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PubMed:26260795 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-180 Sentence denotes Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris.
T2 181-328 Sentence denotes Pemphigus vulgaris (PV) is a life-long, potentially fatal IgG autoantibody-mediated blistering disease targeting mucocutaneous keratinocytes (KCs).
T3 329-530 Sentence denotes PV patients develop pathogenic anti-desmoglein (Dsg) 3 ± 1 and antimitochondrial antibodies (AMA), but it remained unknown whether and how AMA enter KCs and why other cell types are not affected in PV.
T4 531-639 Sentence denotes Therefore, we sought to elucidate mechanisms of cell entry, trafficking, and pathogenic action of AMA in PV.
T5 640-816 Sentence denotes We found that PVIgGs associated with neonatal Fc receptor (FcRn) on the cell membrane, and the PVIgG-FcRn complexes entered KCs and reached mitochondria where they dissociated.
T6 817-1080 Sentence denotes The liberated AMA altered mitochondrial membrane potential, respiration, and ATP production and induced cytochrome c release, although the lack or inactivation of FcRn abolished the ability of PVIgG to reach and damage mitochondria and to cause detachment of KCs.
T7 1081-1348 Sentence denotes The assays of mitochondrial functions and keratinocyte adhesion demonstrated that although the pathobiological effects of AMA on KCs are reversible, they become irreversible, leading to epidermal blistering (acantholysis), when AMA synergize with anti-Dsg antibodies.
T8 1349-1625 Sentence denotes Thus, it appears that AMA enter a keratinocyte in a complex with FcRn, become liberated from the endosome in the cytosol, and are trafficked to the mitochondria, wherein they trigger pro-apoptotic events leading to shrinkage of basal KCs uniquely expressing FcRn in epidermis.
T9 1626-1834 Sentence denotes During recovery, KCs extend their cytoplasmic aprons toward neighboring cells, but anti-Dsg antibodies prevent assembly of nascent desmosomes due to steric hindrance, thus rendering acantholysis irreversible.
T10 1835-2132 Sentence denotes In conclusion, FcRn is a common acceptor protein for internalization of AMA and, perhaps, for PV autoantibodies to other intracellular antigens, and PV is a novel disease paradigm for investigating and elucidating the role of FcRn in this autoimmune disease and possibly other autoimmune diseases.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1615-1624 http://purl.obolibrary.org/obo/MAT_0000154 denotes epidermis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
26260795-0#21#41#gene2217 21-41 gene2217 denotes Neonatal Fc Receptor
26260795-0#43#47#gene2217 43-47 gene2217 denotes FcRn
26260795-0#161#179#diseaseC0030809 161-179 diseaseC0030809 denotes Pemphigus Vulgaris
26260795-9#15#19#gene2217 1850-1854 gene2217 denotes FcRn
26260795-9#226#230#gene2217 2061-2065 gene2217 denotes FcRn
26260795-9#239#257#diseaseC0004364 2074-2092 diseaseC0004364 denotes autoimmune disease
26260795-9#277#296#diseaseC0004364 2112-2131 diseaseC0004364 denotes autoimmune diseases
26260795-9#239#257#diseaseC0004364 2074-2092 diseaseC0004364 denotes autoimmune disease
26260795-9#277#296#diseaseC0004364 2112-2131 diseaseC0004364 denotes autoimmune diseases
21#41#gene2217161#179#diseaseC0030809 26260795-0#21#41#gene2217 26260795-0#161#179#diseaseC0030809 associated_with Neonatal Fc Receptor,Pemphigus Vulgaris
43#47#gene2217161#179#diseaseC0030809 26260795-0#43#47#gene2217 26260795-0#161#179#diseaseC0030809 associated_with FcRn,Pemphigus Vulgaris
15#19#gene2217239#257#diseaseC0004364 26260795-9#15#19#gene2217 26260795-9#239#257#diseaseC0004364 associated_with FcRn,autoimmune disease
15#19#gene2217277#296#diseaseC0004364 26260795-9#15#19#gene2217 26260795-9#277#296#diseaseC0004364 associated_with FcRn,autoimmune diseases
15#19#gene2217239#257#diseaseC0004364 26260795-9#15#19#gene2217 26260795-9#239#257#diseaseC0004364 associated_with FcRn,autoimmune disease
15#19#gene2217277#296#diseaseC0004364 26260795-9#15#19#gene2217 26260795-9#277#296#diseaseC0004364 associated_with FcRn,autoimmune diseases
226#230#gene2217239#257#diseaseC0004364 26260795-9#226#230#gene2217 26260795-9#239#257#diseaseC0004364 associated_with FcRn,autoimmune disease
226#230#gene2217277#296#diseaseC0004364 26260795-9#226#230#gene2217 26260795-9#277#296#diseaseC0004364 associated_with FcRn,autoimmune diseases
226#230#gene2217239#257#diseaseC0004364 26260795-9#226#230#gene2217 26260795-9#239#257#diseaseC0004364 associated_with FcRn,autoimmune disease
226#230#gene2217277#296#diseaseC0004364 26260795-9#226#230#gene2217 26260795-9#277#296#diseaseC0004364 associated_with FcRn,autoimmune diseases

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 161-179 Disease denotes Pemphigus Vulgaris http://purl.obolibrary.org/obo/MONDO_0008219
T2 181-199 Disease denotes Pemphigus vulgaris http://purl.obolibrary.org/obo/MONDO_0008219
T3 201-203 Disease denotes PV http://purl.obolibrary.org/obo/MONDO_0008219
T4 329-331 Disease denotes PV http://purl.obolibrary.org/obo/MONDO_0008219
T5 527-529 Disease denotes PV http://purl.obolibrary.org/obo/MONDO_0008219
T6 636-638 Disease denotes PV http://purl.obolibrary.org/obo/MONDO_0008219
T7 1929-1931 Disease denotes PV http://purl.obolibrary.org/obo/MONDO_0008219
T8 1984-1986 Disease denotes PV http://purl.obolibrary.org/obo/MONDO_0008219
T9 2074-2092 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T10 2112-2131 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 161-170 OrganismTaxon denotes Pemphigus 13192
T2 181-190 OrganismTaxon denotes Pemphigus 13192

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 308-321 Body_part denotes keratinocytes http://purl.obolibrary.org/obo/CL_0000312
T2 323-326 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T3 478-481 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T4 712-725 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886
T5 764-767 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T6 857-865 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T9 1076-1079 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T10 1123-1135 Body_part denotes keratinocyte http://purl.obolibrary.org/obo/CL_0000312
T11 1210-1213 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T12 1383-1395 Body_part denotes keratinocyte http://purl.obolibrary.org/obo/CL_0000312
T13 1462-1469 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T14 1583-1586 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T15 1615-1624 Body_part denotes epidermis http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0007376
T17 1643-1646 Body_part denotes KCs http://purl.obolibrary.org/obo/CL_0000312
T18 1660-1671 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T19 1956-1969 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1615-1624 Body_part denotes epidermis http://purl.obolibrary.org/obo/MAT_0000154