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GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-8 7456 denotes Nitrogen
T5 0-16 D008466 denotes Nitrogen Mustard
T6 0-16 D008466 denotes Nitrogen Mustard
T7 0-16 CHEBI:37598 denotes Nitrogen Mustard
T8 0-16 CHEBI:28925 denotes Nitrogen Mustard
T9 9-16 D009149 denotes Mustard
T10 25-39 D065306 denotes Corneal Injury
T11 25-39 D065306 denotes Corneal Injury
T16 49-52 SO:0000352 denotes DNA
T15 49-52 CHEBI:16991 denotes DNA
T17 49-52 D004247 denotes DNA
T14 49-52 GO:0005574 denotes DNA
T18 84-96 GO:0006954 denotes Inflammation
T19 84-96 D007249 denotes Inflammation
T20 84-96 D007249 denotes Inflammation
T21 229-235 UBERON:0000479 denotes tissue
T22 269-277 7456 denotes nitrogen
T25 269-285 D008466 denotes nitrogen mustard
T26 269-285 D008466 denotes nitrogen mustard
T27 269-285 CHEBI:37598 denotes nitrogen mustard
T28 269-285 CHEBI:28925 denotes nitrogen mustard
T29 278-285 D009149 denotes mustard
T30 332-354 D002619 denotes chemical warfare agent
T33 355-361 10223 denotes sulfur
T36 355-369 D009151 denotes sulfur mustard
T37 355-369 CHEBI:25434 denotes sulfur mustard
T38 355-369 D009151 denotes sulfur mustard
T39 362-369 D009149 denotes mustard
T40 464-470 UBERON:0000479 denotes tissue
T41 498-503 D006801 denotes human
T43 524-527 CVCL_1272 denotes HCE
T49 524-527 CVCL_M619 denotes HCE
T46 524-527 C007907 denotes HCE
T48 524-527 C007907 denotes HCE
T42 524-527 O55236 denotes HCE
T44 524-527 PR:000014142 denotes HCE
T45 524-527 O60942 denotes HCE
T47 524-527 P02242 denotes HCE
T51 579-585 813859 denotes rabbit
T50 579-585 D011817 denotes rabbit
T52 579-585 9986 denotes rabbit
T53 586-593 UBERON:0000964 denotes corneas
T54 628-648 GO:0006915 denotes apoptotic cell death
T56 717-751 D042461 denotes vascular endothelial growth factor
T58 717-751 D042461 denotes vascular endothelial growth factor
T57 717-751 GO:0005172 denotes vascular endothelial growth factor
T61 738-751 P08441 denotes growth factor
T62 738-751 P08072 denotes growth factor
T63 738-751 Q776B5 denotes growth factor
T64 738-751 Q6RZT5 denotes growth factor
T65 738-751 Q8V307 denotes growth factor
T78 753-769 D051546 denotes cyclooxygenase 2
T67 753-769 O62725 denotes cyclooxygenase 2
T68 753-769 Q05769 denotes cyclooxygenase 2
T69 753-769 P35355 denotes cyclooxygenase 2
T70 753-769 P79208 denotes cyclooxygenase 2
T71 753-769 P35354 denotes cyclooxygenase 2
T72 753-769 O02768 denotes cyclooxygenase 2
T73 753-769 PR:000013428 denotes cyclooxygenase 2
T74 753-769 P27607 denotes cyclooxygenase 2
T75 753-769 O19183 denotes cyclooxygenase 2
T76 753-769 O62698 denotes cyclooxygenase 2
T77 753-769 P70682 denotes cyclooxygenase 2
T79 775-781 UBERON:0027368 denotes matrix
T80 775-801 D020780 denotes matrix metalloproteinase-9
T81 775-801 P14780 denotes matrix metalloproteinase-9
T82 775-801 P41246 denotes matrix metalloproteinase-9
T83 775-801 P41245 denotes matrix metalloproteinase-9
T84 775-801 P50282 denotes matrix metalloproteinase-9
T85 775-801 PR:000010491 denotes matrix metalloproteinase-9
T86 775-801 P52176 denotes matrix metalloproteinase-9
T87 775-801 O18733 denotes matrix metalloproteinase-9
T92 806-809 C007907 denotes HCE
T94 806-809 C007907 denotes HCE
T88 806-809 O55236 denotes HCE
T90 806-809 PR:000014142 denotes HCE
T91 806-809 O60942 denotes HCE
T93 806-809 P02242 denotes HCE
T89 806-809 CVCL_1272 denotes HCE
T95 806-809 CVCL_M619 denotes HCE
T96 889-902 UBERON:2000098 denotes proliferation
T99 930-933 SO:0000352 denotes DNA
T98 930-933 CHEBI:16991 denotes DNA
T100 930-933 D004247 denotes DNA
T97 930-933 GO:0005574 denotes DNA
T101 968-971 PR:P04637 denotes p53
T102 968-971 PR:000003035 denotes p53
T103 968-971 PR:P02340 denotes p53
T104 968-971 PR:Q42578 denotes p53
T105 968-971 PR:P10361 denotes p53
T112 972-975 SO:0001444 denotes ser
T106 972-975 CHEBI:32838 denotes ser
T107 972-975 CHEBI:32839 denotes ser
T109 972-975 CHEBI:29999 denotes ser
T113 972-975 CHEBI:17115 denotes ser
T110 972-975 Q62230 denotes ser
T111 972-975 PR:000001931 denotes ser
T114 972-975 PR:P18168 denotes ser
T108 972-975 GO:0005790 denotes ser
T115 985-988 PR:P04637 denotes p53
T116 985-988 PR:000003035 denotes p53
T117 985-988 PR:P02340 denotes p53
T118 985-988 PR:Q42578 denotes p53
T119 985-988 PR:P10361 denotes p53
T121 994-999 P27661 denotes H2A.X
T122 994-999 PR:P27661 denotes H2A.X
T123 994-999 Q7ZUY3 denotes H2A.X
T124 994-999 Q54WG6 denotes H2A.X
T125 994-999 PR:000008418 denotes H2A.X
T126 994-999 Q6GM86 denotes H2A.X
T127 994-999 P16104 denotes H2A.X
T134 1000-1003 SO:0001444 denotes ser
T128 1000-1003 CHEBI:32838 denotes ser
T129 1000-1003 CHEBI:32839 denotes ser
T131 1000-1003 CHEBI:29999 denotes ser
T135 1000-1003 CHEBI:17115 denotes ser
T132 1000-1003 Q62230 denotes ser
T133 1000-1003 PR:000001931 denotes ser
T136 1000-1003 PR:P18168 denotes ser
T130 1000-1003 GO:0005790 denotes ser
T139 1040-1049 P55866 denotes caspase-3
T140 1040-1049 Q8MJC3 denotes caspase-3
T141 1040-1049 Q2PFV2 denotes caspase-3
T142 1040-1049 Q08DY9 denotes caspase-3
T143 1040-1049 Q5IS54 denotes caspase-3
T144 1040-1049 Q8MKI5 denotes caspase-3
T145 1040-1049 PR:000002312 denotes caspase-3
T146 1040-1049 Q8MJU1 denotes caspase-3
T147 1040-1049 Q60431 denotes caspase-3
T148 1040-1049 P42574 denotes caspase-3
T149 1040-1049 Q5IS99 denotes caspase-3
T150 1040-1049 Q95ND5 denotes caspase-3
T151 1040-1049 P70677 denotes caspase-3
T152 1040-1049 P55213 denotes caspase-3
T138 1040-1049 D053148 denotes caspase-3
T153 1054-1058 CL:0000775 denotes poly
T154 1054-1058 CL:0000096 denotes poly
T158 1054-1080 P35875 denotes poly ADP ribose polymerase
T159 1054-1080 Q11208 denotes poly ADP ribose polymerase
T160 1054-1080 Q9VBP3 denotes poly ADP ribose polymerase
T157 1054-1080 D011065 denotes poly ADP ribose polymerase
T178 1157-1163 813859 denotes rabbit
T177 1157-1163 D011817 denotes rabbit
T179 1157-1163 9986 denotes rabbit
T180 1164-1170 UBERON:0000964 denotes cornea
T181 1175-1178 O55236 denotes HCE
T183 1175-1178 PR:000014142 denotes HCE
T184 1175-1178 O60942 denotes HCE
T186 1175-1178 P02242 denotes HCE
T185 1175-1178 C007907 denotes HCE
T187 1175-1178 C007907 denotes HCE
T182 1175-1178 CVCL_1272 denotes HCE
T188 1175-1178 CVCL_M619 denotes HCE
T190 1197-1203 813859 denotes rabbit
T189 1197-1203 D011817 denotes rabbit
T191 1197-1203 9986 denotes rabbit
T192 1204-1210 UBERON:0000964 denotes cornea
T194 1246-1262 O62725 denotes cyclooxygenase 2
T195 1246-1262 Q05769 denotes cyclooxygenase 2
T196 1246-1262 P35355 denotes cyclooxygenase 2
T197 1246-1262 P79208 denotes cyclooxygenase 2
T198 1246-1262 P35354 denotes cyclooxygenase 2
T199 1246-1262 O02768 denotes cyclooxygenase 2
T200 1246-1262 PR:000013428 denotes cyclooxygenase 2
T201 1246-1262 P27607 denotes cyclooxygenase 2
T202 1246-1262 O19183 denotes cyclooxygenase 2
T203 1246-1262 O62698 denotes cyclooxygenase 2
T204 1246-1262 P70682 denotes cyclooxygenase 2
T205 1246-1262 D051546 denotes cyclooxygenase 2
T206 1264-1270 UBERON:0027368 denotes matrix
T208 1264-1290 P14780 denotes matrix metalloproteinase-9
T209 1264-1290 P41246 denotes matrix metalloproteinase-9
T210 1264-1290 P41245 denotes matrix metalloproteinase-9
T211 1264-1290 P50282 denotes matrix metalloproteinase-9
T212 1264-1290 PR:000010491 denotes matrix metalloproteinase-9
T213 1264-1290 P52176 denotes matrix metalloproteinase-9
T214 1264-1290 O18733 denotes matrix metalloproteinase-9
T207 1264-1290 D020780 denotes matrix metalloproteinase-9
T215 1296-1330 D042461 denotes vascular endothelial growth factor
T217 1296-1330 D042461 denotes vascular endothelial growth factor
T216 1296-1330 GO:0005172 denotes vascular endothelial growth factor
T220 1317-1330 P08441 denotes growth factor
T221 1317-1330 P08072 denotes growth factor
T222 1317-1330 Q776B5 denotes growth factor
T223 1317-1330 Q6RZT5 denotes growth factor
T224 1317-1330 Q8V307 denotes growth factor
T226 1341-1344 CVCL_1272 denotes HCE
T232 1341-1344 CVCL_M619 denotes HCE
T225 1341-1344 O55236 denotes HCE
T227 1341-1344 PR:000014142 denotes HCE
T228 1341-1344 O60942 denotes HCE
T230 1341-1344 P02242 denotes HCE
T229 1341-1344 C007907 denotes HCE
T231 1341-1344 C007907 denotes HCE
T233 1379-1388 CHEBI:25367 denotes molecules
T234 1432-1444 GO:0006954 denotes inflammation
T235 1432-1444 D007249 denotes inflammation
T236 1432-1444 D007249 denotes inflammation
T237 1540-1559 P56432 denotes activator protein 1
T238 1540-1559 P05627 denotes activator protein 1
T239 1540-1559 O77627 denotes activator protein 1
T240 1540-1559 P05412 denotes activator protein 1
T241 1540-1559 P17325 denotes activator protein 1
T242 1540-1559 PR:000009232 denotes activator protein 1
T243 1540-1559 D018808 denotes activator protein 1
T248 1550-1557 SO:0000104 denotes protein
T244 1550-1557 GO:0003675 denotes protein
T250 1560-1573 GO:0006351 denotes transcription
T251 1560-1580 GO:0000981 denotes transcription factor
T252 1581-1589 CHEBI:36080 denotes proteins
T253 1594-1602 SO:0001635 denotes upstream
T254 1603-1612 GO:0023052 denotes signaling
T256 1632-1665 D020928 denotes mitogen-activated protein kinases
T261 1650-1657 SO:0000104 denotes protein
T260 1650-1657 PR:000000001 denotes protein
T257 1650-1657 GO:0003675 denotes protein
T263 1670-1673 PR:000029189 denotes Akt
T264 1670-1673 PR:P54644 denotes Akt
T265 1670-1673 PR:P31750 denotes Akt
T266 1670-1673 PR:000002190 denotes Akt
T267 1670-1673 Q8INB9 denotes Akt
T272 1674-1681 SO:0000104 denotes protein
T271 1674-1681 PR:000000001 denotes protein
T268 1674-1681 GO:0003675 denotes protein
T273 1674-1688 D011494 denotes protein kinase
T274 1756-1770 D065306 denotes corneal injury
T275 1756-1770 D065306 denotes corneal injury
T276 1902-1918 D065306 denotes corneal injuries
T277 1902-1918 D065306 denotes corneal injuries
T278 1988-1996 CHEBI:78592 denotes vesicant

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 162-370 OBJECTIVE denotes To evaluate the toxic effects and associated mechanisms in corneal tissue exposed to the vesicating agent, nitrogen mustard (NM), a bifunctional alkylating analog of the chemical warfare agent sulfur mustard.
T2 380-549 METHODS denotes Toxic effects and associated mechanisms were examined in maximally affected corneal tissue using corneal cultures and human corneal epithelial (HCE) cells exposed to NM.
T3 559-1771 RESULTS denotes Analysis of ex vivo rabbit corneas showed that NM exposure increased apoptotic cell death, epithelial thickness, epithelial-stromal separation, and levels of vascular endothelial growth factor, cyclooxygenase 2, and matrix metalloproteinase-9. In HCE cells, NM exposure resulted in a dose-dependent decrease in cell viability and proliferation, which was associated with DNA damage in terms of an increase in p53 ser15, total p53, and H2A.X ser139 levels. NM exposure also induced caspase-3 and poly ADP ribose polymerase cleavage, suggesting their involvement in NM-induced apoptotic death in the rabbit cornea and HCE cells. Similar to rabbit cornea, NM exposure caused an increase in cyclooxygenase 2, matrix metalloproteinase-9, and vascular endothelial growth factor levels in HCE cells, indicating a role of these molecules and related pathways in NM-induced corneal inflammation, epithelial-stromal separation, and neovascularization. NM exposure also induced activation of activator protein 1 transcription factor proteins and upstream signaling pathways including mitogen-activated protein kinases and Akt protein kinase, suggesting that these could be key factors involved in NM-induced corneal injury.
T4 1785-2086 CONCLUSIONS denotes Results from this study provide insight into the molecular targets and pathways that could be involved in NM-induced corneal injuries laying the background for further investigation of these pathways in vesicant-induced ocular injuries, which could be helpful in the development of targeted therapies.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 292-293 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 524-527 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T3 524-527 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T4 806-809 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T5 806-809 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T6 841-842 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T7 953-955 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T8 953-955 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T9 1175-1178 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T10 1175-1178 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T11 1231-1233 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T12 1231-1233 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T13 1341-1344 CVCL_1272|Transformed_cell_line|Homo sapiens denotes HCE
T14 1341-1344 CVCL_M619|Cancer_cell_line|Homo sapiens denotes HCE
T15 1363-1364 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 1526-1536 CVCL_C410|Hybridoma|Mus musculus denotes activation
T17 1540-1549 CVCL_C410|Hybridoma|Mus musculus denotes activator
T18 1640-1649 CVCL_C410|Hybridoma|Mus musculus denotes activated

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-152 Sentence denotes Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization.
T2 153-161 Sentence denotes PURPOSE:
T3 162-370 Sentence denotes To evaluate the toxic effects and associated mechanisms in corneal tissue exposed to the vesicating agent, nitrogen mustard (NM), a bifunctional alkylating analog of the chemical warfare agent sulfur mustard.
T4 371-379 Sentence denotes METHODS:
T5 380-549 Sentence denotes Toxic effects and associated mechanisms were examined in maximally affected corneal tissue using corneal cultures and human corneal epithelial (HCE) cells exposed to NM.
T6 550-558 Sentence denotes RESULTS:
T7 559-802 Sentence denotes Analysis of ex vivo rabbit corneas showed that NM exposure increased apoptotic cell death, epithelial thickness, epithelial-stromal separation, and levels of vascular endothelial growth factor, cyclooxygenase 2, and matrix metalloproteinase-9.
T8 803-1014 Sentence denotes In HCE cells, NM exposure resulted in a dose-dependent decrease in cell viability and proliferation, which was associated with DNA damage in terms of an increase in p53 ser15, total p53, and H2A.X ser139 levels.
T9 1015-1185 Sentence denotes NM exposure also induced caspase-3 and poly ADP ribose polymerase cleavage, suggesting their involvement in NM-induced apoptotic death in the rabbit cornea and HCE cells.
T10 1186-1500 Sentence denotes Similar to rabbit cornea, NM exposure caused an increase in cyclooxygenase 2, matrix metalloproteinase-9, and vascular endothelial growth factor levels in HCE cells, indicating a role of these molecules and related pathways in NM-induced corneal inflammation, epithelial-stromal separation, and neovascularization.
T11 1501-1771 Sentence denotes NM exposure also induced activation of activator protein 1 transcription factor proteins and upstream signaling pathways including mitogen-activated protein kinases and Akt protein kinase, suggesting that these could be key factors involved in NM-induced corneal injury.
T12 1772-1784 Sentence denotes CONCLUSIONS:
T13 1785-2086 Sentence denotes Results from this study provide insight into the molecular targets and pathways that could be involved in NM-induced corneal injuries laying the background for further investigation of these pathways in vesicant-induced ocular injuries, which could be helpful in the development of targeted therapies.
T1 0-152 Sentence denotes Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization.
T2 153-161 Sentence denotes PURPOSE:
T3 162-370 Sentence denotes To evaluate the toxic effects and associated mechanisms in corneal tissue exposed to the vesicating agent, nitrogen mustard (NM), a bifunctional alkylating analog of the chemical warfare agent sulfur mustard.
T4 371-379 Sentence denotes METHODS:
T5 380-549 Sentence denotes Toxic effects and associated mechanisms were examined in maximally affected corneal tissue using corneal cultures and human corneal epithelial (HCE) cells exposed to NM.
T6 550-558 Sentence denotes RESULTS:
T7 559-802 Sentence denotes Analysis of ex vivo rabbit corneas showed that NM exposure increased apoptotic cell death, epithelial thickness, epithelial-stromal separation, and levels of vascular endothelial growth factor, cyclooxygenase 2, and matrix metalloproteinase-9.
T8 803-1014 Sentence denotes In HCE cells, NM exposure resulted in a dose-dependent decrease in cell viability and proliferation, which was associated with DNA damage in terms of an increase in p53 ser15, total p53, and H2A.X ser139 levels.
T9 1015-1185 Sentence denotes NM exposure also induced caspase-3 and poly ADP ribose polymerase cleavage, suggesting their involvement in NM-induced apoptotic death in the rabbit cornea and HCE cells.
T10 1186-1500 Sentence denotes Similar to rabbit cornea, NM exposure caused an increase in cyclooxygenase 2, matrix metalloproteinase-9, and vascular endothelial growth factor levels in HCE cells, indicating a role of these molecules and related pathways in NM-induced corneal inflammation, epithelial-stromal separation, and neovascularization.
T11 1501-1771 Sentence denotes NM exposure also induced activation of activator protein 1 transcription factor proteins and upstream signaling pathways including mitogen-activated protein kinases and Akt protein kinase, suggesting that these could be key factors involved in NM-induced corneal injury.
T12 1772-1784 Sentence denotes CONCLUSIONS:
T13 1785-2086 Sentence denotes Results from this study provide insight into the molecular targets and pathways that could be involved in NM-induced corneal injuries laying the background for further investigation of these pathways in vesicant-induced ocular injuries, which could be helpful in the development of targeted therapies.