PubMed:26269588
Annnotations
Inflammaging
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-86 | Sentence | denotes | Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium. |
T2 | 87-222 | Sentence | denotes | The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β. |
T3 | 223-333 | Sentence | denotes | Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium. |
T4 | 334-429 | Sentence | denotes | However, the mechanism by which endothelial cells (ECs) release IL-1β remains to be elucidated. |
T5 | 430-610 | Sentence | denotes | We investigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human carotid plaques, as a potential "trigger" for IL-1β processing and release. |
T6 | 611-732 | Sentence | denotes | This study tested the hypothesis that NE potentiates the processing and release of IL-1β from human coronary endothelium. |
T7 | 733-869 | Sentence | denotes | We found that NE cleaves the pro-isoform of IL-1β in ECs and causes significant secretion of bioactive IL-1β via extracellular vesicles. |
T8 | 870-967 | Sentence | denotes | This release was attenuated significantly by inhibition of neutrophil elastase but not caspase-1. |
T9 | 968-1052 | Sentence | denotes | Transient increases in intracellular Ca(2+) levels were observed prior to secretion. |
T10 | 1053-1158 | Sentence | denotes | Inside ECs, and after NE treatment only, IL-1β was detected within LAMP-1-positive multivesicular bodies. |
T11 | 1159-1207 | Sentence | denotes | The released vesicles contained bioactive IL-1β. |
T12 | 1208-1351 | Sentence | denotes | In vivo, in experimental atherosclerosis, NE was detected in mature atherosclerotic plaques, predominantly in the endothelium, alongside IL-1β. |
T13 | 1352-1513 | Sentence | denotes | This study reveals a novel mechanistic link between NE expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1β secretion from ECs. |
T14 | 1514-1678 | Sentence | denotes | This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights into the inflammatory process by which vascular disease develops. |
T1 | 0-86 | Sentence | denotes | Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium. |
T2 | 87-222 | Sentence | denotes | The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β. |
T3 | 223-333 | Sentence | denotes | Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium. |
T4 | 334-429 | Sentence | denotes | However, the mechanism by which endothelial cells (ECs) release IL-1β remains to be elucidated. |
T5 | 430-610 | Sentence | denotes | We investigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human carotid plaques, as a potential "trigger" for IL-1β processing and release. |
T6 | 611-732 | Sentence | denotes | This study tested the hypothesis that NE potentiates the processing and release of IL-1β from human coronary endothelium. |
T7 | 733-869 | Sentence | denotes | We found that NE cleaves the pro-isoform of IL-1β in ECs and causes significant secretion of bioactive IL-1β via extracellular vesicles. |
T8 | 870-967 | Sentence | denotes | This release was attenuated significantly by inhibition of neutrophil elastase but not caspase-1. |
T9 | 968-1052 | Sentence | denotes | Transient increases in intracellular Ca(2+) levels were observed prior to secretion. |
T10 | 1053-1158 | Sentence | denotes | Inside ECs, and after NE treatment only, IL-1β was detected within LAMP-1-positive multivesicular bodies. |
T11 | 1159-1207 | Sentence | denotes | The released vesicles contained bioactive IL-1β. |
T12 | 1208-1351 | Sentence | denotes | In vivo, in experimental atherosclerosis, NE was detected in mature atherosclerotic plaques, predominantly in the endothelium, alongside IL-1β. |
T13 | 1352-1513 | Sentence | denotes | This study reveals a novel mechanistic link between NE expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1β secretion from ECs. |
T14 | 1514-1678 | Sentence | denotes | This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights into the inflammatory process by which vascular disease develops. |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-86 | Sentence | denotes | Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium. |
T2 | 87-222 | Sentence | denotes | The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β. |
T3 | 223-333 | Sentence | denotes | Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium. |
T4 | 334-429 | Sentence | denotes | However, the mechanism by which endothelial cells (ECs) release IL-1β remains to be elucidated. |
T5 | 430-610 | Sentence | denotes | We investigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human carotid plaques, as a potential "trigger" for IL-1β processing and release. |
T6 | 611-732 | Sentence | denotes | This study tested the hypothesis that NE potentiates the processing and release of IL-1β from human coronary endothelium. |
T7 | 733-869 | Sentence | denotes | We found that NE cleaves the pro-isoform of IL-1β in ECs and causes significant secretion of bioactive IL-1β via extracellular vesicles. |
T8 | 870-967 | Sentence | denotes | This release was attenuated significantly by inhibition of neutrophil elastase but not caspase-1. |
T9 | 968-1052 | Sentence | denotes | Transient increases in intracellular Ca(2+) levels were observed prior to secretion. |
T10 | 1053-1158 | Sentence | denotes | Inside ECs, and after NE treatment only, IL-1β was detected within LAMP-1-positive multivesicular bodies. |
T11 | 1159-1207 | Sentence | denotes | The released vesicles contained bioactive IL-1β. |
T12 | 1208-1351 | Sentence | denotes | In vivo, in experimental atherosclerosis, NE was detected in mature atherosclerotic plaques, predominantly in the endothelium, alongside IL-1β. |
T13 | 1352-1513 | Sentence | denotes | This study reveals a novel mechanistic link between NE expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1β secretion from ECs. |
T14 | 1514-1678 | Sentence | denotes | This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights into the inflammatory process by which vascular disease develops. |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 232-240 | http://purl.obolibrary.org/obo/MAT_0000034 | denotes | arteries |
T2 | 269-274 | http://purl.obolibrary.org/obo/MAT_0000036 | denotes | heart |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
26269588-13#44#49#gene3553 | 1558-1563 | gene3553 | denotes | IL-1β |
26269588-13#138#154#diseaseC0042373 | 1652-1668 | diseaseC0042373 | denotes | vascular disease |
26269588-2#85#90#gene3553 | 308-313 | gene3553 | denotes | IL-1β |
26269588-2#37#59#diseaseC0151744 | 260-282 | diseaseC0151744 | denotes | ischemic heart disease |
44#49#gene3553138#154#diseaseC0042373 | 26269588-13#44#49#gene3553 | 26269588-13#138#154#diseaseC0042373 | associated_with | IL-1β,vascular disease |
85#90#gene355337#59#diseaseC0151744 | 26269588-2#85#90#gene3553 | 26269588-2#37#59#diseaseC0151744 | associated_with | IL-1β,ischemic heart disease |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 149-164 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
T2 | 260-282 | Disease | denotes | ischemic heart disease | http://purl.obolibrary.org/obo/MONDO_0024644 |
T3 | 1233-1248 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
T4 | 1652-1668 | Disease | denotes | vascular disease | http://purl.obolibrary.org/obo/MONDO_0005385 |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 232-240 | Body_part | denotes | arteries | http://purl.obolibrary.org/obo/MAT_0000034 |
T2 | 269-274 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 59-64 | OrganismTaxon | denotes | human | 9606 |
T2 | 529-534 | OrganismTaxon | denotes | human | 9606 |
T3 | 705-710 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 0-10 | Body_part | denotes | Neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
T2 | 74-85 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
T3 | 91-102 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
T4 | 223-240 | Body_part | denotes | Coronary arteries | http://purl.obolibrary.org/obo/UBERON_0001621 |
T5 | 269-274 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
T9 | 321-332 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
T10 | 366-383 | Body_part | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL_0000115 |
T11 | 385-388 | Body_part | denotes | ECs | http://purl.obolibrary.org/obo/CL_0000115 |
T12 | 446-456 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
T13 | 535-542 | Body_part | denotes | carotid | http://purl.obolibrary.org/obo/UBERON_0005396 |
T14 | 720-731 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
T15 | 786-789 | Body_part | denotes | ECs | http://purl.obolibrary.org/obo/CL_0000115 |
T16 | 846-868 | Body_part | denotes | extracellular vesicles | http://purl.obolibrary.org/obo/GO_1903561 |
T17 | 929-939 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
T18 | 991-1004 | Body_part | denotes | intracellular | http://purl.obolibrary.org/obo/GO_0005622 |
T19 | 1060-1063 | Body_part | denotes | ECs | http://purl.obolibrary.org/obo/CL_0000115 |
T20 | 1322-1333 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
T21 | 1509-1512 | Body_part | denotes | ECs | http://purl.obolibrary.org/obo/CL_0000115 |