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PubMed:26338710 JSONTXT

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GlyCosmos15-Species-PubTator

Id Subject Object Predicate Lexical cue db_id
6865 76-81 Species denotes Human 9606
6883 821-826 Species denotes human 9606

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T3 898-901 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T5 1178-1181 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T7 1225-1228 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T9 1294-1297 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T11 1433-1436 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T13 1579-1582 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI

sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.
T2 110-274 Sentence denotes Vascular endothelial cells (ECs) play central roles in physiologically important functions of blood vessels and contribute to the maintenance of vascular integrity.
T3 275-385 Sentence denotes Therefore, it is considered that the impairment of EC functions leads to the development of vascular diseases.
T4 386-507 Sentence denotes However, the molecular mechanisms of the EC dysfunctions that accompany senescence and aging have not yet been clarified.
T5 508-724 Sentence denotes The carbohydrate antigens carried by glycoconjugates (e.g. glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules.
T6 725-859 Sentence denotes In this study, we have investigated the abundance and functional roles of glycosphingolipids in human ECs during senescence and aging.
T7 860-1046 Sentence denotes Among glycosphingolipids, ganglioside GM1 was highly expressed in abundance on the surface of replicatively and prematurely senescent ECs and also of ECs derived from an elderly subject.
T8 1047-1148 Sentence denotes Insulin signaling, which regulates important functions of ECs, is impaired in senescent and aged ECs.
T9 1149-1369 Sentence denotes Actually, by down-regulating GM1 on senescent ECs and overloading exogenous GM1 onto non-senescent ECs, we showed that an increased abundance of GM1 functionally contributes to the impairment of insulin signaling in ECs.
T10 1370-1578 Sentence denotes Taken together, these findings provide the first evidence that GM1 increases in abundance on the cell surface of ECs under the conditions of cellular senescence and aging and causes insulin resistance in ECs.
T11 1579-1736 Sentence denotes GM1 may be an attractive target for the detection, prevention, and therapy of insulin resistance and related vascular diseases, particularly in older people.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 12-15 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 898-901 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 1178-1181 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1225-1228 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 1294-1297 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 1433-1436 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 1579-1582 GlycoEpitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 12-15 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T2 12-15 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T3 898-901 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T4 898-901 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T5 1178-1181 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T6 1178-1181 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T7 1225-1228 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T8 1225-1228 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T9 1294-1297 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T10 1294-1297 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T11 1433-1436 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T12 1433-1436 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T13 1579-1582 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T14 1579-1582 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 82-90 http://purl.obolibrary.org/obo/MAT_0000034 denotes Arterial
T2 204-217 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessels
T3 204-209 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 204-209 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 367-384 Disease denotes vascular diseases http://purl.obolibrary.org/obo/MONDO_0005385
T2 1688-1705 Disease denotes vascular diseases http://purl.obolibrary.org/obo/MONDO_0005385

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 898-901 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 1178-1181 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 1225-1228 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T5 1294-1297 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T6 1433-1436 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T7 1579-1582 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 82-90 Body_part denotes Arterial http://purl.obolibrary.org/obo/MAT_0000034
T2 204-217 Body_part denotes blood vessels http://purl.obolibrary.org/obo/MAT_0000393

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 44-62 Phenotype denotes Insulin Resistance HP:0000855
T2 1552-1570 Phenotype denotes insulin resistance HP:0000855
T3 1657-1675 Phenotype denotes insulin resistance HP:0000855

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 898-901 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 1178-1181 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 1225-1228 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T5 1294-1297 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T6 1433-1436 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T7 1579-1582 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 12-15 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 898-901 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 1178-1181 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1225-1228 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 1294-1297 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 1433-1436 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 1579-1582 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 44-62 Phenotype denotes Insulin Resistance HP:0000855
T2 1552-1570 Phenotype denotes insulin resistance HP:0000855
T3 1657-1675 Phenotype denotes insulin resistance HP:0000855

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 82-108 Cell denotes Arterial Endothelial Cells http://purl.obolibrary.org/obo/CL:1000413
T2 110-136 Cell denotes Vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139
T3 138-141 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T4 827-830 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T5 994-997 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T6 1010-1013 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T7 1105-1108 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T8 1144-1147 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T9 1195-1198 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T10 1248-1251 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T11 1365-1368 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T12 1483-1486 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T13 1574-1577 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 12-15 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 898-901 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 1178-1181 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1225-1228 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T5 1294-1297 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T6 1433-1436 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T7 1579-1582 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.
T2 110-274 Sentence denotes Vascular endothelial cells (ECs) play central roles in physiologically important functions of blood vessels and contribute to the maintenance of vascular integrity.
T3 275-385 Sentence denotes Therefore, it is considered that the impairment of EC functions leads to the development of vascular diseases.
T4 386-507 Sentence denotes However, the molecular mechanisms of the EC dysfunctions that accompany senescence and aging have not yet been clarified.
T5 508-724 Sentence denotes The carbohydrate antigens carried by glycoconjugates (e.g. glycoproteins, glycosphingolipids, and proteoglycans) mainly present on the cell surface serve not only as marker molecules but also as functional molecules.
T6 725-859 Sentence denotes In this study, we have investigated the abundance and functional roles of glycosphingolipids in human ECs during senescence and aging.
T7 860-1046 Sentence denotes Among glycosphingolipids, ganglioside GM1 was highly expressed in abundance on the surface of replicatively and prematurely senescent ECs and also of ECs derived from an elderly subject.
T8 1047-1148 Sentence denotes Insulin signaling, which regulates important functions of ECs, is impaired in senescent and aged ECs.
T9 1149-1369 Sentence denotes Actually, by down-regulating GM1 on senescent ECs and overloading exogenous GM1 onto non-senescent ECs, we showed that an increased abundance of GM1 functionally contributes to the impairment of insulin signaling in ECs.
T10 1370-1578 Sentence denotes Taken together, these findings provide the first evidence that GM1 increases in abundance on the cell surface of ECs under the conditions of cellular senescence and aging and causes insulin resistance in ECs.
T11 1579-1736 Sentence denotes GM1 may be an attractive target for the detection, prevention, and therapy of insulin resistance and related vascular diseases, particularly in older people.

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 82-108 Body_part denotes Arterial Endothelial Cells http://purl.obolibrary.org/obo/CL_1000413
T2 110-136 Body_part denotes Vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T3 138-141 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T4 204-217 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0004537
T5 827-830 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T6 994-997 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T7 1010-1013 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T8 1105-1108 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T9 1144-1147 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T10 1195-1198 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T11 1248-1251 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T12 1365-1368 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T13 1483-1486 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T14 1574-1577 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 76-81 OrganismTaxon denotes Human 9606
T2 821-826 OrganismTaxon denotes human 9606

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 91-108 Body_part denotes Endothelial Cells FMA:66772
T2 119-136 Body_part denotes endothelial cells FMA:66772
T3 138-141 Body_part denotes ECs FMA:66772
T4 204-217 Body_part denotes blood vessels FMA:63183
T5 643-655 Body_part denotes cell surface FMA:67653
T6 827-830 Body_part denotes ECs FMA:66772
T7 994-997 Body_part denotes ECs FMA:66772
T8 1010-1013 Body_part denotes ECs FMA:66772
T9 1105-1108 Body_part denotes ECs FMA:66772
T10 1144-1147 Body_part denotes ECs FMA:66772
T11 1195-1198 Body_part denotes ECs FMA:66772
T12 1248-1251 Body_part denotes ECs FMA:66772
T13 1365-1368 Body_part denotes ECs FMA:66772
T14 1467-1479 Body_part denotes cell surface FMA:67653
T15 1483-1486 Body_part denotes ECs FMA:66772
T16 1574-1577 Body_part denotes ECs FMA:66772

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 82-90 Body_part denotes Arterial http://purl.obolibrary.org/obo/MAT_0000034
T2 204-217 Body_part denotes blood vessels http://purl.obolibrary.org/obo/MAT_0000393

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 76-81 OrganismTaxon denotes Human 9606
T2 821-826 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 82-108 Body_part denotes Arterial Endothelial Cells http://purl.obolibrary.org/obo/CL_1000413
T2 110-136 Body_part denotes Vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T3 138-141 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T4 204-217 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0004537
T5 827-830 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T6 994-997 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T7 1010-1013 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T8 1105-1108 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T9 1144-1147 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T10 1195-1198 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T11 1248-1251 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T12 1365-1368 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T13 1483-1486 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T14 1574-1577 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 82-108 Cell denotes Arterial Endothelial Cells http://purl.obolibrary.org/obo/CL:1000413
T2 110-136 Cell denotes Vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139
T3 138-141 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T4 827-830 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T5 994-997 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T6 1010-1013 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T7 1105-1108 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T8 1144-1147 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T9 1195-1198 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T10 1248-1251 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T11 1365-1368 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T12 1483-1486 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115
T13 1574-1577 Cell denotes ECs http://purl.obolibrary.org/obo/CL:0000115