PubMed:26667790 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/26667790","sourcedb":"PubMed","sourceid":"26667790","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/26667790","text":"Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.\nRepetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double cone coil rTMS, followed by stimulation of the temporo-parietal junction area with a figure-of-eight coil. The study was conducted as a randomized, double-blind pilot trial in 40 patients suffering from chronic tinnitus. We compared mediofrontal stimulation with double-cone-coil, (2000 stimuli, 10 Hz) followed by left temporo-parietal stimulation with figure-of-eight-coil (2000 stimuli, 1 Hz) to left dorsolateral-prefrontal-cortex stimulation with figure-of-eight-coil (2000 stimuli, 10 Hz) followed by temporo-parietal stimulation with figure-of-eight-coil (2000 stimuli, 1 Hz). The stimulation was feasible with comparable dropout rates in both study arms; no severe adverse events were registered. Responder rates did not differ in both study arms. There was a significant main effect of time for the change in the TQ score, but no significant time x group interaction. This pilot study demonstrated the feasibility of combined mediofrontal/temporoparietal-rTMS-stimulation with double cone coil in tinnitus patients but failed to show better outcome compared to an actively rTMS treated control group.","tracks":[{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":110,"end":118},"obj":"Phenotype"},{"id":"T2","span":{"begin":195,"end":203},"obj":"Phenotype"},{"id":"T3","span":{"begin":650,"end":658},"obj":"Phenotype"},{"id":"T4","span":{"begin":1445,"end":1453},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0000360"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0000360"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0000360"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"HP:0000360"},{"subj":"T1","pred":"source","obj":"HP-phenotype"},{"subj":"T2","pred":"source","obj":"HP-phenotype"},{"subj":"T3","pred":"source","obj":"HP-phenotype"},{"subj":"T4","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":38,"end":56},"obj":"Body_part"},{"id":"T2","span":{"begin":65,"end":80},"obj":"Body_part"},{"id":"T4","span":{"begin":297,"end":304},"obj":"Body_part"},{"id":"T5","span":{"begin":318,"end":323},"obj":"Body_part"},{"id":"T7","span":{"begin":395,"end":420},"obj":"Body_part"},{"id":"T8","span":{"begin":422,"end":425},"obj":"Body_part"},{"id":"T9","span":{"begin":439,"end":443},"obj":"Body_part"},{"id":"T10","span":{"begin":486,"end":511},"obj":"Body_part"},{"id":"T11","span":{"begin":709,"end":713},"obj":"Body_part"},{"id":"T12","span":{"begin":767,"end":775},"obj":"Body_part"},{"id":"T13","span":{"begin":843,"end":873},"obj":"Body_part"},{"id":"T14","span":{"begin":954,"end":962},"obj":"Body_part"},{"id":"T15","span":{"begin":1432,"end":1436},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002756"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001871"},{"id":"A3","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0016538"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000209"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A6","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_6110636"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0009835"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0009835"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL_0000573"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0023852"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL_0000573"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000210"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0009834"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000210"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL_0000573"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T5","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T7","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T8","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T9","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T10","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T11","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T12","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T13","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T14","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T15","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":289,"end":296},"obj":"Body_part"},{"id":"T2","span":{"begin":318,"end":323},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000488"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":439,"end":443},"obj":"Cell"},{"id":"T2","span":{"begin":709,"end":713},"obj":"Cell"},{"id":"T3","span":{"begin":1432,"end":1436},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000573"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000573"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000573"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"HP-phenotype","color":"#93cdec","default":true},{"id":"Anatomy-UBERON","color":"#e7ec93"},{"id":"Anatomy-MAT","color":"#d793ec"},{"id":"CL-cell","color":"#93ecbd"}]}]}}