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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
T2 112-249 Sentence denotes Pre-eclampsia (PE) is one of the most severe syndromes in human pregnancy, and the underlying mechanisms of PE have yet to be determined.
T3 250-434 Sentence denotes Pre-eclampsia is characterized by the alteration of the immune system's activation status, an increase in inflammatory Th1/Th17/APC cells, and a decrease in Th2/Treg subsets/cytokines.
T4 435-639 Sentence denotes Moreover, inflammatory infiltrates have been detected in the amniotic membranes of pre-eclamptic placentae, and to this date limited data are available regarding the role of amniotic membrane cells in PE.
T5 640-844 Sentence denotes Interestingly, we and others have previously shown that human amniotic mesenchymal stromal cells (hAMSC) possess anti-inflammatory properties towards almost all immune cells described to be altered in PE.
T6 845-943 Sentence denotes In this study we investigated whether the immunomodulatory properties of hAMSC were altered in PE.
T7 944-1174 Sentence denotes We performed a comprehensive study of cell phenotype and investigated the in vitro immunomodulatory properties of hAMSC isolated from pre-eclamptic pregnancies (PE-hAMSC), comparing them to hAMSC from normal pregnancies (N-hAMSC).
T8 1175-1366 Sentence denotes We demonstrate that PE-hAMSC inhibit CD4/CD8 T-cell proliferation, suppress Th1/Th2/Th17 polarization, induce Treg and block dendritic cells and M1 differentiation switching them to M2 cells.
T9 1367-1610 Sentence denotes Notably, PE-hAMSC generated a more prominent induction of Treg and higher suppression of interferon-γ when compared to N-hAMSC, and this was associated with higher transforming growth factor-β1 secretion and PD-L2/PD-L1 expression in PE-hAMSC.
T10 1611-1743 Sentence denotes In conclusion, for the first time we demonstrate that there is no intrinsic impairment of the immunomodulatory features of PE-hAMSC.
T11 1744-1938 Sentence denotes Our results suggest that amniotic mesenchymal stromal cells do not contribute to the disease, but conversely, could participate in offsetting the inflammatory environment which characterizes PE.
T1 0-111 Sentence denotes Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
T2 112-249 Sentence denotes Pre-eclampsia (PE) is one of the most severe syndromes in human pregnancy, and the underlying mechanisms of PE have yet to be determined.
T3 250-434 Sentence denotes Pre-eclampsia is characterized by the alteration of the immune system's activation status, an increase in inflammatory Th1/Th17/APC cells, and a decrease in Th2/Treg subsets/cytokines.
T4 435-639 Sentence denotes Moreover, inflammatory infiltrates have been detected in the amniotic membranes of pre-eclamptic placentae, and to this date limited data are available regarding the role of amniotic membrane cells in PE.
T5 640-844 Sentence denotes Interestingly, we and others have previously shown that human amniotic mesenchymal stromal cells (hAMSC) possess anti-inflammatory properties towards almost all immune cells described to be altered in PE.
T6 845-943 Sentence denotes In this study we investigated whether the immunomodulatory properties of hAMSC were altered in PE.
T7 944-1174 Sentence denotes We performed a comprehensive study of cell phenotype and investigated the in vitro immunomodulatory properties of hAMSC isolated from pre-eclamptic pregnancies (PE-hAMSC), comparing them to hAMSC from normal pregnancies (N-hAMSC).
T8 1175-1366 Sentence denotes We demonstrate that PE-hAMSC inhibit CD4/CD8 T-cell proliferation, suppress Th1/Th2/Th17 polarization, induce Treg and block dendritic cells and M1 differentiation switching them to M2 cells.
T9 1367-1610 Sentence denotes Notably, PE-hAMSC generated a more prominent induction of Treg and higher suppression of interferon-γ when compared to N-hAMSC, and this was associated with higher transforming growth factor-β1 secretion and PD-L2/PD-L1 expression in PE-hAMSC.
T10 1611-1743 Sentence denotes In conclusion, for the first time we demonstrate that there is no intrinsic impairment of the immunomodulatory features of PE-hAMSC.
T11 1744-1938 Sentence denotes Our results suggest that amniotic mesenchymal stromal cells do not contribute to the disease, but conversely, could participate in offsetting the inflammatory environment which characterizes PE.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
TextSentencer_T2 112-249 Sentence denotes Pre-eclampsia (PE) is one of the most severe syndromes in human pregnancy, and the underlying mechanisms of PE have yet to be determined.
TextSentencer_T3 250-434 Sentence denotes Pre-eclampsia is characterized by the alteration of the immune system's activation status, an increase in inflammatory Th1/Th17/APC cells, and a decrease in Th2/Treg subsets/cytokines.
TextSentencer_T4 435-639 Sentence denotes Moreover, inflammatory infiltrates have been detected in the amniotic membranes of pre-eclamptic placentae, and to this date limited data are available regarding the role of amniotic membrane cells in PE.
TextSentencer_T5 640-844 Sentence denotes Interestingly, we and others have previously shown that human amniotic mesenchymal stromal cells (hAMSC) possess anti-inflammatory properties towards almost all immune cells described to be altered in PE.
TextSentencer_T6 845-943 Sentence denotes In this study we investigated whether the immunomodulatory properties of hAMSC were altered in PE.
TextSentencer_T7 944-1174 Sentence denotes We performed a comprehensive study of cell phenotype and investigated the in vitro immunomodulatory properties of hAMSC isolated from pre-eclamptic pregnancies (PE-hAMSC), comparing them to hAMSC from normal pregnancies (N-hAMSC).
TextSentencer_T8 1175-1366 Sentence denotes We demonstrate that PE-hAMSC inhibit CD4/CD8 T-cell proliferation, suppress Th1/Th2/Th17 polarization, induce Treg and block dendritic cells and M1 differentiation switching them to M2 cells.
TextSentencer_T9 1367-1610 Sentence denotes Notably, PE-hAMSC generated a more prominent induction of Treg and higher suppression of interferon-γ when compared to N-hAMSC, and this was associated with higher transforming growth factor-β1 secretion and PD-L2/PD-L1 expression in PE-hAMSC.
TextSentencer_T10 1611-1743 Sentence denotes In conclusion, for the first time we demonstrate that there is no intrinsic impairment of the immunomodulatory features of PE-hAMSC.
TextSentencer_T11 1744-1938 Sentence denotes Our results suggest that amniotic mesenchymal stromal cells do not contribute to the disease, but conversely, could participate in offsetting the inflammatory environment which characterizes PE.
T1 0-111 Sentence denotes Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
T2 112-249 Sentence denotes Pre-eclampsia (PE) is one of the most severe syndromes in human pregnancy, and the underlying mechanisms of PE have yet to be determined.
T3 250-434 Sentence denotes Pre-eclampsia is characterized by the alteration of the immune system's activation status, an increase in inflammatory Th1/Th17/APC cells, and a decrease in Th2/Treg subsets/cytokines.
T4 435-639 Sentence denotes Moreover, inflammatory infiltrates have been detected in the amniotic membranes of pre-eclamptic placentae, and to this date limited data are available regarding the role of amniotic membrane cells in PE.
T5 640-844 Sentence denotes Interestingly, we and others have previously shown that human amniotic mesenchymal stromal cells (hAMSC) possess anti-inflammatory properties towards almost all immune cells described to be altered in PE.
T6 845-943 Sentence denotes In this study we investigated whether the immunomodulatory properties of hAMSC were altered in PE.
T7 944-1174 Sentence denotes We performed a comprehensive study of cell phenotype and investigated the in vitro immunomodulatory properties of hAMSC isolated from pre-eclamptic pregnancies (PE-hAMSC), comparing them to hAMSC from normal pregnancies (N-hAMSC).
T8 1175-1366 Sentence denotes We demonstrate that PE-hAMSC inhibit CD4/CD8 T-cell proliferation, suppress Th1/Th2/Th17 polarization, induce Treg and block dendritic cells and M1 differentiation switching them to M2 cells.
T9 1367-1610 Sentence denotes Notably, PE-hAMSC generated a more prominent induction of Treg and higher suppression of interferon-γ when compared to N-hAMSC, and this was associated with higher transforming growth factor-β1 secretion and PD-L2/PD-L1 expression in PE-hAMSC.
T10 1611-1743 Sentence denotes In conclusion, for the first time we demonstrate that there is no intrinsic impairment of the immunomodulatory features of PE-hAMSC.
T11 1744-1938 Sentence denotes Our results suggest that amniotic mesenchymal stromal cells do not contribute to the disease, but conversely, could participate in offsetting the inflammatory environment which characterizes PE.

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 112-125 ORPHA:275555 denotes Pre-eclampsia
PD-Preeclampsia-B_T2 250-263 ORPHA:275555 denotes Pre-eclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 32-45 ORPHA:275555 denotes pre-eclamptic
PD-Preeclampsia-B_T2 112-125 ORPHA:275555 denotes Pre-eclampsia
PD-Preeclampsia-B_T3 250-263 ORPHA:275555 denotes Pre-eclampsia
PD-Preeclampsia-B_T4 518-531 ORPHA:275555 denotes pre-eclamptic
PD-Preeclampsia-B_T5 1078-1091 ORPHA:275555 denotes pre-eclamptic

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 9-20 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T2 711-722 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T3 1778-1789 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T4 46-55 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentae
PD-UBERON-AE-B_T5 532-541 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentae
PD-UBERON-AE-B_T6 306-321 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system's

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 46-55 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentae
PD-UBERON-AE-B_T2 532-541 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentae
PD-UBERON-AE-B_T3 9-20 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T4 711-722 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T5 1778-1789 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal
PD-UBERON-AE-B_T6 306-321 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system's