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PubMed:26402627 JSONTXT

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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26402627-0#22#26#gene627 22-26 gene627 denotes BDNF
26402627-0#6#17#diseaseC0002726 6-17 diseaseC0002726 denotes Amyloidosis
26402627-3#169#202#gene627 518-551 gene627 denotes brain-derived neurotrophic factor
26402627-3#204#208#gene627 553-557 gene627 denotes BDNF
26402627-3#125#139#diseaseC0333463 474-488 diseaseC0333463 denotes amyloid plaque
26402627-3#125#139#diseaseC2936349 474-488 diseaseC2936349 denotes amyloid plaque
26402627-3#125#139#diseaseC0333463 474-488 diseaseC0333463 denotes amyloid plaque
26402627-3#125#139#diseaseC2936349 474-488 diseaseC2936349 denotes amyloid plaque
22#26#gene6276#17#diseaseC0002726 26402627-0#22#26#gene627 26402627-0#6#17#diseaseC0002726 associated_with BDNF,Amyloidosis
169#202#gene627125#139#diseaseC0333463 26402627-3#169#202#gene627 26402627-3#125#139#diseaseC0333463 associated_with brain-derived neurotrophic factor,amyloid plaque
169#202#gene627125#139#diseaseC2936349 26402627-3#169#202#gene627 26402627-3#125#139#diseaseC2936349 associated_with brain-derived neurotrophic factor,amyloid plaque
169#202#gene627125#139#diseaseC0333463 26402627-3#169#202#gene627 26402627-3#125#139#diseaseC0333463 associated_with brain-derived neurotrophic factor,amyloid plaque
169#202#gene627125#139#diseaseC2936349 26402627-3#169#202#gene627 26402627-3#125#139#diseaseC2936349 associated_with brain-derived neurotrophic factor,amyloid plaque
204#208#gene627125#139#diseaseC0333463 26402627-3#204#208#gene627 26402627-3#125#139#diseaseC0333463 associated_with BDNF,amyloid plaque
204#208#gene627125#139#diseaseC2936349 26402627-3#204#208#gene627 26402627-3#125#139#diseaseC2936349 associated_with BDNF,amyloid plaque
204#208#gene627125#139#diseaseC0333463 26402627-3#204#208#gene627 26402627-3#125#139#diseaseC0333463 associated_with BDNF,amyloid plaque
204#208#gene627125#139#diseaseC2936349 26402627-3#204#208#gene627 26402627-3#125#139#diseaseC2936349 associated_with BDNF,amyloid plaque

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1666 518-551 gene:627 denotes brain-derived neurotrophic factor
T1667 474-488 disease:C0333463 denotes amyloid plaque
T1668 553-557 gene:627 denotes BDNF
R1 T1666 T1667 associated_with brain-derived neurotrophic factor,amyloid plaque
R2 T1666 T1667 associated_with brain-derived neurotrophic factor,amyloid plaque
R3 T1668 T1667 associated_with BDNF,amyloid plaque
R4 T1668 T1667 associated_with BDNF,amyloid plaque

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-119 Sentence denotes Brain Amyloidosis and BDNF Deficiency Have Opposite Effects on Brain Volumes in AβPP/PS1 Mice Both in vivo and ex vivo.
TextSentencer_T2 120-261 Sentence denotes Magnetic resonance imaging (MRI) volumetry is widely used in Alzheimer's disease (AD) research and diagnostics alongside clinical assessment.
TextSentencer_T3 262-348 Sentence denotes Yet few MRI volumetry studies have been conducted in AD model mice with mixed results.
TextSentencer_T4 349-568 Sentence denotes We performed in vivo and ex vivo MRI and extensive postmortem histological analysis in transgenic mice derived from crossing amyloid plaque producing AβPP/PS1 mice with brain-derived neurotrophic factor (BDNF) +/- mice.
TextSentencer_T5 569-705 Sentence denotes This allowed us to compare developmental volumetric changes due to BDNF deficiency with progressive changes due to amyloid accumulation.
TextSentencer_T6 706-913 Sentence denotes We found decreased whole brain volume at 3 months and decreased cortical volume at both 3 and 8 months in vivo in BDNF +/- Tg mice but increased whole brain and cortical volumes at 8 months in AβPP/PS1 mice.
TextSentencer_T7 914-1063 Sentence denotes Consistent with this, the postmortem histological analysis showed decreased brain parenchymal area in BDNF +/- mice but an increase in AβPP/PS1 mice.
TextSentencer_T8 1064-1284 Sentence denotes BDNF gene deficiency did not affect brain amyloid load or astrogliosis, but led to decreased dentate gyrus length, whereas AβPP/PS1 mice had significantly increased amyloid load, astrogliosis, and decreased neurogenesis.
TextSentencer_T9 1285-1381 Sentence denotes Distinct and layer-specific effects were found in the hippocampus of AβPP/PS1 and BDNF +/- mice.
TextSentencer_T10 1382-1565 Sentence denotes In contrast to human AD patients, brain atrophy in amyloid producing mice appears to be masked by volume increase due to amyloid accumulation and especially accompanying astrogliosis.
TextSentencer_T11 1566-1709 Sentence denotes Our results indicate that cortical MRI volumetry can be used to some extent as a proxy to progressive brain amyloidosis in preclinical studies.
T1 0-119 Sentence denotes Brain Amyloidosis and BDNF Deficiency Have Opposite Effects on Brain Volumes in AβPP/PS1 Mice Both in vivo and ex vivo.
T2 120-261 Sentence denotes Magnetic resonance imaging (MRI) volumetry is widely used in Alzheimer's disease (AD) research and diagnostics alongside clinical assessment.
T3 262-348 Sentence denotes Yet few MRI volumetry studies have been conducted in AD model mice with mixed results.
T4 349-568 Sentence denotes We performed in vivo and ex vivo MRI and extensive postmortem histological analysis in transgenic mice derived from crossing amyloid plaque producing AβPP/PS1 mice with brain-derived neurotrophic factor (BDNF) +/- mice.
T5 569-705 Sentence denotes This allowed us to compare developmental volumetric changes due to BDNF deficiency with progressive changes due to amyloid accumulation.
T6 706-913 Sentence denotes We found decreased whole brain volume at 3 months and decreased cortical volume at both 3 and 8 months in vivo in BDNF +/- Tg mice but increased whole brain and cortical volumes at 8 months in AβPP/PS1 mice.
T7 914-1063 Sentence denotes Consistent with this, the postmortem histological analysis showed decreased brain parenchymal area in BDNF +/- mice but an increase in AβPP/PS1 mice.
T8 1064-1284 Sentence denotes BDNF gene deficiency did not affect brain amyloid load or astrogliosis, but led to decreased dentate gyrus length, whereas AβPP/PS1 mice had significantly increased amyloid load, astrogliosis, and decreased neurogenesis.
T9 1285-1381 Sentence denotes Distinct and layer-specific effects were found in the hippocampus of AβPP/PS1 and BDNF +/- mice.
T10 1382-1565 Sentence denotes In contrast to human AD patients, brain atrophy in amyloid producing mice appears to be masked by volume increase due to amyloid accumulation and especially accompanying astrogliosis.
T11 1566-1709 Sentence denotes Our results indicate that cortical MRI volumetry can be used to some extent as a proxy to progressive brain amyloidosis in preclinical studies.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 0-5 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
PD-UBERON-AE-B_T2 63-68 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
PD-UBERON-AE-B_T3 518-523 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T4 731-736 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T5 857-862 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T6 990-995 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T7 1100-1105 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T8 1416-1421 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T9 1668-1673 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T10 390-399 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T11 996-1007 http://purl.obolibrary.org/obo/UBERON_0000353 denotes parenchymal
PD-UBERON-AE-B_T12 1165-1170 http://purl.obolibrary.org/obo/UBERON_0000200 denotes gyrus

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 390-399 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T2 0-5 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
PD-UBERON-AE-B_T3 63-68 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
PD-UBERON-AE-B_T4 518-523 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T5 731-736 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T6 857-862 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T7 990-995 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T8 1100-1105 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T9 1416-1421 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T10 1668-1673 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T11 996-1007 http://purl.obolibrary.org/obo/UBERON_0000353 denotes parenchymal
PD-UBERON-AE-B_T12 1165-1170 http://purl.obolibrary.org/obo/UBERON_0000200 denotes gyrus