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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 363-369 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 363-369 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 363-369 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Design of an α-l-transfucosidase for the synthesis of fucosylated HMOs.
TextSentencer_T2 72-172 Sentence denotes Human milk oligosaccharides (HMOs) are recognized as benefiting breast-fed infants in multiple ways.
TextSentencer_T3 173-271 Sentence denotes As a result, there is growing interest in the synthesis of HMOs mimicking their natural diversity.
TextSentencer_T4 272-408 Sentence denotes Most HMOs are fucosylated oligosaccharides. α-l-Fucosidases catalyze the hydrolysis of α-l-fucose from the non-reducing end of a glucan.
TextSentencer_T5 409-471 Sentence denotes They fall into the glycoside hydrolase GH29 and GH95 families.
TextSentencer_T6 472-591 Sentence denotes The GH29 family fucosidases display a classic retaining mechanism and are good candidates for transfucosidase activity.
TextSentencer_T7 592-782 Sentence denotes We recently demonstrated that the α-l-fucosidase from Thermotoga maritima (TmαFuc) from the GH29 family can be evolved into an efficient transfucosidase by directed evolution ( Osanjo et al.
TextSentencer_T8 783-789 Sentence denotes 2007).
TextSentencer_T9 790-991 Sentence denotes In this work, we developed semi-rational approaches to design an α-l-transfucosidase starting with the α-l-fucosidase from commensal bacteria Bifidobacterium longum subsp. infantis (BiAfcB, Blon_2336).
TextSentencer_T10 992-1215 Sentence denotes Efficient fucosylation was obtained with enzyme mutants (L321P-BiAfcB and F34I/L321P-BiAfcB) enabling in vitro synthesis of lactodifucotetraose, lacto-N-fucopentaose II, lacto-N-fucopentaose III and lacto-N-difucohexaose I.
TextSentencer_T11 1216-1393 Sentence denotes The enzymes also generated more complex HMOs like fucosylated para-lacto-N-neohexaose (F-p-LNnH) and mono- or difucosylated lacto-N-neohexaose (F-LNnH-I, F-LNnH-II and DF-LNnH).
TextSentencer_T12 1394-1619 Sentence denotes It is worth noting that mutation at these two positions did not result in a strong decrease in the overall activity of the enzyme, which makes these variants interesting candidates for large-scale transfucosylation reactions.
TextSentencer_T13 1620-1736 Sentence denotes For the first time, this work provides an efficient enzymatic method to synthesize the majority of fucosylated HMOs.
T1 0-71 Sentence denotes Design of an α-l-transfucosidase for the synthesis of fucosylated HMOs.
T2 72-172 Sentence denotes Human milk oligosaccharides (HMOs) are recognized as benefiting breast-fed infants in multiple ways.
T3 173-271 Sentence denotes As a result, there is growing interest in the synthesis of HMOs mimicking their natural diversity.
T4 272-408 Sentence denotes Most HMOs are fucosylated oligosaccharides. α-l-Fucosidases catalyze the hydrolysis of α-l-fucose from the non-reducing end of a glucan.
T5 409-471 Sentence denotes They fall into the glycoside hydrolase GH29 and GH95 families.
T6 472-591 Sentence denotes The GH29 family fucosidases display a classic retaining mechanism and are good candidates for transfucosidase activity.
T7 592-782 Sentence denotes We recently demonstrated that the α-l-fucosidase from Thermotoga maritima (TmαFuc) from the GH29 family can be evolved into an efficient transfucosidase by directed evolution ( Osanjo et al.
T8 783-789 Sentence denotes 2007).
T9 790-991 Sentence denotes In this work, we developed semi-rational approaches to design an α-l-transfucosidase starting with the α-l-fucosidase from commensal bacteria Bifidobacterium longum subsp. infantis (BiAfcB, Blon_2336).
T10 992-1393 Sentence denotes Efficient fucosylation was obtained with enzyme mutants (L321P-BiAfcB and F34I/L321P-BiAfcB) enabling in vitro synthesis of lactodifucotetraose, lacto-N-fucopentaose II, lacto-N-fucopentaose III and lacto-N-difucohexaose I. The enzymes also generated more complex HMOs like fucosylated para-lacto-N-neohexaose (F-p-LNnH) and mono- or difucosylated lacto-N-neohexaose (F-LNnH-I, F-LNnH-II and DF-LNnH).
T11 1394-1619 Sentence denotes It is worth noting that mutation at these two positions did not result in a strong decrease in the overall activity of the enzyme, which makes these variants interesting candidates for large-scale transfucosylation reactions.
T12 1620-1736 Sentence denotes For the first time, this work provides an efficient enzymatic method to synthesize the majority of fucosylated HMOs.
T1 0-71 Sentence denotes Design of an α-l-transfucosidase for the synthesis of fucosylated HMOs.
T2 72-172 Sentence denotes Human milk oligosaccharides (HMOs) are recognized as benefiting breast-fed infants in multiple ways.
T3 173-271 Sentence denotes As a result, there is growing interest in the synthesis of HMOs mimicking their natural diversity.
T4 272-408 Sentence denotes Most HMOs are fucosylated oligosaccharides. α-l-Fucosidases catalyze the hydrolysis of α-l-fucose from the non-reducing end of a glucan.
T5 409-471 Sentence denotes They fall into the glycoside hydrolase GH29 and GH95 families.
T6 472-591 Sentence denotes The GH29 family fucosidases display a classic retaining mechanism and are good candidates for transfucosidase activity.
T7 592-782 Sentence denotes We recently demonstrated that the α-l-fucosidase from Thermotoga maritima (TmαFuc) from the GH29 family can be evolved into an efficient transfucosidase by directed evolution ( Osanjo et al.
T8 783-789 Sentence denotes 2007).
T9 790-991 Sentence denotes In this work, we developed semi-rational approaches to design an α-l-transfucosidase starting with the α-l-fucosidase from commensal bacteria Bifidobacterium longum subsp. infantis (BiAfcB, Blon_2336).
T10 992-1215 Sentence denotes Efficient fucosylation was obtained with enzyme mutants (L321P-BiAfcB and F34I/L321P-BiAfcB) enabling in vitro synthesis of lactodifucotetraose, lacto-N-fucopentaose II, lacto-N-fucopentaose III and lacto-N-difucohexaose I.
T11 1216-1393 Sentence denotes The enzymes also generated more complex HMOs like fucosylated para-lacto-N-neohexaose (F-p-LNnH) and mono- or difucosylated lacto-N-neohexaose (F-LNnH-I, F-LNnH-II and DF-LNnH).
T12 1394-1619 Sentence denotes It is worth noting that mutation at these two positions did not result in a strong decrease in the overall activity of the enzyme, which makes these variants interesting candidates for large-scale transfucosylation reactions.
T13 1620-1736 Sentence denotes For the first time, this work provides an efficient enzymatic method to synthesize the majority of fucosylated HMOs.

ICD10

Id Subject Object Predicate Lexical cue
T1 414-418 http://purl.bioontology.org/ontology/ICD10/W00-W19.9 denotes fall

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 78-82 FMAID:165676 denotes milk
_T2 83-99 FMAID:196731 denotes oligosaccharides
_T3 83-99 FMAID:82742 denotes oligosaccharides
_T4 136-142 FMAID:9601 denotes breast
_T5 136-142 FMAID:97486 denotes breast
_T6 298-314 FMAID:82742 denotes oligosaccharides
_T7 298-314 FMAID:196731 denotes oligosaccharides
_T8 363-369 FMAID:82790 denotes fucose
_T9 363-369 FMAID:196784 denotes fucose

uniprot-human

Id Subject Object Predicate Lexical cue
T1 1384-1386 http://www.uniprot.org/uniprot/P00746 denotes DF

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 379-382 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non
T2 528-537 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T3 646-656 http://purl.bioontology.org/ontology/NCBITAXON/2335 denotes Thermotoga
T4 646-656 http://purl.bioontology.org/ontology/NCBITAXON/188709 denotes Thermotoga
T5 646-656 http://purl.bioontology.org/ontology/NCBITAXON/188708 denotes Thermotoga
T6 646-656 http://purl.bioontology.org/ontology/NCBITAXON/200918 denotes Thermotoga
T7 646-665 http://purl.bioontology.org/ontology/NCBITAXON/2336 denotes Thermotoga maritima
T8 923-931 http://purl.bioontology.org/ontology/NCBITAXON/629395 denotes bacteria
T9 923-931 http://purl.bioontology.org/ontology/NCBITAXON/2 denotes bacteria
T10 923-954 http://purl.bioontology.org/ontology/NCBITAXON/767694 denotes bacteria Bifidobacterium longum
T11 923-960 http://purl.bioontology.org/ontology/NCBITAXON/77635 denotes bacteria Bifidobacterium longum subsp
T12 932-947 http://purl.bioontology.org/ontology/NCBITAXON/1685 denotes Bifidobacterium
T13 932-947 http://purl.bioontology.org/ontology/NCBITAXON/78448 denotes Bifidobacterium
T14 932-947 http://purl.bioontology.org/ontology/NCBITAXON/78345 denotes Bifidobacterium
T15 932-947 http://purl.bioontology.org/ontology/NCBITAXON/35760 denotes Bifidobacterium
T16 932-947 http://purl.bioontology.org/ontology/NCBITAXON/1691 denotes Bifidobacterium
T17 932-947 http://purl.bioontology.org/ontology/NCBITAXON/78344 denotes Bifidobacterium
T18 932-947 http://purl.bioontology.org/ontology/NCBITAXON/180216 denotes Bifidobacterium
T19 932-947 http://purl.bioontology.org/ontology/NCBITAXON/78342 denotes Bifidobacterium
T20 932-947 http://purl.bioontology.org/ontology/NCBITAXON/1689 denotes Bifidobacterium
T21 932-947 http://purl.bioontology.org/ontology/NCBITAXON/41200 denotes Bifidobacterium
T22 932-947 http://purl.bioontology.org/ontology/NCBITAXON/638617 denotes Bifidobacterium
T23 932-947 http://purl.bioontology.org/ontology/NCBITAXON/85004 denotes Bifidobacterium
T24 932-947 http://purl.bioontology.org/ontology/NCBITAXON/1683 denotes Bifidobacterium
T25 932-947 http://purl.bioontology.org/ontology/NCBITAXON/1681 denotes Bifidobacterium
T26 932-947 http://purl.bioontology.org/ontology/NCBITAXON/471511 denotes Bifidobacterium
T27 932-954 http://purl.bioontology.org/ontology/NCBITAXON/216816 denotes Bifidobacterium longum
T28 1278-1282 http://purl.bioontology.org/ontology/NCBITAXON/507091 denotes para
T29 1278-1282 http://purl.bioontology.org/ontology/NCBITAXON/218705 denotes para

GO-BP

Id Subject Object Predicate Lexical cue
T1 41-50 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T2 219-228 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T3 1103-1112 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T4 54-65 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylated
T5 286-297 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylated
T6 1266-1277 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylated
T7 1002-1014 http://purl.obolibrary.org/obo/GO_0036065 denotes fucosylation
T8 776-778 http://purl.obolibrary.org/obo/GO_0004306 denotes et
T9 807-816 http://purl.obolibrary.org/obo/GO_0032502 denotes developed
T10 913-922 http://purl.obolibrary.org/obo/GO_0085031 denotes commensal
T11 1501-1523 http://purl.obolibrary.org/obo/GO_0003824 denotes activity of the enzyme

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 78-82 http://purl.obolibrary.org/obo/UBERON_0001913 denotes milk
T2 136-142 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T3 1585-1590 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 779-781 https://acgg.asia/db/lfdb/LfDB0344 denotes al

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 379-382 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 379-382 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 379-382 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 379-382 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 379-382 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 379-382 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 379-382 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 379-382 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 379-382 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 379-382 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 379-382 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 78-82 http://purl.obolibrary.org/obo/UBERON_0001913 denotes milk
PD-UBERON-AE-B_T2 136-142 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 1585-1590 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 72-77 OrganismTaxon denotes Human 9606
T2 646-665 OrganismTaxon denotes Thermotoga maritima 2336
T3 923-931 OrganismTaxon denotes bacteria 2|629395
T5 932-970 OrganismTaxon denotes Bifidobacterium longum subsp. infantis 1682

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 78-82 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T2 136-142 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 1585-1590 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542