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PubMed:26356817 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-99 Sentence denotes An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC.
TextSentencer_T2 100-332 Sentence denotes The downregulation of transforming growth factor-β (TGF-β) type II receptor (TβRII) expression and function plays a pivotal role in the loss of the TGF-β-induced tumor suppressor function that contributes to lung cancer progression.
TextSentencer_T3 333-455 Sentence denotes The aberrant expression of miRNAs has been shown to be involved in the regulation of oncogenes and tumor suppressor genes.
TextSentencer_T4 456-664 Sentence denotes Our current study involving miRNA microarray, northern blot and QRT-PCR analysis shows an inverse correlation between miR-20a and TβRII expression in non-small cell lung cancer (NSCLC) tissues and cell lines.
TextSentencer_T5 665-860 Sentence denotes Stable expression of miR-20a downregulates TβRII in lung epithelial cells which results in an inhibition of TGF-β signaling and attenuation of TGF-β-induced cell growth suppression and apoptosis.
TextSentencer_T6 861-974 Sentence denotes Stable knock down of miR-20a increases TβRII expression and inhibits tumorigenicity of lung cancer cells in vivo.
TextSentencer_T7 975-1111 Sentence denotes Oncogene c-Myc promotes miR-20a expression by activating its promoter leading to downregulation of TβRII expression and TGF-ß signaling.
TextSentencer_T8 1112-1232 Sentence denotes MiR-145, which is upregulated by TGF-β, inhibits miR-20a expression by targeting c-Myc and upregulates TβRII expression.
TextSentencer_T9 1233-1347 Sentence denotes These correlations among miRNAs and cellular proteins are supported by TCGA public database using NSCLC specimens.
TextSentencer_T10 1348-1552 Sentence denotes These results suggest a novel mechanism for the loss of TβRII expression and TGF-β-induced tumor suppressor functions in lung cancer through a complex auto-feedback loop TGF-β/miR-145/c-Myc/miR-20a/TβRII.
T1 0-99 Sentence denotes An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC.
T2 100-332 Sentence denotes The downregulation of transforming growth factor-β (TGF-β) type II receptor (TβRII) expression and function plays a pivotal role in the loss of the TGF-β-induced tumor suppressor function that contributes to lung cancer progression.
T3 333-455 Sentence denotes The aberrant expression of miRNAs has been shown to be involved in the regulation of oncogenes and tumor suppressor genes.
T4 456-664 Sentence denotes Our current study involving miRNA microarray, northern blot and QRT-PCR analysis shows an inverse correlation between miR-20a and TβRII expression in non-small cell lung cancer (NSCLC) tissues and cell lines.
T5 665-860 Sentence denotes Stable expression of miR-20a downregulates TβRII in lung epithelial cells which results in an inhibition of TGF-β signaling and attenuation of TGF-β-induced cell growth suppression and apoptosis.
T6 861-974 Sentence denotes Stable knock down of miR-20a increases TβRII expression and inhibits tumorigenicity of lung cancer cells in vivo.
T7 975-1111 Sentence denotes Oncogene c-Myc promotes miR-20a expression by activating its promoter leading to downregulation of TβRII expression and TGF-ß signaling.
T8 1112-1232 Sentence denotes MiR-145, which is upregulated by TGF-β, inhibits miR-20a expression by targeting c-Myc and upregulates TβRII expression.
T9 1233-1347 Sentence denotes These correlations among miRNAs and cellular proteins are supported by TCGA public database using NSCLC specimens.
T10 1348-1552 Sentence denotes These results suggest a novel mechanism for the loss of TβRII expression and TGF-β-induced tumor suppressor functions in lung cancer through a complex auto-feedback loop TGF-β/miR-145/c-Myc/miR-20a/TβRII.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26356817-0#43#65#gene7048 43-65 gene7048 denotes TGF-β type II receptor
26356817-0#93#98#diseaseC0007131 93-98 diseaseC0007131 denotes NSCLC
26356817-3#118#125#gene406982 574-581 gene406982 denotes miR-20a
26356817-3#150#176#diseaseC0007131 606-632 diseaseC0007131 denotes non-small cell lung cancer
26356817-3#178#183#diseaseC0007131 634-639 diseaseC0007131 denotes NSCLC
26356817-5#21#28#gene406982 882-889 gene406982 denotes miR-20a
26356817-5#87#98#diseaseC0242379 948-959 diseaseC0242379 denotes lung cancer
26356817-5#87#98#diseaseC0684249 948-959 diseaseC0684249 denotes lung cancer
26356817-5#87#98#diseaseC1306460 948-959 diseaseC1306460 denotes lung cancer
26356817-9#56#61#gene7048 1404-1409 gene7048 denotes TβRII
26356817-9#121#132#diseaseC0242379 1469-1480 diseaseC0242379 denotes lung cancer
26356817-9#121#132#diseaseC0684249 1469-1480 diseaseC0684249 denotes lung cancer
26356817-9#121#132#diseaseC1306460 1469-1480 diseaseC1306460 denotes lung cancer
43#65#gene704893#98#diseaseC0007131 26356817-0#43#65#gene7048 26356817-0#93#98#diseaseC0007131 associated_with TGF-β type II receptor,NSCLC
118#125#gene406982150#176#diseaseC0007131 26356817-3#118#125#gene406982 26356817-3#150#176#diseaseC0007131 associated_with miR-20a,non-small cell lung cancer
118#125#gene406982178#183#diseaseC0007131 26356817-3#118#125#gene406982 26356817-3#178#183#diseaseC0007131 associated_with miR-20a,NSCLC
21#28#gene40698287#98#diseaseC0242379 26356817-5#21#28#gene406982 26356817-5#87#98#diseaseC0242379 associated_with miR-20a,lung cancer
21#28#gene40698287#98#diseaseC0684249 26356817-5#21#28#gene406982 26356817-5#87#98#diseaseC0684249 associated_with miR-20a,lung cancer
21#28#gene40698287#98#diseaseC1306460 26356817-5#21#28#gene406982 26356817-5#87#98#diseaseC1306460 associated_with miR-20a,lung cancer
56#61#gene7048121#132#diseaseC0242379 26356817-9#56#61#gene7048 26356817-9#121#132#diseaseC0242379 associated_with TβRII,lung cancer
56#61#gene7048121#132#diseaseC0684249 26356817-9#56#61#gene7048 26356817-9#121#132#diseaseC0684249 associated_with TβRII,lung cancer
56#61#gene7048121#132#diseaseC1306460 26356817-9#56#61#gene7048 26356817-9#121#132#diseaseC1306460 associated_with TβRII,lung cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2202 882-889 gene:406982 denotes miR-20a
T2203 948-959 disease:C0242379 denotes lung cancer
T2204 1404-1409 gene:7048 denotes TβRII
T2205 1469-1480 disease:C0242379 denotes lung cancer
R1 T2202 T2203 associated_with miR-20a,lung cancer
R2 T2202 T2203 associated_with miR-20a,lung cancer
R3 T2202 T2203 associated_with miR-20a,lung cancer
R4 T2204 T2205 associated_with TβRII,lung cancer
R5 T2204 T2205 associated_with TβRII,lung cancer
R6 T2204 T2205 associated_with TβRII,lung cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 308-312 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 621-625 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 717-721 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 948-952 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T5 1469-1473 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T6 641-648 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 641-648 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 308-312 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 621-625 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 717-721 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T5 948-952 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T6 1469-1473 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung