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PubMed:26510177 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-29 Sentence denotes Epigenetics and Preeclampsia:
TextSentencer_T2 30-121 Sentence denotes Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway.
TextSentencer_T3 122-222 Sentence denotes Preeclampsia is a potentially fatal pregnancy disorder affecting millions of women around the globe.
TextSentencer_T4 223-379 Sentence denotes Dysregulation in gene and protein expression within key biological pathways controlling angiogenesis has been implicated in the development of preeclampsia.
TextSentencer_T5 380-468 Sentence denotes Altered CpG methylation, a type of epimutation, may underlie this pathway dysregulation.
TextSentencer_T6 469-659 Sentence denotes In the present study, placental tissue from preeclamptic cases and normotensive controls was analyzed for genome-wide differential CpG methylation and concomitant changes in gene expression.
TextSentencer_T7 660-802 Sentence denotes A set of 123 genes, representing 19.9% of all genes with altered CpG methylation, was associated with functional changes in transcript levels.
TextSentencer_T8 803-1014 Sentence denotes Underscoring the complex relationships between CpG methylation and gene expression, here hypermethylation was never associated with gene silencing, nor was hypomethylation always associated with gene activation.
TextSentencer_T9 1015-1149 Sentence denotes Moreover, the genomic region of the CpG mark was important in predicting the relationship between CpG methylation and gene expression.
TextSentencer_T10 1150-1332 Sentence denotes The 123 genes were enriched for their involvement in the transforming growth factor beta (TGF-β) signaling pathway, a known regulator of placental trophoblast invasion and migration.
TextSentencer_T11 1333-1470 Sentence denotes This is the first study to identify CpG hypomethylation as an activator of TGF-β-associated gene expression in the preeclamptic placenta.
TextSentencer_T12 1471-1630 Sentence denotes The results suggest functional epimutations are associated with preeclampsia disease status and the identified genes may represent novel biomarkers of disease.
T1 0-29 Sentence denotes Epigenetics and Preeclampsia:
T2 30-121 Sentence denotes Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway.
T3 122-222 Sentence denotes Preeclampsia is a potentially fatal pregnancy disorder affecting millions of women around the globe.
T4 223-379 Sentence denotes Dysregulation in gene and protein expression within key biological pathways controlling angiogenesis has been implicated in the development of preeclampsia.
T5 380-468 Sentence denotes Altered CpG methylation, a type of epimutation, may underlie this pathway dysregulation.
T6 469-659 Sentence denotes In the present study, placental tissue from preeclamptic cases and normotensive controls was analyzed for genome-wide differential CpG methylation and concomitant changes in gene expression.
T7 660-802 Sentence denotes A set of 123 genes, representing 19.9% of all genes with altered CpG methylation, was associated with functional changes in transcript levels.
T8 803-1014 Sentence denotes Underscoring the complex relationships between CpG methylation and gene expression, here hypermethylation was never associated with gene silencing, nor was hypomethylation always associated with gene activation.
T9 1015-1149 Sentence denotes Moreover, the genomic region of the CpG mark was important in predicting the relationship between CpG methylation and gene expression.
T10 1150-1332 Sentence denotes The 123 genes were enriched for their involvement in the transforming growth factor beta (TGF-β) signaling pathway, a known regulator of placental trophoblast invasion and migration.
T11 1333-1470 Sentence denotes This is the first study to identify CpG hypomethylation as an activator of TGF-β-associated gene expression in the preeclamptic placenta.
T12 1471-1630 Sentence denotes The results suggest functional epimutations are associated with preeclampsia disease status and the identified genes may represent novel biomarkers of disease.

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 16-28 ORPHA:275555 denotes Preeclampsia
PD-Preeclampsia-B_T2 122-134 ORPHA:275555 denotes Preeclampsia
PD-Preeclampsia-B_T3 366-378 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1535-1547 ORPHA:275555 denotes preeclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 16-28 ORPHA:275555 denotes Preeclampsia
PD-Preeclampsia-B_T2 70-82 ORPHA:275555 denotes Preeclamptic
PD-Preeclampsia-B_T3 122-134 ORPHA:275555 denotes Preeclampsia
PD-Preeclampsia-B_T4 366-378 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 513-525 ORPHA:275555 denotes preeclamptic
PD-Preeclampsia-B_T6 1448-1469 ORPHA:275555 denotes preeclamptic placenta
PD-Preeclampsia-B_T7 1535-1547 ORPHA:275555 denotes preeclampsia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 83-91 http://purl.obolibrary.org/obo/UBERON_0001987 denotes Placenta
PD-UBERON-AE-B_T2 1461-1469 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placenta
PD-UBERON-AE-B_T3 501-507 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 1297-1308 http://purl.obolibrary.org/obo/UBERON_0000088 denotes trophoblast

preeclampsia_genes

Id Subject Object Predicate Lexical cue
PD-PreeclampsiaGenes-B_T3 1207-1238 HGNC:TGFB3 denotes transforming growth factor beta
PD-PreeclampsiaGenes-B_T1 1207-1238 HGNC:TGFB2 denotes transforming growth factor beta
PD-PreeclampsiaGenes-B_T2 1207-1238 HGNC:TGFB1 denotes transforming growth factor beta

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 501-507 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 83-91 http://purl.obolibrary.org/obo/UBERON_0001987 denotes Placenta
PD-UBERON-AE-B_T3 491-500 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placental
PD-UBERON-AE-B_T4 1287-1296 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placental
PD-UBERON-AE-B_T5 1461-1469 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placenta
PD-UBERON-AE-B_T6 1297-1308 http://purl.obolibrary.org/obo/UBERON_0000088 denotes trophoblast