PubMed:26490087 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":95,"end":407},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":408,"end":514},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":515,"end":549},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":550,"end":608},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":609,"end":657},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":658,"end":899},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":900,"end":1039},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1040,"end":1235},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1236,"end":1433},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1434,"end":1649},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"T2","span":{"begin":95,"end":407},"obj":"Sentence"},{"id":"T3","span":{"begin":408,"end":514},"obj":"Sentence"},{"id":"T4","span":{"begin":515,"end":549},"obj":"Sentence"},{"id":"T5","span":{"begin":550,"end":608},"obj":"Sentence"},{"id":"T6","span":{"begin":609,"end":657},"obj":"Sentence"},{"id":"T7","span":{"begin":658,"end":899},"obj":"Sentence"},{"id":"T8","span":{"begin":900,"end":1039},"obj":"Sentence"},{"id":"T9","span":{"begin":1040,"end":1235},"obj":"Sentence"},{"id":"T10","span":{"begin":1236,"end":1433},"obj":"Sentence"},{"id":"T11","span":{"begin":1434,"end":1649},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia.\nThe aim of this study was to determine the predictive value of the combination of serum angiopoietin-2 (Ang-2) levels and uterine artery Doppler for the detection of preeclampsia in women at 16-18 weeks of gestation and to identify other pregnancy complications that could be predicted with these combined tests. Maternal serum Ang-2 levels were measured, and uterine artery Doppler was performed in 400 pregnant women. The main outcome was preeclampsia. The predictive values of this combination were calculated. Twenty-five women (6.3%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with serum Ang-2 levels for the prediction of preeclampsia were 24.0%, 94.4%, 22.2% and 94.9%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 57.1%, 94.1%, 14.8% and 99.2%, respectively. Patients with abnormal uterine artery Doppler and abnormal serum Ang-2 levels (above 19.5 ng ml(-1)) were at higher risk for preterm delivery (relative risk=2.7, 95% confidence interval 1.2-5.8). Our findings revealed that the combination of uterine artery Doppler and serum Ang-2 levels at 16-18 weeks of gestation can be used to predict early-onset preeclampsia but not overall preeclampsia. Thus, this combination may be a useful early second trimester screening test for the prediction of early-onset preeclampsia.Hypertension Research advance online publication, 22 October 2015; doi:10.1038/hr.2015.113."}

{"project":"Preeclampsia","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":81,"end":93},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T2","span":{"begin":261,"end":273},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T3","span":{"begin":536,"end":548},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T4","span":{"begin":644,"end":656},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T5","span":{"begin":837,"end":849},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T6","span":{"begin":934,"end":946},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T7","span":{"begin":1391,"end":1403},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T8","span":{"begin":1420,"end":1432},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"text":"Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia.\nThe aim of this study was to determine the predictive value of the combination of serum angiopoietin-2 (Ang-2) levels and uterine artery Doppler for the detection of preeclampsia in women at 16-18 weeks of gestation and to identify other pregnancy complications that could be predicted with these combined tests. Maternal serum Ang-2 levels were measured, and uterine artery Doppler was performed in 400 pregnant women. The main outcome was preeclampsia. The predictive values of this combination were calculated. Twenty-five women (6.3%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with serum Ang-2 levels for the prediction of preeclampsia were 24.0%, 94.4%, 22.2% and 94.9%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 57.1%, 94.1%, 14.8% and 99.2%, respectively. Patients with abnormal uterine artery Doppler and abnormal serum Ang-2 levels (above 19.5 ng ml(-1)) were at higher risk for preterm delivery (relative risk=2.7, 95% confidence interval 1.2-5.8). Our findings revealed that the combination of uterine artery Doppler and serum Ang-2 levels at 16-18 weeks of gestation can be used to predict early-onset preeclampsia but not overall preeclampsia. Thus, this combination may be a useful early second trimester screening test for the prediction of early-onset preeclampsia.Hypertension Research advance online publication, 22 October 2015; doi:10.1038/hr.2015.113."}

{"project":"Preeclampsia-compare","denotations":[{"id":"PD-Preeclampsia-B_T1","span":{"begin":81,"end":93},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T2","span":{"begin":261,"end":273},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T3","span":{"begin":536,"end":548},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T4","span":{"begin":644,"end":656},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T5","span":{"begin":837,"end":849},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T6","span":{"begin":934,"end":946},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T7","span":{"begin":1391,"end":1403},"obj":"ORPHA:275555"},{"id":"PD-Preeclampsia-B_T8","span":{"begin":1420,"end":1432},"obj":"ORPHA:275555"}],"namespaces":[{"prefix":"ORPHA","uri":"www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN\u0026Expert="}],"text":"Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia.\nThe aim of this study was to determine the predictive value of the combination of serum angiopoietin-2 (Ang-2) levels and uterine artery Doppler for the detection of preeclampsia in women at 16-18 weeks of gestation and to identify other pregnancy complications that could be predicted with these combined tests. Maternal serum Ang-2 levels were measured, and uterine artery Doppler was performed in 400 pregnant women. The main outcome was preeclampsia. The predictive values of this combination were calculated. Twenty-five women (6.3%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with serum Ang-2 levels for the prediction of preeclampsia were 24.0%, 94.4%, 22.2% and 94.9%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 57.1%, 94.1%, 14.8% and 99.2%, respectively. Patients with abnormal uterine artery Doppler and abnormal serum Ang-2 levels (above 19.5 ng ml(-1)) were at higher risk for preterm delivery (relative risk=2.7, 95% confidence interval 1.2-5.8). Our findings revealed that the combination of uterine artery Doppler and serum Ang-2 levels at 16-18 weeks of gestation can be used to predict early-onset preeclampsia but not overall preeclampsia. Thus, this combination may be a useful early second trimester screening test for the prediction of early-onset preeclampsia.Hypertension Research advance online publication, 22 October 2015; doi:10.1038/hr.2015.113."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":15,"end":20},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":177,"end":182},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":417,"end":422},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":796,"end":801},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1099,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":1309,"end":1314},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":40,"end":54},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":217,"end":231},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T9","span":{"begin":455,"end":469},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T10","span":{"begin":759,"end":773},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T11","span":{"begin":1063,"end":1077},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T12","span":{"begin":1282,"end":1296},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T13","span":{"begin":48,"end":54},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T14","span":{"begin":225,"end":231},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T15","span":{"begin":463,"end":469},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T16","span":{"begin":767,"end":773},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T17","span":{"begin":1071,"end":1077},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T18","span":{"begin":1290,"end":1296},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"}],"text":"Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia.\nThe aim of this study was to determine the predictive value of the combination of serum angiopoietin-2 (Ang-2) levels and uterine artery Doppler for the detection of preeclampsia in women at 16-18 weeks of gestation and to identify other pregnancy complications that could be predicted with these combined tests. Maternal serum Ang-2 levels were measured, and uterine artery Doppler was performed in 400 pregnant women. The main outcome was preeclampsia. The predictive values of this combination were calculated. Twenty-five women (6.3%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with serum Ang-2 levels for the prediction of preeclampsia were 24.0%, 94.4%, 22.2% and 94.9%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 57.1%, 94.1%, 14.8% and 99.2%, respectively. Patients with abnormal uterine artery Doppler and abnormal serum Ang-2 levels (above 19.5 ng ml(-1)) were at higher risk for preterm delivery (relative risk=2.7, 95% confidence interval 1.2-5.8). Our findings revealed that the combination of uterine artery Doppler and serum Ang-2 levels at 16-18 weeks of gestation can be used to predict early-onset preeclampsia but not overall preeclampsia. Thus, this combination may be a useful early second trimester screening test for the prediction of early-onset preeclampsia.Hypertension Research advance online publication, 22 October 2015; doi:10.1038/hr.2015.113."}

{"project":"preeclampsia_genes","denotations":[{"id":"PD-PreeclampsiaGenes-B_T1","span":{"begin":21,"end":33},"obj":"HGNC:ANGPT1"},{"id":"PD-PreeclampsiaGenes-B_T2","span":{"begin":183,"end":195},"obj":"HGNC:ANGPT1"}],"text":"Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia.\nThe aim of this study was to determine the predictive value of the combination of serum angiopoietin-2 (Ang-2) levels and uterine artery Doppler for the detection of preeclampsia in women at 16-18 weeks of gestation and to identify other pregnancy complications that could be predicted with these combined tests. Maternal serum Ang-2 levels were measured, and uterine artery Doppler was performed in 400 pregnant women. The main outcome was preeclampsia. The predictive values of this combination were calculated. Twenty-five women (6.3%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with serum Ang-2 levels for the prediction of preeclampsia were 24.0%, 94.4%, 22.2% and 94.9%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 57.1%, 94.1%, 14.8% and 99.2%, respectively. Patients with abnormal uterine artery Doppler and abnormal serum Ang-2 levels (above 19.5 ng ml(-1)) were at higher risk for preterm delivery (relative risk=2.7, 95% confidence interval 1.2-5.8). Our findings revealed that the combination of uterine artery Doppler and serum Ang-2 levels at 16-18 weeks of gestation can be used to predict early-onset preeclampsia but not overall preeclampsia. Thus, this combination may be a useful early second trimester screening test for the prediction of early-onset preeclampsia.Hypertension Research advance online publication, 22 October 2015; doi:10.1038/hr.2015.113."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":15,"end":20},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":177,"end":182},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":417,"end":422},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":796,"end":801},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1099,"end":1104},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":1309,"end":1314},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":40,"end":54},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":217,"end":231},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T9","span":{"begin":455,"end":469},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T10","span":{"begin":759,"end":773},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T11","span":{"begin":1063,"end":1077},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T12","span":{"begin":1282,"end":1296},"obj":"http://purl.obolibrary.org/obo/UBERON_0002493"},{"id":"PD-UBERON-AE-B_T13","span":{"begin":48,"end":54},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T14","span":{"begin":225,"end":231},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T15","span":{"begin":463,"end":469},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T16","span":{"begin":767,"end":773},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T17","span":{"begin":1071,"end":1077},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"PD-UBERON-AE-B_T18","span":{"begin":1290,"end":1296},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"}],"text":"Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia.\nThe aim of this study was to determine the predictive value of the combination of serum angiopoietin-2 (Ang-2) levels and uterine artery Doppler for the detection of preeclampsia in women at 16-18 weeks of gestation and to identify other pregnancy complications that could be predicted with these combined tests. Maternal serum Ang-2 levels were measured, and uterine artery Doppler was performed in 400 pregnant women. The main outcome was preeclampsia. The predictive values of this combination were calculated. Twenty-five women (6.3%) developed preeclampsia. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of uterine artery Doppler combined with serum Ang-2 levels for the prediction of preeclampsia were 24.0%, 94.4%, 22.2% and 94.9%, respectively. For the prediction of early-onset preeclampsia, the sensitivity, specificity, PPV and NPV were 57.1%, 94.1%, 14.8% and 99.2%, respectively. Patients with abnormal uterine artery Doppler and abnormal serum Ang-2 levels (above 19.5 ng ml(-1)) were at higher risk for preterm delivery (relative risk=2.7, 95% confidence interval 1.2-5.8). Our findings revealed that the combination of uterine artery Doppler and serum Ang-2 levels at 16-18 weeks of gestation can be used to predict early-onset preeclampsia but not overall preeclampsia. Thus, this combination may be a useful early second trimester screening test for the prediction of early-onset preeclampsia.Hypertension Research advance online publication, 22 October 2015; doi:10.1038/hr.2015.113."}