.uniprot.org/uniprot/P51161 denotes GT

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 297-299 http://www.uniprot.org/uniprot/Q03404 denotes sp
T2 686-688 http://www.uniprot.org/uniprot/P51162 denotes GT

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 220-234 http://purl.bioontology.org/ontology/NCBITAXON/102234 denotes cyanobacterial
T2 220-234 http://purl.bioontology.org/ontology/NCBITAXON/1117 denotes cyanobacterial
T3 288-299 http://purl.bioontology.org/ontology/NCBITAXON/1167 denotes Anabaena sp
T4 288-299 http://purl.bioontology.org/ontology/NCBITAXON/1447071 denotes Anabaena sp
T5 349-355 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes termed
T6 445-451 http://purl.bioontology.org/ontology/NCBITAXON/62951 denotes termed
T7 1288-1296 http://purl.bioontology.org/ontology/STY/T033 denotes findings

GO-BP

Id Subject Object Predicate Lexical cue
T1 112-139 http://purl.obolibrary.org/obo/GO_0000271 denotes polysaccharide biosynthesis
T2 127-139 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T3 1381-1393 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T4 127-150 http://purl.obolibrary.org/obo/GO_0015943 denotes biosynthesis. Formation
T5 141-150 http://purl.obolibrary.org/obo/GO_0009058 denotes Formation
T6 141-168 http://purl.obolibrary.org/obo/GO_0043158 denotes Formation of the heterocyst
T7 235-261 http://purl.obolibrary.org/obo/GO_0043158 denotes heterocyst differentiation

GO-MF

Id Subject Object Predicate Lexical cue
T1 574-578 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T2 809-816 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1231-1238 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 574-578 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T5 809-816 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 1231-1238 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 574-578 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T8 809-816 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1231-1238 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 574-578 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T11 809-816 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 1231-1238 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 104-111 http://purl.obolibrary.org/obo/GO_0009274 denotes envelop
T2 169-177 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 220-234 http://purl.obolibrary.org/obo/MAT_0000192 denotes cyanobacterial

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 194-197 "http://rdf.glycoinfo.org/glycan/G53038OI" denotes HEP
GlycanIUPAC_T2 281-284 "http://rdf.glycoinfo.org/glycan/G53038OI" denotes HEP
GlycanIUPAC_T3 356-359 "http://rdf.glycoinfo.org/glycan/G53038OI" denotes HEP
GlycanIUPAC_T4 1377-1380 "http://rdf.glycoinfo.org/glycan/G53038OI" denotes HEP
GlycanIUPAC_T5 194-197 "http://rdf.glycoinfo.org/glycan/G71412NI" denotes HEP
GlycanIUPAC_T6 281-284 "http://rdf.glycoinfo.org/glycan/G71412NI" denotes HEP
GlycanIUPAC_T7 356-359 "http://rdf.glycoinfo.org/glycan/G71412NI" denotes HEP
GlycanIUPAC_T8 1377-1380 "http://rdf.glycoinfo.org/glycan/G71412NI" denotes HEP
GlycanIUPAC_T9 194-197 "http://rdf.glycoinfo.org/glycan/G95181HA" denotes HEP
GlycanIUPAC_T10 281-284 "http://rdf.glycoinfo.org/glycan/G95181HA" denotes HEP
GlycanIUPAC_T11 356-359 "http://rdf.glycoinfo.org/glycan/G95181HA" denotes HEP
GlycanIUPAC_T12 1377-1380 "http://rdf.glycoinfo.org/glycan/G95181HA" denotes HEP
GlycanIUPAC_T13 194-197 "http://rdf.glycoinfo.org/glycan/G33888ZV" denotes HEP
GlycanIUPAC_T14 281-284 "http://rdf.glycoinfo.org/glycan/G33888ZV" denotes HEP
GlycanIUPAC_T15 356-359 "http://rdf.glycoinfo.org/glycan/G33888ZV" denotes HEP
GlycanIUPAC_T16 1377-1380 "http://rdf.glycoinfo.org/glycan/G33888ZV" denotes HEP
GlycanIUPAC_T17 194-197 "http://rdf.glycoinfo.org/glycan/G72383QV" denotes HEP
GlycanIUPAC_T18 281-284 "http://rdf.glycoinfo.org/glycan/G72383QV" denotes HEP
GlycanIUPAC_T19 356-359 "http://rdf.glycoinfo.org/glycan/G72383QV" denotes HEP
GlycanIUPAC_T20 1377-1380 "http://rdf.glycoinfo.org/glycan/G72383QV" denotes HEP
GlycanIUPAC_T21 194-197 "http://rdf.glycoinfo.org/glycan/G52595WA" denotes HEP
GlycanIUPAC_T22 281-284 "http://rdf.glycoinfo.org/glycan/G52595WA" denotes HEP
GlycanIUPAC_T23 356-359 "http://rdf.glycoinfo.org/glycan/G52595WA" denotes HEP
GlycanIUPAC_T24 1377-1380 "http://rdf.glycoinfo.org/glycan/G52595WA" denotes HEP
GlycanIUPAC_T25 194-197 "http://rdf.glycoinfo.org/glycan/G65441IM" denotes HEP
GlycanIUPAC_T26 281-284 "http://rdf.glycoinfo.org/glycan/G65441IM" denotes HEP
GlycanIUPAC_T27 356-359 "http://rdf.glycoinfo.org/glycan/G65441IM" denotes HEP
GlycanIUPAC_T28 1377-1380 "http://rdf.glycoinfo.org/glycan/G65441IM" denotes HEP
GlycanIUPAC_T29 194-197 "http://rdf.glycoinfo.org/glycan/G64989KP" denotes HEP
GlycanIUPAC_T30 281-284 "http://rdf.glycoinfo.org/glycan/G64989KP" denotes HEP
GlycanIUPAC_T31 356-359 "http://rdf.glycoinfo.org/glycan/G64989KP" denotes HEP
GlycanIUPAC_T32 1377-1380 "http://rdf.glycoinfo.org/glycan/G64989KP" denotes HEP
GlycanIUPAC_T33 194-197 "http://rdf.glycoinfo.org/glycan/G39900ZC" denotes HEP
GlycanIUPAC_T34 281-284 "http://rdf.glycoinfo.org/glycan/G39900ZC" denotes HEP
GlycanIUPAC_T35 356-359 "http://rdf.glycoinfo.org/glycan/G39900ZC" denotes HEP
GlycanIUPAC_T36 1377-1380 "http://rdf.glycoinfo.org/glycan/G39900ZC" denotes HEP
GlycanIUPAC_T37 194-197 "http://rdf.glycoinfo.org/glycan/G51147IJ" denotes HEP
GlycanIUPAC_T38 281-284 "http://rdf.glycoinfo.org/glycan/G51147IJ" denotes HEP
GlycanIUPAC_T39 356-359 "http://rdf.glycoinfo.org/glycan/G51147IJ" denotes HEP
GlycanIUPAC_T40 1377-1380 "http://rdf.glycoinfo.org/glycan/G51147IJ" denotes HEP
GlycanIUPAC_T41 194-197 "http://rdf.glycoinfo.org/glycan/G42761PO" denotes HEP
GlycanIUPAC_T42 281-284 "http://rdf.glycoinfo.org/glycan/G42761PO" denotes HEP
GlycanIUPAC_T43 356-359 "http://rdf.glycoinfo.org/glycan/G42761PO" denotes HEP
GlycanIUPAC_T44 1377-1380 "http://rdf.glycoinfo.org/glycan/G42761PO" denotes HEP
GlycanIUPAC_T45 937-942 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T46 1040-1045 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T47 937-942 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T48 1040-1045 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T49 937-942 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar
GlycanIUPAC_T50 1040-1045 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 308-311 Disease denotes PCC http://purl.obolibrary.org/obo/MONDO_0004974|http://purl.obolibrary.org/obo/MONDO_0022673

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 84-92 OrganismTaxon denotes Anabaena 1163
T2 288-296 OrganismTaxon denotes Anabaena 1163

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 104-111 Body_part denotes envelop http://purl.obolibrary.org/obo/GO_0031975
T2 169-177 Body_part denotes envelope http://purl.obolibrary.org/obo/GO_0031975

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 93-103 Cell denotes heterocyst http://purl.obolibrary.org/obo/CL:0000724
T2 158-168 Cell denotes heterocyst http://purl.obolibrary.org/obo/CL:0000724
T3 235-245 Cell denotes heterocyst http://purl.obolibrary.org/obo/CL:0000724