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PubMed:26651604 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-7 GO:0043005 denotes Neurite
T4 24-31 1895 denotes Calcium
T2 24-31 D002118 denotes Calcium
T3 24-31 CHEBI:22984 denotes Calcium
T5 24-31 D002118 denotes Calcium
T10 81-100 D010300 denotes Parkinson's Disease
T11 81-100 D010300 denotes Parkinson's Disease
T14 109-114 PR:Q5S006 denotes LRRK2
T15 109-114 PR:000003033 denotes LRRK2
T16 109-114 PR:Q5S007 denotes LRRK2
T17 122-130 SO:0000109 denotes Mutation
T19 145-152 6308 denotes leucine
T20 145-152 SO:0001437 denotes leucine
T18 145-152 CHEBI:15603 denotes leucine
T21 145-152 D007930 denotes leucine
T22 145-152 CHEBI:25017 denotes leucine
T23 145-152 D007930 denotes leucine
T24 158-164 SO:0001068 denotes repeat
T25 175-180 PR:Q5S006 denotes LRRK2
T26 175-180 PR:000003033 denotes LRRK2
T27 175-180 PR:Q5S007 denotes LRRK2
T32 226-245 D010300 denotes Parkinson's disease
T33 226-245 D010300 denotes Parkinson's disease
T36 263-271 SO:0000109 denotes mutation
T37 333-348 GO:0016301 denotes kinase activity
T42 372-380 3628 denotes dopamine
T38 372-380 CHEBI:59905 denotes dopamine
T39 372-380 CHEBI:18243 denotes dopamine
T40 372-380 D004298 denotes dopamine
T41 372-380 D004298 denotes dopamine
T43 397-404 GO:0043005 denotes neurite
T44 477-484 32644 denotes unknown
T49 562-570 3628 denotes dopamine
T45 562-570 CHEBI:59905 denotes dopamine
T46 562-570 CHEBI:18243 denotes dopamine
T47 562-570 D004298 denotes dopamine
T48 562-570 D004298 denotes dopamine
T50 571-577 CL:0000540 denotes neuron
T51 712-717 PR:Q5S006 denotes LRRK2
T52 712-717 PR:000003033 denotes LRRK2
T53 712-717 PR:Q5S007 denotes LRRK2
T54 771-778 GO:0043005 denotes neurite
T55 800-811 GO:0005874 denotes microtubule
T56 823-830 GO:0043005 denotes neurite
T57 859-864 PR:Q5S006 denotes LRRK2
T58 859-864 PR:000003033 denotes LRRK2
T59 859-864 PR:Q5S007 denotes LRRK2
T60 919-926 1895 denotes calcium
T61 919-926 CHEBI:29320 denotes calcium
T62 919-926 CHEBI:22984 denotes calcium
T63 952-957 PR:Q5S006 denotes LRRK2
T64 952-957 PR:000003033 denotes LRRK2
T65 952-957 PR:Q5S007 denotes LRRK2
T66 965-975 CHEBI:35222 denotes inhibitors
T67 1048-1054 SO:0000814 denotes rescue
T68 1087-1092 PR:Q5S006 denotes LRRK2
T69 1087-1092 PR:000003033 denotes LRRK2
T70 1087-1092 PR:Q5S007 denotes LRRK2
T71 1093-1108 GO:0016301 denotes kinase activity
T72 1112-1126 CL:0000101 denotes sensory neuron
T74 1185-1199 CL:0000101 denotes sensory neuron

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 132-251 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most-common genetic determinants of Parkinson's disease (PD).
T2 252-349 DRI_Background denotes The G2019S mutation is detected most frequently and is associated with increased kinase activity.
T3 350-485 DRI_Challenge denotes Whereas G2019S mutant dopamine neurons exhibit neurite elongation deficits, the effect of G2019S on other neuronal subtypes is unknown.
T4 486-711 DRI_Challenge denotes As PD patients also suffer from non-motor symptoms that may be unrelated to dopamine neuron loss, we used induced pluripotent stem cells (iPSCs) to assess morphological and functional properties of peripheral sensory neurons.
T5 712-724 REPLACED denotes LRRK2 G2019S
T6 738-844 DRI_Background denotes sensory neurons exhibited normal neurite length but had large microtubule-containing neurite aggregations.
T7 845-858 DRI_Background denotes Additionally,
T8 885-936 DRI_Background denotes sensory neurons displayed altered calcium dynamics.
T9 937-1055 DRI_Background denotes Treatment with LRRK2 kinase inhibitors resulted in significant, but not complete, morphological and functional rescue.
T10 1056-1215 DRI_Challenge denotes These data indicate a role for LRRK2 kinase activity in sensory neuron structure and function, which when disrupted, may lead to sensory neuron deficits in PD.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
26651604-0#115#121#geners34637584 115-121 geners34637584 denotes G2019S
26651604-0#32#43#diseaseC3887505 32-43 diseaseC3887505 denotes Dysfunction
26651604-0#81#100#diseaseC0030567 81-100 diseaseC0030567 denotes Parkinson's Disease
115#121#geners3463758432#43#diseaseC3887505 26651604-0#115#121#geners34637584 26651604-0#32#43#diseaseC3887505 associated_with G2019S,Dysfunction
115#121#geners3463758481#100#diseaseC0030567 26651604-0#115#121#geners34637584 26651604-0#81#100#diseaseC0030567 associated_with G2019S,Parkinson's Disease

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26651604-0#109#114#gene120892 109-114 gene120892 denotes LRRK2
26651604-0#32#43#diseaseC3887505 32-43 diseaseC3887505 denotes Dysfunction
26651604-0#81#100#diseaseC0030567 81-100 diseaseC0030567 denotes Parkinson's Disease
109#114#gene12089232#43#diseaseC3887505 26651604-0#109#114#gene120892 26651604-0#32#43#diseaseC3887505 associated_with LRRK2,Dysfunction
109#114#gene12089281#100#diseaseC0030567 26651604-0#109#114#gene120892 26651604-0#81#100#diseaseC0030567 associated_with LRRK2,Parkinson's Disease