PubMed:26272614
Annnotations
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 96-108 | Cell | denotes | schwann cell | http://purl.obolibrary.org/obo/CL:0000218|http://purl.obolibrary.org/obo/CL:0000692|http://purl.obolibrary.org/obo/CL:0002376|http://purl.obolibrary.org/obo/CL:0002377|http://purl.obolibrary.org/obo/CL:0002573 |
| T6 | 328-341 | Cell | denotes | Schwann cells | http://purl.obolibrary.org/obo/CL:0000218|http://purl.obolibrary.org/obo/CL:0000692|http://purl.obolibrary.org/obo/CL:0002376|http://purl.obolibrary.org/obo/CL:0002377|http://purl.obolibrary.org/obo/CL:0002573 |
| T11 | 343-346 | Cell | denotes | SCs | http://purl.obolibrary.org/obo/CL:0000218 |
| T12 | 445-448 | Cell | denotes | SCs | http://purl.obolibrary.org/obo/CL:0000218 |
| T13 | 597-600 | Cell | denotes | SCs | http://purl.obolibrary.org/obo/CL:0000218 |
| T14 | 675-678 | Cell | denotes | SCs | http://purl.obolibrary.org/obo/CL:0000218 |
| T15 | 1205-1208 | Cell | denotes | SCs | http://purl.obolibrary.org/obo/CL:0000218 |
| T16 | 1449-1452 | Cell | denotes | SCs | http://purl.obolibrary.org/obo/CL:0000218 |
| T17 | 1467-1477 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-144 | Sentence | denotes | Microprocessor complex subunit DiGeorge syndrome critical region gene 8 (Dgcr8) is required for schwann cell myelination and myelin maintenance. |
| T2 | 145-281 | Sentence | denotes | We investigated the role of a key component of the Microprocessor complex, DGCR8, in the regulation of myelin formation and maintenance. |
| T3 | 282-410 | Sentence | denotes | We found that conditionally ablating Dgcr8 in Schwann cells (SCs) during development results in an arrest of SC differentiation. |
| T4 | 411-545 | Sentence | denotes | Dgcr8 conditional knock-out (cKO) SCs fail to form 1:1 relationships with axons or, having achieved this, fail to form myelin sheaths. |
| T5 | 546-826 | Sentence | denotes | The expression of genes normally found in immature SCs, such as sex-determining region Y-box 2 (Sox2), is increased in Dgcr8 cKO SCs, whereas the expression of myelin-related genes, including the master regulatory transcription factor early growth response 2 (Egr2), is decreased. |
| T6 | 827-1167 | Sentence | denotes | Additionally, expression of a novel gene expression program involving sonic hedgehog (Shh), activated de novo in injured nerves, is elevated in Dgcr8 cKOs but not in Egr2 null mice, a model of SC differentiation arrest, suggesting that the injury-related gene expression program in Dgcr8 cKOs cannot be attributed to differentiation arrest. |
| T7 | 1168-1332 | Sentence | denotes | Inducible ablation of Dgcr8 in adult SCs results in gene expression changes similar to those found in cKOs, including an increase in the expression of Sox2 and Shh. |
| T8 | 1333-1491 | Sentence | denotes | Analyses of these nerves mainly reveal normal myelin thickness and axon size distribution but some dedifferentiated SCs and increased macrophage infiltration. |
| T9 | 1492-1699 | Sentence | denotes | Together our data suggest that Dgcr8 is responsible for modulation of gene expression programs underlying myelin formation and maintenance as well as suppression of an injury-related gene expression program. |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 31-48 | Disease | denotes | DiGeorge syndrome | http://purl.obolibrary.org/obo/MONDO_0008564|http://purl.obolibrary.org/obo/MONDO_0018923 |
| T3 | 1067-1073 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T4 | 1660-1666 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1003-1007 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 96-108 | Body_part | denotes | schwann cell | http://purl.obolibrary.org/obo/CL_0000218|http://purl.obolibrary.org/obo/CL_0002377|http://purl.obolibrary.org/obo/CL_0002573 |
| T4 | 125-131 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T5 | 248-254 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T6 | 328-341 | Body_part | denotes | Schwann cells | http://purl.obolibrary.org/obo/CL_0000218|http://purl.obolibrary.org/obo/CL_0002377|http://purl.obolibrary.org/obo/CL_0002573 |
| T9 | 343-346 | Body_part | denotes | SCs | http://purl.obolibrary.org/obo/CL_0000218 |
| T10 | 445-448 | Body_part | denotes | SCs | http://purl.obolibrary.org/obo/CL_0000218 |
| T11 | 530-544 | Body_part | denotes | myelin sheaths | http://purl.obolibrary.org/obo/GO_0043209 |
| T12 | 597-600 | Body_part | denotes | SCs | http://purl.obolibrary.org/obo/CL_0000218 |
| T13 | 675-678 | Body_part | denotes | SCs | http://purl.obolibrary.org/obo/CL_0000218 |
| T14 | 706-712 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T15 | 948-954 | Body_part | denotes | nerves | http://purl.obolibrary.org/obo/UBERON_0001021 |
| T16 | 1205-1208 | Body_part | denotes | SCs | http://purl.obolibrary.org/obo/CL_0000218 |
| T17 | 1351-1357 | Body_part | denotes | nerves | http://purl.obolibrary.org/obo/UBERON_0001021 |
| T18 | 1379-1385 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T19 | 1400-1404 | Body_part | denotes | axon | http://purl.obolibrary.org/obo/GO_0030424 |
| T20 | 1449-1452 | Body_part | denotes | SCs | http://purl.obolibrary.org/obo/CL_0000218 |
| T21 | 1467-1477 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T22 | 1598-1604 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |