PubMed:26351076
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/26351076","sourcedb":"PubMed","sourceid":"26351076","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/26351076","text":"STAT1 modification improves therapeutic effects of interferons on lung cancer cells.\nBACKGROUND: Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it difficult to achieve sustained therapeutic levels especially in solid tumors.\nMETHODS: Signal Transducer and Activator of Transcription 1 (STAT1) or a modified STAT1 (designated STAT1-CC) that is hyper-responsive to IFN were overexpressed in lung cancer SPC-A-1 and H1299 cells using lentiviral vectors. Transduction efficiency was monitored using enhanced green fluorescent protein (EGFP) expression. After transduction, cells were treated with interferon-gamma (IFN-γ) or interferon-beta (IFN-β) and monitored for cell proliferation, migration, and invasiveness using Cell Counting Kit-8 and transwell chamber assays and for apoptosis using Annexin V detection by flow cytometry. In addition, levels of STAT1, STAT1 Tyr-701 phosphorylation (pSTAT1), fibronectin, and β-catenin were determined using western blotting. In the case of IFN-γ stimulation, levels of S100A4, proliferating cell nuclear antigen (PCNA), and c-fos expression were also determined.\nRESULTS: We found that expression of STAT1 or STAT1-CC enhanced the effect of IFN-γ and, IFN-β on inhibition of human lung cancer cell proliferation, migration and invasiveness. Moreover, STAT1 and STAT1-CC expression caused increases in pSTAT1 and decreases in fibronectin and β-catenin levels. STAT1-CC showed increased effects compared to STAT1 on IFN-γ induced pSTAT1 and down-regulation of S100A4, PCNA, and c-fos levels.\nCONCLUSION: The results show that STAT1-CC exhibited more strength in improving the antitumor response of IFNs in lung cancer cells. Results from this study suggest that combined treatment of IFNs and STAT1-CC might be a feasible approach for the clinical management of lung cancer in the future.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":66,"end":70},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":545,"end":549},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1378,"end":1382},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1801,"end":1805},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1957,"end":1961},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":85,"end":96},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":97,"end":210},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":211,"end":380},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":381,"end":389},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":390,"end":606},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":607,"end":704},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":705,"end":984},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":985,"end":1121},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1122,"end":1259},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1260,"end":1268},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1269,"end":1437},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1438,"end":1555},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1556,"end":1686},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1687,"end":1698},"obj":"Sentence"},{"id":"TextSentencer_T16","span":{"begin":1699,"end":1819},"obj":"Sentence"},{"id":"TextSentencer_T17","span":{"begin":1820,"end":1983},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T2","span":{"begin":85,"end":96},"obj":"Sentence"},{"id":"T3","span":{"begin":97,"end":210},"obj":"Sentence"},{"id":"T4","span":{"begin":211,"end":380},"obj":"Sentence"},{"id":"T5","span":{"begin":381,"end":389},"obj":"Sentence"},{"id":"T6","span":{"begin":390,"end":606},"obj":"Sentence"},{"id":"T7","span":{"begin":607,"end":704},"obj":"Sentence"},{"id":"T8","span":{"begin":705,"end":984},"obj":"Sentence"},{"id":"T9","span":{"begin":985,"end":1121},"obj":"Sentence"},{"id":"T10","span":{"begin":1122,"end":1259},"obj":"Sentence"},{"id":"T11","span":{"begin":1260,"end":1268},"obj":"Sentence"},{"id":"T12","span":{"begin":1269,"end":1437},"obj":"Sentence"},{"id":"T13","span":{"begin":1438,"end":1555},"obj":"Sentence"},{"id":"T14","span":{"begin":1556,"end":1686},"obj":"Sentence"},{"id":"T15","span":{"begin":1687,"end":1698},"obj":"Sentence"},{"id":"T16","span":{"begin":1699,"end":1819},"obj":"Sentence"},{"id":"T17","span":{"begin":1820,"end":1983},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T13","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T14","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T15","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T16","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T17","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T15","pred":"source","obj":"sentences"},{"subj":"T16","pred":"source","obj":"sentences"},{"subj":"T17","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":66,"end":70},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":545,"end":549},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1378,"end":1382},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1801,"end":1805},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":1957,"end":1961},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"UBERON-AE"}]},{"project":"DisGeNet-2017-sample","denotations":[{"id":"T2373","span":{"begin":0,"end":5},"obj":"gene:6772"},{"id":"T2374","span":{"begin":66,"end":77},"obj":"disease:C0242379"},{"id":"T2375","span":{"begin":557,"end":560},"obj":"gene:5541"},{"id":"T2376","span":{"begin":545,"end":556},"obj":"disease:C0242379"},{"id":"T2379","span":{"begin":1349,"end":1354},"obj":"gene:3456"},{"id":"T2380","span":{"begin":1378,"end":1389},"obj":"disease:C0242379"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T2373","obj":"T2374"},{"id":"R2","pred":"associated_with","subj":"T2373","obj":"T2374"},{"id":"R3","pred":"associated_with","subj":"T2373","obj":"T2374"},{"id":"R4","pred":"associated_with","subj":"T2375","obj":"T2376"},{"id":"R5","pred":"associated_with","subj":"T2375","obj":"T2376"},{"id":"R6","pred":"associated_with","subj":"T2375","obj":"T2376"},{"id":"R7","pred":"associated_with","subj":"T2375","obj":"T2376"},{"id":"R8","pred":"associated_with","subj":"T2375","obj":"T2376"},{"id":"R9","pred":"associated_with","subj":"T2375","obj":"T2376"},{"id":"R1","pred":"associated_with","subj":"T2379","obj":"T2380"},{"id":"R2","pred":"associated_with","subj":"T2379","obj":"T2380"},{"id":"R3","pred":"associated_with","subj":"T2379","obj":"T2380"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T2373","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2374","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2375","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2376","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2379","pred":"source","obj":"DisGeNet-2017-sample"},{"subj":"T2380","pred":"source","obj":"DisGeNet-2017-sample"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"26351076-0#0#5#gene6772","span":{"begin":481,"end":486},"obj":"gene6772"},{"id":"26351076-0#66#77#diseaseC0242379","span":{"begin":1801,"end":1812},"obj":"diseaseC0242379"},{"id":"26351076-0#66#77#diseaseC0684249","span":{"begin":1801,"end":1812},"obj":"diseaseC0684249"},{"id":"26351076-0#66#77#diseaseC1306460","span":{"begin":1801,"end":1812},"obj":"diseaseC1306460"},{"id":"26351076-3#167#170#gene5541","span":{"begin":557,"end":560},"obj":"gene5541"},{"id":"26351076-3#167#170#gene114131","span":{"begin":557,"end":560},"obj":"gene114131"},{"id":"26351076-3#0#50#gene6772","span":{"begin":390,"end":440},"obj":"gene6772"},{"id":"26351076-3#52#57#gene6772","span":{"begin":442,"end":447},"obj":"gene6772"},{"id":"26351076-3#73#78#gene6772","span":{"begin":463,"end":468},"obj":"gene6772"},{"id":"26351076-3#91#96#gene6772","span":{"begin":481,"end":486},"obj":"gene6772"},{"id":"26351076-3#155#166#diseaseC0242379","span":{"begin":545,"end":556},"obj":"diseaseC0242379"},{"id":"26351076-3#155#166#diseaseC0684249","span":{"begin":545,"end":556},"obj":"diseaseC0684249"},{"id":"26351076-3#155#166#diseaseC1306460","span":{"begin":545,"end":556},"obj":"diseaseC1306460"},{"id":"26351076-3#155#166#diseaseC0242379","span":{"begin":545,"end":556},"obj":"diseaseC0242379"},{"id":"26351076-3#155#166#diseaseC0684249","span":{"begin":545,"end":556},"obj":"diseaseC0684249"},{"id":"26351076-3#155#166#diseaseC1306460","span":{"begin":545,"end":556},"obj":"diseaseC1306460"},{"id":"26351076-3#109#114#diseaseC0424295","span":{"begin":499,"end":504},"obj":"diseaseC0424295"},{"id":"26351076-8#80#85#gene3456","span":{"begin":1349,"end":1354},"obj":"gene3456"},{"id":"26351076-8#109#120#diseaseC0242379","span":{"begin":1378,"end":1389},"obj":"diseaseC0242379"},{"id":"26351076-8#109#120#diseaseC0684249","span":{"begin":1378,"end":1389},"obj":"diseaseC0684249"},{"id":"26351076-8#109#120#diseaseC1306460","span":{"begin":1378,"end":1389},"obj":"diseaseC1306460"}],"relations":[{"id":"0#5#gene677266#77#diseaseC0242379","pred":"associated_with","subj":"26351076-0#0#5#gene6772","obj":"26351076-0#66#77#diseaseC0242379"},{"id":"0#5#gene677266#77#diseaseC0684249","pred":"associated_with","subj":"26351076-0#0#5#gene6772","obj":"26351076-0#66#77#diseaseC0684249"},{"id":"0#5#gene677266#77#diseaseC1306460","pred":"associated_with","subj":"26351076-0#0#5#gene6772","obj":"26351076-0#66#77#diseaseC1306460"},{"id":"167#170#gene5541155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"167#170#gene5541155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"167#170#gene5541155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"167#170#gene5541155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"167#170#gene5541155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"167#170#gene5541155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"167#170#gene5541109#114#diseaseC0424295","pred":"associated_with","subj":"26351076-3#167#170#gene5541","obj":"26351076-3#109#114#diseaseC0424295"},{"id":"167#170#gene114131155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"167#170#gene114131155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"167#170#gene114131155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"167#170#gene114131155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"167#170#gene114131155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"167#170#gene114131155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"167#170#gene114131109#114#diseaseC0424295","pred":"associated_with","subj":"26351076-3#167#170#gene114131","obj":"26351076-3#109#114#diseaseC0424295"},{"id":"0#50#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"0#50#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"0#50#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"0#50#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"0#50#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"0#50#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"0#50#gene6772109#114#diseaseC0424295","pred":"associated_with","subj":"26351076-3#0#50#gene6772","obj":"26351076-3#109#114#diseaseC0424295"},{"id":"52#57#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"52#57#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"52#57#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"52#57#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"52#57#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"52#57#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"52#57#gene6772109#114#diseaseC0424295","pred":"associated_with","subj":"26351076-3#52#57#gene6772","obj":"26351076-3#109#114#diseaseC0424295"},{"id":"73#78#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"73#78#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"73#78#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"73#78#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"73#78#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"73#78#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"73#78#gene6772109#114#diseaseC0424295","pred":"associated_with","subj":"26351076-3#73#78#gene6772","obj":"26351076-3#109#114#diseaseC0424295"},{"id":"91#96#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"91#96#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"91#96#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"91#96#gene6772155#166#diseaseC0242379","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#155#166#diseaseC0242379"},{"id":"91#96#gene6772155#166#diseaseC0684249","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#155#166#diseaseC0684249"},{"id":"91#96#gene6772155#166#diseaseC1306460","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#155#166#diseaseC1306460"},{"id":"91#96#gene6772109#114#diseaseC0424295","pred":"associated_with","subj":"26351076-3#91#96#gene6772","obj":"26351076-3#109#114#diseaseC0424295"},{"id":"80#85#gene3456109#120#diseaseC0242379","pred":"associated_with","subj":"26351076-8#80#85#gene3456","obj":"26351076-8#109#120#diseaseC0242379"},{"id":"80#85#gene3456109#120#diseaseC0684249","pred":"associated_with","subj":"26351076-8#80#85#gene3456","obj":"26351076-8#109#120#diseaseC0684249"},{"id":"80#85#gene3456109#120#diseaseC1306460","pred":"associated_with","subj":"26351076-8#80#85#gene3456","obj":"26351076-8#109#120#diseaseC1306460"}],"attributes":[{"subj":"26351076-0#0#5#gene6772","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-0#66#77#diseaseC0242379","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-0#66#77#diseaseC0684249","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-0#66#77#diseaseC1306460","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#167#170#gene5541","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#167#170#gene114131","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#0#50#gene6772","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#52#57#gene6772","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#73#78#gene6772","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#91#96#gene6772","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#155#166#diseaseC0242379","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#155#166#diseaseC0684249","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#155#166#diseaseC1306460","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#155#166#diseaseC0242379","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#155#166#diseaseC0684249","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#155#166#diseaseC1306460","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-3#109#114#diseaseC0424295","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-8#80#85#gene3456","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-8#109#120#diseaseC0242379","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-8#109#120#diseaseC0684249","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"26351076-8#109#120#diseaseC1306460","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#93b0ec","default":true},{"id":"sentences","color":"#caec93"},{"id":"UBERON-AE","color":"#ec93e4"},{"id":"DisGeNet-2017-sample","color":"#93ecda"},{"id":"DisGeNET5_gene_disease","color":"#ecc093"}]}]}}