> top > docs > PubMed:26282470 > annotations

PubMed:26282470 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 18-23 PR:Q5S006 denotes LRRK2
T2 18-23 PR:000003033 denotes LRRK2
T3 18-23 PR:Q5S007 denotes LRRK2
T4 46-50 original_id denotes term
T5 79-88 SO:0000817 denotes wild-type
T6 100-105 PR:Q5S006 denotes LRRK2
T7 100-105 PR:000003033 denotes LRRK2
T8 100-105 PR:Q5S007 denotes LRRK2
T9 169-179 GO:0065007 denotes regulation
T14 183-191 3628 denotes dopamine
T10 183-191 CHEBI:59905 denotes dopamine
T11 183-191 CHEBI:18243 denotes dopamine
T12 183-191 D004298 denotes dopamine
T13 183-191 D004298 denotes dopamine
T19 252-259 SO:0000104 denotes protein
T18 252-259 PR:000000001 denotes protein
T16 252-259 CHEBI:36080 denotes protein
T17 252-259 CHEBI:11122 denotes protein
T15 252-259 GO:0003675 denotes protein
T20 260-265 PR:Q5S006 denotes LRRK2
T21 260-265 PR:000003033 denotes LRRK2
T22 260-265 PR:Q5S007 denotes LRRK2
T24 281-290 70602 denotes glutamate
T23 281-290 CHEBI:29987 denotes glutamate
T25 281-290 D018698 denotes glutamate
T26 281-290 CHEBI:16015 denotes glutamate
T27 281-290 D018698 denotes glutamate
T28 281-290 CHEBI:14321 denotes glutamate
T29 281-290 CHEBI:18237 denotes glutamate
T34 294-302 3628 denotes dopamine
T30 294-302 CHEBI:59905 denotes dopamine
T31 294-302 CHEBI:18243 denotes dopamine
T32 294-302 D004298 denotes dopamine
T33 294-302 D004298 denotes dopamine
T35 314-319 UBERON:0007023 denotes adult
T37 320-324 D051379 denotes mice
T39 320-324 10095 denotes mice
T36 320-324 PR:000005054 denotes mice
T38 320-324 O89094 denotes mice
T40 385-391 GO:0007568 denotes ageing
T41 423-428 D006801 denotes human
T42 429-434 PR:Q5S006 denotes LRRK2
T43 429-434 PR:000003033 denotes LRRK2
T44 429-434 PR:Q5S007 denotes LRRK2
T45 518-526 CHEBI:59905 denotes dopamine
T46 518-526 CHEBI:18243 denotes dopamine
T47 518-526 D004298 denotes dopamine
T48 518-526 D004298 denotes dopamine
T49 518-526 3628 denotes dopamine
T50 582-586 PR:000005054 denotes mice
T52 582-586 O89094 denotes mice
T51 582-586 D051379 denotes mice
T53 582-586 10095 denotes mice
T54 642-647 PR:Q5S006 denotes LRRK2
T55 642-647 PR:000003033 denotes LRRK2
T56 642-647 PR:Q5S007 denotes LRRK2
T57 691-695 PR:000005054 denotes mice
T59 691-695 O89094 denotes mice
T58 691-695 D051379 denotes mice
T60 691-695 10095 denotes mice
T61 853-862 SO:0000077 denotes antisense
T62 853-878 CHEBI:76720 denotes antisense oligonucleotide
T64 863-878 SO:0000696 denotes oligonucleotide
T65 941-946 PR:Q5S006 denotes LRRK2
T66 941-946 PR:000003033 denotes LRRK2
T67 941-946 PR:Q5S007 denotes LRRK2
T68 973-981 CHEBI:59905 denotes dopamine
T69 973-981 CHEBI:18243 denotes dopamine
T70 973-981 D004298 denotes dopamine
T71 973-981 D004298 denotes dopamine
T72 973-981 3628 denotes dopamine
T73 1041-1045 PR:000005054 denotes mice
T75 1041-1045 O89094 denotes mice
T74 1041-1045 D051379 denotes mice
T76 1041-1045 10095 denotes mice
T77 1076-1084 CHEBI:59905 denotes dopamine
T78 1076-1084 CHEBI:18243 denotes dopamine
T79 1076-1084 D004298 denotes dopamine
T80 1076-1084 D004298 denotes dopamine
T81 1076-1084 3628 denotes dopamine
T82 1111-1123 D017660 denotes autoreceptor
T83 1166-1171 PR:Q5S006 denotes LRRK2
T84 1166-1171 PR:000003033 denotes LRRK2
T85 1166-1171 PR:Q5S007 denotes LRRK2
T86 1184-1188 original_id denotes term
T87 1375-1379 PR:000005054 denotes mice
T89 1375-1379 O89094 denotes mice
T88 1375-1379 D051379 denotes mice
T90 1375-1379 10095 denotes mice
T91 1470-1474 PR:000005054 denotes mice
T93 1470-1474 O89094 denotes mice
T92 1470-1474 D051379 denotes mice
T94 1470-1474 10095 denotes mice
T95 1530-1536 GO:0007613 denotes memory
T96 1619-1627 SO:0000109 denotes mutation
T101 1654-1662 3628 denotes dopamine
T97 1654-1662 CHEBI:59905 denotes dopamine
T98 1654-1662 CHEBI:18243 denotes dopamine
T99 1654-1662 D004298 denotes dopamine
T100 1654-1662 D004298 denotes dopamine
T102 1741-1746 PR:Q5S006 denotes LRRK2
T103 1741-1746 PR:000003033 denotes LRRK2
T104 1741-1746 PR:Q5S007 denotes LRRK2
T105 1778-1783 10090 denotes mouse
T106 1778-1783 D051379 denotes mouse
T107 1817-1822 PR:Q5S006 denotes LRRK2
T108 1817-1822 PR:000003033 denotes LRRK2
T109 1817-1822 PR:Q5S007 denotes LRRK2
T110 1870-1875 PR:Q5S006 denotes LRRK2
T111 1870-1875 PR:000003033 denotes LRRK2
T112 1870-1875 PR:Q5S007 denotes LRRK2
T115 1969-1988 D018450 denotes disease progression
T116 1969-1988 D018450 denotes disease progression
T117 2009-2013 SO:0001742 denotes gain
T118 2017-2022 PR:Q5S006 denotes LRRK2
T119 2017-2022 PR:000003033 denotes LRRK2
T120 2017-2022 PR:Q5S007 denotes LRRK2
T121 2039-2051 GO:0009405 denotes pathogenesis

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 215-729 BACKGROUND denotes Germline silencing of the PD-related protein LRRK2 does not alter glutamate or dopamine release in adult mice, but some exploratory abnormalities have been reported with ageing. Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice. Comparative cognitive and motor behavioral testing of LRRK2 KO, overexpressor and mutant overexpressor mice has not previously been reported.
T2 739-1136 METHODS denotes Parallel, comparative behavioral characterization was performed assessing motor and cognitive abilities. Striatal antisense oligonucleotide injections were conducted to investigate the effects of acute LRRK2 silencing on behavior and dopamine fiber density. Striatal synaptosomes prepared from hG2019S mice assessed vesicular release of dopamine and its sensitivity to D2 autoreceptor stimulation.
T3 1146-1728 RESULTS denotes Genetic ablation of LRRK2 has no long-term consequences on motor or cognitive function. Consistently, no effects on behavior or dopaminergic fiber density were observed following acute striatal silencing. Conversely, 12-month OE mice show persistent locomotor deficits and worsening of cognitive abilities; whereas, hG2019S mice display early hyperactivity and effective learning and memory that progress to decreased motor and cognitive deficits at older ages. The G2019S mutation does not affect vesicular dopamine release, but decreases its sensitivity to D2-mediated inhibition.
T4 1741-2058 CONCLUSIONS denotes LRRK2 silencing is well tolerated in mouse, arguing PD does not result from LRRK2 loss of function. High levels of WT and G2019S LRRK2 produce similar but temporally distinct phenotypes, potentially modeling different stages of disease progression. The data implicate gain of LRRK2 function in the pathogenesis of PD.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
26282470-2#175#181#geners34637584 568-574 geners34637584 denotes G2019S
26282470-2#74#92#diseaseC0009241 467-485 diseaseC0009241 denotes cognitive deficits
26282470-2#74#92#diseaseC0338656 467-485 diseaseC0338656 denotes cognitive deficits
175#181#geners3463758474#92#diseaseC0009241 26282470-2#175#181#geners34637584 26282470-2#74#92#diseaseC0009241 associated_with G2019S,cognitive deficits
175#181#geners3463758474#92#diseaseC0338656 26282470-2#175#181#geners34637584 26282470-2#74#92#diseaseC0338656 associated_with G2019S,cognitive deficits

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26282470-0#18#23#gene120892 18-23 gene120892 denotes LRRK2
26282470-0#100#105#gene120892 100-105 gene120892 denotes LRRK2
26282470-0#138#156#diseaseC0009241 138-156 diseaseC0009241 denotes cognitive deficits
26282470-0#138#156#diseaseC0338656 138-156 diseaseC0338656 denotes cognitive deficits
26282470-0#138#156#diseaseC0009241 138-156 diseaseC0009241 denotes cognitive deficits
26282470-0#138#156#diseaseC0338656 138-156 diseaseC0338656 denotes cognitive deficits
18#23#gene120892138#156#diseaseC0009241 26282470-0#18#23#gene120892 26282470-0#138#156#diseaseC0009241 associated_with LRRK2,cognitive deficits
18#23#gene120892138#156#diseaseC0338656 26282470-0#18#23#gene120892 26282470-0#138#156#diseaseC0338656 associated_with LRRK2,cognitive deficits
18#23#gene120892138#156#diseaseC0009241 26282470-0#18#23#gene120892 26282470-0#138#156#diseaseC0009241 associated_with LRRK2,cognitive deficits
18#23#gene120892138#156#diseaseC0338656 26282470-0#18#23#gene120892 26282470-0#138#156#diseaseC0338656 associated_with LRRK2,cognitive deficits
100#105#gene120892138#156#diseaseC0009241 26282470-0#100#105#gene120892 26282470-0#138#156#diseaseC0009241 associated_with LRRK2,cognitive deficits
100#105#gene120892138#156#diseaseC0338656 26282470-0#100#105#gene120892 26282470-0#138#156#diseaseC0338656 associated_with LRRK2,cognitive deficits
100#105#gene120892138#156#diseaseC0009241 26282470-0#100#105#gene120892 26282470-0#138#156#diseaseC0009241 associated_with LRRK2,cognitive deficits
100#105#gene120892138#156#diseaseC0338656 26282470-0#100#105#gene120892 26282470-0#138#156#diseaseC0338656 associated_with LRRK2,cognitive deficits