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sonoma2

Id Subject Object Predicate Lexical cue
T0 19-28 GENE denotes ephrin-B2
T1 47-55 POSREG denotes promotes
T2 56-71 CPA denotes chemoresistance
T3 76-82 POSREG denotes drives
T4 83-86 CPA denotes EMT
T5 90-110 DISEASE denotes colorectal carcinoma
T6 121-127 VAR denotes mutant
T7 128-131 GENE denotes p53
T8 133-141 VAR denotes Mutation
T9 149-153 GENE denotes TP53
T10 170-180 REG denotes correlates
T11 238-245 DISEASE denotes cancers
T12 295-310 CPA denotes chemoresistance
T13 315-351 CPA denotes epithelial-to-mesenchymal transition
T14 353-356 CPA denotes EMT
T15 361-371 DISEASE denotes colorectal
T16 361-378 DISEASE denotes colorectal cancer
T17 393-409 POSREG denotes gain-of-function
T18 411-414 POSREG denotes GOF
T19 416-422 VAR denotes mutant
T20 423-436 GENE denotes p53/ephrin-B2
T21 540-545 GENE denotes EFNB2
T22 560-563 POSREG denotes GOF
T23 571-574 GENE denotes p53
T24 588-599 REG denotes responsible
T25 638-644 VAR denotes mutant
T26 645-653 GENE denotes p53-NF-Y
T27 680-691 POSREG denotes upregulates
T28 692-697 GENE denotes EFNB2
T29 698-708 MPA denotes expression
T30 769-775 VAR denotes mutant
T31 776-787 GENE denotes p53 protein
T32 776-779 GENE denotes p53
T33 808-813 GENE denotes EFNB2
T34 827-837 POSREG denotes positively
T35 852-862 MPA denotes expression
T36 895-899 GENE denotes p300
T37 957-962 GENE denotes EFNB2
T38 963-972 VAR denotes silencing
T39 973-981 POSREG denotes restores
T40 982-998 CPA denotes chemosensitivity
T41 1002-1008 VAR denotes mutant
T42 1009-1022 GENE denotes p53-harboring
T43 1023-1029 DISEASE denotes tumors
T44 1061-1071 MPA denotes expression
T45 1075-1080 GENE denotes EFNB2
T46 1126-1146 DISEASE denotes colorectal carcinoma
T47 1286-1295 GENE denotes ephrin-B2
T48 1314-1321 POSREG denotes induces
T49 1322-1327 GENE denotes ABCG2
T50 1328-1338 MPA denotes expression
T51 1397-1403 VAR denotes mutant
T52 1404-1407 GENE denotes p53
T53 1448-1457 GENE denotes ephrin-B2
T54 1476-1484 POSREG denotes promotes
T55 1485-1498 CPA denotes tumorigenesis
T56 1511-1526 PATHWAY denotes Src-ERK pathway
T57 1511-1518 GENE denotes Src-ERK
T58 1532-1538 POSREG denotes drives
T59 1539-1542 CPA denotes EMT
T60 1551-1558 GENE denotes Src-FAK
T61 1600-1609 GENE denotes ephrin-B2
T62 1616-1623 POSREG denotes enhance
T63 1628-1639 CPA denotes therapeutic
T64 1693-1699 VAR denotes mutant
T65 1700-1711 GENE denotes p53-bearing
T66 1718-1724 DISEASE denotes tumors
R0 T2 T1 ThemeOf chemoresistance,promotes
R1 T4 T3 ThemeOf EMT,drives
R2 T5 T1 ThemeOf colorectal carcinoma,promotes
R3 T5 T3 ThemeOf colorectal carcinoma,drives
R4 T5 T4 ThemeOf colorectal carcinoma,EMT
R5 T6 T1 CauseOf mutant,promotes
R6 T6 T3 CauseOf mutant,drives
R7 T7 T6 ThemeOf p53,mutant
R8 T8 T10 CauseOf Mutation,correlates
R9 T9 T8 ThemeOf TP53,Mutation
R10 T14 T12 ThemeOf EMT,chemoresistance
R11 T12 T17 ThemeOf chemoresistance,gain-of-function
R12 T12 T18 ThemeOf chemoresistance,GOF
R13 T14 T13 ThemeOf EMT,epithelial-to-mesenchymal transition
R14 T13 T17 ThemeOf epithelial-to-mesenchymal transition,gain-of-function
R15 T14 T17 ThemeOf EMT,gain-of-function
R16 T14 T18 ThemeOf EMT,GOF
R17 T15 T12 ThemeOf colorectal,chemoresistance
R18 T15 T13 ThemeOf colorectal,epithelial-to-mesenchymal transition
R19 T15 T14 ThemeOf colorectal,EMT
R20 T15 T17 ThemeOf colorectal,gain-of-function
R21 T15 T18 ThemeOf colorectal,GOF
R22 T18 T17 CauseOf GOF,gain-of-function
R23 T19 T17 CauseOf mutant,gain-of-function
R24 T19 T18 CauseOf mutant,GOF
R25 T20 T19 ThemeOf p53/ephrin-B2,mutant
R26 T22 T24 CauseOf GOF,responsible
R27 T25 T27 CauseOf mutant,upregulates
R28 T26 T25 ThemeOf p53-NF-Y,mutant
R29 T29 T27 ThemeOf expression,upregulates
R30 T28 T27 ThemeOf EFNB2,upregulates
R31 T28 T29 ThemeOf EFNB2,expression
R32 T31 T30 ThemeOf p53 protein,mutant
R33 T31 T34 ThemeOf p53 protein,positively
R34 T33 T30 ThemeOf EFNB2,mutant
R35 T35 T34 ThemeOf expression,positively
R36 T36 T35 ThemeOf p300,expression
R37 T37 T38 ThemeOf EFNB2,silencing
R38 T38 T39 CauseOf silencing,restores
R39 T40 T39 ThemeOf chemosensitivity,restores
R40 T41 T39 CauseOf mutant,restores
R41 T45 T44 ThemeOf EFNB2,expression
R42 T46 T44 ThemeOf colorectal carcinoma,expression
R43 T49 T48 ThemeOf ABCG2,induces
R44 T49 T50 ThemeOf ABCG2,expression
R45 T50 T48 ThemeOf expression,induces
R46 T51 T48 CauseOf mutant,induces
R47 T52 T51 ThemeOf p53,mutant
R48 T55 T54 ThemeOf tumorigenesis,promotes
R49 T55 T58 ThemeOf tumorigenesis,drives
R50 T56 T54 ThemeOf Src-ERK pathway,promotes
R51 T59 T58 ThemeOf EMT,drives
R52 T63 T62 ThemeOf therapeutic,enhance
R53 T64 T62 CauseOf mutant,enhance

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53.
T2 133-246 Sentence denotes Mutation in the TP53 gene positively correlates with increased incidence of chemoresistance in different cancers.
T3 247-452 Sentence denotes In this study, we investigated the mechanism of chemoresistance and epithelial-to-mesenchymal transition (EMT) in colorectal cancer involving the gain-of-function (GOF) mutant p53/ephrin-B2 signaling axis.
T4 453-620 Sentence denotes Bioinformatic analysis of the NCI-60 data set and subsequent hub prediction identified EFNB2 as a possible GOF mutant p53 target gene, responsible for chemoresistance.
T5 621-735 Sentence denotes We show that the mutant p53-NF-Y complex transcriptionally upregulates EFNB2 expression in response to DNA damage.
T6 736-900 Sentence denotes Moreover, the acetylated form of mutant p53 protein is recruited on the EFNB2 promoter and positively regulates its expression in conjunction with coactivator p300.
T7 901-1030 Sentence denotes In vitro cell line and in vivo nude mice data show that EFNB2 silencing restores chemosensitivity in mutant p53-harboring tumors.
T8 1031-1207 Sentence denotes In addition, we observed high expression of EFNB2 in patients having neoadjuvant non-responder colorectal carcinoma compared with those having responder version of the disease.
T9 1208-1414 Sentence denotes In the course of deciphering the drug resistance mechanism, we also show that ephrin-B2 reverse signaling induces ABCG2 expression after drug treatment that involves JNK-c-Jun signaling in mutant p53 cells.
T10 1415-1567 Sentence denotes Moreover, 5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src-ERK pathway, and drives EMT via the Src-FAK pathway.
T11 1568-1826 Sentence denotes We thus conclude that targeting ephrin-B2 might enhance the therapeutic potential of DNA-damaging chemotherapeutic agents in mutant p53-bearing human tumors.Cell Death and Differentiation advance online publication, 23 October 2015; doi:10.1038/cdd.2015.133.
T1 0-132 Sentence denotes DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53.
T2 133-246 Sentence denotes Mutation in the TP53 gene positively correlates with increased incidence of chemoresistance in different cancers.
T3 247-452 Sentence denotes In this study, we investigated the mechanism of chemoresistance and epithelial-to-mesenchymal transition (EMT) in colorectal cancer involving the gain-of-function (GOF) mutant p53/ephrin-B2 signaling axis.
T4 453-620 Sentence denotes Bioinformatic analysis of the NCI-60 data set and subsequent hub prediction identified EFNB2 as a possible GOF mutant p53 target gene, responsible for chemoresistance.
T5 621-735 Sentence denotes We show that the mutant p53-NF-Y complex transcriptionally upregulates EFNB2 expression in response to DNA damage.
T6 736-900 Sentence denotes Moreover, the acetylated form of mutant p53 protein is recruited on the EFNB2 promoter and positively regulates its expression in conjunction with coactivator p300.
T7 901-1030 Sentence denotes In vitro cell line and in vivo nude mice data show that EFNB2 silencing restores chemosensitivity in mutant p53-harboring tumors.
T8 1031-1207 Sentence denotes In addition, we observed high expression of EFNB2 in patients having neoadjuvant non-responder colorectal carcinoma compared with those having responder version of the disease.
T9 1208-1414 Sentence denotes In the course of deciphering the drug resistance mechanism, we also show that ephrin-B2 reverse signaling induces ABCG2 expression after drug treatment that involves JNK-c-Jun signaling in mutant p53 cells.
T10 1415-1567 Sentence denotes Moreover, 5-fluorouracil-induced ephrin-B2 reverse signaling promotes tumorigenesis through the Src-ERK pathway, and drives EMT via the Src-FAK pathway.
T11 1568-1826 Sentence denotes We thus conclude that targeting ephrin-B2 might enhance the therapeutic potential of DNA-damaging chemotherapeutic agents in mutant p53-bearing human tumors.Cell Death and Differentiation advance online publication, 23 October 2015; doi:10.1038/cdd.2015.133.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26494468-0#19#28#gene1948 19-28 gene1948 denotes ephrin-B2
26494468-0#128#131#gene7157 128-131 gene7157 denotes p53
26494468-0#90#110#diseaseC0009402 90-110 diseaseC0009402 denotes colorectal carcinoma
26494468-9#100#103#gene2048 1515-1518 gene2048 denotes ERK
26494468-9#100#103#gene5594 1515-1518 gene5594 denotes ERK
26494468-9#33#42#gene1948 1448-1457 gene1948 denotes ephrin-B2
26494468-9#70#83#diseaseC0596263 1485-1498 diseaseC0596263 denotes tumorigenesis
26494468-9#70#83#diseaseC0596263 1485-1498 diseaseC0596263 denotes tumorigenesis
19#28#gene194890#110#diseaseC0009402 26494468-0#19#28#gene1948 26494468-0#90#110#diseaseC0009402 associated_with ephrin-B2,colorectal carcinoma
128#131#gene715790#110#diseaseC0009402 26494468-0#128#131#gene7157 26494468-0#90#110#diseaseC0009402 associated_with p53,colorectal carcinoma
100#103#gene204870#83#diseaseC0596263 26494468-9#100#103#gene2048 26494468-9#70#83#diseaseC0596263 associated_with ERK,tumorigenesis
100#103#gene204870#83#diseaseC0596263 26494468-9#100#103#gene2048 26494468-9#70#83#diseaseC0596263 associated_with ERK,tumorigenesis
100#103#gene559470#83#diseaseC0596263 26494468-9#100#103#gene5594 26494468-9#70#83#diseaseC0596263 associated_with ERK,tumorigenesis
100#103#gene559470#83#diseaseC0596263 26494468-9#100#103#gene5594 26494468-9#70#83#diseaseC0596263 associated_with ERK,tumorigenesis
33#42#gene194870#83#diseaseC0596263 26494468-9#33#42#gene1948 26494468-9#70#83#diseaseC0596263 associated_with ephrin-B2,tumorigenesis
33#42#gene194870#83#diseaseC0596263 26494468-9#33#42#gene1948 26494468-9#70#83#diseaseC0596263 associated_with ephrin-B2,tumorigenesis

kaiyin_test

Id Subject Object Predicate Lexical cue
T1 638-644 Var denotes mutant
T2 645-648 Gene denotes p53
T3 680-691 PosReg denotes upregulates
T4 692-697 Gene denotes EFNB2
T5 698-708 MPA denotes expression
T6 712-734 MPA denotes response to DNA damage
T7 769-775 Var denotes mutant
T8 776-779 Gene denotes p53
T9 780-787 Protein denotes protein
T10 791-800 PosReg denotes recruited
T11 838-847 Reg denotes regulates
T12 852-862 MPA denotes expression
T13 1314-1321 PosReg denotes induces
T14 1322-1327 Gene denotes ABCG2
T15 1328-1338 MPA denotes expression
T16 1374-1393 MPA denotes JNK-c-Jun signaling
T17 1397-1403 Var denotes mutant
T18 1404-1407 Gene denotes p53
R1 T2 T1 ThemeOf p53,mutant
R10 T12 T11 ThemeOf expression,regulates
R11 T14 T15 ThemeOf ABCG2,expression
R13 T16 T13 ThemeOf JNK-c-Jun signaling,induces
R14 T15 T13 ThemeOf expression,induces
R15 T18 T17 ThemeOf p53,mutant
R16 T17 T13 CauseOf mutant,induces
R2 T1 T3 CauseOf mutant,upregulates
R3 T4 T5 ThemeOf EFNB2,expression
R4 T5 T3 ThemeOf expression,upregulates
R5 T6 T3 ThemeOf response to DNA damage,upregulates
R6 T7 T10 CauseOf mutant,recruited
R7 T8 T9 ThemeOf p53,protein
R8 T9 T7 ThemeOf protein,mutant
R9 T7 T11 CauseOf mutant,regulates

name_no

Id Subject Object Predicate Lexical cue
T1 638-644 Var denotes mutant
T2 645-648 Gene denotes p53
T3 680-691 PosReg denotes upregulates
T4 692-697 Gene denotes EFNB2
T5 698-708 MPA denotes expression
T6 712-734 MPA denotes response to DNA damage
T7 769-775 Var denotes mutant
T8 776-779 Gene denotes p53
T9 780-787 Protein denotes protein
T10 791-800 PosReg denotes recruited
T11 838-847 Reg denotes regulates
T12 852-862 MPA denotes expression
T13 1314-1321 PosReg denotes induces
T14 1322-1327 Gene denotes ABCG2
T15 1328-1338 MPA denotes expression
T16 1374-1393 MPA denotes JNK-c-Jun signaling
T17 1397-1403 Var denotes mutant
T18 1404-1407 Gene denotes p53
R1 T2 T1 ThemeOf p53,mutant
R10 T12 T11 ThemeOf expression,regulates
R11 T14 T15 ThemeOf ABCG2,expression
R13 T16 T13 ThemeOf JNK-c-Jun signaling,induces
R14 T15 T13 ThemeOf expression,induces
R15 T18 T17 ThemeOf p53,mutant
R16 T17 T13 CauseOf mutant,induces
R2 T1 T3 CauseOf mutant,upregulates
R3 T4 T5 ThemeOf EFNB2,expression
R4 T5 T3 ThemeOf expression,upregulates
R5 T6 T3 ThemeOf response to DNA damage,upregulates
R6 T7 T10 CauseOf mutant,recruited
R7 T8 T9 ThemeOf p53,protein
R8 T9 T7 ThemeOf protein,mutant
R9 T7 T11 CauseOf mutant,regulates