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c_corpus

Id Subject Object Predicate Lexical cue
T1 8-12 PR:000005054 denotes Mice
T3 8-12 O89094 denotes Mice
T2 8-12 D051379 denotes Mice
T4 8-12 10095 denotes Mice
T5 37-47 CHEBI:25212 denotes Metabolite
T6 79-84 CHEBI:18059 denotes Lipid
T7 103-106 PR:P51111 denotes HTT
T8 103-106 PR:000015189 denotes HTT
T9 103-106 PR:Q76P24 denotes HTT
T10 103-106 PR:P31645 denotes HTT
T11 103-106 PR:P42859 denotes HTT
T12 103-106 PR:Q60857 denotes HTT
T13 103-106 PR:P42858 denotes HTT
T14 103-106 PR:000008840 denotes HTT
T15 107-110 CVCL_D569 denotes CAG
T16 121-129 SO:0000109 denotes mutation
T21 137-157 D006816 denotes Huntington's Disease
T22 137-157 D006816 denotes Huntington's Disease
T25 238-248 GO:0008152 denotes metabolism
T26 261-267 SO:0001023 denotes allele
T27 313-321 UBERON:0002435 denotes striatum
T28 313-321 UBERON:0005383 denotes striatum
T29 326-332 UBERON:0001851 denotes cortex
T30 405-411 UBERON:0000479 denotes tissue
T31 438-445 D004194 denotes disease
T32 438-445 D004194 denotes disease
T33 486-492 PR:Q54JW9 denotes impact
T34 486-492 PR:Q642J4 denotes impact
T35 507-510 CVCL_D569 denotes CAG
T36 520-526 SO:0001023 denotes allele
T38 556-560 D051379 denotes mice
T40 556-560 10095 denotes mice
T37 556-560 PR:000005054 denotes mice
T39 556-560 O89094 denotes mice
T41 623-629 UBERON:0000479 denotes tissue
T42 756-766 CHEBI:25212 denotes metabolite
T43 807-813 UBERON:0001969 denotes plasma
T44 815-835 UBERON:0001348 denotes brown adipose tissue
T48 837-847 UBERON:0002037 denotes cerebellum
T49 849-857 UBERON:0002435 denotes striatum
T50 849-857 UBERON:0005383 denotes striatum
T51 859-864 UBERON:0002107 denotes liver
T52 866-886 UBERON:0001347 denotes white adipose tissue
T56 999-1008 SO:0000817 denotes wild-type
T57 1020-1024 PR:000005054 denotes mice
T59 1020-1024 O89094 denotes mice
T58 1020-1024 D051379 denotes mice
T60 1020-1024 10095 denotes mice
T61 1065-1068 UBERON:0001013 denotes fat
T62 1065-1068 CHEBI:24021 denotes fat
T63 1138-1149 CHEBI:25212 denotes metabolites
T64 1197-1205 UBERON:0002435 denotes striatum
T65 1197-1205 UBERON:0005383 denotes striatum
T66 1225-1245 UBERON:0001347 denotes white adipose tissue
T70 1271-1274 CVCL_D569 denotes CAG
T71 1284-1290 SO:0001023 denotes allele
T72 1310-1315 UBERON:6110636 denotes brain
T73 1310-1315 UBERON:0000955 denotes brain
T74 1316-1327 CHEBI:25212 denotes metabolites
T75 1350-1361 CHEBI:25212 denotes metabolites
T76 1397-1406 SO:0000817 denotes wild-type
T77 1411-1419 UBERON:0002435 denotes striatum
T78 1411-1419 UBERON:0005383 denotes striatum
T79 1444-1454 UBERON:0002037 denotes cerebellum
T80 1481-1484 CVCL_D569 denotes CAG
T81 1494-1500 SO:0001023 denotes allele
T82 1515-1525 CHEBI:25212 denotes metabolite
T83 1558-1564 UBERON:0000479 denotes tissue
T84 1582-1593 SO:0000068 denotes overlapping
T85 1613-1621 SO:0000109 denotes mutation
T86 1755-1760 CHEBI:18059 denotes lipid
T87 1781-1789 SO:0001027 denotes genotype
T88 1801-1811 CHEBI:25212 denotes metabolite
T89 1827-1835 UBERON:0002435 denotes striatum
T90 1827-1835 UBERON:0005383 denotes striatum
T91 1894-1899 CHEBI:18059 denotes lipid
T92 1992-2002 CHEBI:25212 denotes metabolite
T93 2026-2029 CVCL_D569 denotes CAG
T94 2040-2048 SO:0000109 denotes mutation
T95 2062-2068 UBERON:0000479 denotes tissue
T96 2098-2103 UBERON:6110636 denotes brain
T97 2098-2103 UBERON:0000955 denotes brain
T98 2115-2123 UBERON:0002435 denotes striatum
T99 2115-2123 UBERON:0005383 denotes striatum
T100 2133-2142 SO:0001978 denotes signature
T101 2168-2174 D008055 denotes lipids
T102 2168-2174 CHEBI:18059 denotes lipids
T103 2168-2174 D008055 denotes lipids
T104 2185-2198 CHEBI:89483 denotes sphingomyelin
T105 2185-2198 CHEBI:62490 denotes sphingomyelin
T106 2185-2198 CHEBI:89490 denotes sphingomyelin
T107 2185-2198 CHEBI:89482 denotes sphingomyelin
T108 2185-2198 CHEBI:17636 denotes sphingomyelin
T109 2185-2198 CHEBI:64583 denotes sphingomyelin
T110 2185-2198 CHEBI:89488 denotes sphingomyelin
T111 2185-2198 CHEBI:89491 denotes sphingomyelin
T112 2200-2219 D010713 denotes phosphatidylcholine
T113 2200-2219 CHEBI:64482 denotes phosphatidylcholine
T114 2200-2219 CHEBI:16110 denotes phosphatidylcholine
T115 2200-2219 D010713 denotes phosphatidylcholine
T116 2200-2219 CHEBI:57643 denotes phosphatidylcholine
T119 2221-2232 2438 denotes cholesterol
T121 2221-2238 CHEBI:17002 denotes cholesterol ester
T123 2243-2255 CHEBI:17855 denotes triglyceride
T124 2243-2255 CHEBI:88980 denotes triglyceride
T125 2243-2255 CHEBI:89757 denotes triglyceride
T126 2243-2255 CHEBI:89950 denotes triglyceride
T127 2243-2255 CHEBI:89011 denotes triglyceride
T128 2243-2255 CHEBI:89016 denotes triglyceride
T129 2243-2255 CHEBI:90053 denotes triglyceride
T130 2243-2255 CHEBI:89754 denotes triglyceride
T131 2243-2255 CHEBI:88982 denotes triglyceride
T132 2243-2255 CHEBI:90054 denotes triglyceride
T133 2243-2255 CHEBI:89765 denotes triglyceride
T134 2243-2255 CHEBI:88986 denotes triglyceride
T135 2243-2255 CHEBI:89759 denotes triglyceride
T136 2243-2255 CHEBI:88941 denotes triglyceride
T137 2243-2255 CHEBI:89024 denotes triglyceride
T138 2243-2255 CHEBI:89776 denotes triglyceride
T139 2243-2255 CHEBI:88971 denotes triglyceride
T140 2243-2255 CHEBI:88899 denotes triglyceride
T141 2243-2255 CHEBI:89958 denotes triglyceride
T142 2243-2255 CHEBI:88891 denotes triglyceride
T143 2243-2255 CHEBI:88984 denotes triglyceride
T144 2243-2255 CHEBI:90072 denotes triglyceride
T145 2243-2255 CHEBI:89841 denotes triglyceride
T146 2243-2255 CHEBI:89948 denotes triglyceride
T147 2243-2255 CHEBI:88993 denotes triglyceride
T148 2243-2255 CHEBI:89768 denotes triglyceride
T149 2243-2255 CHEBI:88977 denotes triglyceride
T150 2243-2255 CHEBI:88995 denotes triglyceride
T151 2243-2255 CHEBI:88994 denotes triglyceride
T152 2243-2255 CHEBI:89779 denotes triglyceride
T153 2243-2255 CHEBI:88979 denotes triglyceride
T154 2243-2255 CHEBI:89767 denotes triglyceride
T155 2243-2255 CHEBI:89166 denotes triglyceride
T156 2243-2255 CHEBI:88967 denotes triglyceride
T157 2243-2255 CHEBI:88978 denotes triglyceride
T158 2243-2255 CHEBI:88881 denotes triglyceride
T159 2243-2255 CHEBI:89025 denotes triglyceride
T160 2243-2255 CHEBI:90051 denotes triglyceride
T161 2243-2255 CHEBI:89777 denotes triglyceride
T162 2243-2255 CHEBI:88987 denotes triglyceride
T163 2243-2255 CHEBI:90048 denotes triglyceride
T164 2243-2255 CHEBI:90069 denotes triglyceride
T165 2243-2255 CHEBI:89971 denotes triglyceride
T166 2243-2255 CHEBI:89018 denotes triglyceride
T167 2243-2255 CHEBI:88875 denotes triglyceride
T168 2243-2255 CHEBI:88976 denotes triglyceride
T169 2243-2255 CHEBI:90073 denotes triglyceride
T170 2243-2255 CHEBI:90066 denotes triglyceride
T171 2243-2255 CHEBI:89019 denotes triglyceride
T172 2243-2255 CHEBI:90050 denotes triglyceride
T173 2243-2255 CHEBI:89756 denotes triglyceride
T174 2243-2255 CHEBI:89840 denotes triglyceride
T175 2243-2255 CHEBI:88898 denotes triglyceride
T176 2243-2255 CHEBI:89764 denotes triglyceride
T177 2243-2255 CHEBI:88901 denotes triglyceride
T178 2243-2255 CHEBI:89021 denotes triglyceride
T179 2243-2255 CHEBI:89772 denotes triglyceride
T180 2243-2255 CHEBI:89775 denotes triglyceride
T181 2243-2255 CHEBI:88943 denotes triglyceride
T182 2243-2255 CHEBI:89959 denotes triglyceride
T183 2243-2255 CHEBI:89842 denotes triglyceride
T184 2243-2255 CHEBI:88970 denotes triglyceride
T185 2243-2255 CHEBI:89003 denotes triglyceride
T186 2243-2255 CHEBI:88946 denotes triglyceride
T187 2243-2255 CHEBI:89758 denotes triglyceride
T188 2243-2255 CHEBI:88945 denotes triglyceride
T189 2243-2255 CHEBI:88999 denotes triglyceride
T190 2243-2255 CHEBI:88968 denotes triglyceride
T191 2243-2255 CHEBI:89774 denotes triglyceride
T192 2243-2255 CHEBI:89960 denotes triglyceride
T193 2243-2255 CHEBI:88890 denotes triglyceride
T194 2243-2255 CHEBI:89022 denotes triglyceride
T195 2243-2255 CHEBI:88940 denotes triglyceride
T196 2243-2255 CHEBI:89952 denotes triglyceride
T197 2243-2255 CHEBI:89017 denotes triglyceride
T198 2243-2255 CHEBI:88997 denotes triglyceride
T199 2243-2255 CHEBI:90067 denotes triglyceride
T200 2243-2255 CHEBI:89001 denotes triglyceride
T201 2243-2255 CHEBI:88972 denotes triglyceride
T202 2243-2255 CHEBI:90070 denotes triglyceride
T203 2243-2255 CHEBI:88882 denotes triglyceride
T204 2243-2255 CHEBI:88892 denotes triglyceride
T205 2243-2255 CHEBI:89020 denotes triglyceride
T206 2243-2255 CHEBI:89005 denotes triglyceride
T207 2243-2255 CHEBI:89961 denotes triglyceride
T208 2243-2255 CHEBI:88998 denotes triglyceride
T209 2243-2255 CHEBI:90042 denotes triglyceride
T210 2243-2255 CHEBI:88880 denotes triglyceride
T211 2243-2255 CHEBI:88983 denotes triglyceride
T212 2243-2255 CHEBI:88973 denotes triglyceride
T213 2243-2255 CHEBI:89763 denotes triglyceride
T214 2243-2255 CHEBI:90049 denotes triglyceride
T215 2243-2255 CHEBI:90052 denotes triglyceride
T216 2243-2255 CHEBI:89023 denotes triglyceride
T217 2243-2255 CHEBI:90047 denotes triglyceride
T218 2243-2255 CHEBI:88985 denotes triglyceride
T219 2243-2255 CHEBI:89962 denotes triglyceride
T220 2301-2304 CVCL_D569 denotes CAG
T221 2305-2313 SO:0000109 denotes mutation
T222 2315-2325 CHEBI:25212 denotes metabolite
T223 2393-2404 D004041 denotes dietary fat
T224 2393-2404 D004041 denotes dietary fat
T225 2401-2404 UBERON:0001013 denotes fat
T227 2478-2486 SO:0000109 denotes mutation
T228 2487-2495 CHEBI:78059 denotes carriers

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-98 DRI_Outcome denotes HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.
T2 99-249 DRI_Challenge denotes The HTT CAG expansion mutation causes Huntington's Disease and is associated with a wide range of cellular consequences, including altered metabolism.
T3 250-374 DRI_Challenge denotes The mutant allele is expressed widely, in all tissues, but the striatum and cortex are especially vulnerable to its effects.
T4 375-698 DRI_Challenge denotes To more fully understand this tissue-specificity, early in the disease process, we asked whether the metabolic impact of the mutant CAG expanded allele in heterozygous B6.HdhQ111/+ mice would be common across tissues, or whether tissues would have tissue-specific responses and whether such changes may be affected by diet.
T5 699-1075 DRI_Approach denotes Specifically, we cross-sectionally examined steady state metabolite concentrations from a range of tissues (plasma, brown adipose tissue, cerebellum, striatum, liver, white adipose tissue), using an established liquid chromatography-mass spectrometry pipeline, from cohorts of 8 month old mutant and wild-type littermate mice that were fed one of two different high-fat diets.
T6 1076-1246 DRI_Approach denotes The differential response to diet highlighted a proportion of metabolites in all tissues, ranging from 3% (7/219) in the striatum to 12% (25/212) in white adipose tissue.
T7 1247-1455 DRI_Background denotes By contrast, the mutant CAG-expanded allele primarily affected brain metabolites, with 14% (30/219) of metabolites significantly altered, compared to wild-type, in striatum and 11% (25/224) in the cerebellum.
T8 1456-1686 DRI_Outcome denotes In general, diet and the CAG-expanded allele both elicited metabolite changes that were predominantly tissue-specific and non-overlapping, with evidence for mutation-by-diet interaction in peripheral tissues most affected by diet.
T9 1687-1836 DRI_Background denotes Machine-learning approaches highlighted the accumulation of diverse lipid species as the most genotype-predictive metabolite changes in the striatum.
T10 1837-1985 DRI_Background denotes Validation experiments in cell culture demonstrated that lipid accumulation was also a defining feature of mutant HdhQ111 striatal progenitor cells.
T11 1986-2264 DRI_Outcome denotes Thus, metabolite-level responses to the CAG expansion mutation in vivo were tissue specific and most evident in brain, where the striatum featured signature accumulation of a set of lipids including sphingomyelin, phosphatidylcholine, cholesterol ester and triglyceride species.
T12 2265-2535 DRI_Challenge denotes Importantly, in the presence of the CAG mutation, metabolite changes were unmasked in peripheral tissues by an interaction with dietary fat, implying that the design of studies to discover metabolic changes in HD mutation carriers should include metabolic perturbations.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26295712-1#4#7#gene3064 103-106 gene3064 denotes HTT
26295712-1#38#58#diseaseC0020179 137-157 diseaseC0020179 denotes Huntington's Disease
4#7#gene306438#58#diseaseC0020179 26295712-1#4#7#gene3064 26295712-1#38#58#diseaseC0020179 associated_with HTT,Huntington's Disease