> top > docs > PubMed:26365279 > annotations

PubMed:26365279 JSONTXT

Annnotations TAB JSON ListView MergeView

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-21 D029121 denotes Avian metapneumovirus
T2 0-21 38525 denotes Avian metapneumovirus
T4 22-31 D007239 denotes infection
T5 22-31 D007239 denotes infection
T8 35-42 892653 denotes chicken
T6 35-42 D002645 denotes chicken
T7 35-42 9031 denotes chicken
T10 47-53 975119 denotes turkey
T9 47-53 9103 denotes turkey
T11 63-68 UBERON:0000062 denotes organ
T12 63-68 UBERON:0003103 denotes organ
T13 124-139 D029121 denotes metapneumovirus
T14 239-246 D011200 denotes poultry
T15 267-276 D007239 denotes infection
T16 267-276 D007239 denotes infection
T17 284-307 UBERON:0001557 denotes upper respiratory tract
T19 290-307 D012140 denotes respiratory tract
T20 290-307 D012140 denotes respiratory tract
T23 316-324 D002645 denotes chickens
T24 316-324 9031 denotes chickens
T25 329-336 D014422 denotes turkeys
T26 347-354 D014422 denotes turkeys
T27 464-473 D007239 denotes infection
T28 464-473 D007239 denotes infection
T29 484-489 UBERON:0000062 denotes organ
T30 484-489 UBERON:0003103 denotes organ
T31 500-503 PR:P02930 denotes TOC
T32 500-503 C536164 denotes TOC
T33 541-563 GO:0019048 denotes virus-host interaction
T34 571-593 UBERON:0004802 denotes respiratory epithelium
T38 672-679 892653 denotes chicken
T36 672-679 D002645 denotes chicken
T37 672-679 9031 denotes chicken
T40 684-690 975119 denotes turkey
T39 684-690 9103 denotes turkey
T41 691-694 PR:P02930 denotes TOC
T42 691-694 C536164 denotes TOC
T43 701-710 D007239 denotes infection
T44 701-710 D007239 denotes infection
T45 765-787 GO:0045087 denotes innate immune response
T47 797-807 P51526 denotes interferon
T48 797-807 P51527 denotes interferon
T49 797-807 D007372 denotes interferon
T50 797-807 D007372 denotes interferon
T51 797-807 CHEBI:52999 denotes interferon
T52 814-845 D052247 denotes inducible nitric oxide synthase
T56 824-836 7442 denotes nitric oxide
T57 824-845 O61309 denotes nitric oxide synthase
T58 824-845 Q8T8C0 denotes nitric oxide synthase
T59 824-845 Q9I9M2 denotes nitric oxide synthase
T60 824-845 Q27571 denotes nitric oxide synthase
T62 824-845 O61608 denotes nitric oxide synthase
T67 846-850 SO:0000234 denotes mRNA
T65 846-850 D012333 denotes mRNA
T66 846-850 CHEBI:33699 denotes mRNA
T68 888-897 GO:0097194 denotes apoptosis
T69 888-897 GO:0006915 denotes apoptosis
T71 955-961 975119 denotes turkey
T70 955-961 9103 denotes turkey
T74 981-988 892653 denotes chicken
T72 981-988 D002645 denotes chicken
T73 981-988 9031 denotes chicken
T75 989-992 PR:P02930 denotes TOC
T76 989-992 C536164 denotes TOC
T77 1058-1065 D014422 denotes turkeys
T78 1095-1105 P51526 denotes interferon
T79 1095-1105 P51527 denotes interferon
T80 1095-1105 D007372 denotes interferon
T81 1095-1105 D007372 denotes interferon
T82 1095-1105 CHEBI:52999 denotes interferon
T83 1126-1135 SO:0000119 denotes regulated
T84 1161-1170 D007239 denotes infection
T85 1161-1170 D007239 denotes infection
T86 1277-1308 D052247 denotes Inducible nitric oxide synthase
T90 1287-1299 7442 denotes nitric oxide
T91 1287-1308 O61309 denotes nitric oxide synthase
T92 1287-1308 Q8T8C0 denotes nitric oxide synthase
T93 1287-1308 Q9I9M2 denotes nitric oxide synthase
T94 1287-1308 Q27571 denotes nitric oxide synthase
T96 1287-1308 O61608 denotes nitric oxide synthase
T99 1341-1350 SO:0000119 denotes regulated
T100 1499-1511 GO:0009405 denotes pathogenesis
T101 1520-1527 D014422 denotes turkeys
T102 1532-1540 D002645 denotes chickens
T103 1532-1540 9031 denotes chickens
T104 1572-1581 GO:0097194 denotes apoptosis
T105 1572-1581 GO:0006915 denotes apoptosis
T106 1669-1691 GO:0045087 denotes innate immune response
T108 1692-1702 GO:0065007 denotes regulation
T109 1878-1898 D060085 denotes secondary infections
T110 1878-1898 D060085 denotes secondary infections
T111 1902-1909 D014422 denotes turkeys

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 118-247 DRI_Challenge denotes Avian metapneumovirus (aMPV) is a pathogen with worldwide distribution, which can cause high economic losses in infected poultry.
T2 248-383 DRI_Background denotes aMPV mainly causes infection of the upper respiratory tract in both chickens and turkeys, although turkeys seem to be more susceptible.
T3 384-474 DRI_Background denotes Little is known about virus-host interactions at epithelial surfaces after aMPV infection.
T4 475-594 DRI_Background denotes Tracheal organ cultures (TOC) are a suitable model to investigate virus-host interaction in the respiratory epithelium.
T5 595-749 DRI_Approach denotes Therefore, we investigated virus replication rates and lesion development in chicken and turkey TOC after infection with a virulent aMPV subtype A strain.
T6 750-914 DRI_Background denotes Aspects of the innate immune response, such as interferon-α and inducible nitric oxide synthase mRNA expression, as well as virus-induced apoptosis were determined.
T7 915-1090 DRI_Outcome denotes The aMPV-replication rate was higher in turkey (TTOC) compared to chicken TOC (CTOC) (P < 0.05), providing circumstantial evidence that indeed turkeys may be more susceptible.
T8 1091-1276 DRI_Outcome denotes The interferon-α response was down-regulated from 2 to 144 hours post infection in both species compared to virus-free controls (P < 0.05); this was more significant for CTOC than TTOC.
T9 1277-1353 DRI_Background denotes Inducible nitric oxide synthase expression was significantly up-regulated in
T10 1375-1427 DRI_Background denotes and CTOC compared to virus-free controls (P < 0.05).
T11 1428-1626 DRI_Challenge denotes However, the results suggest that NO may play a different role in aMPV pathogenesis between turkeys and chickens as indicated by differences in apoptosis rate and lesion development between species.
T12 1627-1910 DRI_Outcome denotes Overall, our study reveals differences in innate immune response regulation and therefore may explain differences in aMPV - A replication rates between infected TTOC and CTOC, which subsequently lead to more severe clinical signs and a higher rate of secondary infections in turkeys.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 150-151 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 509-510 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 606-608 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T4 628-639 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T5 716-717 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 740-741 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T7 924-935 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T8 1066-1069 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T9 1141-1145 CVCL_R880|Spontaneously_immortalized_cell_line|Oreochromis mossambicus x Oreochromis niloticus denotes 2 to
T10 1146-1149 CVCL_D328|Transformed_cell_line|Homo sapiens denotes 144
T11 1359-1360 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T12 1465-1468 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T13 1474-1475 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 1717-1720 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may
T15 1751-1752 CVCL_6479|Finite_cell_line|Mus musculus denotes A
T16 1753-1764 CVCL_XY58|Transformed_cell_line|Mus musculus denotes replication
T17 1861-1862 CVCL_6479|Finite_cell_line|Mus musculus denotes a