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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium.
T2 87-222 Sentence denotes The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β.
T3 223-333 Sentence denotes Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium.
T4 334-429 Sentence denotes However, the mechanism by which endothelial cells (ECs) release IL-1β remains to be elucidated.
T5 430-610 Sentence denotes We investigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human carotid plaques, as a potential "trigger" for IL-1β processing and release.
T6 611-732 Sentence denotes This study tested the hypothesis that NE potentiates the processing and release of IL-1β from human coronary endothelium.
T7 733-869 Sentence denotes We found that NE cleaves the pro-isoform of IL-1β in ECs and causes significant secretion of bioactive IL-1β via extracellular vesicles.
T8 870-967 Sentence denotes This release was attenuated significantly by inhibition of neutrophil elastase but not caspase-1.
T9 968-1052 Sentence denotes Transient increases in intracellular Ca(2+) levels were observed prior to secretion.
T10 1053-1158 Sentence denotes Inside ECs, and after NE treatment only, IL-1β was detected within LAMP-1-positive multivesicular bodies.
T11 1159-1207 Sentence denotes The released vesicles contained bioactive IL-1β.
T12 1208-1351 Sentence denotes In vivo, in experimental atherosclerosis, NE was detected in mature atherosclerotic plaques, predominantly in the endothelium, alongside IL-1β.
T13 1352-1513 Sentence denotes This study reveals a novel mechanistic link between NE expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1β secretion from ECs.
T14 1514-1678 Sentence denotes This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights into the inflammatory process by which vascular disease develops.
T1 0-86 Sentence denotes Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium.
T2 87-222 Sentence denotes The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β.
T3 223-333 Sentence denotes Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium.
T4 334-429 Sentence denotes However, the mechanism by which endothelial cells (ECs) release IL-1β remains to be elucidated.
T5 430-610 Sentence denotes We investigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human carotid plaques, as a potential "trigger" for IL-1β processing and release.
T6 611-732 Sentence denotes This study tested the hypothesis that NE potentiates the processing and release of IL-1β from human coronary endothelium.
T7 733-869 Sentence denotes We found that NE cleaves the pro-isoform of IL-1β in ECs and causes significant secretion of bioactive IL-1β via extracellular vesicles.
T8 870-967 Sentence denotes This release was attenuated significantly by inhibition of neutrophil elastase but not caspase-1.
T9 968-1052 Sentence denotes Transient increases in intracellular Ca(2+) levels were observed prior to secretion.
T10 1053-1158 Sentence denotes Inside ECs, and after NE treatment only, IL-1β was detected within LAMP-1-positive multivesicular bodies.
T11 1159-1207 Sentence denotes The released vesicles contained bioactive IL-1β.
T12 1208-1351 Sentence denotes In vivo, in experimental atherosclerosis, NE was detected in mature atherosclerotic plaques, predominantly in the endothelium, alongside IL-1β.
T13 1352-1513 Sentence denotes This study reveals a novel mechanistic link between NE expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1β secretion from ECs.
T14 1514-1678 Sentence denotes This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights into the inflammatory process by which vascular disease develops.

sentences

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Neutrophil elastase promotes interleukin-1β secretion from human coronary endothelium.
T2 87-222 Sentence denotes The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β.
T3 223-333 Sentence denotes Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium.
T4 334-429 Sentence denotes However, the mechanism by which endothelial cells (ECs) release IL-1β remains to be elucidated.
T5 430-610 Sentence denotes We investigated neutrophil elastase (NE), a potent serine protease detected in vulnerable areas of human carotid plaques, as a potential "trigger" for IL-1β processing and release.
T6 611-732 Sentence denotes This study tested the hypothesis that NE potentiates the processing and release of IL-1β from human coronary endothelium.
T7 733-869 Sentence denotes We found that NE cleaves the pro-isoform of IL-1β in ECs and causes significant secretion of bioactive IL-1β via extracellular vesicles.
T8 870-967 Sentence denotes This release was attenuated significantly by inhibition of neutrophil elastase but not caspase-1.
T9 968-1052 Sentence denotes Transient increases in intracellular Ca(2+) levels were observed prior to secretion.
T10 1053-1158 Sentence denotes Inside ECs, and after NE treatment only, IL-1β was detected within LAMP-1-positive multivesicular bodies.
T11 1159-1207 Sentence denotes The released vesicles contained bioactive IL-1β.
T12 1208-1351 Sentence denotes In vivo, in experimental atherosclerosis, NE was detected in mature atherosclerotic plaques, predominantly in the endothelium, alongside IL-1β.
T13 1352-1513 Sentence denotes This study reveals a novel mechanistic link between NE expression in atherosclerotic plaques and concomitant pro-inflammatory bioactive IL-1β secretion from ECs.
T14 1514-1678 Sentence denotes This could reveal additional potential anti-IL-1β therapeutic targets and provide further insights into the inflammatory process by which vascular disease develops.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 232-240 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T2 269-274 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26269588-13#44#49#gene3553 1558-1563 gene3553 denotes IL-1β
26269588-13#138#154#diseaseC0042373 1652-1668 diseaseC0042373 denotes vascular disease
26269588-2#85#90#gene3553 308-313 gene3553 denotes IL-1β
26269588-2#37#59#diseaseC0151744 260-282 diseaseC0151744 denotes ischemic heart disease
44#49#gene3553138#154#diseaseC0042373 26269588-13#44#49#gene3553 26269588-13#138#154#diseaseC0042373 associated_with IL-1β,vascular disease
85#90#gene355337#59#diseaseC0151744 26269588-2#85#90#gene3553 26269588-2#37#59#diseaseC0151744 associated_with IL-1β,ischemic heart disease

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 149-164 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T2 260-282 Disease denotes ischemic heart disease http://purl.obolibrary.org/obo/MONDO_0024644
T3 1233-1248 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T4 1652-1668 Disease denotes vascular disease http://purl.obolibrary.org/obo/MONDO_0005385

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 232-240 Body_part denotes arteries http://purl.obolibrary.org/obo/MAT_0000034
T2 269-274 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 59-64 OrganismTaxon denotes human 9606
T2 529-534 OrganismTaxon denotes human 9606
T3 705-710 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-10 Body_part denotes Neutrophil http://purl.obolibrary.org/obo/CL_0000775
T2 74-85 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T3 91-102 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T4 223-240 Body_part denotes Coronary arteries http://purl.obolibrary.org/obo/UBERON_0001621
T5 269-274 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T9 321-332 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T10 366-383 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T11 385-388 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T12 446-456 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T13 535-542 Body_part denotes carotid http://purl.obolibrary.org/obo/UBERON_0005396
T14 720-731 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T15 786-789 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T16 846-868 Body_part denotes extracellular vesicles http://purl.obolibrary.org/obo/GO_1903561
T17 929-939 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T18 991-1004 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T19 1060-1063 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115
T20 1322-1333 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T21 1509-1512 Body_part denotes ECs http://purl.obolibrary.org/obo/CL_0000115