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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes The effect of moderate alcohol consumption on biomarkers of inflammation and hemostatic factors in postmenopausal women.
T2 121-143 Sentence denotes BACKGROUND/OBJECTIVES:
T3 144-225 Sentence denotes Inflammation and hemostasis contribute to the etiology of cardiovascular disease.
T4 226-386 Sentence denotes We previously demonstrated that moderate alcohol consumption (1-2 drinks/day) may decrease risk for cardiovascular disease because of an improved lipid profile.
T5 387-524 Sentence denotes In addition to these beneficial changes, the alcohol-mediated reduction in risk may be through its effect on inflammation and hemostasis.
T6 525-680 Sentence denotes The objective of the study was to evaluate the effect of moderate alcohol consumption on biomarkers of inflammation and hemostasis in postmenopausal women.
T7 681-698 Sentence denotes SUBJECTS/METHODS:
T8 699-880 Sentence denotes As part of a controlled diet study, 53 postmenopausal women each consumed a weight-maintaining diet plus 0, 15 and 30 g/day of alcohol for 8 weeks, in a randomized crossover design.
T9 881-987 Sentence denotes The controlled diet contained 15%, 53% and 32% of energy from protein, carbohydrate and fat, respectively.
T10 988-996 Sentence denotes RESULTS:
T11 997-1112 Sentence denotes Soluble intercellular adhesion molecule-1 decreased by 5% (P<0.05) with consumption of both 15 and 30 g of alcohol.
T12 1113-1226 Sentence denotes Fibrinogen concentrations decreased by 4% and 6% (P<0.05) after consumption of 15 and 30 g alcohol, respectively.
T13 1227-1305 Sentence denotes Fibrin D-dimer decreased by 24% (P<0.05) after consumption of 30 g of alcohol.
T14 1306-1442 Sentence denotes Plasminogen activator inhibitor-1 (PAI-1) concentrations were increased 27 and 54% (P<0.05) after consumption of 15 and 30 g of alcohol.
T15 1443-1575 Sentence denotes Plasma high-sensitivity C-reactive protein, interleukin-6 and factor VII coagulant activity did not change with alcohol consumption.
T16 1576-1588 Sentence denotes CONCLUSIONS:
T17 1589-1896 Sentence denotes These data suggest that moderate alcohol consumption may have beneficial effects on inflammation and hemostasis in postmenopausal women, and this may be somewhat mitigated by an increase in PAI-1.European Journal of Clinical Nutrition advance online publication, 11 November 2015; doi:10.1038/ejcn.2015.182.
T1 0-120 Sentence denotes The effect of moderate alcohol consumption on biomarkers of inflammation and hemostatic factors in postmenopausal women.
T2 121-143 Sentence denotes BACKGROUND/OBJECTIVES:
T3 144-225 Sentence denotes Inflammation and hemostasis contribute to the etiology of cardiovascular disease.
T4 226-386 Sentence denotes We previously demonstrated that moderate alcohol consumption (1-2 drinks/day) may decrease risk for cardiovascular disease because of an improved lipid profile.
T5 387-524 Sentence denotes In addition to these beneficial changes, the alcohol-mediated reduction in risk may be through its effect on inflammation and hemostasis.
T6 525-680 Sentence denotes The objective of the study was to evaluate the effect of moderate alcohol consumption on biomarkers of inflammation and hemostasis in postmenopausal women.
T7 681-698 Sentence denotes SUBJECTS/METHODS:
T8 699-880 Sentence denotes As part of a controlled diet study, 53 postmenopausal women each consumed a weight-maintaining diet plus 0, 15 and 30 g/day of alcohol for 8 weeks, in a randomized crossover design.
T9 881-987 Sentence denotes The controlled diet contained 15%, 53% and 32% of energy from protein, carbohydrate and fat, respectively.
T10 988-996 Sentence denotes RESULTS:
T11 997-1112 Sentence denotes Soluble intercellular adhesion molecule-1 decreased by 5% (P<0.05) with consumption of both 15 and 30 g of alcohol.
T12 1113-1226 Sentence denotes Fibrinogen concentrations decreased by 4% and 6% (P<0.05) after consumption of 15 and 30 g alcohol, respectively.
T13 1227-1305 Sentence denotes Fibrin D-dimer decreased by 24% (P<0.05) after consumption of 30 g of alcohol.
T14 1306-1442 Sentence denotes Plasminogen activator inhibitor-1 (PAI-1) concentrations were increased 27 and 54% (P<0.05) after consumption of 15 and 30 g of alcohol.
T15 1443-1575 Sentence denotes Plasma high-sensitivity C-reactive protein, interleukin-6 and factor VII coagulant activity did not change with alcohol consumption.
T16 1576-1588 Sentence denotes CONCLUSIONS:
T17 1589-1896 Sentence denotes These data suggest that moderate alcohol consumption may have beneficial effects on inflammation and hemostasis in postmenopausal women, and this may be somewhat mitigated by an increase in PAI-1.European Journal of Clinical Nutrition advance online publication, 11 November 2015; doi:10.1038/ejcn.2015.182.