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PubMed:26411452 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T4 382-680 Sentence denotes We integrated chromatin-immunoprecipitation-coupled sequencing and microarray expression profiling in TMPRSS2-ERG gene rearrangement positive DUCaP cells with the GWAS PCa risk SNPs catalog to identify disease susceptibility SNPs localized within functional androgen receptor-binding sites (ARBSs).
T1 0-166 Sentence denotes Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites.
T2 167-310 Sentence denotes Genome-wide association studies have identified genomic loci, whose single-nucleotide polymorphisms (SNPs) predispose to prostate cancer (PCa).
T3 311-381 Sentence denotes However, the mechanisms of most of these variants are largely unknown.
T5 681-769 Sentence denotes Among the 48 GWAS index risk SNPs and 3,917 linked SNPs, 80 were found located in ARBSs.
T6 770-976 Sentence denotes Of these, rs11891426:T>G in an intron of the melanophilin gene (MLPH) was within a novel putative auxiliary AR-binding motif, which is enriched in the neighborhood of canonical androgen-responsive elements.
T7 977-1071 Sentence denotes T→G exchange attenuated the transcriptional activity of the ARBS in an AR reporter gene assay.
T8 1072-1238 Sentence denotes The expression of MLPH in primary prostate tumors was significantly lower in those with the G compared with the T allele and correlated significantly with AR protein.
T9 1239-1368 Sentence denotes Higher melanophilin level in prostate tissue of patients with a favorable PCa risk profile points out a tumor-suppressive effect.
T10 1369-1530 Sentence denotes These results unravel a hidden link between AR and a functional putative PCa risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
10816 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer MESH:D011471
10817 40-57 GeneOrGeneProduct denotes Androgen Receptor NCBIGene:367
10818 78-90 GeneOrGeneProduct denotes Melanophilin NCBIGene:79083
10819 135-152 GeneOrGeneProduct denotes Androgen Receptor NCBIGene:367
10820 288-303 DiseaseOrPhenotypicFeature denotes prostate cancer MESH:D011471
10821 305-308 DiseaseOrPhenotypicFeature denotes PCa MESH:D011471
10822 484-491 GeneOrGeneProduct denotes TMPRSS2 NCBIGene:7113
10823 492-495 GeneOrGeneProduct denotes ERG NCBIGene:2078
10824 524-529 CellLine denotes DUCaP NCBITaxon:9606
10825 550-553 DiseaseOrPhenotypicFeature denotes PCa MESH:D011471
10826 640-657 GeneOrGeneProduct denotes androgen receptor NCBIGene:367
10827 673-675 GeneOrGeneProduct denotes AR NCBIGene:367
10828 763-765 GeneOrGeneProduct denotes AR NCBIGene:367
10829 780-790 SequenceVariant denotes rs11891426 DBSNP:rs11891426
10830 791-794 SequenceVariant denotes T>G DBSNP:rs11891426
10831 815-827 GeneOrGeneProduct denotes melanophilin NCBIGene:79083
10832 834-838 GeneOrGeneProduct denotes MLPH NCBIGene:79083
10833 878-880 GeneOrGeneProduct denotes AR NCBIGene:367
10834 947-955 ChemicalEntity denotes androgen MESH:D000728
10835 977-980 SequenceVariant denotes T→G DBSNP:rs11891426
10836 1037-1039 GeneOrGeneProduct denotes AR NCBIGene:367
10837 1048-1050 GeneOrGeneProduct denotes AR NCBIGene:367
10838 1090-1094 GeneOrGeneProduct denotes MLPH NCBIGene:79083
10839 1106-1121 DiseaseOrPhenotypicFeature denotes prostate tumors MESH:D011471
10840 1227-1229 GeneOrGeneProduct denotes AR NCBIGene:367
10841 1246-1258 GeneOrGeneProduct denotes melanophilin NCBIGene:79083
10842 1287-1295 OrganismTaxon denotes patients NCBITaxon:9606
10843 1313-1316 DiseaseOrPhenotypicFeature denotes PCa MESH:D011471
10844 1343-1348 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
10845 1413-1415 GeneOrGeneProduct denotes AR NCBIGene:367
10846 1442-1445 DiseaseOrPhenotypicFeature denotes PCa MESH:D011471
10847 1488-1496 ChemicalEntity denotes androgen MESH:D000728
10848 1525-1529 GeneOrGeneProduct denotes MLPH NCBIGene:79083

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer 0008315
T2 288-303 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T3 297-303 DiseaseOrPhenotypicFeature denotes cancer 0004992
T4 584-606 DiseaseOrPhenotypicFeature denotes disease susceptibility 0042489
T5 1106-1114 DiseaseOrPhenotypicFeature denotes prostate 0005280
T6 1268-1276 DiseaseOrPhenotypicFeature denotes prostate 0005280

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 780-790 SequenceVariant denotes rs11891426

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Putative
T2 40-57 GeneOrGeneProduct denotes Androgen Receptor
T3 58-65 GeneOrGeneProduct denotes Binding
T4 78-90 GeneOrGeneProduct denotes Melanophilin
T5 135-152 GeneOrGeneProduct denotes Androgen Receptor
T6 274-303 GeneOrGeneProduct denotes predispose to prostate cancer
T7 305-308 GeneOrGeneProduct denotes PCa
T8 373-380 GeneOrGeneProduct denotes unknown
T9 484-491 GeneOrGeneProduct denotes TMPRSS2
T10 492-500 GeneOrGeneProduct denotes ERG gene
T11 550-553 GeneOrGeneProduct denotes PCa
T12 640-657 GeneOrGeneProduct denotes androgen receptor
T13 658-665 GeneOrGeneProduct denotes binding
T14 815-827 GeneOrGeneProduct denotes melanophilin
T15 834-838 GeneOrGeneProduct denotes MLPH
T16 853-858 GeneOrGeneProduct denotes novel
T17 859-867 GeneOrGeneProduct denotes putative
T18 881-888 GeneOrGeneProduct denotes binding
T19 990-1000 GeneOrGeneProduct denotes attenuated
T20 1005-1020 GeneOrGeneProduct denotes transcriptional
T21 1090-1094 GeneOrGeneProduct denotes MLPH
T22 1230-1237 GeneOrGeneProduct denotes protein
T23 1246-1258 GeneOrGeneProduct denotes melanophilin
T24 1313-1316 GeneOrGeneProduct denotes PCa
T25 1400-1404 GeneOrGeneProduct denotes link
T26 1433-1441 GeneOrGeneProduct denotes putative
T27 1442-1445 GeneOrGeneProduct denotes PCa
T28 1525-1529 GeneOrGeneProduct denotes MLPH

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-8 GeneOrGeneProduct denotes Putative
T2 40-57 GeneOrGeneProduct denotes Androgen Receptor
T3 58-65 GeneOrGeneProduct denotes Binding
T4 78-90 GeneOrGeneProduct denotes Melanophilin
T5 135-152 GeneOrGeneProduct denotes Androgen Receptor
T6 274-303 GeneOrGeneProduct denotes predispose to prostate cancer
T7 305-308 GeneOrGeneProduct denotes PCa
T8 365-372 GeneOrGeneProduct denotes largely
T9 373-380 GeneOrGeneProduct denotes unknown
T10 484-491 GeneOrGeneProduct denotes TMPRSS2
T11 492-500 GeneOrGeneProduct denotes ERG gene
T12 530-535 GeneOrGeneProduct denotes cells
T13 550-553 GeneOrGeneProduct denotes PCa
T14 640-657 GeneOrGeneProduct denotes androgen receptor
T15 658-665 GeneOrGeneProduct denotes binding
T16 725-731 GeneOrGeneProduct denotes linked
T17 815-827 GeneOrGeneProduct denotes melanophilin
T18 834-838 GeneOrGeneProduct denotes MLPH
T19 853-858 GeneOrGeneProduct denotes novel
T20 859-867 GeneOrGeneProduct denotes putative
T21 881-888 GeneOrGeneProduct denotes binding
T22 990-1000 GeneOrGeneProduct denotes attenuated
T23 1005-1020 GeneOrGeneProduct denotes transcriptional
T24 1021-1029 GeneOrGeneProduct denotes activity
T25 1090-1094 GeneOrGeneProduct denotes MLPH
T26 1115-1121 GeneOrGeneProduct denotes tumors
T27 1230-1237 GeneOrGeneProduct denotes protein
T28 1246-1258 GeneOrGeneProduct denotes melanophilin
T29 1313-1316 GeneOrGeneProduct denotes PCa
T30 1330-1336 GeneOrGeneProduct denotes points
T31 1337-1340 GeneOrGeneProduct denotes out
T32 1343-1348 GeneOrGeneProduct denotes tumor
T33 1400-1404 GeneOrGeneProduct denotes link
T34 1413-1421 GeneOrGeneProduct denotes AR and a
T35 1433-1441 GeneOrGeneProduct denotes putative
T36 1442-1445 GeneOrGeneProduct denotes PCa
T37 1497-1507 GeneOrGeneProduct denotes regulation
T38 1525-1529 GeneOrGeneProduct denotes MLPH

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer D011471
T2 274-303 DiseaseOrPhenotypicFeature denotes predispose to prostate cancer C566426
T3 305-308 DiseaseOrPhenotypicFeature denotes PCa C566426
T4 550-553 DiseaseOrPhenotypicFeature denotes PCa C566426
T5 584-606 DiseaseOrPhenotypicFeature denotes disease susceptibility D004198
T6 640-648 DiseaseOrPhenotypicFeature denotes androgen D014770
T7 947-955 DiseaseOrPhenotypicFeature denotes androgen D014770
T8 1115-1121 DiseaseOrPhenotypicFeature denotes tumors D009369
T9 1313-1316 DiseaseOrPhenotypicFeature denotes PCa C566426
T10 1343-1348 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 1442-1445 DiseaseOrPhenotypicFeature denotes PCa C566426
T12 1488-1496 DiseaseOrPhenotypicFeature denotes androgen D014770

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 40-57 GeneOrGeneProduct denotes Androgen Receptor
T2 78-90 GeneOrGeneProduct denotes Melanophilin
T3 135-152 GeneOrGeneProduct denotes Androgen Receptor
T4 484-491 GeneOrGeneProduct denotes TMPRSS2
T5 492-500 GeneOrGeneProduct denotes ERG gene
T6 640-657 GeneOrGeneProduct denotes androgen receptor
T7 815-827 GeneOrGeneProduct denotes melanophilin
T8 834-838 GeneOrGeneProduct denotes MLPH
T9 1005-1029 GeneOrGeneProduct denotes transcriptional activity
T10 1090-1094 GeneOrGeneProduct denotes MLPH
T11 1246-1258 GeneOrGeneProduct denotes melanophilin
T12 1525-1529 GeneOrGeneProduct denotes MLPH

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer 0008315
T2 288-303 DiseaseOrPhenotypicFeature denotes prostate cancer 0008315
T3 305-308 DiseaseOrPhenotypicFeature denotes PCa 0008315
T4 550-553 DiseaseOrPhenotypicFeature denotes PCa 0008315
T5 1313-1316 DiseaseOrPhenotypicFeature denotes PCa 0008315
T6 1343-1348 DiseaseOrPhenotypicFeature denotes tumor 0005070
T7 1442-1445 DiseaseOrPhenotypicFeature denotes PCa 0008315

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer D011471
T2 274-303 DiseaseOrPhenotypicFeature denotes predispose to prostate cancer C566426
T3 305-308 DiseaseOrPhenotypicFeature denotes PCa C566426
T4 550-553 DiseaseOrPhenotypicFeature denotes PCa C566426
T5 584-606 DiseaseOrPhenotypicFeature denotes disease susceptibility D004198
T6 1115-1121 DiseaseOrPhenotypicFeature denotes tumors DISEASE|D009369
T8 1313-1316 DiseaseOrPhenotypicFeature denotes PCa C566426
T9 1343-1348 DiseaseOrPhenotypicFeature denotes tumor D009369
T10 1442-1445 DiseaseOrPhenotypicFeature denotes PCa C566426

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 524-529 CellLine denotes DUCaP CVCL_2025

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer D011471
T2 274-303 DiseaseOrPhenotypicFeature denotes predispose to prostate cancer C566426
T3 305-308 DiseaseOrPhenotypicFeature denotes PCa C566426
T4 550-553 DiseaseOrPhenotypicFeature denotes PCa C566426
T5 584-606 DiseaseOrPhenotypicFeature denotes disease susceptibility D004198
T6 1115-1121 DiseaseOrPhenotypicFeature denotes tumors D009369
T7 1313-1316 DiseaseOrPhenotypicFeature denotes PCa C566426
T8 1343-1348 DiseaseOrPhenotypicFeature denotes tumor D009369
T9 1442-1445 DiseaseOrPhenotypicFeature denotes PCa C566426

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 40-48 ChemicalEntity denotes Androgen ChemicalEntity
T2 135-143 ChemicalEntity denotes Androgen ChemicalEntity
T3 640-648 ChemicalEntity denotes androgen ChemicalEntity
T4 947-955 ChemicalEntity denotes androgen ChemicalEntity
T5 1488-1496 ChemicalEntity denotes androgen ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 1287-1295 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T1 524-529 CellLine denotes DUCaP CVCL_2025
T5 1488-1496 ChemicalEntity denotes androgen ChemicalEntity
T4 947-955 ChemicalEntity denotes androgen ChemicalEntity
T3 640-648 ChemicalEntity denotes androgen ChemicalEntity
T2 135-143 ChemicalEntity denotes Androgen ChemicalEntity
T35811 40-48 ChemicalEntity denotes Androgen ChemicalEntity
T12 1525-1529 GeneOrGeneProduct denotes MLPH
T11 1246-1258 GeneOrGeneProduct denotes melanophilin
T10 1090-1094 GeneOrGeneProduct denotes MLPH
T9 1005-1029 GeneOrGeneProduct denotes transcriptional activity
T8 834-838 GeneOrGeneProduct denotes MLPH
T7 815-827 GeneOrGeneProduct denotes melanophilin
T6 640-657 GeneOrGeneProduct denotes androgen receptor
T68614 492-500 GeneOrGeneProduct denotes ERG gene
T32017 484-491 GeneOrGeneProduct denotes TMPRSS2
T24929 135-152 GeneOrGeneProduct denotes Androgen Receptor
T51022 78-90 GeneOrGeneProduct denotes Melanophilin
T71376 40-57 GeneOrGeneProduct denotes Androgen Receptor
T44355 1442-1445 DiseaseOrPhenotypicFeature denotes PCa C566426
T38643 1343-1348 DiseaseOrPhenotypicFeature denotes tumor D009369
T27829 1313-1316 DiseaseOrPhenotypicFeature denotes PCa C566426
T84965 1115-1121 DiseaseOrPhenotypicFeature denotes tumors D009369
T17675 584-606 DiseaseOrPhenotypicFeature denotes disease susceptibility D004198
T77784 550-553 DiseaseOrPhenotypicFeature denotes PCa C566426
T23506 305-308 DiseaseOrPhenotypicFeature denotes PCa C566426
T87555 274-303 DiseaseOrPhenotypicFeature denotes predispose to prostate cancer C566426
T36849 9-24 DiseaseOrPhenotypicFeature denotes Prostate Cancer D011471
T69263 1287-1295 OrganismTaxon denotes patients
T72192 780-790 SequenceVariant denotes rs11891426

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26411452-3#102#109#gene7113 484-491 gene7113 denotes TMPRSS2
26411452-3#110#113#gene2078 492-495 gene2078 denotes ERG
26411452-3#258#275#gene367 640-657 gene367 denotes androgen receptor
26411452-3#168#171#diseaseC0376358 550-553 diseaseC0376358 denotes PCa
26411452-3#168#171#diseaseC0600139 550-553 diseaseC0600139 denotes PCa
26411452-3#168#171#diseaseC0376358 550-553 diseaseC0376358 denotes PCa
26411452-3#168#171#diseaseC0600139 550-553 diseaseC0600139 denotes PCa
26411452-3#168#171#diseaseC0376358 550-553 diseaseC0376358 denotes PCa
26411452-3#168#171#diseaseC0600139 550-553 diseaseC0600139 denotes PCa
26411452-8#7#19#gene79083 1246-1258 gene79083 denotes melanophilin
26411452-8#74#77#diseaseC0376358 1313-1316 diseaseC0376358 denotes PCa
26411452-8#74#77#diseaseC0600139 1313-1316 diseaseC0600139 denotes PCa
102#109#gene7113168#171#diseaseC0376358 26411452-3#102#109#gene7113 26411452-3#168#171#diseaseC0376358 associated_with TMPRSS2,PCa
102#109#gene7113168#171#diseaseC0600139 26411452-3#102#109#gene7113 26411452-3#168#171#diseaseC0600139 associated_with TMPRSS2,PCa
102#109#gene7113168#171#diseaseC0376358 26411452-3#102#109#gene7113 26411452-3#168#171#diseaseC0376358 associated_with TMPRSS2,PCa
102#109#gene7113168#171#diseaseC0600139 26411452-3#102#109#gene7113 26411452-3#168#171#diseaseC0600139 associated_with TMPRSS2,PCa
102#109#gene7113168#171#diseaseC0376358 26411452-3#102#109#gene7113 26411452-3#168#171#diseaseC0376358 associated_with TMPRSS2,PCa
102#109#gene7113168#171#diseaseC0600139 26411452-3#102#109#gene7113 26411452-3#168#171#diseaseC0600139 associated_with TMPRSS2,PCa
110#113#gene2078168#171#diseaseC0376358 26411452-3#110#113#gene2078 26411452-3#168#171#diseaseC0376358 associated_with ERG,PCa
110#113#gene2078168#171#diseaseC0600139 26411452-3#110#113#gene2078 26411452-3#168#171#diseaseC0600139 associated_with ERG,PCa
110#113#gene2078168#171#diseaseC0376358 26411452-3#110#113#gene2078 26411452-3#168#171#diseaseC0376358 associated_with ERG,PCa
110#113#gene2078168#171#diseaseC0600139 26411452-3#110#113#gene2078 26411452-3#168#171#diseaseC0600139 associated_with ERG,PCa
110#113#gene2078168#171#diseaseC0376358 26411452-3#110#113#gene2078 26411452-3#168#171#diseaseC0376358 associated_with ERG,PCa
110#113#gene2078168#171#diseaseC0600139 26411452-3#110#113#gene2078 26411452-3#168#171#diseaseC0600139 associated_with ERG,PCa
258#275#gene367168#171#diseaseC0376358 26411452-3#258#275#gene367 26411452-3#168#171#diseaseC0376358 associated_with androgen receptor,PCa
258#275#gene367168#171#diseaseC0600139 26411452-3#258#275#gene367 26411452-3#168#171#diseaseC0600139 associated_with androgen receptor,PCa
258#275#gene367168#171#diseaseC0376358 26411452-3#258#275#gene367 26411452-3#168#171#diseaseC0376358 associated_with androgen receptor,PCa
258#275#gene367168#171#diseaseC0600139 26411452-3#258#275#gene367 26411452-3#168#171#diseaseC0600139 associated_with androgen receptor,PCa
258#275#gene367168#171#diseaseC0376358 26411452-3#258#275#gene367 26411452-3#168#171#diseaseC0376358 associated_with androgen receptor,PCa
258#275#gene367168#171#diseaseC0600139 26411452-3#258#275#gene367 26411452-3#168#171#diseaseC0600139 associated_with androgen receptor,PCa
7#19#gene7908374#77#diseaseC0376358 26411452-8#7#19#gene79083 26411452-8#74#77#diseaseC0376358 associated_with melanophilin,PCa
7#19#gene7908374#77#diseaseC0600139 26411452-8#7#19#gene79083 26411452-8#74#77#diseaseC0600139 associated_with melanophilin,PCa