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PubMed:26582609 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 785-792 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 785-792 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 1066-1073 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 1066-1073 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 1100-1111 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T6 1202-1209 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T7 1202-1209 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T8 1473-1480 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T9 1473-1480 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 785-792 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 1066-1073 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 1100-1111 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T6 1202-1209 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T8 1473-1480 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 785-792 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 785-792 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 1066-1073 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 1066-1073 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 1100-1111 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T6 1202-1209 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T7 1202-1209 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T8 1473-1480 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T9 1473-1480 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
TextSentencer_T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
TextSentencer_T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
TextSentencer_T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
TextSentencer_T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
TextSentencer_T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
TextSentencer_T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
TextSentencer_T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
TextSentencer_T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
TextSentencer_T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
TextSentencer_T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
TextSentencer_T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.
T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.
T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1075-1090 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 1092-1094 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T3 1100-1111 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T4 1214-1216 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS
T5 1484-1486 http://www.glycoepitope.jp/epitopes/EP0086 denotes HS

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 18-27 FMAID:241982 denotes chemokine
_T2 18-27 FMAID:241983 denotes chemokine
_T3 18-27 FMAID:241981 denotes chemokine
_T4 18-27 FMAID:241980 denotes chemokine
_T5 18-27 FMAID:241985 denotes chemokine
_T6 18-27 FMAID:241984 denotes chemokine
_T7 28-45 FMAID:63011 denotes glycosaminoglycan
_T8 28-45 FMAID:167395 denotes glycosaminoglycan
_T9 62-71 FMAID:241981 denotes chemokine
_T10 62-71 FMAID:241980 denotes chemokine
_T11 62-71 FMAID:241983 denotes chemokine
_T12 62-71 FMAID:241982 denotes chemokine
_T13 62-71 FMAID:241985 denotes chemokine
_T14 62-71 FMAID:241984 denotes chemokine
_T15 94-103 FMAID:241985 denotes chemokine
_T16 94-103 FMAID:241982 denotes chemokine
_T17 94-103 FMAID:241983 denotes chemokine
_T18 94-103 FMAID:241981 denotes chemokine
_T19 94-103 FMAID:241980 denotes chemokine
_T20 94-103 FMAID:241984 denotes chemokine
_T21 135-153 FMAID:63011 denotes glycosaminoglycans
_T22 135-153 FMAID:167395 denotes glycosaminoglycans
_T23 155-159 FMAID:167404 denotes GAGs
_T24 193-200 FMAID:84785 denotes in cell
_T25 193-200 FMAID:199054 denotes in cell
_T26 232-236 FMAID:167404 denotes GAGs
_T27 265-274 FMAID:241985 denotes chemokine
_T28 265-274 FMAID:241984 denotes chemokine
_T29 265-274 FMAID:241983 denotes chemokine
_T30 265-274 FMAID:241981 denotes chemokine
_T31 265-274 FMAID:241982 denotes chemokine
_T32 265-274 FMAID:241980 denotes chemokine
_T33 331-336 FMAID:169002 denotes cells
_T34 331-336 FMAID:68646 denotes cells
_T35 351-360 FMAID:241982 denotes chemokine
_T36 351-360 FMAID:241983 denotes chemokine
_T37 351-360 FMAID:241980 denotes chemokine
_T38 351-360 FMAID:241985 denotes chemokine
_T39 351-360 FMAID:241984 denotes chemokine
_T40 351-360 FMAID:241981 denotes chemokine
_T41 421-424 FMAID:167404 denotes GAG
_T42 476-483 FMAID:50594 denotes surface
_T43 476-483 FMAID:146300 denotes surface
_T44 539-548 FMAID:241982 denotes chemokine
_T45 539-548 FMAID:241984 denotes chemokine
_T46 539-548 FMAID:241985 denotes chemokine
_T47 539-548 FMAID:241981 denotes chemokine
_T48 539-548 FMAID:241980 denotes chemokine
_T49 539-548 FMAID:241983 denotes chemokine
_T50 568-571 FMAID:167404 denotes GAG
_T51 646-656 FMAID:241982 denotes chemokines
_T52 646-656 FMAID:241983 denotes chemokines
_T53 646-656 FMAID:241985 denotes chemokines
_T54 646-656 FMAID:241981 denotes chemokines
_T55 646-656 FMAID:241980 denotes chemokines
_T56 646-656 FMAID:241984 denotes chemokines
_T57 729-732 FMAID:167404 denotes GAG
_T58 785-792 FMAID:167420 denotes heparin
_T59 785-792 FMAID:82839 denotes heparin
_T60 846-856 FMAID:241980 denotes chemokines
_T61 846-856 FMAID:241985 denotes chemokines
_T62 846-856 FMAID:241984 denotes chemokines
_T63 846-856 FMAID:241981 denotes chemokines
_T64 846-856 FMAID:241982 denotes chemokines
_T65 846-856 FMAID:241983 denotes chemokines
_T66 997-1004 FMAID:50594 denotes surface
_T67 997-1004 FMAID:146300 denotes surface
_T68 1066-1073 FMAID:167420 denotes heparin
_T69 1066-1073 FMAID:82839 denotes heparin
_T70 1075-1082 FMAID:67110 denotes heparan
_T71 1075-1082 FMAID:165191 denotes heparan
_T72 1075-1090 FMAID:167405 denotes heparan sulfate
_T73 1075-1090 FMAID:63023 denotes heparan sulfate
_T74 1100-1119 FMAID:196838 denotes chondroitin sulfate
_T75 1100-1119 FMAID:82837 denotes chondroitin sulfate
_T76 1140-1150 FMAID:241982 denotes chemokines
_T77 1140-1150 FMAID:241983 denotes chemokines
_T78 1140-1150 FMAID:241981 denotes chemokines
_T79 1140-1150 FMAID:241980 denotes chemokines
_T80 1140-1150 FMAID:241984 denotes chemokines
_T81 1140-1150 FMAID:241985 denotes chemokines
_T82 1202-1209 FMAID:82839 denotes heparin
_T83 1202-1209 FMAID:167420 denotes heparin
_T84 1343-1348 FMAID:68646 denotes cells
_T85 1343-1348 FMAID:169002 denotes cells
_T86 1390-1397 FMAID:199054 denotes in cell
_T87 1390-1397 FMAID:84785 denotes in cell
_T88 1446-1455 FMAID:241983 denotes chemokine
_T89 1446-1455 FMAID:241982 denotes chemokine
_T90 1446-1455 FMAID:241981 denotes chemokine
_T91 1446-1455 FMAID:241980 denotes chemokine
_T92 1446-1455 FMAID:241984 denotes chemokine
_T93 1446-1455 FMAID:241985 denotes chemokine
_T94 1473-1480 FMAID:167420 denotes heparin
_T95 1473-1480 FMAID:82839 denotes heparin
_T96 1517-1527 FMAID:241984 denotes chemokines
_T97 1517-1527 FMAID:241982 denotes chemokines
_T98 1517-1527 FMAID:241983 denotes chemokines
_T99 1517-1527 FMAID:241981 denotes chemokines
_T100 1517-1527 FMAID:241985 denotes chemokines
_T101 1517-1527 FMAID:241980 denotes chemokines
_T102 1691-1700 FMAID:241983 denotes chemokine
_T103 1691-1700 FMAID:241980 denotes chemokine
_T104 1691-1700 FMAID:241981 denotes chemokine
_T105 1691-1700 FMAID:241984 denotes chemokine
_T106 1691-1700 FMAID:241985 denotes chemokine
_T107 1691-1700 FMAID:241982 denotes chemokine
_T108 1701-1704 FMAID:167404 denotes GAG
_T109 1791-1801 FMAID:241982 denotes chemokines
_T110 1791-1801 FMAID:241983 denotes chemokines
_T111 1791-1801 FMAID:241981 denotes chemokines
_T112 1791-1801 FMAID:241985 denotes chemokines
_T113 1791-1801 FMAID:241980 denotes chemokines
_T114 1791-1801 FMAID:241984 denotes chemokines
_T115 1806-1810 FMAID:167404 denotes GAGs
_T116 1845-1848 FMAID:167404 denotes GAG
_T117 1898-1907 FMAID:241982 denotes chemokine
_T118 1898-1907 FMAID:241980 denotes chemokine
_T119 1898-1907 FMAID:241981 denotes chemokine
_T120 1898-1907 FMAID:241984 denotes chemokine
_T121 1898-1907 FMAID:241985 denotes chemokine
_T122 1898-1907 FMAID:241983 denotes chemokine

uniprot-human

Id Subject Object Predicate Lexical cue
T1 858-862 http://www.uniprot.org/uniprot/P13500 denotes CCL2
T2 864-868 http://www.uniprot.org/uniprot/P10147 denotes CCL3
T3 870-874 http://www.uniprot.org/uniprot/P13501 denotes CCL5
T4 876-880 http://www.uniprot.org/uniprot/P80098 denotes CCL7
T5 882-887 http://www.uniprot.org/uniprot/P02776 denotes CXCL4
T6 889-894 http://www.uniprot.org/uniprot/Q9UCR9 denotes CXCL8
T7 896-902 http://www.uniprot.org/uniprot/O14625 denotes CXCL11
T8 907-913 http://www.uniprot.org/uniprot/Q6ICW0 denotes CXCL12
T9 1123-1125 http://www.uniprot.org/uniprot/O75390 denotes CS
T10 1412-1414 http://www.uniprot.org/uniprot/O75390 denotes CS
T11 1550-1552 http://www.uniprot.org/uniprot/O75390 denotes CS

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 72-87 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T2 72-87 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T3 104-119 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T4 104-119 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T5 331-336 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T6 361-376 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T7 361-376 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T8 549-564 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T9 549-564 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T10 832-845 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerizing
T11 832-845 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerizing
T12 926-941 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T13 926-941 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T14 1248-1263 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T15 1248-1263 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T16 1343-1348 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T17 1374-1389 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T18 1374-1389 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T19 1572-1587 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T20 1572-1587 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T21 1671-1686 http://purl.bioontology.org/ontology/NCBITAXON/265229 denotes oligomerization
T22 1671-1686 http://purl.bioontology.org/ontology/NCBITAXON/441291 denotes oligomerization
T23 1872-1881 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 252-261 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T2 252-274 http://purl.obolibrary.org/obo/GO_0042033 denotes formation of chemokine
T3 321-336 http://purl.obolibrary.org/obo/GO_0016477 denotes migrating cells
T4 1083-1090 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T5 1112-1119 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate

GO-MF

Id Subject Object Predicate Lexical cue
T1 124-131 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 468-475 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 572-579 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 1179-1186 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1539-1546 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 124-131 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 468-475 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 572-579 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 1179-1186 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 1539-1546 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T11 124-131 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 468-475 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 572-579 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T14 1179-1186 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T15 1539-1546 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T16 124-131 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17 468-475 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18 572-579 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19 1179-1186 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20 1539-1546 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T21 124-153 http://purl.obolibrary.org/obo/GO_0005539 denotes binding to glycosaminoglycans

GO-CC

Id Subject Object Predicate Lexical cue
T1 196-200 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 331-336 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 1343-1348 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 458-467 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
T2 593-604 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 785-792 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T2 1066-1073 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T3 1202-1209 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T4 1473-1480 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T5 1100-1111 http://rdf.glycoinfo.org/glycan/G00018MO denotes chondroitin
T6 1100-1119 http://rdf.glycoinfo.org/glycan/G00018MO denotes chondroitin sulfate

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 1100-1111 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
PD-GlycoEpitope-B_T2 1075-1090 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 458-467 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T2 593-604 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1123-1127 Disease denotes CS-A http://purl.obolibrary.org/obo/MONDO_0019569
T2 1412-1416 Disease denotes CS-A http://purl.obolibrary.org/obo/MONDO_0019569
T3 1550-1554 Disease denotes CS-A http://purl.obolibrary.org/obo/MONDO_0019569

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1100-1111 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T3 1075-1090 Glycan denotes heparan sulfate https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW
T2 1092-1094 Glycan denotes HS https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW
T5 1214-1216 Glycan denotes HS https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW
T6 1484-1486 Glycan denotes HS https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1123-1127 Disease denotes CS-A http://purl.obolibrary.org/obo/MONDO_0019569
T2 1412-1416 Disease denotes CS-A http://purl.obolibrary.org/obo/MONDO_0019569
T3 1550-1554 Disease denotes CS-A http://purl.obolibrary.org/obo/MONDO_0019569

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1835-1839 OrganismTaxon denotes idea 76236

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
TextSentencer_T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
TextSentencer_T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
TextSentencer_T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
TextSentencer_T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
TextSentencer_T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
TextSentencer_T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
TextSentencer_T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
TextSentencer_T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
TextSentencer_T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
TextSentencer_T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
TextSentencer_T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.
T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.
T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization.
T2 89-213 Sentence denotes Both chemokine oligomerization and binding to glycosaminoglycans (GAGs) are required for their function in cell recruitment.
T3 214-337 Sentence denotes Interactions with GAGs facilitate the formation of chemokine gradients, which provide directional cues for migrating cells.
T4 338-511 Sentence denotes In contrast, chemokine oligomerization is thought to contribute to the affinity of GAG interactions by providing a more extensive binding surface than single subunits alone.
T5 512-616 Sentence denotes However, the importance of chemokine oligomerization to GAG binding has not been extensively quantified.
T6 617-793 Sentence denotes Additionally, the ability of chemokines to form different oligomers has been suggested to impart specificity to GAG interactions, but most studies have been limited to heparin.
T7 794-1129 Sentence denotes In this study, several differentially oligomerizing chemokines (CCL2, CCL3, CCL5, CCL7, CXCL4, CXCL8, CXCL11 and CXCL12) and select oligomerization-deficient mutants were systematically characterized by surface plasmon resonance to determine their relative affinities for heparin, heparan sulfate (HS) and chondroitin sulfate-A (CS-A).
T8 1130-1264 Sentence denotes Wild-type chemokines demonstrated a hierarchy of binding affinities for heparin and HS that was markedly dependent on oligomerization.
T9 1265-1411 Sentence denotes These results were corroborated by their relative propensity to accumulate on cells and the critical role of oligomerization in cell presentation.
T10 1412-1606 Sentence denotes CS-A was found to exhibit greater chemokine selectivity than heparin or HS, as it only bound a subset of chemokines; moreover, binding to CS-A was ablated with oligomerization-deficient mutants.
T11 1607-1811 Sentence denotes Overall, this study definitively demonstrates the importance of oligomerization for chemokine-GAG interactions, and demonstrates diversity in the affinity and specificity of different chemokines for GAGs.
T12 1812-1917 Sentence denotes These data support the idea that GAG interactions provide a mechanism for fine-tuning chemokine function.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1100-1111 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T3 1075-1090 Glycan denotes heparan sulfate https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW
T2 1092-1094 Glycan denotes HS https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW
T5 1214-1216 Glycan denotes HS https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW
T6 1484-1486 Glycan denotes HS https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1075-1090 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 1092-1094 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T3 1100-1111 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T4 1214-1216 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T5 1484-1486 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1835-1839 OrganismTaxon denotes idea 76236

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1075-1090 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 1092-1094 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T3 1100-1111 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T4 1214-1216 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T5 1484-1486 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086