> top > docs > PubMed:26658904 > annotations

PubMed:26658904 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
T2 110-121 Sentence denotes OBJECTIVES:
T3 122-276 Sentence denotes Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration.
T4 277-369 Sentence denotes Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis.
T5 370-531 Sentence denotes These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface.
T6 532-635 Sentence denotes KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure.
T7 636-776 Sentence denotes Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects.
T8 777-785 Sentence denotes METHODS:
T9 786-941 Sentence denotes In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR).
T10 942-1022 Sentence denotes Differences in the frequency of genes and haplotypes were determined by χ² test.
T11 1023-1122 Sentence denotes RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA.
T12 1123-1266 Sentence denotes KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47).
T13 1267-1291 Sentence denotes Inhibitory haplotype No.
T14 1292-1398 Sentence denotes 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA.
T15 1399-1410 Sentence denotes CONCLUSION:
T16 1411-1464 Sentence denotes Individuals carrying the inhibitory KIR haplotype No.
T17 1465-1512 Sentence denotes 6 have a high potential risk for developing RA.
T1 0-109 Sentence denotes Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
T2 110-121 Sentence denotes OBJECTIVES:
T3 122-276 Sentence denotes Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration.
T4 277-369 Sentence denotes Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis.
T5 370-531 Sentence denotes These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface.
T6 532-635 Sentence denotes KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure.
T7 636-776 Sentence denotes Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects.
T8 777-785 Sentence denotes METHODS:
T9 786-941 Sentence denotes In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR).
T10 942-1022 Sentence denotes Differences in the frequency of genes and haplotypes were determined by χ² test.
T11 1023-1122 Sentence denotes RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA.
T12 1123-1266 Sentence denotes KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47).
T13 1267-1291 Sentence denotes Inhibitory haplotype No.
T14 1292-1398 Sentence denotes 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA.
T15 1399-1410 Sentence denotes CONCLUSION:
T16 1411-1464 Sentence denotes Individuals carrying the inhibitory KIR haplotype No.
T17 1465-1512 Sentence denotes 6 have a high potential risk for developing RA.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26658904-2#25#29#gene940 302-306 gene940 denotes CD28
26658904-0#15#56#gene3806 15-56 gene3806 denotes Killer Cell Immunoglobulin- Like Receptor
26658904-0#15#56#gene3812 15-56 gene3812 denotes Killer Cell Immunoglobulin- Like Receptor
26658904-0#88#108#diseaseC0003873 88-108 diseaseC0003873 denotes Rheumatoid Arthritis
26658904-10#13#20#gene57292 1305-1312 gene57292 denotes KIR2DL5
26658904-10#13#20#gene553128 1305-1312 gene553128 denotes KIR2DL5
26658904-10#39#46#gene3802 1331-1338 gene3802 denotes KIR2DL1
26658904-10#51#58#gene3804 1343-1350 gene3804 denotes KIR2DL3
26658904-10#103#105#diseaseC0003873 1395-1397 diseaseC0003873 denotes RA
26658904-10#103#105#diseaseC0003873 1395-1397 diseaseC0003873 denotes RA
26658904-2#76#78#diseaseC0003873 353-355 diseaseC0003873 denotes RA
26658904-8#0#7#gene3803 1032-1039 gene3803 denotes KIR2DL2
26658904-8#42#49#gene3810 1074-1081 gene3810 denotes KIR2DS5
26658904-8#87#89#diseaseC0003873 1119-1121 diseaseC0003873 denotes RA
15#56#gene380688#108#diseaseC0003873 26658904-0#15#56#gene3806 26658904-0#88#108#diseaseC0003873 associated_with Killer Cell Immunoglobulin- Like Receptor,Rheumatoid Arthritis
15#56#gene381288#108#diseaseC0003873 26658904-0#15#56#gene3812 26658904-0#88#108#diseaseC0003873 associated_with Killer Cell Immunoglobulin- Like Receptor,Rheumatoid Arthritis
13#20#gene57292103#105#diseaseC0003873 26658904-10#13#20#gene57292 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL5,RA
13#20#gene57292103#105#diseaseC0003873 26658904-10#13#20#gene57292 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL5,RA
13#20#gene553128103#105#diseaseC0003873 26658904-10#13#20#gene553128 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL5,RA
13#20#gene553128103#105#diseaseC0003873 26658904-10#13#20#gene553128 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL5,RA
39#46#gene3802103#105#diseaseC0003873 26658904-10#39#46#gene3802 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL1,RA
39#46#gene3802103#105#diseaseC0003873 26658904-10#39#46#gene3802 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL1,RA
51#58#gene3804103#105#diseaseC0003873 26658904-10#51#58#gene3804 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL3,RA
51#58#gene3804103#105#diseaseC0003873 26658904-10#51#58#gene3804 26658904-10#103#105#diseaseC0003873 associated_with KIR2DL3,RA
25#29#gene94076#78#diseaseC0003873 26658904-2#25#29#gene940 26658904-2#76#78#diseaseC0003873 associated_with CD28,RA
0#7#gene380387#89#diseaseC0003873 26658904-8#0#7#gene3803 26658904-8#87#89#diseaseC0003873 associated_with KIR2DL2,RA
42#49#gene381087#89#diseaseC0003873 26658904-8#42#49#gene3810 26658904-8#87#89#diseaseC0003873 associated_with KIR2DS5,RA

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T978 1305-1312 gene:57292 denotes KIR2DL5
T979 1395-1397 disease:C0003873 denotes RA
R1 T978 T979 associated_with KIR2DL5,RA
R2 T978 T979 associated_with KIR2DL5,RA

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
TextSentencer_T2 110-121 Sentence denotes OBJECTIVES:
TextSentencer_T3 122-276 Sentence denotes Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration.
TextSentencer_T4 277-369 Sentence denotes Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis.
TextSentencer_T5 370-531 Sentence denotes These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface.
TextSentencer_T6 532-635 Sentence denotes KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure.
TextSentencer_T7 636-776 Sentence denotes Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects.
TextSentencer_T8 777-785 Sentence denotes METHODS:
TextSentencer_T9 786-941 Sentence denotes In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR).
TextSentencer_T10 942-1022 Sentence denotes Differences in the frequency of genes and haplotypes were determined by χ² test.
TextSentencer_T11 1023-1122 Sentence denotes RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA.
TextSentencer_T12 1123-1266 Sentence denotes KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47).
TextSentencer_T13 1267-1291 Sentence denotes Inhibitory haplotype No.
TextSentencer_T14 1292-1398 Sentence denotes 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA.
TextSentencer_T15 1399-1410 Sentence denotes CONCLUSION:
TextSentencer_T16 1411-1464 Sentence denotes Individuals carrying the inhibitory KIR haplotype No.
TextSentencer_T17 1465-1512 Sentence denotes 6 have a high potential risk for developing RA.
T1 0-109 Sentence denotes Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
T2 110-121 Sentence denotes OBJECTIVES:
T3 122-276 Sentence denotes Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by persistent synovitis, ultimately leading to cartilage and bone degeneration.
T4 277-369 Sentence denotes Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis.
T5 370-531 Sentence denotes These cells are similar in feature and function, as they both exert their cytotoxic effect via Killer Cell Immunoglobulin- Like Receptors (KIR) on their surface.
T6 532-635 Sentence denotes KIR genes have either an inhibitory or activating effect depending on their intracytoplasmic structure.
T7 636-776 Sentence denotes Herein we genotyped 16 KIR genes, 3 pseudo genes and 6 HLA class І genes as their corresponding ligands in RA patients and control subjects.
T8 777-785 Sentence denotes METHODS:
T9 786-941 Sentence denotes In this case-control study, KIR and HLA genes were genotyped in 400 RA patients and 372 matched healthy controls using sequence-specific primers (SSP-PCR).
T10 942-1022 Sentence denotes Differences in the frequency of genes and haplotypes were determined by χ² test.
T11 1023-1122 Sentence denotes RESULTS: KIR2DL2, 2DL5a, 2DL5b and activating KIR: KIR2DS5 and 3DS1 were all protective against RA.
T12 1123-1266 Sentence denotes KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47).
T13 1267-1291 Sentence denotes Inhibitory haplotype No.
T14 1292-1398 Sentence denotes 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA.
T15 1399-1410 Sentence denotes CONCLUSION:
T16 1411-1464 Sentence denotes Individuals carrying the inhibitory KIR haplotype No.
T17 1465-1512 Sentence denotes 6 have a high potential risk for developing RA.