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sentences

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Fibroblast-derived neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma.
T2 104-232 Sentence denotes Rapidly accelerated fibrosarcoma (RAF) inhibitors are first-line treatments for patients harboring V600E/K mutant BRAF melanoma.
T3 233-334 Sentence denotes Although RAF inhibitors produce high response rates, the degree of tumor regression is heterogeneous.
T4 335-565 Sentence denotes Compensatory/adaptive responses to targeted inhibitors are frequently initiated by the activation of growth factor receptor tyrosine kinases, including ErbB3, and factors from the tumor microenvironment may play an important role.
T5 566-731 Sentence denotes We have shown previously that mutant v-raf murine sarcoma viral oncogene homolog B1 (BRAF) melanoma cells have enhanced activation of ErbB3 following RAF inhibition.
T6 732-809 Sentence denotes However, the source of neuregulin 1 (NRG1), the ligand for ErbB3, is unknown.
T7 810-969 Sentence denotes In this study, we demonstrate that NRG1 is highly expressed by dermal fibroblasts and cancer-associated fibroblasts (CAFs) isolated from mutant BRAF melanomas.
T8 970-1128 Sentence denotes Conditioned medium from fibroblasts and CAFs enhanced ErbB3 pathway activation and limited RAF inhibitor cytotoxicity in V600 mutant BRAF-harboring melanomas.
T9 1129-1302 Sentence denotes Targeting the ErbB3/ErbB2 pathway partially reversed the protective effects of fibroblast/CAF-derived NRG1 on cell growth properties of RAF inhibitor-treated melanoma cells.
T10 1303-1552 Sentence denotes These findings support the idea that NRG1, acting in a paracrine manner, promotes resistance to RAF inhibitors and emphasize that targeting the ErbB3/ErbB2 pathway will likely improve the efficacy of RAF inhibitors for mutant BRAF melanoma patients.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 94-102 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T2 124-136 Disease denotes fibrosarcoma http://purl.obolibrary.org/obo/MONDO_0002676|http://purl.obolibrary.org/obo/MONDO_0002678|http://purl.obolibrary.org/obo/MONDO_0005164
T5 223-231 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T6 300-305 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 515-520 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 616-623 Disease denotes sarcoma http://purl.obolibrary.org/obo/MONDO_0005089
T9 657-665 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T10 896-902 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T11 959-968 Disease denotes melanomas http://purl.obolibrary.org/obo/MONDO_0005105
T12 1118-1127 Disease denotes melanomas http://purl.obolibrary.org/obo/MONDO_0005105
T13 1287-1295 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T14 1534-1542 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1330-1334 OrganismTaxon denotes idea 76236

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-10 Body_part denotes Fibroblast http://purl.obolibrary.org/obo/CL_0000057
T2 880-891 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T3 914-925 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T4 994-1005 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T5 1208-1218 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 94-102 Phenotype denotes melanoma HP:0002861
T2 124-136 Phenotype denotes fibrosarcoma HP:0100244
T3 223-231 Phenotype denotes melanoma HP:0002861
T4 300-305 Phenotype denotes tumor HP:0002664
T5 515-520 Phenotype denotes tumor HP:0002664
T6 616-623 Phenotype denotes sarcoma HP:0100242
T7 657-665 Phenotype denotes melanoma HP:0002861
T8 896-902 Phenotype denotes cancer HP:0002664
T9 1287-1295 Phenotype denotes melanoma HP:0002861
T10 1534-1542 Phenotype denotes melanoma HP:0002861

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-10 Cell denotes Fibroblast http://purl.obolibrary.org/obo/CL:0000057
T2 880-891 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T3 914-925 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T4 994-1005 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T5 1208-1218 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057