> top > docs > PubMed:26474493 > annotations

PubMed:26474493 JSONTXT

Annnotations TAB JSON ListView MergeView

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-9 CHEBI:52518 denotes Nanofiber
T2 16-25 D020100 denotes hydrogels
T3 16-25 D020100 denotes hydrogels
T5 31-51 GO:0031012 denotes extracellular matrix
T6 45-51 UBERON:0027368 denotes matrix
T7 58-67 32630 denotes synthetic
T8 68-76 D010455 denotes peptides
T9 68-76 D010455 denotes peptides
T10 68-76 CHEBI:16670 denotes peptides
T11 139-148 D020100 denotes hydrogels
T12 139-148 D020100 denotes hydrogels
T13 150-158 D000080385 denotes nanogels
T14 150-158 D000080385 denotes nanogels
T15 193-201 D010455 denotes peptides
T16 193-201 D010455 denotes peptides
T17 193-201 CHEBI:16670 denotes peptides
T18 218-231 GO:0005576 denotes extracellular
T19 248-252 UBERON:0000965 denotes lens
T20 248-252 UBERON:0005389 denotes lens
T21 345-349 UBERON:0000965 denotes lens
T22 345-349 UBERON:0005389 denotes lens
T23 371-374 UBERON:0000019 denotes eye
T24 371-374 UBERON:0000970 denotes eye
T25 371-374 UBERON:0010230 denotes eye
T26 382-388 UBERON:0000965 denotes Lenses
T28 440-444 UBERON:0000965 denotes lens
T29 440-444 UBERON:0005389 denotes lens
T30 479-487 D002214 denotes capsules
T31 507-514 C413692 denotes nanogel
T32 507-514 C413692 denotes nanogel
T33 523-531 D010455 denotes peptides
T34 523-531 D010455 denotes peptides
T35 523-531 CHEBI:16670 denotes peptides
T36 536-544 D000080385 denotes nanogels
T37 536-544 D000080385 denotes nanogels
T38 581-589 D010455 denotes peptides
T39 581-589 D010455 denotes peptides
T40 581-589 CHEBI:16670 denotes peptides
T41 595-602 D007797 denotes laminin
T42 616-627 Q91400 denotes fibronectin
T43 616-627 Q91740 denotes fibronectin
T44 616-627 Q28275 denotes fibronectin
T45 616-627 Q91289 denotes fibronectin
T47 616-627 PR:000007581 denotes fibronectin
T48 616-627 P11276 denotes fibronectin
T49 616-627 P11722 denotes fibronectin
T50 616-627 P04937 denotes fibronectin
T52 616-627 P07589 denotes fibronectin
T53 616-627 Q28377 denotes fibronectin
T54 616-627 Q28749 denotes fibronectin
T55 616-627 P02751 denotes fibronectin
T46 616-627 CHEBI:5058 denotes fibronectin
T51 616-627 D005353 denotes fibronectin
T57 645-653 2714 denotes collagen
T58 645-653 D003094 denotes collagen
T59 645-653 CHEBI:3815 denotes collagen
T56 645-653 GO:0005202 denotes collagen
T60 665-672 SO:0001064 denotes peptide
T61 665-672 PR:000018264 denotes peptide
T63 665-672 PR:000018263 denotes peptide
T62 665-672 CHEBI:16670 denotes peptide
T64 686-699 GO:0007155 denotes cell adhesion
T65 729-735 UBERON:0000965 denotes lenses
T66 754-764 D006820 denotes hyaluronan
T67 754-764 CHEBI:132153 denotes hyaluronan
T68 754-764 CHEBI:16336 denotes hyaluronan
T69 754-764 D006820 denotes hyaluronan
T70 783-789 UBERON:0000965 denotes lenses
T71 822-825 UBERON:0000019 denotes eye
T72 822-825 UBERON:0000970 denotes eye
T73 822-825 UBERON:0010230 denotes eye
T74 894-899 CHEBI:30216 denotes alpha
T75 900-913 UBERON:0001135 denotes smooth muscle
T76 900-913 UBERON:0000953 denotes smooth muscle
T79 914-919 P53491 denotes actin
T80 914-919 P45520 denotes actin
T81 914-919 O00937 denotes actin
T82 914-919 Q05214 denotes actin
T83 914-919 P13363 denotes actin
T84 914-919 Q39596 denotes actin
T85 914-919 P30161 denotes actin
T86 914-919 P53476 denotes actin
T87 914-919 P51775 denotes actin
T88 914-919 P60011 denotes actin
T89 914-919 Q9P4D1 denotes actin
T90 914-919 P50138 denotes actin
T91 914-919 O65314 denotes actin
T92 914-919 P26183 denotes actin
T93 914-919 Q75D00 denotes actin
T94 914-919 P53502 denotes actin
T95 914-919 P11426 denotes actin
T96 914-919 P80709 denotes actin
T97 914-919 Q8X119 denotes actin
T98 914-919 Q6TCF2 denotes actin
T99 914-919 Q99023 denotes actin
T100 914-919 A5DQP9 denotes actin
T101 914-919 P60009 denotes actin
T102 914-919 O65315 denotes actin
T103 914-919 P26182 denotes actin
T104 914-919 Q9UVF3 denotes actin
T105 914-919 Q2U7A3 denotes actin
T106 914-919 Q92192 denotes actin
T107 914-919 Q9UVZ8 denotes actin
T108 914-919 P53689 denotes actin
T109 914-919 P68555 denotes actin
T110 914-919 P53455 denotes actin
T111 914-919 O13419 denotes actin
T112 914-919 P60010 denotes actin
T113 914-919 Q39758 denotes actin
T114 914-919 P81085 denotes actin
T115 914-919 P48465 denotes actin
T116 914-919 P78711 denotes actin
T117 914-919 P17128 denotes actin
T118 914-919 P91754 denotes actin
T119 914-919 Q24733 denotes actin
T120 914-919 P14235 denotes actin
T121 914-919 Q92193 denotes actin
T122 914-919 Q11212 denotes actin
T123 914-919 P45521 denotes actin
T124 914-919 P53477 denotes actin
T125 914-919 P53499 denotes actin
T126 914-919 P24902 denotes actin
T127 914-919 Q8SWN8 denotes actin
T128 914-919 O17320 denotes actin
T129 914-919 P10365 denotes actin
T131 914-919 O16808 denotes actin
T132 914-919 P53498 denotes actin
T133 914-919 Q9UVX4 denotes actin
T134 914-919 O81221 denotes actin
T135 914-919 P20904 denotes actin
T136 914-919 O65316 denotes actin
T137 914-919 O74258 denotes actin
T138 914-919 P53500 denotes actin
T139 914-919 P10989 denotes actin
T140 914-919 P90689 denotes actin
T130 914-919 D000199 denotes actin
T141 992-1002 D006820 denotes hyaluronan
T142 992-1002 CHEBI:132153 denotes hyaluronan
T143 992-1002 CHEBI:16336 denotes hyaluronan
T144 992-1002 D006820 denotes hyaluronan
T145 1013-1019 UBERON:0000965 denotes lenses
T146 1032-1039 C413692 denotes nanogel
T147 1032-1039 C413692 denotes nanogel
T148 1052-1061 GO:0009058 denotes formation
T149 1185-1192 C413692 denotes nanogel
T150 1185-1192 C413692 denotes nanogel
T151 1257-1263 UBERON:0000965 denotes lenses
T152 1278-1285 C413692 denotes nanogel
T153 1278-1285 C413692 denotes nanogel
T154 1294-1302 D010455 denotes peptides
T155 1294-1302 D010455 denotes peptides
T156 1294-1302 CHEBI:16670 denotes peptides
T159 1329-1332 PR:Q9LJR2 denotes LEC
T158 1329-1332 UBERON:0007225 denotes LEC
T157 1329-1332 CL:0002138 denotes LEC
T160 1378-1386 D000080385 denotes nanogels
T161 1378-1386 D000080385 denotes nanogels
T163 1449-1469 GO:0031012 denotes extracellular matrix
T164 1463-1469 UBERON:0027368 denotes matrix
T165 1470-1478 D010455 denotes peptides
T166 1470-1478 D010455 denotes peptides
T167 1470-1478 CHEBI:16670 denotes peptides
T168 1599-1608 GO:0023052 denotes signaling
T169 1640-1649 MOP:0000569 denotes reduction
T170 1696-1703 C413692 denotes nanogel
T171 1696-1703 C413692 denotes nanogel
T173 1704-1711 PR:000018264 denotes peptide
T175 1704-1711 PR:000018263 denotes peptide
T172 1704-1711 SO:0001064 denotes peptide
T174 1704-1711 CHEBI:16670 denotes peptide

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 123-381 DRI_Approach denotes Nanofiber-based hydrogels (nanogels) with different, covalently bound peptides were used as an extracellular environment for lens epithelial cells (LECs) in order to modulate the capsular opacification (CO) response after lens surgery in a porcine eye model.
T2 382-707 DRI_Approach denotes Lenses were divided into 15 groups (n = 4 per group), the lens content was removed and the empty capsules were refilled with nanogel without peptides and nanogels with 13 combinations of 5 different peptides: two laminin-derived, two fibronectin-derived, and one collagen IV-derived peptide representing cell adhesion motifs.
T3 708-765 DRI_Background denotes A control group of 4 lenses was refilled with hyaluronan.
T4 766-855 DRI_Background denotes After refilling, lenses were extracted from the porcine eye and cultured for three weeks.
T5 856-979 DRI_Background denotes LECs were assessed for morphology and alpha smooth muscle actin (αSMA) expression using confocal laser scanning microscopy.
T6 980-1112 DRI_Background denotes Compared to hyaluronan controls, lenses filled with nanogel had less CO formation, indicated by a lower αSMA expression (P = 0.004).
T7 1113-1209 DRI_Background denotes Microscopy showed differences in morphological cell response within the nanogel refilled groups.
T8 1210-1319 DRI_Background denotes αSMA expression in these groups was highest in lenses refilled with nanogel without peptides (9.54 ± 11.29%).
T9 1320-1508 DRI_Approach denotes Overall, LEC transformation is reduced by the presence of nanogels and the response is improved even further by incorporation of extracellular matrix peptides representing adhesion motifs.
T10 1509-1747 DRI_Approach denotes Thus, nanomaterials targeting biological pathways, in our case interactions with integrin signaling, are a promising avenue toward reduction of CO. Further research is needed to optimize nanogel-peptide combinations that fully prevent CO.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 215-217 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T2 215-217 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T3 326-328 CVCL_J653|Cancer_cell_line|Homo sapiens denotes CO
T4 361-362 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 418-423 CVCL_D440|Transformed_cell_line|Mus musculus denotes n = 4
T6 641-644 CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis denotes one
T7 708-709 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T8 1049-1051 CVCL_J653|Cancer_cell_line|Homo sapiens denotes CO
T9 1076-1077 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T10 1614-1615 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T11 1653-1655 CVCL_J653|Cancer_cell_line|Homo sapiens denotes CO
T12 1744-1746 CVCL_J653|Cancer_cell_line|Homo sapiens denotes CO