> top > docs > PubMed:26260791 > annotations

PubMed:26260791 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.
T2 98-260 Sentence denotes The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility factor of late onset Alzheimer disease in genome-wide association studies.
T3 261-338 Sentence denotes ABCA7 has been shown to mediate phagocytosis and affect membrane trafficking.
T4 339-482 Sentence denotes The current study examined the impact of ABCA7 loss of function on amyloid precursor protein (APP) processing and generation of amyloid-β (Aβ).
T5 483-606 Sentence denotes Suppression of endogenous ABCA7 in several different cell lines resulted in increased β-secretase cleavage and elevated Aβ.
T6 607-704 Sentence denotes ABCA7 knock-out mice displayed an increased production of endogenous murine amyloid Aβ42 species.
T7 705-873 Sentence denotes Crossing ABCA7-deficient animals to an APP transgenic model resulted in significant increases in the soluble Aβ as compared with mice expressing normal levels of ABCA7.
T8 874-1068 Sentence denotes Only modest changes in the amount of insoluble Aβ and amyloid plaque densities were observed once the amyloid pathology was well developed, whereas Aβ deposition was enhanced in younger animals.
T9 1069-1221 Sentence denotes In vitro studies indicated a more rapid endocytosis of APP in ABCA7 knock-out cells that is mechanistically consistent with the increased Aβ production.
T10 1222-1403 Sentence denotes These in vitro and in vivo findings indicate a direct role of ABCA7 in amyloid processing that may be associated with its primary biological function to regulate endocytic pathways.
T11 1404-1599 Sentence denotes Several potential loss-of-function ABCA7 mutations and deletions linked to Alzheimer disease that in some instances have a greater impact than apoE allelic variants have recently been identified.
T12 1600-1791 Sentence denotes A reduction in ABCA7 expression or loss of function would be predicted to increase amyloid production and that may be a contributing factor in the associated Alzheimer disease susceptibility.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 78-85 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 196-224 Disease denotes late onset Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0007089
T3 406-413 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T4 467-474 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T5 683-690 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T6 928-935 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T7 976-983 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T8 1293-1300 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T9 1479-1496 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T10 1683-1690 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T11 1758-1775 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 207-224 Phenotype denotes Alzheimer disease HP:0002511
T2 1479-1496 Phenotype denotes Alzheimer disease HP:0002511
T3 1758-1775 Phenotype denotes Alzheimer disease HP:0002511

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 623-627 OrganismTaxon denotes mice 10088
T2 834-838 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 317-325 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 936-942 Body_part denotes plaque http://purl.obolibrary.org/obo/UBERON_0016482