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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-51 Sentence denotes MICL controls inflammation in rheumatoid arthritis.
T2 52-63 Sentence denotes BACKGROUND:
T3 64-202 Sentence denotes Myeloid inhibitory C-type lectin-like receptor (MICL, Clec12A) is a C-type lectin receptor (CLR) expressed predominantly by myeloid cells.
T4 203-285 Sentence denotes Previous studies have suggested that MICL is involved in controlling inflammation.
T5 286-296 Sentence denotes OBJECTIVE:
T6 297-381 Sentence denotes To determine the role of this CLR in inflammatory pathology using Clec12A(-/-) mice.
T7 382-390 Sentence denotes METHODS:
T8 391-524 Sentence denotes Clec12A(-/-) mice were generated commercially and primarily characterised using the collagen antibody-induced arthritis (CAIA) model.
T9 525-729 Sentence denotes Mechanisms and progress of disease were characterised by clinical scoring, histology, flow cytometry, irradiation bone-marrow chimera generation, administration of blocking antibodies and in vivo imaging.
T10 730-881 Sentence denotes Characterisation of MICL in patients with rheumatoid arthritis (RA) was determined by immunohistochemistry and single nucleotide polymorphism analysis.
T11 882-965 Sentence denotes Anti-MICL antibodies were detected in patient serum by ELISA and dot-blot analysis.
T12 966-1159 Sentence denotes RESULTS: MICL-deficient animals did not present with pan-immune dysfunction, but exhibited markedly exacerbated inflammation during CAIA, owing to the inappropriate activation of myeloid cells.
T13 1160-1314 Sentence denotes Polymorphisms of MICL were not associated with disease in patients with RA, but this CLR was the target of autoantibodies in a subset of patients with RA.
T14 1315-1412 Sentence denotes In wild-type mice the administration of such antibodies recapitulated the Clec12A(-/-) phenotype.
T15 1413-1553 Sentence denotes CONCLUSIONS: MICL plays an essential role in regulating inflammation during arthritis and is an autoantigen in a subset of patients with RA.
T16 1554-1769 Sentence denotes These data suggest an entirely new mechanism underlying RA pathogenesis, whereby the threshold of myeloid cell activation can be modulated by autoantibodies that bind to cell membrane-expressed inhibitory receptors.
T1 0-51 Sentence denotes MICL controls inflammation in rheumatoid arthritis.
T2 52-63 Sentence denotes BACKGROUND:
T3 64-202 Sentence denotes Myeloid inhibitory C-type lectin-like receptor (MICL, Clec12A) is a C-type lectin receptor (CLR) expressed predominantly by myeloid cells.
T4 203-285 Sentence denotes Previous studies have suggested that MICL is involved in controlling inflammation.
T5 286-296 Sentence denotes OBJECTIVE:
T6 297-381 Sentence denotes To determine the role of this CLR in inflammatory pathology using Clec12A(-/-) mice.
T7 382-390 Sentence denotes METHODS:
T8 391-524 Sentence denotes Clec12A(-/-) mice were generated commercially and primarily characterised using the collagen antibody-induced arthritis (CAIA) model.
T9 525-729 Sentence denotes Mechanisms and progress of disease were characterised by clinical scoring, histology, flow cytometry, irradiation bone-marrow chimera generation, administration of blocking antibodies and in vivo imaging.
T10 730-881 Sentence denotes Characterisation of MICL in patients with rheumatoid arthritis (RA) was determined by immunohistochemistry and single nucleotide polymorphism analysis.
T11 882-965 Sentence denotes Anti-MICL antibodies were detected in patient serum by ELISA and dot-blot analysis.
T12 966-1159 Sentence denotes RESULTS: MICL-deficient animals did not present with pan-immune dysfunction, but exhibited markedly exacerbated inflammation during CAIA, owing to the inappropriate activation of myeloid cells.
T13 1160-1314 Sentence denotes Polymorphisms of MICL were not associated with disease in patients with RA, but this CLR was the target of autoantibodies in a subset of patients with RA.
T14 1315-1412 Sentence denotes In wild-type mice the administration of such antibodies recapitulated the Clec12A(-/-) phenotype.
T15 1413-1553 Sentence denotes CONCLUSIONS: MICL plays an essential role in regulating inflammation during arthritis and is an autoantigen in a subset of patients with RA.
T16 1554-1769 Sentence denotes These data suggest an entirely new mechanism underlying RA pathogenesis, whereby the threshold of myeloid cell activation can be modulated by autoantibodies that bind to cell membrane-expressed inhibitory receptors.