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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26578114-8#14#18#gene274 1429-1433 gene274 denotes BIN1
26578114-8#63#76#diseaseC0018801 1478-1491 diseaseC0018801 denotes heart failure
26578114-8#63#76#diseaseC0018802 1478-1491 diseaseC0018802 denotes heart failure
14#18#gene27463#76#diseaseC0018801 26578114-8#14#18#gene274 26578114-8#63#76#diseaseC0018801 associated_with BIN1,heart failure
14#18#gene27463#76#diseaseC0018802 26578114-8#14#18#gene274 26578114-8#63#76#diseaseC0018802 associated_with BIN1,heart failure

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1847 1429-1433 gene:274 denotes BIN1
T1848 1478-1491 disease:C0018801 denotes heart failure
R1 T1847 T1848 associated_with BIN1,heart failure
R2 T1847 T1848 associated_with BIN1,heart failure

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-41 Sentence denotes BIN1 regulates dynamic t-tubule membrane.
TextSentencer_T2 42-224 Sentence denotes Cardiac transverse tubules (t-tubules) are specific membrane organelles critical in calcium signaling and excitation-contraction coupling required for beat-to-beat heart contraction.
TextSentencer_T3 225-377 Sentence denotes T-tubules are highly branched and form an interconnected network that penetrates the myocyte interior to form junctions with the sarcoplasmic reticulum.
TextSentencer_T4 378-603 Sentence denotes T-tubules are selectively enriched with specific ion channels and proteins crucial in calcium transient development necessary in excitation-contraction coupling, thus t-tubules are a key component of cardiac myocyte function.
TextSentencer_T5 604-801 Sentence denotes In this review, we focus primarily on two proteins concentrated within the t-tubular network, the L-type calcium channel (LTCC) and associated membrane anchor protein, bridging integrator 1 (BIN1).
TextSentencer_T6 802-951 Sentence denotes Here, we provide an overview of current knowledge in t-tubule morphology, composition, microdomains, as well as the dynamics of the t-tubule network.
TextSentencer_T7 952-1249 Sentence denotes Secondly, we highlight multiple aspects of BIN1-dependent t-tubule function, which includes forward trafficking of LTCCs to t-tubules, LTCC clustering at t-tubule surface, microdomain organization and regulation at t-tubule membrane, and the formation of a slow diffusion barrier within t-tubules.
TextSentencer_T8 1250-1414 Sentence denotes Lastly, we describe progress in characterizing how acquired human heart failure can be attributed to abnormal BIN1 transcription and associated t-tubule remodeling.
TextSentencer_T9 1415-1614 Sentence denotes Understanding BIN1-regulated cardiac t-tubule biology in human heart failure management has the dual benefit of promoting progress in both biomarker development and therapeutic target identification.
TextSentencer_T10 1615-1664 Sentence denotes This article is part of a Special Issue entitled:
TextSentencer_T11 1665-1687 Sentence denotes Cardiomyocyte Biology:
TextSentencer_T12 1688-1795 Sentence denotes Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
T1 0-41 Sentence denotes BIN1 regulates dynamic t-tubule membrane.
T2 42-224 Sentence denotes Cardiac transverse tubules (t-tubules) are specific membrane organelles critical in calcium signaling and excitation-contraction coupling required for beat-to-beat heart contraction.
T3 225-377 Sentence denotes T-tubules are highly branched and form an interconnected network that penetrates the myocyte interior to form junctions with the sarcoplasmic reticulum.
T4 378-603 Sentence denotes T-tubules are selectively enriched with specific ion channels and proteins crucial in calcium transient development necessary in excitation-contraction coupling, thus t-tubules are a key component of cardiac myocyte function.
T5 604-801 Sentence denotes In this review, we focus primarily on two proteins concentrated within the t-tubular network, the L-type calcium channel (LTCC) and associated membrane anchor protein, bridging integrator 1 (BIN1).
T6 802-951 Sentence denotes Here, we provide an overview of current knowledge in t-tubule morphology, composition, microdomains, as well as the dynamics of the t-tubule network.
T7 952-1249 Sentence denotes Secondly, we highlight multiple aspects of BIN1-dependent t-tubule function, which includes forward trafficking of LTCCs to t-tubules, LTCC clustering at t-tubule surface, microdomain organization and regulation at t-tubule membrane, and the formation of a slow diffusion barrier within t-tubules.
T8 1250-1414 Sentence denotes Lastly, we describe progress in characterizing how acquired human heart failure can be attributed to abnormal BIN1 transcription and associated t-tubule remodeling.
T9 1415-1614 Sentence denotes Understanding BIN1-regulated cardiac t-tubule biology in human heart failure management has the dual benefit of promoting progress in both biomarker development and therapeutic target identification.
T10 1615-1664 Sentence denotes This article is part of a Special Issue entitled:
T11 1665-1687 Sentence denotes Cardiomyocyte Biology:
T12 1688-1795 Sentence denotes Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 206-211 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T2 1316-1321 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T3 1478-1483 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T4 1747-1752 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1136-1148 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organization
PD-UBERON-AE-B_T2 206-211 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T3 1316-1321 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T4 1478-1483 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T5 1747-1752 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1316-1329 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T2 1478-1491 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1316-1329 Phenotype denotes heart failure HP:0001635
T2 1478-1491 Phenotype denotes heart failure HP:0001635

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1310-1315 OrganismTaxon denotes human 9606
T2 1472-1477 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 32-40 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 94-102 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T7 103-113 Body_part denotes organelles http://purl.obolibrary.org/obo/GO_0043226
T8 206-211 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T12 310-317 Body_part denotes myocyte http://purl.obolibrary.org/obo/CL_0000187
T13 335-344 Body_part denotes junctions http://purl.obolibrary.org/obo/UBERON_0007651
T14 354-366 Body_part denotes sarcoplasmic http://purl.obolibrary.org/obo/GO_0016528
T15 367-376 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T16 578-593 Body_part denotes cardiac myocyte http://purl.obolibrary.org/obo/CL_0000746
T17 747-755 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T20 1176-1184 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T23 1316-1321 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T27 1478-1483 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T31 1665-1678 Body_part denotes Cardiomyocyte http://purl.obolibrary.org/obo/CL_0000746
T32 1747-1752 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 206-211 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 1316-1321 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T3 1478-1483 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 1747-1752 Body_part denotes Heart http://purl.obolibrary.org/obo/MAT_0000036

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 310-317 Cell denotes myocyte http://purl.obolibrary.org/obo/CL:0000187
T2 578-593 Cell denotes cardiac myocyte http://purl.obolibrary.org/obo/CL:0000746
T3 586-593 Cell denotes myocyte http://purl.obolibrary.org/obo/CL:0000187
T4 1665-1678 Cell denotes Cardiomyocyte http://purl.obolibrary.org/obo/CL:0000746