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PubMed:26260789 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody.
T2 144-309 Sentence denotes The efficacy of engaging multiple drug targets using bispecific antibodies (BsAbs) is affected by the relative cell-surface protein levels of the respective targets.
T3 310-514 Sentence denotes In this work, the receptor density values were correlated to the in vitro activity of a BsAb (JNJ-61186372) targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-MET).
T4 515-589 Sentence denotes Simultaneous binding of the BsAb to both receptors was confirmed in vitro.
T5 590-828 Sentence denotes By using controlled Fab-arm exchange, a set of BsAbs targeting EGFR and c-MET was generated to establish an accurate receptor quantitation of a panel of lung and gastric cancer cell lines expressing heterogeneous levels of EGFR and c-MET.
T6 829-997 Sentence denotes EGFR and c-MET receptor density levels were correlated to the respective gene expression levels as well as to the respective receptor phosphorylation inhibition values.
T7 998-1208 Sentence denotes We observed a bias in BsAb binding toward the more highly expressed of the two receptors, EGFR or c-MET, which resulted in the enhanced in vitro potency of JNJ-61186372 against the less highly expressed target.
T8 1209-1392 Sentence denotes On the basis of these observations, we propose an avidity model of how JNJ-61186372 engages EGFR and c-MET with potentially broad implications for bispecific drug efficacy and design.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 743-747 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 752-766 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 752-766 Phenotype denotes gastric cancer HP:0012126

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 82-98 Body_part denotes Epidermal Growth http://purl.obolibrary.org/obo/UBERON_0000021
T2 428-444 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T3 472-482 Body_part denotes hepatocyte http://purl.obolibrary.org/obo/CL_0000182
T4 614-617 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460|http://purl.obolibrary.org/obo/UBERON_0003822
T6 743-747 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 743-747 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 472-482 Cell denotes hepatocyte http://purl.obolibrary.org/obo/CL:0000182
T2 760-771 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064