> top > docs > PubMed:26447154 > annotations

PubMed:26447154 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-154 Sentence denotes α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial.
T2 155-166 Sentence denotes BACKGROUND:
T3 167-413 Sentence denotes Increasing dietary fat intake is expected to improve α-tocopherol bioavailability, which could be beneficial for improving α-tocopherol status, especially in cohorts at high cardiometabolic risk who fail to meet dietary α-tocopherol requirements.
T4 414-424 Sentence denotes OBJECTIVE:
T5 425-593 Sentence denotes Our objective was to assess dose-dependent effects of dairy fat and metabolic syndrome (MetS) health status on α-tocopherol pharmacokinetics in plasma and lipoproteins.
T6 594-601 Sentence denotes DESIGN:
T7 602-917 Sentence denotes A randomized, crossover, double-blind study was conducted in healthy and MetS adults (n = 10/group) who ingested encapsulated hexadeuterium-labeled (d6)-RRR-α-tocopherol (15 mg) with 240 mL nonfat (0.2 g fat), reduced-fat (4.8 g fat), or whole (7.9 g fat) milk before blood collection at regular intervals for 72 h.
T8 918-926 Sentence denotes RESULTS:
T9 927-1149 Sentence denotes Compared with healthy participants, those with MetS had lower (P < 0.05) baseline plasma α-tocopherol (μmol/mmol lipid) and greater oxidized low-density lipoprotein (LDL), interleukin (IL)-6, IL-10, and C-reactive protein.
T10 1150-1437 Sentence denotes Regardless of health status, d6-α-tocopherol bioavailability was unaffected by increasing amounts of dairy fat provided by milk beverages, but MetS participants had lower estimated d6-α-tocopherol absorption (±SEM) than did healthy participants (26.1% ± 1.0% compared with 29.5% ± 1.1%).
T11 1438-1541 Sentence denotes They also had lower plasma d6-α-tocopherol AUC from 0 to 72 h, as well as maximal concentrations (Cmax:
T12 1542-1655 Sentence denotes 2.04 ± 0.14 compared with 2.73 ± 0.18 μmol/L) and slower rates of plasma disappearance but similar times to Cmax.
T13 1656-1843 Sentence denotes MetS participants had lower d6-α-tocopherol AUC from t = 0-12 h (AUC0- t final) in lipoprotein fractions [chylomicron, very-low-density lipoprotein (VLDL), LDL, high-density lipoprotein].
T14 1844-2055 Sentence denotes Percentages of d6-α-tocopherol AUC0- t final in both the chylomicron (r = -0.46 to -0.52) and VLDL (r = -0.49 to -0.68) fractions were inversely correlated with oxidized LDL, IL-10, IL-6, and C-reactive protein.
T15 2056-2068 Sentence denotes CONCLUSIONS:
T16 2069-2397 Sentence denotes At dietary intakes equivalent to the Recommended Dietary Allowance, α-tocopherol bioavailability is unaffected by dairy fat quantity but is lower in MetS adults, potentially because of greater inflammation and oxidative stress that limits small intestinal α-tocopherol absorption and/or impairs hepatic α-tocopherol trafficking.
T17 2398-2478 Sentence denotes These findings support higher dietary α-tocopherol requirements for MetS adults.
T18 2479-2546 Sentence denotes This trial was registered at www.clinicaltrials.gov as NCT01787591.
T1 0-154 Sentence denotes α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial.
T2 155-166 Sentence denotes BACKGROUND:
T3 167-413 Sentence denotes Increasing dietary fat intake is expected to improve α-tocopherol bioavailability, which could be beneficial for improving α-tocopherol status, especially in cohorts at high cardiometabolic risk who fail to meet dietary α-tocopherol requirements.
T4 414-424 Sentence denotes OBJECTIVE:
T5 425-593 Sentence denotes Our objective was to assess dose-dependent effects of dairy fat and metabolic syndrome (MetS) health status on α-tocopherol pharmacokinetics in plasma and lipoproteins.
T6 594-601 Sentence denotes DESIGN:
T7 602-917 Sentence denotes A randomized, crossover, double-blind study was conducted in healthy and MetS adults (n = 10/group) who ingested encapsulated hexadeuterium-labeled (d6)-RRR-α-tocopherol (15 mg) with 240 mL nonfat (0.2 g fat), reduced-fat (4.8 g fat), or whole (7.9 g fat) milk before blood collection at regular intervals for 72 h.
T8 918-926 Sentence denotes RESULTS:
T9 927-1149 Sentence denotes Compared with healthy participants, those with MetS had lower (P < 0.05) baseline plasma α-tocopherol (μmol/mmol lipid) and greater oxidized low-density lipoprotein (LDL), interleukin (IL)-6, IL-10, and C-reactive protein.
T10 1150-1437 Sentence denotes Regardless of health status, d6-α-tocopherol bioavailability was unaffected by increasing amounts of dairy fat provided by milk beverages, but MetS participants had lower estimated d6-α-tocopherol absorption (±SEM) than did healthy participants (26.1% ± 1.0% compared with 29.5% ± 1.1%).
T11 1438-1541 Sentence denotes They also had lower plasma d6-α-tocopherol AUC from 0 to 72 h, as well as maximal concentrations (Cmax:
T12 1542-1655 Sentence denotes 2.04 ± 0.14 compared with 2.73 ± 0.18 μmol/L) and slower rates of plasma disappearance but similar times to Cmax.
T13 1656-1843 Sentence denotes MetS participants had lower d6-α-tocopherol AUC from t = 0-12 h (AUC0- t final) in lipoprotein fractions [chylomicron, very-low-density lipoprotein (VLDL), LDL, high-density lipoprotein].
T14 1844-2055 Sentence denotes Percentages of d6-α-tocopherol AUC0- t final in both the chylomicron (r = -0.46 to -0.52) and VLDL (r = -0.49 to -0.68) fractions were inversely correlated with oxidized LDL, IL-10, IL-6, and C-reactive protein.
T15 2056-2068 Sentence denotes CONCLUSIONS:
T16 2069-2397 Sentence denotes At dietary intakes equivalent to the Recommended Dietary Allowance, α-tocopherol bioavailability is unaffected by dairy fat quantity but is lower in MetS adults, potentially because of greater inflammation and oxidative stress that limits small intestinal α-tocopherol absorption and/or impairs hepatic α-tocopherol trafficking.
T17 2398-2478 Sentence denotes These findings support higher dietary α-tocopherol requirements for MetS adults.
T18 2479-2546 Sentence denotes This trial was registered at www.clinicaltrials.gov as NCT01787591.

wangzhuo19_800_2

Id Subject Object Predicate Lexical cue
T1 479-511 DP denotes dairy fat and metabolic syndrome
T2 513-517 DP denotes MetS
T3 675-679 DP denotes MetS
T4 974-978 DP denotes MetS
T5 1293-1297 DP denotes MetS
T6 1656-1660 DP denotes MetS
T7 2466-2470 DP denotes MetS
T8 2218-2222 DP denotes MetS
T9 53-71 DP denotes metabolic syndrome
T10 0-12 CI denotes α-Tocopherol
T11 290-302 CI denotes α-tocopherol
T12 1016-1028 CI denotes α-tocopherol
T13 759-771 CI denotes α-tocopherol
T14 2137-2149 CI denotes α-tocopherol
T15 2372-2384 CI denotes α-tocopherol
T16 2326-2337 CI denotes -tocopherol
T17 1862-1874 CI denotes α-tocopherol
T18 1334-1346 CI denotes α-tocopherol
T19 536-548 CI denotes α-tocopherol
T20 1182-1194 CI denotes α-tocopherol
T21 1468-1480 CI denotes α-tocopherol
T22 2436-2448 CI denotes α-tocopherol
T23 387-399 CI denotes α-tocopherol
T24 220-232 CI denotes α-tocopherol

Zierdiyeerkenaili_800_2

Id Subject Object Predicate Lexical cue
T1 493-511 DP denotes metabolic syndrome
T2 513-517 DP denotes MetS
T3 675-679 DP denotes MetS
T4 974-978 DP denotes MetS
T5 1293-1297 DP denotes MetS
T6 1656-1660 DP denotes MetS
T7 2218-2222 DP denotes MetS
T8 2466-2470 DP denotes MetS
T9 53-71 DP denotes metabolic syndrome

chenxin_473849_800_3

Id Subject Object Predicate Lexical cue
T1 675-679 DP denotes MetS
T2 513-517 DP denotes MetS
T3 974-978 DP denotes MetS
T4 1293-1297 DP denotes MetS
T5 1656-1660 DP denotes MetS
T6 2218-2222 DP denotes MetS
T7 2466-2470 DP denotes MetS
T8 53-71 DP denotes metabolic syndrome
T9 493-511 DP denotes metabolic syndrome

yangbin123xm_800_3

Id Subject Object Predicate Lexical cue
T1 53-71 DP denotes metabolic syndrome
T2 493-511 DP denotes metabolic syndrome
T3 513-517 DP denotes MetS
T4 675-679 DP denotes MetS
T5 974-978 DP denotes MetS
T6 1293-1297 DP denotes MetS
T7 1656-1660 DP denotes MetS
T8 2466-2470 DP denotes MetS
T9 2218-2222 DP denotes MetS