| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-62 |
Sentence |
denotes |
Association Between Preeclampsia and Congenital Heart Defects. |
| TextSentencer_T2 |
63-74 |
Sentence |
denotes |
IMPORTANCE: |
| TextSentencer_T3 |
75-246 |
Sentence |
denotes |
The risk of congenital heart defects in infants of women who had preeclampsia during pregnancy is poorly understood, despite shared angiogenic pathways in both conditions. |
| TextSentencer_T4 |
247-257 |
Sentence |
denotes |
OBJECTIVE: |
| TextSentencer_T5 |
258-354 |
Sentence |
denotes |
To determine the prevalence of congenital heart defects in offspring of women with preeclampsia. |
| TextSentencer_T6 |
355-389 |
Sentence |
denotes |
DESIGN, SETTING, AND PARTICIPANTS: |
| TextSentencer_T7 |
390-553 |
Sentence |
denotes |
Population-level analysis of live births before discharge, 1989-2012, was conducted for the entire province of Quebec, comprising a quarter of Canada's population. |
| TextSentencer_T8 |
554-680 |
Sentence |
denotes |
All women who delivered an infant with or without heart defects in any Quebec hospital were included (N = 1,942,072 neonates). |
| TextSentencer_T9 |
681-691 |
Sentence |
denotes |
EXPOSURES: |
| TextSentencer_T10 |
692-767 |
Sentence |
denotes |
Preeclampsia or eclampsia with onset before or after 34 weeks of gestation. |
| TextSentencer_T11 |
768-795 |
Sentence |
denotes |
MAIN OUTCOMES AND MEASURES: |
| TextSentencer_T12 |
796-960 |
Sentence |
denotes |
Presence of any critical or noncritical congenital heart defect detected in infants at birth, comparing prevalence in those exposed and not exposed to preeclampsia. |
| TextSentencer_T13 |
961-969 |
Sentence |
denotes |
RESULTS: |
| TextSentencer_T14 |
970-1094 |
Sentence |
denotes |
The absolute prevalence of congenital heart defects was higher for infants of women with preeclampsia than those without it. |
| TextSentencer_T15 |
1095-1316 |
Sentence |
denotes |
Infants of women with preeclampsia had no increased prevalence of critical heart defects but did have an increased prevalence of noncritical heart defects compared with infants of nonpreeclamptic women. [table: see text]. |
| TextSentencer_T16 |
1317-1384 |
Sentence |
denotes |
Among specific defects, prevalence was greatest for septal defects. |
| TextSentencer_T17 |
1385-1817 |
Sentence |
denotes |
Compared with infants of women with late-onset preeclampsia, those with early onset (<34 weeks) had greater prevalence of critical heart defects (364.4/100,000 [20/5488]; prevalence ratio, 2.78; 95% CI, 1.71-4.50; prevalence difference, 249.6/100,000; 95%CI, 89.7-409.6) and noncritical heart defects (7306.9/100,000 [401/5488]; prevalence ratio, 5.55; 95%CI, 4.98-6.19; prevalence difference, 6089.2/100,000; 95%CI, 5350.0-6828.3). |
| TextSentencer_T18 |
1818-1844 |
Sentence |
denotes |
CONCLUSIONS AND RELEVANCE: |
| TextSentencer_T19 |
1845-2040 |
Sentence |
denotes |
In this population-based study, preeclampsia was significantly associated with noncritical heart defects in offspring, and preeclampsia before 34 weeks was associated with critical heart defects. |
| TextSentencer_T20 |
2041-2104 |
Sentence |
denotes |
However, the absolute risk of congenital heart defects was low. |
| T1 |
0-62 |
Sentence |
denotes |
Association Between Preeclampsia and Congenital Heart Defects. |
| T2 |
63-74 |
Sentence |
denotes |
IMPORTANCE: |
| T3 |
75-246 |
Sentence |
denotes |
The risk of congenital heart defects in infants of women who had preeclampsia during pregnancy is poorly understood, despite shared angiogenic pathways in both conditions. |
| T4 |
247-257 |
Sentence |
denotes |
OBJECTIVE: |
| T5 |
258-354 |
Sentence |
denotes |
To determine the prevalence of congenital heart defects in offspring of women with preeclampsia. |
| T6 |
355-389 |
Sentence |
denotes |
DESIGN, SETTING, AND PARTICIPANTS: |
| T7 |
390-553 |
Sentence |
denotes |
Population-level analysis of live births before discharge, 1989-2012, was conducted for the entire province of Quebec, comprising a quarter of Canada's population. |
| T8 |
554-680 |
Sentence |
denotes |
All women who delivered an infant with or without heart defects in any Quebec hospital were included (N = 1,942,072 neonates). |
| T9 |
681-691 |
Sentence |
denotes |
EXPOSURES: |
| T10 |
692-767 |
Sentence |
denotes |
Preeclampsia or eclampsia with onset before or after 34 weeks of gestation. |
| T11 |
768-795 |
Sentence |
denotes |
MAIN OUTCOMES AND MEASURES: |
| T12 |
796-960 |
Sentence |
denotes |
Presence of any critical or noncritical congenital heart defect detected in infants at birth, comparing prevalence in those exposed and not exposed to preeclampsia. |
| T13 |
961-969 |
Sentence |
denotes |
RESULTS: |
| T14 |
970-1094 |
Sentence |
denotes |
The absolute prevalence of congenital heart defects was higher for infants of women with preeclampsia than those without it. |
| T15 |
1095-1316 |
Sentence |
denotes |
Infants of women with preeclampsia had no increased prevalence of critical heart defects but did have an increased prevalence of noncritical heart defects compared with infants of nonpreeclamptic women. [table: see text]. |
| T16 |
1317-1384 |
Sentence |
denotes |
Among specific defects, prevalence was greatest for septal defects. |
| T17 |
1385-1817 |
Sentence |
denotes |
Compared with infants of women with late-onset preeclampsia, those with early onset (<34 weeks) had greater prevalence of critical heart defects (364.4/100,000 [20/5488]; prevalence ratio, 2.78; 95% CI, 1.71-4.50; prevalence difference, 249.6/100,000; 95%CI, 89.7-409.6) and noncritical heart defects (7306.9/100,000 [401/5488]; prevalence ratio, 5.55; 95%CI, 4.98-6.19; prevalence difference, 6089.2/100,000; 95%CI, 5350.0-6828.3). |
| T18 |
1818-1844 |
Sentence |
denotes |
CONCLUSIONS AND RELEVANCE: |
| T19 |
1845-2040 |
Sentence |
denotes |
In this population-based study, preeclampsia was significantly associated with noncritical heart defects in offspring, and preeclampsia before 34 weeks was associated with critical heart defects. |
| T20 |
2041-2104 |
Sentence |
denotes |
However, the absolute risk of congenital heart defects was low. |
