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PubMed:26555588 / 559-1771 JSONTXT

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GoldHamster

Id Subject Object Predicate Lexical cue
T51 20-26 813859 denotes rabbit
T50 20-26 D011817 denotes rabbit
T52 20-26 9986 denotes rabbit
T53 27-34 UBERON:0000964 denotes corneas
T54 69-89 GO:0006915 denotes apoptotic cell death
T56 158-192 D042461 denotes vascular endothelial growth factor
T58 158-192 D042461 denotes vascular endothelial growth factor
T57 158-192 GO:0005172 denotes vascular endothelial growth factor
T61 179-192 P08441 denotes growth factor
T62 179-192 P08072 denotes growth factor
T63 179-192 Q776B5 denotes growth factor
T64 179-192 Q6RZT5 denotes growth factor
T65 179-192 Q8V307 denotes growth factor
T78 194-210 D051546 denotes cyclooxygenase 2
T67 194-210 O62725 denotes cyclooxygenase 2
T68 194-210 Q05769 denotes cyclooxygenase 2
T69 194-210 P35355 denotes cyclooxygenase 2
T70 194-210 P79208 denotes cyclooxygenase 2
T71 194-210 P35354 denotes cyclooxygenase 2
T72 194-210 O02768 denotes cyclooxygenase 2
T73 194-210 PR:000013428 denotes cyclooxygenase 2
T74 194-210 P27607 denotes cyclooxygenase 2
T75 194-210 O19183 denotes cyclooxygenase 2
T76 194-210 O62698 denotes cyclooxygenase 2
T77 194-210 P70682 denotes cyclooxygenase 2
T79 216-222 UBERON:0027368 denotes matrix
T80 216-242 D020780 denotes matrix metalloproteinase-9
T81 216-242 P14780 denotes matrix metalloproteinase-9
T82 216-242 P41246 denotes matrix metalloproteinase-9
T83 216-242 P41245 denotes matrix metalloproteinase-9
T84 216-242 P50282 denotes matrix metalloproteinase-9
T85 216-242 PR:000010491 denotes matrix metalloproteinase-9
T86 216-242 P52176 denotes matrix metalloproteinase-9
T87 216-242 O18733 denotes matrix metalloproteinase-9
T92 247-250 C007907 denotes HCE
T94 247-250 C007907 denotes HCE
T88 247-250 O55236 denotes HCE
T90 247-250 PR:000014142 denotes HCE
T91 247-250 O60942 denotes HCE
T93 247-250 P02242 denotes HCE
T89 247-250 CVCL_1272 denotes HCE
T95 247-250 CVCL_M619 denotes HCE
T96 330-343 UBERON:2000098 denotes proliferation
T99 371-374 SO:0000352 denotes DNA
T98 371-374 CHEBI:16991 denotes DNA
T100 371-374 D004247 denotes DNA
T97 371-374 GO:0005574 denotes DNA
T101 409-412 PR:P04637 denotes p53
T102 409-412 PR:000003035 denotes p53
T103 409-412 PR:P02340 denotes p53
T104 409-412 PR:Q42578 denotes p53
T105 409-412 PR:P10361 denotes p53
T112 413-416 SO:0001444 denotes ser
T106 413-416 CHEBI:32838 denotes ser
T107 413-416 CHEBI:32839 denotes ser
T109 413-416 CHEBI:29999 denotes ser
T113 413-416 CHEBI:17115 denotes ser
T110 413-416 Q62230 denotes ser
T111 413-416 PR:000001931 denotes ser
T114 413-416 PR:P18168 denotes ser
T108 413-416 GO:0005790 denotes ser
T115 426-429 PR:P04637 denotes p53
T116 426-429 PR:000003035 denotes p53
T117 426-429 PR:P02340 denotes p53
T118 426-429 PR:Q42578 denotes p53
T119 426-429 PR:P10361 denotes p53
T121 435-440 P27661 denotes H2A.X
T122 435-440 PR:P27661 denotes H2A.X
T123 435-440 Q7ZUY3 denotes H2A.X
T124 435-440 Q54WG6 denotes H2A.X
T125 435-440 PR:000008418 denotes H2A.X
T126 435-440 Q6GM86 denotes H2A.X
T127 435-440 P16104 denotes H2A.X
T134 441-444 SO:0001444 denotes ser
T128 441-444 CHEBI:32838 denotes ser
T129 441-444 CHEBI:32839 denotes ser
T131 441-444 CHEBI:29999 denotes ser
T135 441-444 CHEBI:17115 denotes ser
T132 441-444 Q62230 denotes ser
T133 441-444 PR:000001931 denotes ser
T136 441-444 PR:P18168 denotes ser
T130 441-444 GO:0005790 denotes ser
T139 481-490 P55866 denotes caspase-3
T140 481-490 Q8MJC3 denotes caspase-3
T141 481-490 Q2PFV2 denotes caspase-3
T142 481-490 Q08DY9 denotes caspase-3
T143 481-490 Q5IS54 denotes caspase-3
T144 481-490 Q8MKI5 denotes caspase-3
T145 481-490 PR:000002312 denotes caspase-3
T146 481-490 Q8MJU1 denotes caspase-3
T147 481-490 Q60431 denotes caspase-3
T148 481-490 P42574 denotes caspase-3
T149 481-490 Q5IS99 denotes caspase-3
T150 481-490 Q95ND5 denotes caspase-3
T151 481-490 P70677 denotes caspase-3
T152 481-490 P55213 denotes caspase-3
T138 481-490 D053148 denotes caspase-3
T153 495-499 CL:0000775 denotes poly
T154 495-499 CL:0000096 denotes poly
T158 495-521 P35875 denotes poly ADP ribose polymerase
T159 495-521 Q11208 denotes poly ADP ribose polymerase
T160 495-521 Q9VBP3 denotes poly ADP ribose polymerase
T157 495-521 D011065 denotes poly ADP ribose polymerase
T178 598-604 813859 denotes rabbit
T177 598-604 D011817 denotes rabbit
T179 598-604 9986 denotes rabbit
T180 605-611 UBERON:0000964 denotes cornea
T181 616-619 O55236 denotes HCE
T183 616-619 PR:000014142 denotes HCE
T184 616-619 O60942 denotes HCE
T186 616-619 P02242 denotes HCE
T185 616-619 C007907 denotes HCE
T187 616-619 C007907 denotes HCE
T182 616-619 CVCL_1272 denotes HCE
T188 616-619 CVCL_M619 denotes HCE
T190 638-644 813859 denotes rabbit
T189 638-644 D011817 denotes rabbit
T191 638-644 9986 denotes rabbit
T192 645-651 UBERON:0000964 denotes cornea
T194 687-703 O62725 denotes cyclooxygenase 2
T195 687-703 Q05769 denotes cyclooxygenase 2
T196 687-703 P35355 denotes cyclooxygenase 2
T197 687-703 P79208 denotes cyclooxygenase 2
T198 687-703 P35354 denotes cyclooxygenase 2
T199 687-703 O02768 denotes cyclooxygenase 2
T200 687-703 PR:000013428 denotes cyclooxygenase 2
T201 687-703 P27607 denotes cyclooxygenase 2
T202 687-703 O19183 denotes cyclooxygenase 2
T203 687-703 O62698 denotes cyclooxygenase 2
T204 687-703 P70682 denotes cyclooxygenase 2
T205 687-703 D051546 denotes cyclooxygenase 2
T206 705-711 UBERON:0027368 denotes matrix
T208 705-731 P14780 denotes matrix metalloproteinase-9
T209 705-731 P41246 denotes matrix metalloproteinase-9
T210 705-731 P41245 denotes matrix metalloproteinase-9
T211 705-731 P50282 denotes matrix metalloproteinase-9
T212 705-731 PR:000010491 denotes matrix metalloproteinase-9
T213 705-731 P52176 denotes matrix metalloproteinase-9
T214 705-731 O18733 denotes matrix metalloproteinase-9
T207 705-731 D020780 denotes matrix metalloproteinase-9
T215 737-771 D042461 denotes vascular endothelial growth factor
T217 737-771 D042461 denotes vascular endothelial growth factor
T216 737-771 GO:0005172 denotes vascular endothelial growth factor
T220 758-771 P08441 denotes growth factor
T221 758-771 P08072 denotes growth factor
T222 758-771 Q776B5 denotes growth factor
T223 758-771 Q6RZT5 denotes growth factor
T224 758-771 Q8V307 denotes growth factor
T226 782-785 CVCL_1272 denotes HCE
T232 782-785 CVCL_M619 denotes HCE
T225 782-785 O55236 denotes HCE
T227 782-785 PR:000014142 denotes HCE
T228 782-785 O60942 denotes HCE
T230 782-785 P02242 denotes HCE
T229 782-785 C007907 denotes HCE
T231 782-785 C007907 denotes HCE
T233 820-829 CHEBI:25367 denotes molecules
T234 873-885 GO:0006954 denotes inflammation
T235 873-885 D007249 denotes inflammation
T236 873-885 D007249 denotes inflammation
T237 981-1000 P56432 denotes activator protein 1
T238 981-1000 P05627 denotes activator protein 1
T239 981-1000 O77627 denotes activator protein 1
T240 981-1000 P05412 denotes activator protein 1
T241 981-1000 P17325 denotes activator protein 1
T242 981-1000 PR:000009232 denotes activator protein 1
T243 981-1000 D018808 denotes activator protein 1
T248 991-998 SO:0000104 denotes protein
T244 991-998 GO:0003675 denotes protein
T250 1001-1014 GO:0006351 denotes transcription
T251 1001-1021 GO:0000981 denotes transcription factor
T252 1022-1030 CHEBI:36080 denotes proteins
T253 1035-1043 SO:0001635 denotes upstream
T254 1044-1053 GO:0023052 denotes signaling
T256 1073-1106 D020928 denotes mitogen-activated protein kinases
T261 1091-1098 SO:0000104 denotes protein
T260 1091-1098 PR:000000001 denotes protein
T257 1091-1098 GO:0003675 denotes protein
T263 1111-1114 PR:000029189 denotes Akt
T264 1111-1114 PR:P54644 denotes Akt
T265 1111-1114 PR:P31750 denotes Akt
T266 1111-1114 PR:000002190 denotes Akt
T267 1111-1114 Q8INB9 denotes Akt
T272 1115-1122 SO:0000104 denotes protein
T271 1115-1122 PR:000000001 denotes protein
T268 1115-1122 GO:0003675 denotes protein
T273 1115-1129 D011494 denotes protein kinase
T274 1197-1211 D065306 denotes corneal injury
T275 1197-1211 D065306 denotes corneal injury

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T3 0-1212 RESULTS denotes Analysis of ex vivo rabbit corneas showed that NM exposure increased apoptotic cell death, epithelial thickness, epithelial-stromal separation, and levels of vascular endothelial growth factor, cyclooxygenase 2, and matrix metalloproteinase-9. In HCE cells, NM exposure resulted in a dose-dependent decrease in cell viability and proliferation, which was associated with DNA damage in terms of an increase in p53 ser15, total p53, and H2A.X ser139 levels. NM exposure also induced caspase-3 and poly ADP ribose polymerase cleavage, suggesting their involvement in NM-induced apoptotic death in the rabbit cornea and HCE cells. Similar to rabbit cornea, NM exposure caused an increase in cyclooxygenase 2, matrix metalloproteinase-9, and vascular endothelial growth factor levels in HCE cells, indicating a role of these molecules and related pathways in NM-induced corneal inflammation, epithelial-stromal separation, and neovascularization. NM exposure also induced activation of activator protein 1 transcription factor proteins and upstream signaling pathways including mitogen-activated protein kinases and Akt protein kinase, suggesting that these could be key factors involved in NM-induced corneal injury.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T4 247-250 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T5 247-250 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T6 282-283 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 394-396 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T8 394-396 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T9 616-619 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T10 616-619 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T11 672-674 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T12 672-674 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T13 782-785 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T14 782-785 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T15 804-805 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 967-977 CVCL_C410|Hybridoma|Mus musculus denotes activation
T17 981-990 CVCL_C410|Hybridoma|Mus musculus denotes activator
T18 1081-1090 CVCL_C410|Hybridoma|Mus musculus denotes activated

Inflammaging

Id Subject Object Predicate Lexical cue
T7 0-243 Sentence denotes Analysis of ex vivo rabbit corneas showed that NM exposure increased apoptotic cell death, epithelial thickness, epithelial-stromal separation, and levels of vascular endothelial growth factor, cyclooxygenase 2, and matrix metalloproteinase-9.
T8 244-455 Sentence denotes In HCE cells, NM exposure resulted in a dose-dependent decrease in cell viability and proliferation, which was associated with DNA damage in terms of an increase in p53 ser15, total p53, and H2A.X ser139 levels.
T9 456-626 Sentence denotes NM exposure also induced caspase-3 and poly ADP ribose polymerase cleavage, suggesting their involvement in NM-induced apoptotic death in the rabbit cornea and HCE cells.
T10 627-941 Sentence denotes Similar to rabbit cornea, NM exposure caused an increase in cyclooxygenase 2, matrix metalloproteinase-9, and vascular endothelial growth factor levels in HCE cells, indicating a role of these molecules and related pathways in NM-induced corneal inflammation, epithelial-stromal separation, and neovascularization.
T11 942-1212 Sentence denotes NM exposure also induced activation of activator protein 1 transcription factor proteins and upstream signaling pathways including mitogen-activated protein kinases and Akt protein kinase, suggesting that these could be key factors involved in NM-induced corneal injury.
T7 0-243 Sentence denotes Analysis of ex vivo rabbit corneas showed that NM exposure increased apoptotic cell death, epithelial thickness, epithelial-stromal separation, and levels of vascular endothelial growth factor, cyclooxygenase 2, and matrix metalloproteinase-9.
T8 244-455 Sentence denotes In HCE cells, NM exposure resulted in a dose-dependent decrease in cell viability and proliferation, which was associated with DNA damage in terms of an increase in p53 ser15, total p53, and H2A.X ser139 levels.
T9 456-626 Sentence denotes NM exposure also induced caspase-3 and poly ADP ribose polymerase cleavage, suggesting their involvement in NM-induced apoptotic death in the rabbit cornea and HCE cells.
T10 627-941 Sentence denotes Similar to rabbit cornea, NM exposure caused an increase in cyclooxygenase 2, matrix metalloproteinase-9, and vascular endothelial growth factor levels in HCE cells, indicating a role of these molecules and related pathways in NM-induced corneal inflammation, epithelial-stromal separation, and neovascularization.
T11 942-1212 Sentence denotes NM exposure also induced activation of activator protein 1 transcription factor proteins and upstream signaling pathways including mitogen-activated protein kinases and Akt protein kinase, suggesting that these could be key factors involved in NM-induced corneal injury.