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PubMed:26263924 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 67-70 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T2 67-70 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T3 100-103 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T4 100-103 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2
T5 344-355 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 357-360 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sia
T7 549-552 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sia
T8 659-662 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sia
T9 670-673 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sia
T10 872-875 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T11 872-875 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T12 905-908 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T13 905-908 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2
T14 1013-1016 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T15 1013-1016 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T16 1017-1020 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T17 1017-1020 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2
T18 1085-1088 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T19 1085-1088 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T20 1089-1092 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T21 1089-1092 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 67-70 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T3 100-103 Glycan_Motif denotes GD2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G41759HA|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02657AK
T5 344-355 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 357-360 Glycan_Motif denotes Sia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 549-552 Glycan_Motif denotes Sia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T8 659-662 Glycan_Motif denotes Sia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T9 670-673 Glycan_Motif denotes Sia https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 872-875 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T12 905-908 Glycan_Motif denotes GD2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G41759HA|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02657AK
T14 1013-1016 Glycan_Motif denotes GM2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC
T16 1017-1020 Glycan_Motif denotes GD2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G41759HA|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02657AK
T18 1085-1088 Glycan_Motif denotes GM2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC
T20 1089-1092 Glycan_Motif denotes GD2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G41759HA|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02657AK

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
TextSentencer_T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
TextSentencer_T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
TextSentencer_T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
TextSentencer_T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
TextSentencer_T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.
T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.
T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 67-70 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T2 67-70 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T3 100-103 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T4 100-103 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2
T5 344-355 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 872-875 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T7 872-875 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T8 905-908 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T9 905-908 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2
T10 1013-1016 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T11 1013-1016 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T12 1017-1020 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T13 1017-1020 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2
T14 1085-1088 https://glytoucan.org/Structures/Glycans/G61168WC denotes GM2
T15 1085-1088 https://glytoucan.org/Structures/Glycans/G79389NT denotes GM2
T16 1089-1092 https://glytoucan.org/Structures/Glycans/G02657AK denotes GD2
T17 1089-1092 https://glytoucan.org/Structures/Glycans/G41759HA denotes GD2

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 26-34 FMAID:202192 denotes Th cells
_T2 29-34 FMAID:169002 denotes cells
_T3 29-34 FMAID:68646 denotes cells
_T4 45-52 FMAID:146300 denotes surface
_T5 45-52 FMAID:50594 denotes surface
_T6 144-164 FMAID:70572 denotes T helper lymphocytes
_T7 144-164 FMAID:198532 denotes T helper lymphocytes
_T8 146-164 FMAID:197891 denotes helper lymphocytes
_T9 146-164 FMAID:171416 denotes helper lymphocytes
_T10 153-164 FMAID:167163 denotes lymphocytes
_T11 153-164 FMAID:167171 denotes lymphocytes
_T12 153-164 FMAID:167174 denotes lymphocytes
_T13 153-164 FMAID:62869 denotes lymphocytes
_T14 153-164 FMAID:62870 denotes lymphocytes
_T15 153-164 FMAID:167176 denotes lymphocytes
_T16 153-164 FMAID:62863 denotes lymphocytes
_T17 153-164 FMAID:167173 denotes lymphocytes
_T18 228-252 FMAID:273572 denotes antigen-presenting cells
_T19 228-252 FMAID:273564 denotes antigen-presenting cells
_T20 228-252 FMAID:273565 denotes antigen-presenting cells
_T21 228-252 FMAID:273566 denotes antigen-presenting cells
_T22 247-252 FMAID:68646 denotes cells
_T23 247-252 FMAID:169002 denotes cells
_T24 274-282 FMAID:202192 denotes Th cells
_T25 277-282 FMAID:169002 denotes cells
_T26 277-282 FMAID:68646 denotes cells
_T27 321-331 FMAID:212854 denotes in surface
_T28 321-331 FMAID:213249 denotes in surface
_T29 324-331 FMAID:146300 denotes surface
_T30 324-331 FMAID:50594 denotes surface
_T31 501-509 FMAID:202192 denotes Th cells
_T32 504-509 FMAID:68646 denotes cells
_T33 504-509 FMAID:169002 denotes cells
_T34 538-548 FMAID:212854 denotes in surface
_T35 538-548 FMAID:213249 denotes in surface
_T36 541-548 FMAID:50594 denotes surface
_T37 541-548 FMAID:146300 denotes surface
_T38 617-625 FMAID:202192 denotes Th cells
_T39 620-625 FMAID:68646 denotes cells
_T40 620-625 FMAID:169002 denotes cells
_T41 678-693 FMAID:82782 denotes glycoconjugates
_T42 678-693 FMAID:196776 denotes glycoconjugates
_T43 738-749 FMAID:82816 denotes ganglioside
_T44 738-749 FMAID:196811 denotes ganglioside
_T45 823-831 FMAID:202192 denotes Th cells
_T46 826-831 FMAID:169002 denotes cells
_T47 826-831 FMAID:68646 denotes cells
_T48 861-871 FMAID:212854 denotes in surface
_T49 861-871 FMAID:213249 denotes in surface
_T50 864-871 FMAID:50594 denotes surface
_T51 864-871 FMAID:146300 denotes surface
_T52 897-904 FMAID:50594 denotes surface
_T53 897-904 FMAID:146300 denotes surface
_T54 909-921 FMAID:82816 denotes gangliosides
_T55 909-921 FMAID:196811 denotes gangliosides
_T56 927-933 FMAID:171168 denotes latter
_T57 927-933 FMAID:30332 denotes latter
_T58 1127-1135 FMAID:202192 denotes Th cells
_T59 1130-1135 FMAID:68646 denotes cells
_T60 1130-1135 FMAID:169002 denotes cells
_T61 1235-1239 FMAID:197974 denotes IL-2
_T62 1262-1270 FMAID:50596 denotes pointing
_T63 1262-1270 FMAID:146304 denotes pointing
_T64 1336-1344 FMAID:202192 denotes Th cells
_T65 1339-1344 FMAID:68646 denotes cells
_T66 1339-1344 FMAID:169002 denotes cells

uniprot-human

Id Subject Object Predicate Lexical cue
T1 139-142 http://www.uniprot.org/uniprot/P01730 denotes CD4
T2 465-469 http://www.uniprot.org/uniprot/Q8WXJ2 denotes CD28
T3 1013-1029 http://www.uniprot.org/uniprot/Q00973 denotes GM2/GD2 synthase
T4 1085-1101 http://www.uniprot.org/uniprot/Q00973 denotes GM2/GD2 synthase
T5 1235-1239 http://www.uniprot.org/uniprot/P60568 denotes IL-2

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 139-142 http://www.uniprot.org/uniprot/P06332 denotes CD4
T2 465-469 http://www.uniprot.org/uniprot/P31041 denotes CD28
T3 1013-1029 http://www.uniprot.org/uniprot/Q09200 denotes GM2/GD2 synthase
T4 1085-1101 http://www.uniprot.org/uniprot/Q09200 denotes GM2/GD2 synthase
T5 1235-1239 http://www.uniprot.org/uniprot/P04351 denotes IL-2

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 29-34 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 247-252 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 277-282 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 357-360 http://purl.bioontology.org/ontology/NCBITAXON/208766 denotes Sia
T5 357-360 http://purl.bioontology.org/ontology/NCBITAXON/172412 denotes Sia
T6 504-509 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 549-552 http://purl.bioontology.org/ontology/NCBITAXON/208766 denotes Sia
T8 549-552 http://purl.bioontology.org/ontology/NCBITAXON/172412 denotes Sia
T9 620-625 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 659-662 http://purl.bioontology.org/ontology/NCBITAXON/172412 denotes Sia
T11 659-662 http://purl.bioontology.org/ontology/NCBITAXON/208766 denotes Sia
T12 670-673 http://purl.bioontology.org/ontology/NCBITAXON/208766 denotes Sia
T13 670-673 http://purl.bioontology.org/ontology/NCBITAXON/172412 denotes Sia
T14 826-831 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T15 1041-1051 http://purl.bioontology.org/ontology/NCBITAXON/11646 denotes lentiviral
T16 1130-1135 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T17 1339-1344 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 125-128 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T2 971-974 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T3 1154-1157 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T4 186-201 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T5 214-246 http://purl.obolibrary.org/obo/GO_0002579 denotes activation by antigen-presenting
T6 228-246 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen-presenting
T7 247-264 http://purl.obolibrary.org/obo/GO_0001775 denotes cells. Activation
T8 569-578 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic
T9 603-610 http://purl.obolibrary.org/obo/GO_0043336 denotes resting
T10 753-763 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11 954-969 http://purl.obolibrary.org/obo/GO_0032393 denotes T cell receptor
T12 954-969 http://purl.obolibrary.org/obo/GO_0032394 denotes T cell receptor
T13 954-969 http://purl.obolibrary.org/obo/GO_0032395 denotes T cell receptor
T14 1013-1029 http://purl.obolibrary.org/obo/GO_0003947 denotes GM2/GD2 synthase
T15 1085-1114 http://purl.obolibrary.org/obo/GO_0003947 denotes GM2/GD2 synthase in activated
T16 1093-1114 http://purl.obolibrary.org/obo/GO_0004517 denotes synthase in activated
T17 1184-1193 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18 1244-1249 http://purl.obolibrary.org/obo/GO_0004911 denotes IL-2R
T19 1300-1320 http://purl.obolibrary.org/obo/GO_0003824 denotes enzyme in activation

GO-MF

Id Subject Object Predicate Lexical cue
T1 1238-1246 http://purl.obolibrary.org/obo/GO_0005134 denotes 2 and IL

GO-CC

Id Subject Object Predicate Lexical cue
T1 29-34 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 247-252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 277-282 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 504-509 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 620-625 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 826-831 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1130-1135 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 956-960 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 927-933 http://purl.obolibrary.org/obo/MAT_0000488 denotes latter

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 579-587 id denotes labeling
PD-GlycoEpitope-B_T2 100-103 http://www.glycoepitope.jp/epitopes/EP0061 denotes GD2
PD-GlycoEpitope-B_T3 905-908 http://www.glycoepitope.jp/epitopes/EP0061 denotes GD2
PD-GlycoEpitope-B_T4 1017-1020 http://www.glycoepitope.jp/epitopes/EP0061 denotes GD2
PD-GlycoEpitope-B_T5 1089-1092 http://www.glycoepitope.jp/epitopes/EP0061 denotes GD2

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 67-70 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 100-103 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T3 872-875 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 905-908 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T5 1013-1016 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T6 1017-1020 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T7 1085-1088 Glycan denotes GM2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T8 1089-1092 Glycan denotes GD2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 14-19 OrganismTaxon denotes human 9606
T2 489-494 OrganismTaxon denotes human 9606
T3 811-816 OrganismTaxon denotes human 9606
T4 1035-1039 OrganismTaxon denotes mice 10088
T5 1115-1120 OrganismTaxon denotes human 9606
T6 1324-1329 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 153-164 Cell denotes lymphocytes http://purl.obolibrary.org/obo/CL:0000542
T2 954-960 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 153-164 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T2 954-960 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
TextSentencer_T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
TextSentencer_T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
TextSentencer_T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
TextSentencer_T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
TextSentencer_T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.
T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.
T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Activation of human naïve Th cells increases surface expression of GD3 and induces neoexpression of GD2 that colocalize with TCR clusters.
T2 139-253 Sentence denotes CD4+ T helper lymphocytes (Th) orchestrate the immune response after their activation by antigen-presenting cells.
T3 254-388 Sentence denotes Activation of naïve Th cells is reported to generate the reduction in surface epitopes of sialic acid (Sia) in α2,3 and α2,6 linkages.
T4 389-694 Sentence denotes In this work, we report that in spite of this glycophenotype, anti-CD3/anti-CD28-activated purified human naïve Th cells show a significant increase in surface Sia, as assessed by metabolic labeling, compared with resting naïve Th cells, suggesting an increased flux of Sia toward Siaα2,8 glycoconjugates.
T5 695-976 Sentence denotes To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naïve Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).
T6 977-1345 Sentence denotes Also, we report that in contrast to GM2/GD2 synthase null mice, lentiviral vector-mediated silencing of the GM2/GD2 synthase in activated human naïve Th cells reduced efficient TCR clustering and downstream signaling, as assessed by proliferation assays and IL-2 and IL-2R expression, pointing to an important role of this enzyme in activation of human naive Th cells.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue glycosmos_id image
T1 67-70 Glycan denotes GD3 https://glycosmos.org/glycans/show/G98544DH https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 100-103 Glycan denotes GD2 https://glycosmos.org/glycans/show/G02657AK https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T3 872-875 Glycan denotes GD3 https://glycosmos.org/glycans/show/G98544DH https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 905-908 Glycan denotes GD2 https://glycosmos.org/glycans/show/G02657AK https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T5 1013-1016 Glycan denotes GM2 https://glycosmos.org/glycans/show/G79389NT https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T6 1017-1020 Glycan denotes GD2 https://glycosmos.org/glycans/show/G02657AK https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK
T7 1085-1088 Glycan denotes GM2 https://glycosmos.org/glycans/show/G79389NT https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT
T8 1089-1092 Glycan denotes GD2 https://glycosmos.org/glycans/show/G02657AK https://api.glycosmos.org/wurcs2image/latest/png/binary/G02657AK

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 14-19 OrganismTaxon denotes human 9606
T2 489-494 OrganismTaxon denotes human 9606
T3 811-816 OrganismTaxon denotes human 9606
T4 1035-1039 OrganismTaxon denotes mice 10088
T5 1115-1120 OrganismTaxon denotes human 9606
T6 1324-1329 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 153-164 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T2 954-960 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 153-164 Cell denotes lymphocytes http://purl.obolibrary.org/obo/CL:0000542
T2 954-960 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084