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PubMed:26507663 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 33-56 Cell denotes Germinal Center B-cells http://purl.obolibrary.org/obo/CL:0000844
T2 130-136 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T3 413-423 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T4 479-493 Cell denotes memory B-cells http://purl.obolibrary.org/obo/CL:0000787
T5 579-589 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T6 892-905 Cell denotes naive B-cells http://purl.obolibrary.org/obo/CL:0000788
T7 951-961 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T8 1074-1081 Cell denotes B-cells http://purl.obolibrary.org/obo/CL:0000236
T9 1256-1266 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T10 1296-1310 Cell denotes memory B-cells http://purl.obolibrary.org/obo/CL:0000787
T11 1385-1395 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T12 1518-1528 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T13 1597-1607 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T14 1708-1722 Cell denotes memory B-cells http://purl.obolibrary.org/obo/CL:0000787

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 180-191 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 193-196 Glycan_Motif denotes Sia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 736-739 Glycan_Motif denotes Sia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 807-830 Glycan_Motif denotes N-acetylneuraminic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T6 832-838 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 847-858 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T8 1222-1233 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T9 1272-1278 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 1489-1495 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 180-191 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 807-830 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T3 807-830 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T4 832-838 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T5 847-858 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 1222-1233 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T7 1272-1278 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T8 1489-1495 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac

sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.
T2 108-221 Sentence denotes CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands.
T3 222-336 Sentence denotes Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence.
T4 337-534 Sentence denotes Here, we show in both mice and humans that loss of high affinity ligands on GC B-cells unmasks the binding site of CD22 relative to naive and memory B-cells, promoting recognition of trans ligands.
T5 535-668 Sentence denotes The conserved modulation of CD22 ligands on GC B-cells is striking because high affinity glycan ligands of CD22 are species-specific.
T6 669-785 Sentence denotes In both species, the high affinity ligand is based on the sequence Siaα2-6Galβ1-4GlcNAc, which terminates N-glycans.
T7 786-941 Sentence denotes The human ligand has N-acetylneuraminic acid (Neu5Ac) as the sialic acid, and the high affinity ligand on naive B-cells contains 6-O-sulfate on the GlcNAc.
T8 942-1041 Sentence denotes On human GC B-cells, this sulfate modification is lost, giving rise to lower affinity CD22 ligands.
T9 1042-1126 Sentence denotes Ligands of CD22 on naive murine B-cells do not contain the 6-O-sulfate modification.
T10 1127-1279 Sentence denotes Instead, the high affinity ligand for mouse CD22 has N-glycolylneuraminic acid (Neu5Gc) as the sialic acid, which is replaced on GC B-cells with Neu5Ac.
T11 1280-1396 Sentence denotes Human naive and memory B-cells express sulfated glycans as high affinity CD22 ligands, which are lost on GC B-cells.
T12 1397-1529 Sentence denotes In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.
T13 1530-1723 Sentence denotes Our results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells.

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 934-940 chem:24139 denotes GlcNAc

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 832-838 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1272-1278 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 1489-1495 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 93-98 OrganismTaxon denotes Mouse 10088|10090
T3 359-363 OrganismTaxon denotes mice 10088
T4 790-795 OrganismTaxon denotes human 9606
T5 945-950 OrganismTaxon denotes human 9606
T6 1165-1170 OrganismTaxon denotes mouse 10088|10090
T8 1280-1285 OrganismTaxon denotes Human 9606
T9 1400-1404 OrganismTaxon denotes mice 10088
T10 1623-1627 OrganismTaxon denotes mice 10088

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 33-56 Cell denotes Germinal Center B-cells http://purl.obolibrary.org/obo/CL:0000844
T2 130-136 Cell denotes B-cell http://purl.obolibrary.org/obo/CL:0000236
T3 413-423 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T4 479-493 Cell denotes memory B-cells http://purl.obolibrary.org/obo/CL:0000787
T5 579-589 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T6 892-905 Cell denotes naive B-cells http://purl.obolibrary.org/obo/CL:0000788
T7 951-961 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T8 1074-1081 Cell denotes B-cells http://purl.obolibrary.org/obo/CL:0000236
T9 1256-1266 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T10 1296-1310 Cell denotes memory B-cells http://purl.obolibrary.org/obo/CL:0000787
T11 1385-1395 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T12 1518-1528 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T13 1597-1607 Cell denotes GC B-cells http://purl.obolibrary.org/obo/CL:0000844
T14 1708-1722 Cell denotes memory B-cells http://purl.obolibrary.org/obo/CL:0000787

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 33-56 Body_part denotes Germinal Center B-cells http://purl.obolibrary.org/obo/CL_0000844
T2 130-136 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T3 247-262 Body_part denotes germinal center http://purl.obolibrary.org/obo/UBERON_0009039|http://purl.obolibrary.org/obo/UBERON_0010754
T5 264-266 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T6 413-423 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T7 413-415 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T8 479-493 Body_part denotes memory B-cells http://purl.obolibrary.org/obo/CL_0000787
T9 579-589 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T10 579-581 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T11 892-905 Body_part denotes naive B-cells http://purl.obolibrary.org/obo/CL_0000788
T12 951-961 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T13 951-953 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T14 1256-1266 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T15 1256-1258 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T16 1296-1310 Body_part denotes memory B-cells http://purl.obolibrary.org/obo/CL_0000787
T17 1385-1395 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T18 1385-1387 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T19 1518-1528 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T20 1518-1520 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T21 1597-1607 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T22 1597-1599 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T23 1708-1722 Body_part denotes memory B-cells http://purl.obolibrary.org/obo/CL_0000787

sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.
T2 108-221 Sentence denotes CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands.
T3 222-336 Sentence denotes Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence.
T4 337-534 Sentence denotes Here, we show in both mice and humans that loss of high affinity ligands on GC B-cells unmasks the binding site of CD22 relative to naive and memory B-cells, promoting recognition of trans ligands.
T5 535-668 Sentence denotes The conserved modulation of CD22 ligands on GC B-cells is striking because high affinity glycan ligands of CD22 are species-specific.
T6 669-785 Sentence denotes In both species, the high affinity ligand is based on the sequence Siaα2-6Galβ1-4GlcNAc, which terminates N-glycans.
T7 786-941 Sentence denotes The human ligand has N-acetylneuraminic acid (Neu5Ac) as the sialic acid, and the high affinity ligand on naive B-cells contains 6-O-sulfate on the GlcNAc.
T8 942-1041 Sentence denotes On human GC B-cells, this sulfate modification is lost, giving rise to lower affinity CD22 ligands.
T9 1042-1126 Sentence denotes Ligands of CD22 on naive murine B-cells do not contain the 6-O-sulfate modification.
T10 1127-1279 Sentence denotes Instead, the high affinity ligand for mouse CD22 has N-glycolylneuraminic acid (Neu5Gc) as the sialic acid, which is replaced on GC B-cells with Neu5Ac.
T11 1280-1396 Sentence denotes Human naive and memory B-cells express sulfated glycans as high affinity CD22 ligands, which are lost on GC B-cells.
T12 1397-1529 Sentence denotes In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.
T13 1530-1723 Sentence denotes Our results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.
T2 108-221 Sentence denotes CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands.
T3 222-336 Sentence denotes Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence.
T4 337-534 Sentence denotes Here, we show in both mice and humans that loss of high affinity ligands on GC B-cells unmasks the binding site of CD22 relative to naive and memory B-cells, promoting recognition of trans ligands.
T5 535-668 Sentence denotes The conserved modulation of CD22 ligands on GC B-cells is striking because high affinity glycan ligands of CD22 are species-specific.
T6 669-785 Sentence denotes In both species, the high affinity ligand is based on the sequence Siaα2-6Galβ1-4GlcNAc, which terminates N-glycans.
T7 786-941 Sentence denotes The human ligand has N-acetylneuraminic acid (Neu5Ac) as the sialic acid, and the high affinity ligand on naive B-cells contains 6-O-sulfate on the GlcNAc.
T8 942-1041 Sentence denotes On human GC B-cells, this sulfate modification is lost, giving rise to lower affinity CD22 ligands.
T9 1042-1126 Sentence denotes Ligands of CD22 on naive murine B-cells do not contain the 6-O-sulfate modification.
T10 1127-1279 Sentence denotes Instead, the high affinity ligand for mouse CD22 has N-glycolylneuraminic acid (Neu5Gc) as the sialic acid, which is replaced on GC B-cells with Neu5Ac.
T11 1280-1396 Sentence denotes Human naive and memory B-cells express sulfated glycans as high affinity CD22 ligands, which are lost on GC B-cells.
T12 1397-1529 Sentence denotes In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.
T13 1530-1723 Sentence denotes Our results demonstrate that loss of high affinity CD22 ligands on GC B-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 832-838 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 1272-1278 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 1489-1495 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 93-98 OrganismTaxon denotes Mouse 10088|10090
T3 359-363 OrganismTaxon denotes mice 10088
T4 790-795 OrganismTaxon denotes human 9606
T5 945-950 OrganismTaxon denotes human 9606
T6 1165-1170 OrganismTaxon denotes mouse 10088|10090
T8 1280-1285 OrganismTaxon denotes Human 9606
T9 1400-1404 OrganismTaxon denotes mice 10088
T10 1623-1627 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 33-56 Body_part denotes Germinal Center B-cells http://purl.obolibrary.org/obo/CL_0000844
T2 130-136 Body_part denotes B-cell http://purl.obolibrary.org/obo/CL_0000236
T3 247-262 Body_part denotes germinal center http://purl.obolibrary.org/obo/UBERON_0009039|http://purl.obolibrary.org/obo/UBERON_0010754
T5 264-266 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T6 413-423 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T7 413-415 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T8 479-493 Body_part denotes memory B-cells http://purl.obolibrary.org/obo/CL_0000787
T9 579-589 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T10 579-581 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T11 892-905 Body_part denotes naive B-cells http://purl.obolibrary.org/obo/CL_0000788
T12 951-961 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T13 951-953 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T14 1256-1266 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T15 1256-1258 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T16 1296-1310 Body_part denotes memory B-cells http://purl.obolibrary.org/obo/CL_0000787
T17 1385-1395 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T18 1385-1387 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T19 1518-1528 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T20 1518-1520 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T21 1597-1607 Body_part denotes GC B-cells http://purl.obolibrary.org/obo/CL_0000844
T22 1597-1599 Body_part denotes GC http://purl.obolibrary.org/obo/UBERON_0009039
T23 1708-1722 Body_part denotes memory B-cells http://purl.obolibrary.org/obo/CL_0000787